| A case of transient diabetes mellitus and diabetic ketoacidosis induced by L-asparaginase and prednisolone administration in a patient with relapsed acute lymphocytic leukemia. |
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Won Kyu Choi, Mee Kyung Namgoong, Har Yong Lee, Hwang Min Kim, Jong Soo Kim |
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Department of Pediatrics, Wonju College of Medicine, Yonsei University, Wonju, Korea |
| 재발성 급성 임파구성백 혈병 환아에서 Prednisolone과
L-Asparaginase 투여중 발생한 당뇨병성 케톤산증과
일과성 당뇨병 1례 |
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최원규, 남궁미경, 이해용, 김황민, 김종수 |
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연세대학교 원주의과대학 소아과학교실 |
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Received: 11 April 1991 • Accepted: 25 June 1991 |
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| Abstract |
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L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute
lymphocytic leukemia. The side effects or toxicities of L-asparaginase and prednisolone are hypersen-
sitivity reaction, hepatotoxicity, pancreatitis and transient diabetes mellitus, CNS toxicity, disorder
of coagulation system and mild cytotoxicity.
We experienced a case of transient diabetes mellitus and diabetic ketoacidosis induced by L-
asparaginase, prednisolone, vincristine and MTX administration in patient with acute lymphocytic
leukemia.
A brief review of the related literature was made. |
| Key Words:
Diabetic Ketoacidosis, Diabetes mellitus, L-asparaginase, Predmisolone |
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