Journal of the Korean Pediatric Society 1990;33(10):1441-1446.
Published online October 31, 1990.
A Case of Acute Megakaryoblastic Leukemia in infantwith down Syndrome.
Jang Sik Moon1, Hae Young Hwang1, Sejung Sohn1, Hak Soo Lee1, Heum Rye Park2
1Department of Pediatrics, Gil General Hospital, Inchon, Korea
2Department of Pathology, Gil General Hospital, Inchon, Korea
Down 증후군과 동반된 급성 거핵아구성 백혈병 1례*
문종식1, 황혜영1, 손세정1, 이학수1, 박흠례2
1중앙길병원 소아과
2중앙길병원 병리과
Received: 24 April 1990   • Accepted: 9 July 1990
Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have more than relationship to it. The authors report a case of acute megakaryoblastic leukemia in a 17 day-old male patient who was admitted for evaluation of high fever and dyspnea. The infiltration of atypical megakaryocytes into multiple organs was confirmed on autopsy, and 21 trisomy with Philadelphia chromosome was revealed by the chromosomal analysis.
Key Words: Acute Megakaryoblastic Leukemia, Down Syndrome

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