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Original Article
Cardiology
Differentiation between incomplete Kawasaki disease and secondary hemophagocytic lymphohistiocytosis following Kawasaki disease using N-terminal pro-brain natriuretic peptide
Jung Eun Choi, Yujin Kwak, Jung Won Huh, Eun-Sun Yoo, Kyung-Ha Ryu, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2018;61(5):167-173.   Published online May 28, 2018
Purpose

Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome with many causes, including Kawasaki disease (KD). The purpose of this study was to identify the laboratory tests needed to easily differentiate KD with HLH from incomplete KD alone.

Methods

We performed a retrospective study on patients diagnosed with incomplete KD and incomplete KD with HLH (HLH-KD) between January 2012 and March 2015. We compared...

C-reactive protein and N-terminal pro-brain natriuretic peptide discrepancy: a differentiation of adenoviral pharyngoconjunctival fever from Kawasaki disease
Jung Eun Choi, Hee Won Kang, Young Mi Hong, Sejung Sohn
Clin Exp Pediatr. 2018;61(1):12-16.   Published online January 22, 2018
Purpose

To differentiate adenoviral pharyngoconjunctival fever (PCF) from acute Kawasaki disease (KD) using laboratory tests before results of virus-real time polymerase chain reaction and ophthalmologic examination are obtained.

Methods

Baseline patient characteristics and laboratory measurements were compared between 40 patients with adenovirus infection and 123 patients with KD.

Results

The patients with adenovirus infection were generally older than those with KD (median: 3.9 years vs....

Uveitis as an important ocular sign to help early diagnosis in Kawasaki disease
Han Seul Choi, Seul Bee Lee, Jung Hyun Kwon, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2015;58(10):374-379.   Published online October 21, 2015
Purpose

Incomplete Kawasaki disease (KD) is frequently associated with delayed diagnosis and treatment. Delayed diagnosis leads to increasing risk of coronary artery aneurysm. Anterior uveitis is an important ocular sign of KD. The purpose of this study was to assess differences in laboratory findings, including echocardiographic measurements, clinical characteristics such as fever duration and treatment responses between KD patients with and...

Clinical characteristics and serum N-terminal pro-brain natriuretic peptide as a diagnostic marker of Kawasaki disease in infants younger than 3 months of age
Hyun Kyung Bae, Do Kyung Lee, Jung Hyun Kwon, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2014;57(8):357-362.   Published online August 25, 2014
Purpose

The incidence of Kawasaki disease (KD) is rare in young infants (less than 3 months of age), who present with only a few symptoms that fulfill the clinical diagnostic criteria. The diagnosis for KD can therefore be delayed, leading to a high risk of cardiac complications. We examined the clinical characteristics and measured the serum levels of N-terminal pro-brain natriuretic...

An inhibitory effect of tumor necrosis factor-alpha antagonist to gene expression in monocrotaline-induced pulmonary hypertensive rats model
Jung Hyun Kwon, Kwan Chang Kim, Min-Sun Cho, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2013;56(3):116-124.   Published online March 18, 2013
Purpose

Tumor necrosis factor (TNF)-α is thought to contribute to pulmonary hypertension. We aimed to investigate the effect of infliximab (TNF-α antagonist) treatment on pathologic findings and gene expression in a monocrotaline-induced pulmonary hypertension rat model.

Methods

Six-week-old male Sprague-Dawley rats were allocated to 3 groups: control (C), single subcutaneous injection of normal saline (0.1 mL/kg); monocrotaline (M), single subcutaneous injection of monocrotaline...

Mycoplasma pneumoniae infection in patients with Kawasaki disease
Mi Na Lee, Jie Hae Cha, Hye Mi Ahn, Jeong Hyun Yoo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2011;54(3):123-127.   Published online March 31, 2011
Purpose

Kawasaki disease (KD) is the main cause of acquired heart disease in children. In addition to cardiovascular involvement, many complications have been recognized in KD. However, respiratory complications have been rarely reported. We investigated the differences in clinical characteristics, laboratory findings, radiography findings, and echocardiography findings of Mycoplasma pneumoniae infection and other types of pneumonia in KD patients.

Methods

Among 358 patients...

Serum interleukin-6, tumor necrosis factor-α and adiponectin levels in Kawasaki disease
Jung Ahn, Han Gyu Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2010;53(1):41-47.   Published online January 15, 2010
Purpose : Adiponectin is an endogenous modulator of vascular remodeling that suppresses vascular inflammation. However, the role of adiponectin in Kawasaki disease (KD) has not been elucidated. The purpose of this study is to investigate the correlation between serum adiponectin level and several parameters, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, lipid profile, and C reactive protein (CRP), and...
Low T3 syndrome in Kawasaki disease: Relation to serum levels of tumor necrosis factor-α, interleukin-6 and NT-proBNP
Hye Kyung Cho, Jin A Sohn, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2009;52(2):234-241.   Published online February 15, 2009
Purpose : We investigated the relationship between thyroid hormone and serum tumor necrosis factor (TNF-α), interleukin (IL-6) and N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) in patients with Kawasaki disease (KD). Methods : Serum levels of thyroid hormone, TNF-α, IL-6, and NT-proBNP were measured in 52 KD patients in the acute and subacute phase and 10 patients with acute...
Bacterial meningitis in children experienced at a university hospital, 1993-2006
Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
Clin Exp Pediatr. 2008;51(10):1077-1084.   Published online October 15, 2008
Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea. Methods : The medical records containing the data on bacterial meningitis patients...
Case Report
Kawasaki disease presenting as retropharyngeal abscess
Sung Yoon Cho, Hye Kyung Cho, Ky Young Cho, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2008;51(9):1023-1027.   Published online September 15, 2008
A group of patients with Kawasaki disease (KD) initially present with cervical lymphadenitis or deep neck infection. These unusual KD presentations lead to unnecessary antibiotic therapy or surgical intervention, thereby delaying intravenous immunoglobulin treatment and increasing the risk of coronary artery damage. We present four KD patients whose initial presentations mimicked a retropharyngeal abscess. Nonsuppurative cervical lymphadenitis or suspected neck...
Original Article
The pharmacological treatment of patent ductus arteriosus in premature infants with respiratory distress syndrome: oral ibuprofen vs. indomethacin
Soo Jin Lee, Ji Young Kim, Eun Ae Park, Sejung Sohn
Clin Exp Pediatr. 2008;51(9):956-963.   Published online September 15, 2008
Purpose : Indomethacin is widely used for the prophylaxis and treatment of patent ductus arteriosus (PDA); however, it is associated with side effects such as renal failure, intraventricular hemorrhage, and gastrointestinal bleeding. Intravenous ibuprofen has been shown to be as effective as indomethacin in prompting PDA closure. If treatment with oral ibuprofen is as effective as indomethacin, it would have...
Case Report
Bronchial foreign body aspiration diagnosed with MDCT
Hye Kyung Cho, Ky Young Cho, Sung Yoon Cho, Sejung Sohn
Clin Exp Pediatr. 2007;50(8):781-784.   Published online August 15, 2007
Foreign body aspiration (FBA) is a common accident in young children. Undiagnosed and retained foreign bodies may result in severe early and late complications such as asphyxia, pneumonia, atelectasis and bronchiectasis. Moreover, because it can mimic bronchiolitis, croup or asthma, an accurate history and a high index of suspicion are of paramount importance for early diagnosis. With our experience on...
Original Article
Clinical fetures of kawasaki disease in school-aged children
Eun Young Park, Ji Hye Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2007;50(3):292-297.   Published online March 15, 2007
Purpose : Kawasaki disease (KD) rarely occurs in school-aged children. We clarified the characteristics of KD in this age group to provide tips for a high index of suspicion. Methods : Features of 38 patients with KD who were 7 years of age or older were retrospectively reviewed. Results : The incidence of the KD patients ≥7 years was 4.9 percent. The...
Case Report
Infliximab treatment for a patient with refractory Kawasaki disease
Hyo-Jung Yu, Soo-Jin Lee, Sejung Sohn
Clin Exp Pediatr. 2006;49(9):987-990.   Published online September 15, 2006
Intravenous immunoglobulin (IVIG) infusion is an effective therapy for acute Kawasaki disease (KD). Nonetheless, approximately 10 percent to 20 percent of patients have persistent or recrudescent fever despite IVIG treatment, leading to a higher risk for coronary artery aneurysms (CAA). This unresponsiveness may pose a challenge to the clinicians. Tumor necrosis factor-α levels are elevated in the acute phase of...
Original Article
NT-pro BNP : A new diagnostic screening tool for Kawasaki disease
Hyunju Lee, Heejung Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2006;49(5):539-544.   Published online May 15, 2006
Purpose : The purpose of this study was to determine whether N-terminal fragment of B-type natriuretic peptide(NT-proBNP) may be used to differentiate acute Kawasaki disease(KD) from other clinically similar diseases. Methods : Using electrochemiluminescence immunoassay, NT-proBNP concentrations were measured in the acute phase within 10 days after the onset of KD(n=58) and in the convalescent phase, 60 to 81 days after...
Clinical Characteristics of Recurrent Kawasaki Disease
Hyun Ji Lee, Ae Ra Cho, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2004;47(8):879-883.   Published online August 15, 2004
Purpose : The purpose of this study is to investigate the clinical manifestations and the risk factors of recurrent Kawasaki disease(KD). Methods : From March 1995 to June 2003, 14 children with recurrent KD in Ewha Womans University Hospital were retrospectively evaluated by reviewing their admission reports. The clinical characteristics, laboratory findings, treatment and complications of the recurrent KD group were...
Methylenetetrahydrofolate Reductase(MTHFR) Gene Expression in Kawasaki Disease
Hye Ryung Choi, Ae Ra Joo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2004;47(7):774-778.   Published online July 15, 2004
Purpose : Hyperhomocysteinemia is known as an independent risk factor for cardiovascular diseases such as atherosclesosis and myocardiac infarct. A common mutation in 5, 10-methylenetetrahydrofolate reductase(MTHFR) gene results in a valine for alanine substitution, which makes enzyme thermolabile and reduces enzymal activity. We examined the relation of MTHFR genetic mutation and Kawasaki disease. Methods : We extracted DNA from the peripheral...
Safety and Efficacy of Early Treatment with Intravenous Immunoglobulin in Patients with Kawasaki Disease
Hyun Jin Kim, Hae Won Yom, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2003;46(10):1019-1023.   Published online October 15, 2003
Purpose : To determine the differences in clinical characteristics, blood chemistry and coronary artery complications between patients with Kawasaki disease who received intravenous immunoglobulin (IVIG) within the fourth day of illness and after the fifth day of illness. Methods : A retrospective chart review was conducted of all children with Kawasaki disease who were admitted to Ewha Mokdong Hospital between January...
Clinical Characteristics of Kawasaki Disease in Infants Younger than 3 Months of Age
Soo Jeong Lee, So Jung Kim, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2003;46(6):591-596.   Published online June 15, 2003
Purpose : Kawasaki disease(KD) is rare in infants <3 months of age. In this younger group, the diagnosis may be delayed due to lack of most of the clinical criteria, resulting in a high risk of cardiac complications. We examined clinical characteristics in these patients for early recognition and treatment. Methods : We conducted a retrospective study on the infants...
Case Report
A Case of Kawasaki Disease Associated with Acute Renal Failure and Necrotizing Myositis
So Hyun Ahn, So Yun Shim, Sejung Sohn, Seung Joo Lee, Un Seop Han
Clin Exp Pediatr. 2003;46(2):207-209.   Published online February 15, 2003
Kawasaki disease is an acute febrile vasculitis affecting primarily infants and young children. In addition to the cardiovascular involvement, it may cause inflammatory changes in various organs and body systems : digestive, respiratory, urinary, nervous and musculoskeletal. A case is reported of atypical Kawasaki disease associated with acute renal failure and necrotizing myositis in the right gastrocnemius in a 10-year-old...
Original Article
Usefulness of Low Risk Criteria for Serious Bacterial Infection Among Febrile Infants Younger than Three Months of Age
So Hyun Kim, Ji Ah Jung, Hae-Soon Kim, Eun Sun Yoo, Sejung Sohn, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 2002;45(8):967-972.   Published online August 15, 2002
Purpose : A retrospective study was undertaken to evaluate the usefulness of low risk criteria for identifying febrile infants younger than three months unlikely to have serious bacterial infection. Methods : We conducted a retrospective study of 527 infants younger than three month with a axillary temperature ≥37.4℃. If they met the following all four criteria, appear well, WBC 5,000- 20,000/mm3,...
Clinical Features of Atypical Kawasaki Disease
Mi Young Heo, Su Jung Choi, Hae Soon Kim, Sejung Sohn
Clin Exp Pediatr. 2002;45(3):376-382.   Published online March 15, 2002
Purpose : To identify clinical and laboratory features of atypical Kawasaki disease(KD), and to develop criteria for early diagnosis of atypical KD patients. Methods : All patients with KD treated at our hospital from January 1998 to June 2000 were reviewed retrospectively. Results : Among a total of 167 patients, 28(16.8%) were atypical KD of which seven(25%) were infants. Among the...
Effects of Umbilical Arterial Catheterization on Intestinal Hemodynamics
Sejung Sohn, Su Jung Choi, Jung An Yang, Eun Ae Park
Clin Exp Pediatr. 2000;43(5):650-657.   Published online May 15, 2000
Purpose : An umbilical arterial catheter(UAC) in the high position reduces the lumen of the aorta and may thereby impair blood supply to the intestine. Effects of UAC on intestinal blood flow were investigated. Methods : With the measurement of the aortic diameter, pulsed Doppler ultrasonography was performed in 23 fasting newborns to measure blood flow velocities(peak systolic velocity, end-diastolic velocity,...
Doppler Echocardiographic Assessment of the Changes in Pulmonary Arterial Pressure in Preterm Infants with Respiratory Distress Syndrome
Sejung Sohn, Eun Ae Park
Clin Exp Pediatr. 1999;42(6):790-799.   Published online June 15, 1999
Purpose : The ratio of time to peak velocity(AT) and right ventricular ejection time(ET) as measured from the pulmonary artery Doppler waveform showed a close inverse correlation with pulmonary arterial pressure. The purpose of this study was to see the pattern of change in pulmonary arterial pressure assessed by AT/ET in preterm infants with respiratory distress syndrome (RDS). Methods : The...
Percutaneous Closure of Patent Ductus Arteriosus Using Coil Embolization
Mi Jung Kang, Sejung Sohn, Eun Jung Bae, In Seng Park, Seong Ho Kim
Clin Exp Pediatr. 1998;41(3):369-377.   Published online March 15, 1998
Purpose : Percutaneous closure with occluding coils has been recently described as a method of nonsurgical treatment of the small patent ductus arteriosus(PDA). The snare-assisted technique or detachable coil has been newly developed, improving coil delivery and eliminating the incidence of coil embolization. This method is also applicable to residual PDA following surgical ligation or device implantation. The study purpose...
The Effects of Lipo Prostaglandin E1(EglandinⓇ) in Patients with Ductus Dependent Congenital Heart Disease
Sejung Sohn, Seong Ho Kim, Eun Jung Bae, In Seung Park
Clin Exp Pediatr. 1996;39(8):1111-1121.   Published online August 15, 1996
Purpose : The adverse reactions of prostaglandin E1(PGE1) are troublesome in the preoperative management of critical patients with ductus dependent congenital heart disease, and a preparation with less adverse reactions is preferable. The effects of Lipo PGE1, a new preparation of PGE1 contained in lipid microspheres, were compared with those of conventional PGE1(PGE1-CD). Methods : Lipo PGE1 was infused at a rate of 5...
The Effects of Adriamycin on Ionic Currents in Single Cardiac Myocytes of the Rabbit
Sejung Sohn
Clin Exp Pediatr. 1995;38(8):1093-1106.   Published online August 15, 1995
Purpose : The study objective was to elucidate the possible pathophysiologic mechanism of Ca overload by adriamycin (ADR) which is associated with ADR- induced cardiotoxicity. Methods : The effects of ADR on ionic currents were studied using the whole cell voltage clamp technique in single cardiac myocytes of the rabbit. Results : The magnitude of the inward tail current, recorded at -70mV...
Periventricular Leukomalacia -Ultrasonographic Findings, Risk Factors and Neurological Outcome-
Kyeong Hee Cho, Myoung Jae Chey, Sejung Sohn, Kil Hyun Kim, Hak Soo Lee, Young Seok Lee, Dae Joong Kim
Clin Exp Pediatr. 1993;36(5):693-704.   Published online May 15, 1993
The thirty eight newborn infants with periventricular leukomalacia who were admitted to the neonatal intensive care unit of Gil General Hospital from March 1, 1988 to June 30, 1991, were investigated for ultrasonographic findings, risk factors and neurological outcome. The results were as follows: 1) There were 38 cases of PVL including 21 echogenic flarings and 17 cystic PVL뭩. 2) Mean birth weight...
A Case of Acute Megakaryoblastic Leukemia in infantwith down Syndrome.
Jang Sik Moon, Hae Young Hwang, Sejung Sohn, Hak Soo Lee, Heum Rye Park
Clin Exp Pediatr. 1990;33(10):1441-1446.   Published online October 31, 1990
Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have more than relationship to it. The authors report a case of acute megakaryoblastic leukemia in a 17 day-old male patient who was admitted for evaluation of high fever and dyspnea. The infiltration of atypical megakaryocytes...
A Case of Ulcerative Colitis.
Yang Mi Jung, Jong Sik Moon, Sejung Sohn, Hak Soo Lee
Clin Exp Pediatr. 1989;32(8):1144-1149.   Published online August 31, 1989
Ulcerative colitis is a chronic inflammatory bowel disease of unknown etiology affecting the mucosa of colon and rectum. We have recently experienced a case of ulcerative colitis in a 13 year-old girl. The diagnosis was established by clinical feature, barium enema, colonoscopy and rectal biopsy.
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