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Original Article
A case of primary hepatocellular carcinoma following vertical transmission of hepatitis B virus in a child.
Soo Kyoung Lee, Ki Sup Chung, Sun Won Hong, Chan Il Park
Clin Exp Pediatr. 1991;34(11):1573-1580.   Published online November 30, 1991
Authors experienced a case of primary hepatocellular carcinoma in a 7 year 9 month old male patient, who was admitted to our hospital due to abdominal pain on right upper quadrant and anorexia during last two months. On family history, his mother was HBs Ag and HBe Ag carrier. On past history, he was admitted to a hospital due to persistant jaundice at...
Epidemics of aseptic meningitis in Seoul area during 1989-90.
Eun young Cho, Mi Koo Kang, Soo Jong Hong, Ki Soo Kim, Young Seo Park, In Sook Park, Hyung Nam Moon, Chang Yee Hong
Clin Exp Pediatr. 1991;34(11):1565-1572.   Published online November 30, 1991
We performed clinical and virological studies on 200 children with aseptic meningitis who had been admitted to the department of Pediatrics, Asan Medical Center from June, 1989 to August, 1990. The results were as follows; 1) There were total of 236 meningitis cases during this period, 13(5.5%) with bacterial meningitis, 3(1%) with tuberculous meningitis, 220(93.2%) with aseptic meningitis. Am이lg aseptic meningitis, 20(8.5%) were mumps meningitis. 2) Aseptic meningitis...
Clinical studies of aseptic meningitis.
Kang Woo Park, Dae Young Choi, Sung Won Kim
Clin Exp Pediatr. 1991;34(10):1400-1408.   Published online October 31, 1991
Fifty-six cases of aseptic meningitis were clinically observed from Jan., 1990 to Aug., 1990. Etiologic classification showed that 53cases (94.6%) were of unknown etiology because virus was not identified and 3 cases (5.4%) were mumps meningitis. The most frequent age group was early childhood (55.4%) and more frequent in male. The symptoms were fever, vomiting and headache in order of frequency. The finding of spinal...
A case of transient diabetes mellitus and diabetic ketoacidosis induced by L-asparaginase and prednisolone administration in a patient with relapsed acute lymphocytic leukemia.
Won Kyu Choi, Mee Kyung Namgoong, Har Yong Lee, Hwang Min Kim, Jong Soo Kim
Clin Exp Pediatr. 1991;34(9):1316-1322.   Published online September 30, 1991
L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase and prednisolone are hypersen- sitivity reaction, hepatotoxicity, pancreatitis and transient diabetes mellitus, CNS toxicity, disorder of coagulation system and mild cytotoxicity. We experienced a case of transient diabetes mellitus and diabetic ketoacidosis induced by L- asparaginase, prednisolone, vincristine and MTX administration in...
Immune response induced by live attenuated varicella vaccine(Biken@) in children with acute lymphoblastic leukemia.
Hyo Seop Ahn, Joong Gon Kim
Clin Exp Pediatr. 1991;34(9):1255-1260.   Published online September 30, 1991
To determine the safety and efficacy of varicella vaccine, we studied 10 healthy children and 12 children in remission from acute lymphoblastic leukemia. They were immunized with the Oka strain of live attenuated varicella vaccine (Biken®). All the healthy children and 6 children with leukemia received the vaccine of 1,000 plaque-forming units (PFU), and 6 leukemic children received the vaccine of 500 PFU. The...
A case of bone marrow necrosis in acute lymphoblastic leukemia.
Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(8):1163-1168.   Published online August 31, 1991
Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke- mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections. Recently it is regarded as a more common finding frequently overlooked and carrying not so poor prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of diagnosis and achieved complete...
The diagnosis of mycoplasma pneumoniae pneumonia by high density composite particles agglutinin test.
Hae Jin Choeh, Jung Hae Park, Chong Sung Chung, Kyu Chul Choeh
Clin Exp Pediatr. 1991;34(8):1102-1109.   Published online August 31, 1991
In a prospective investigation of 21 chi Idem 3 years of age or more with Mycoplasma pneumoniae pneumonia, we analyzed the diagnostic efficacy of High Density Composite Particles Agglutinin(HDDA) test comparing with cold agglutinin tests and clinical findings. The results obtained were as followed. 1) Among 24 total cases, the number of cases showing positive reaction to HDPA and to cold agglutination test were 17 and...
Observation on neurocysticercosis in childhood.
Hae Jung Park, Seong Hee Jang, Se Hee Hwang, Jae Il Sohn, Yong Seung Hwang, Kyu Chang Wang, Byug Kyu Cho, In One Kim, Kyung Mo Yeun, Je Geun Chi, Seung Yull Cho
Clin Exp Pediatr. 1991;34(6):877-889.   Published online June 30, 1991
A clinical study was performed on 5 patients of neurocysticercosis in childhood who admitted to the Seoul National University Hospital for the last two years. The conclusions were as follows: 1) Boys were more than girls with the ratio of 4:1. The average age was 9.5. 2) Three out of five lived in Jeju Island. Three had familial history of taeniasis. 3) Three out of five were...
One case of hereditary spherocytosis with aplastic crisis.
Kee Young Park, Ho Kyung Choi, Jong Jin Seo, Keon Su Rhee, Yong Hun Chung
Clin Exp Pediatr. 1991;34(6):843-848.   Published online June 30, 1991
We experienced one case of hereditiary spherocytosis with aplastic crisis who was 3 year-old female. On admission, there were pallor and fever. Diagnosis was made by pressence of spherocytes in peripheral blood smear, osmotic fragility test, and bone marrow examination. A brief review of related literature was made.
A case of pancytopenia associated with mycoplasmal pneumonia.
Young Mee Yoo, Beom Soo Park, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn, Se Jung Sohn
Clin Exp Pediatr. 1991;34(6):826-831.   Published online June 30, 1991
Mycoplasma pneumoniae infection is manifestated as pneumonia and extra-pulmonary symptoms such as hematologic, neurologic, gastrointestinal, musculoskeletal, dermatologic and cardiac manifes- tations. Among the hematologic changes, hemolytic anemia is most frequently seen. Throm- bocytopenic purpura, lymphocytosis or rarely lymphopenia, elevated erythrocyte sedimentation rate, positive direct Coombs test, reticulocytosis and DIC are known hematologic features. This 12 years old female patient was presented with pneumonia and pancytopenia....
Re-evaluation of the indication for renal biopsy in childhood nephrotic syndrome.
Eun Kyoung Sohn, Byung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1991;34(6):805-811.   Published online June 30, 1991
Renal biopsy is indicated in nephrotic syndrome when histopathologic types other than minimal change pattern or the secondary nephrotic syndrome are suspected. But renal biopsy in children has some limitation because of the technical problem. In order to assess the clinicopathologic correlation and to re-evaluate the biopsy indication, the clinical manifestations and histopathologic types were analyzed statisically on the 86 cases of childhood nephrotic syndrome...
Diagnosis and hydrostatic saline reduction of intussusception under ultrasonographic guidance.
Jong Yul Jeon, Jae Yun Kim, Chong Woo Bae, Sung Ho Cha, Chang Il Ahn, Sun Wha Lee, Jae Hoon Lim
Clin Exp Pediatr. 1991;34(6):771-778.   Published online June 30, 1991
Recently, a new technique of reduction for intussusception using saline solution and ultrasonogram instead of barium enema is being used in several centers. In order to evaluate its efficacy, we have conducted the clinical observation in 40 patients with intussusception who were treated by hydrostatic saline reduction under the ultrasonographic guidance in Kyung-Hee University Hospital from June 1989 to July 1990. We have observed...
A case of acute lymphoblastic leukemia complicating neuroblastoma in remission.
Dong Woo Son, Bum Soo Park, Jun Jae Kim, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(5):720-729.   Published online May 31, 1991
As childhood cancer survivors are now increasing in number owing to the improvements in diagnosis, staging, and treatment, concerns have been raised regarding the quality of survival of these patients. One of the limitation to quality and length of survival has been the development of second malignant neoplasm (SMN). In Korea, only one case of SMN has been reported. However, one can expect that...
Clinical analysis and prognostic factors in Henoch-Schonlein purpura .
Ha Young Lee, Chong Sung Chung, Kyu Chul Choeh, Byoung Soo Cho, Young Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1991;34(5):682-690.   Published online May 31, 1991
This study was undertaken to evaluate the prognostic factors of recurrence and renal involvement in Henoch-Sch公nlein purpura. Total 110 cases of anaphylactoid purpura below 15 years of age who admitted to Pediatric Departmen of Kyung Hee University for 8 years from January 1st 1979 to December 31st 1986 were analyzed clinically and statistically. The results were obtained as follows. 1) The peak incidence of age was 4...
A case of histiocytic necrotizing lymphadenitis.
Jin Kuk Kim, Jong Bum Shin, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1991;34(4):582-586.   Published online April 30, 1991
We experienced a case of histiocytic necrotizing lymphadenitis in a 10-year old male child with complaints of high fever and painful swelling on right cervical area for 11 days. The diagnosis was based on histopathologic findings of right cervical lymph node, clinical features and laboratory findings. A review of literatures was also presented briefly.
A case of hypomelanosis of Ito accompanying ureteral duplication and hypomelanotic scalp hair.
Dong Woo Son, Beom Soo Park, Heon Seok Han, Hae Il Jung, Yong Choi, Hyung Ro Moon, Seon Hoon Kim, Hwang Choi
Clin Exp Pediatr. 1991;34(2):281-286.   Published online February 28, 1991
Hypomelanosis of Ito (incontinentia pigmenti achromians) is a cutaneous abnormality consisting of bizarre, whorly, linear, or patchy hypopigmentation over variable portion of body surface. Multiple assocaited defects in other systems occur in three quarters of the affected individuals. Most common- ly, the central nervous system, eye, and musculoskeletal structures are involved. It is suggested that the cutaneous abnormality, which is often detectable at birth...
Prevalence of asymptomatic hematuria, proteinemia and glucosuria in primary school children in Chonju area.
Jin Oh Kim, Joseph Choi, Soo Cheol Cho, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1991;34(2):223-229.   Published online February 28, 1991
The present study was performed to define the prevalene of asymptomatic hematuria, proteinuria,and glucosuria. A total of 5011 primary school children in Chonju city were examined with test strip urinalysis during the period of one month from June to July 1989. Test strip (Hema-Combistix) was used in this examination. The results were as. follows: 1) Prevalence of hematuria, proteinuria and glucosuria were 0.8% (40 children), 0.78%...
Upper gastrointestinal diseases diagnosed by upper gastrointestinal fiberoptic endoscopy in children.
Jong Moon Hwang, Pal Dong Kim, Tae Won Paik, Chin Moo Kang
Clin Exp Pediatr. 1991;34(2):217-222.   Published online February 28, 1991
A clinical analysis was carried out on 83 cases of upper gastrointestinal diseases, diagnosed by fiberoptic endoscopic examination in children, who had visited the department of pediatrics, Keimyung University, Dong San Hospital from January 1980 to June 1987. Following results were obtained: Out of 83 cases, 61 (73.5%) were between 11-15 years of age and the male to female ratio was 3. 6:1. The disease distribution...
Treatment of severe aplastic anemia: comparison between bone marrow transplantation and immunomodulation.
Dae Chul Jeong, Sung Dong Choi, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Du Bong Lee
Clin Exp Pediatr. 1991;34(2):172-179.   Published online February 28, 1991
Twenty, six children younger than 15 years with severe aplastic anemia underwent either bone marrow transplantation or immunomodulation therapy (antilymphocyte globulin with cyclosporin A therapy). Six patients who had an HLA-identical sibling donor underwent bone marrow transplantation after conditioning with cyclophosphamide, procarbazine and antilymphocyte globulin. Twenty children who did not have an HLA-identical donor recieved antilymphocyte globulin and cyclosporin A. The results were as follows; 1) Hematologic responses:...
Adrenocortical carcinoma in a twelve month old male infant.
Woo Ryoung Lee, Kyoung Whan Oh, Chang Hwi Kim, Sang Jhoo Lee
Clin Exp Pediatr. 1991;34(1):137-143.   Published online January 31, 1991
Adrenocortical carcinoma is a rare disease in childhood. Most of these carcinomas are functional, produc- ing endocrine abnormalities such as Cushing syndrome, virilization, precocious puberty, hyperaldosteronism or feminization. We experienced a case of adrenocortical carcinoma in a 12 month old male infant who exhibited features of Cushing syndrome, Virilization, precocious puberty and hyperaldosteronism, which were due to functional adrenocortical carcinoma. Microscopic examination revealed cellular pleomorphism...
Transient symptomatic zinc deficiency in a breast-fed, post term infant.
Jin Bok Hwang, Soon Young Song, Woo Hyun Kwon, Chang Ho Han, Hye Li Chung, Young Dae Kwon
Clin Exp Pediatr. 1991;34(1):101-106.   Published online January 31, 1991
Acrdermititis enteropathica is a rare autosomal recessive disorder of zinc absorption and its cardinal symptoms appear at the time of weaning from breast milk which has been referred to as most appropriate formula to prevent and treat this disease. However, recent reports presented Transient Symptomatic Zinc deficiency (TSZD) in infants fed breast milk whom they treated with transitory zinc supplement with no recurrence. We experienced...
A case of congenital lactic acidosis.
Suk Min Choi, Myeong Ku Cho, Dong Hwan Lee, Sang Jhoo Lee, Kikumaro Aoki, Shuichi Yamaguchi
Clin Exp Pediatr. 1991;34(1):95-100.   Published online January 31, 1991
The congenital lactic acidosis represent a sizable group of metabolic disorders. They are in all likelihood genetically determined, and they are clearly heterogenous. They may be considered broadly as disorders of pyruvate metabolism in which there are two general categories: defects in gluconeogenesis and defects in pyruvate oxidation. We experienced a case of congenital lactic acidosis in neonate who was diagnosed by urinary organic acid...
A Case of Hypohydrotic Ectodermal Dysplasia.
Chun Oh Lee, Byung Min Moon, Young Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 1990;33(12):1718-1722.   Published online December 31, 1990
Hypohidrotic ectodermal dysplasia is a group of disorders characterized characterized by faulty development of ectodermal structures including the skin, teeth, skin appendages, resulting in hypohi- drosis, hypotrichosis, and abnormal dentition. Here, we report a case of typical hypohidrotic ectodermal dysplasia in a 16-month-old male who had unexplained recurring fever, hypohidrosis, hypotrichosis, anodontia, and characteristic facial features.
A Case of Diabetic Ketoacidosis Associated with Acute Lymphocytic Leukemia during Remission Induction Chemotherapy.
Gyu Jin Oh, Hwa Jeong Lee, Heui Jeong Kwon, In Sil Lee
Clin Exp Pediatr. 1990;33(11):1598-1603.   Published online November 30, 1990
L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase are hypersensitivity reaction, hepatotoxicity, pancreatitis, transient diabetes mellitus, CNS toxicity, disorders of coagulation system and mild cytotoxicity. We report a female patient with acute lymphocytic leukemia develop- ing diabetic ketoacidosis during induction chemotherapy with L-asparaginase, parednisolone, vincris- tine and intrathecal methotrexate, who...
A Case of Interrupted Aortic Arch.
Yeong Sook Kang, Sun Hee Jung, Tae Chan Kwon, Chin Moo Kang, Seok Kil Zeon, Kwang Sook Lee, Yeong Sun Yoo
Clin Exp Pediatr. 1990;33(11):1579-1585.   Published online November 30, 1990
Interrupted aortic arch is a congenital anomaly in which discontinuity is present between ascending and descending aorta, and is associated frequently with ventricular septal defect and patent ductus arteriosus. Authors experienced a case of interrupted aortic arch in a 4 year old boy associated with a ventriculalr septal defect and patent ductus arteriosus. Diagnostic confirmation was made by 2-D echocardiography, cardiac cathetrization and angiogra- phy. Direct closure...
Cardiac Tumor in Children.
Eun Jung Bae, Young Hwue Kim, Jung Yun Choi, Yong Seung Hwang, Hyo Seop Ahn, Yong Soo Yun
Clin Exp Pediatr. 1990;33(11):1540-1547.   Published online November 30, 1990
Primary cardiac tumor is very rare and has been a medical curiosity but is potentially curable by current management with improvements of the imaging apparatus and the surgical technique. Metastatic cardiac tumor is also very rare and is more difficult to diagnose than primary ones because of lack of specific symptoms. Twelve cases of cardiac tumor, collected from 1978 to 1989 at the Department...
Statistical Survey on Pediatric patients admitted to Kwangju Christian Hospital during 5 years.
Song Nyeon Choi, Young Hee Chung, Young Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 1990;33(11):1479-1488.   Published online November 30, 1990
We made a statistical survey on the patients admitted to the Department of Pediatrics of Kwangju Christian Hospital during the past 5 years from Jan. 1984 to Dec. 1988 The results were as follows: 1) The pediatric inpatients during the period totaled 16,119, of which 10,020 were male, with the sex ratio being 1.6:1. 2) Pediatric patients amounted to 17.8% of all admission cases of Kwangju Christian...
A Case of Acute Megakaryoblastic Leukemia in infantwith down Syndrome.
Jang Sik Moon, Hae Young Hwang, Sejung Sohn, Hak Soo Lee, Heum Rye Park
Clin Exp Pediatr. 1990;33(10):1441-1446.   Published online October 31, 1990
Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have more than relationship to it. The authors report a case of acute megakaryoblastic leukemia in a 17 day-old male patient who was admitted for evaluation of high fever and dyspnea. The infiltration of atypical megakaryocytes...
One Case of Recovery Phase of Aplastic Crisis in Hereditary Spherocytosis with Family History.
Eun Kyung Won, Dong Hyeon Kim, Ho Seung, Chang Hee Choi
Clin Exp Pediatr. 1990;33(10):1434-1440.   Published online October 31, 1990
We experienced a case of hereditary spherocytosis patient who was in a recovery phase of aplastic crisis at the time of presentation. This was a 7 years old boy with complaints of pallor and intermit- tent abdominal pain. Asymptomatic jaundice was also found in the patient's grandfather and two maternal uncles. Patient’s mother had splenectomy due to hereditary spherocytosis. Diagnosis was made by morphology,...
A Case of Arthrogryposis Multiplex Congenita in Identical Twin.
Chang Il An, Byeong Gu Min, Kyeng Sook Cho, Jong Dai Jo
Clin Exp Pediatr. 1990;33(10):1429-1433.   Published online October 31, 1990
Arthrogryposis Multiplex Congenita is a very rare disease of persistent joint abnormalities present at birth. We experienced a case of arthrogryposis multiplex congenita in identical twin, and a review of literature was made.
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