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Adrenocortical carcinoma in a twelve month old male infant.

Journal of the Korean Pediatric Society 1991;34(1):137-143.
Published online January 31, 1991.
Adrenocortical carcinoma in a twelve month old male infant.
Woo Ryoung Lee, Kyoung Whan Oh, Chang Hwi Kim, Sang Jhoo Lee
Department of Pediatrics, College of Medicine, Soon Chun Hyang University, Seoul, Korea
소아 부신피질 종양 1례*
이우령, 오경환, 김창휘, 이상주
순천향대학 의학부 소아과학교실
Received: 28 June 1990   • Accepted: 28 September 1990
Adrenocortical carcinoma is a rare disease in childhood. Most of these carcinomas are functional, produc- ing endocrine abnormalities such as Cushing syndrome, virilization, precocious puberty, hyperaldosteronism or feminization. We experienced a case of adrenocortical carcinoma in a 12 month old male infant who exhibited features of Cushing syndrome, Virilization, precocious puberty and hyperaldosteronism, which were due to functional adrenocortical carcinoma. Microscopic examination revealed cellular pleomorphism and bizzare multinu- cleated nuclei. He was successfully treated by total left adrenalectomy and has been followed up without problem over 13 months. A review of literatures was also made.
Key Words: Adrenocortical carcinoma, Cushing syndrome, Vilirization, Precocious puberty

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