| Studies on the Changes of Serum Osmolality Electrolytes, Digoxin-like Substance and Plasma Renin Activity Following Angiocardiography using Hypertonic Contrast Media. |
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Heon Seob Song, Hyeong Won Shin, Chan Uhung Joo, Dae Yeol Lee, Jin Gon Jun |
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Department of Pediatrics, Chonbuk National University Medical School |
| 심혈관 조영술에 따른 혈청 Osmolality，전해질，Digoxin-like substance 및 혈장 Renin 활성도의 변동
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송헌섭, 신형원, 주찬웅, 이대열, 김정수 |
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전북대학교 의과대학 소아과학교실 |
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| Abstract |
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Angiocardiography and cineangiocardiography have been employed with increasing frequency for
the diagnosis of cardiovascular diseases. These commonplace technics of cardiovascular radiology
depend upon the rapid injection of hypertonic contrast media into the heart or central circulation.
In order to study the effects of concentrated radiopaque materials(Conray®, 1382 mOsm/L, 1-2 ml/
kg) on hemodynamic consequences, the changes of serum osmolality, sodium, potassium, chloride,
digoxin-like substance and plasma renin activity were evaluated during angiocardiography on 25
cases of congenital heart disease. Blood samples were obtained before and 1, 5, 10, 15 minutes after
angiocardiography.
The results were as follows:
1) Serum osmolality was significantly increased until 5 minutes after angiocardiography(p < 0.05).
2) Serum sodium and hematocrit values were also significantly decreased until 1 minute after
angiocardiography(p < 0.05), while serum potassium and chloride values were not.
3) The values of plasma renin activity were slightly decreased without significance(p > 0.05).
4) Digoxin-like substance was only detected in the patients administrated digoxin and was not
detected at all in the patients not administrated digoxin.
These results suggest that it is safe to wait at least 5 minutes until hemodynamic changes have
returned to the preangiocardiographic level before proceeding with another injection.
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| Key Words:
Angiocardiography, Digoxin-like substance, Plasma renin activity, Hypertonic contrast media. |
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