Purpose : AHC characterized by sudden onset of gross hematuria, dysuria and frequency oc curs in children and young adults as a self-limited disease that should be differentiated from se rious renal disorders. We have performed this study to establish the cause and characterize the clinical features of this illness in Korean children. Methods : 19 cases collected prospectively for 30... |
A marked low concentration of serum uric acid(0.7-1.2mg/dl) was detected in a 14-year-old boy with recurrent episodes of gross hematuria. The hypouricemia accompanied with a markedly increased urinary clearance of uric acid (32.6-56.0ml/min), which was only minimally changed after both the administration of pyrazinamide, and inhibitor of the renal tubular secretion of uric acid, and the administration of probenecid, and... |
We Reviewed 10 hypertensive children with pheochromocytoma retrospectively and the following results were obtained. 1) Out of 10 patients, 7 were male and 3 female. Age ranged from 5.5 years to 13.8 years and their median age was 9.9 years. 2) They complained of sweating, lethargy, headache, or chest pain and so on, Hypertension were noticed in all patients. Heart murmurs were... |
We reviewed the clinical features, histrologic patterns and clinical courses of 30 children with lupus nephritis retrospectively, and the results were summerized as follows; 1) The male to female ratio was 1:2.8, and the mean age at the onset was 108/12 years. 2) The clinical symptoms were diverse, and malaise, weight loss, anorexia, fever and malar rash were the most frequent findings. 3)... |
The clinical data of 27 patients with hypophosphatemic rickets treated with phosphate and 1 α-hydroxyvitamin D were analysed retrospectively. The median age at diagnosis was 4 years, and the main clinical manifestations were bowleg and short stature. Among total 24 families, 5 families(21%) had X-linked dominant mode of inheritance, 1 family (4%) had autosomal dominant mode and 17 families (71%)... |
There had been total 20 patients with early onset (4 months~2 years) primary nephrotic syndrome in the Deparment of Pediatrics, Seoul National University Children's Hospital, during the period from March 1987 to February 1993. We analysed clinical courses, response to treatment, pathological findings and prognosis of the patients And the results were as follows; 1) The initial responders to steroid treatment... |
Serum alkaline phosphatase(AP) activity is elevated in hepatobiliary disease, bone disease, pregnancy and certain neoplasms. Recently we experienced marked elevation of serum AP activity after administration of ablumin preparation in nephrotic patients who suffered from hypovolemic symptoms. So serum AP activity and the isoenzymes in the albumin preparations & patient뭩 serum after the administration of albumin preparation were studied. Serum... |
The authors studied the growth-promoting effect of yeast-derived methionyl-hGH in short statured children with uremic chronic renal failure. The subjects were prepubertal chronic renal insufficient patients whose height standard deviation scores were below -2.0. Two boys and two girls participated in this study. Chronic renal insufficiency was the only cause for the short stature. HGH was given to the subjects in dose... |
A retrospective study of 452 patients who undertook cardiac surgery was performed to determine the pevalence, etiology, and clinical features of postoperative acute renal failure(ARF). The overall incidence of ARF following cardiac surgery was 4.65%(21/452). The incidence of ARF following open heart surgery(OHS) was 5.11%, and that following closed heart surgery was 2.50%. Preoperactive risk factors noted in the development... |
The authors evaluated 19 childrenwith chronic renal failure patients diagnosed and followed up at the Department of Pediatrics, Seoul National University Hospital for the detection of acquired renal cystic disease (ARCD) with two radiologists by the means of ultrasonography. The results were as follows: 1) Of the 19 patients, male to femals ratio was 14:5 and of them, hemodialysis and peritoneal dialysis... |
We reviewed the medical records of 14 children (8 girls, 6 boys), diagnosed as hemolytic uremic syndrome at Seoul National University Children뭩 Hospital from 1981 to 1990. The age at presentation ranged from 1 month to 10 years, with a mean age of 2.7 years. Only eight (57.1%) of the children had diarrheal prodrome and five (35.7%) had grossly bloody... |
We analyzed medical records of 35 patients with Hepatitis B virus-associated Membranous Nephropathy proven by kidney biopsy at SNUCH from Jan. 1975 to Jun. 1990. Clinical presentation, laboratory and pathologic findings were compared between remission group (who are free of proteinuria and edema in current status) and nonremission group (who have either proteinuria or edema). Age at onset was younger in remission group (4.51 ±2.93... |
Hybridoma technology를 이용하여 human albumin에 선택적으로 반응하는 4 종류의 단세포군 항 처 1(HSA-1,HSA-2, HSA-3, HSA-4) 를 개발하였다. 단세포군의 isotype 및 subclass를 효소 결합 면역 측정법으로 검색한 결과 IgGi 이었다. 단세포군 항체 HSA-1 을 제외한 HSA-2, HSA-3, HSA-4 모두 human albumin에 선택적으로 반 응함을 효소 결합면역 측정 법과 Western blot immunoassay로 알아내 었다. HSA-1, HSA-2, HSA-3는 albumin의 reduction 여부와 관계 없이 albumin molecule과 반응하였 으나,HSA-4는 albumin을 reduction하지... |
We have experienced one case of acute renal failure without clinical rhabdomyolysis characterized by preceding exercise and back pain. This patient showed patch renal increased uptakes in bone scan with 99mTechnetium-methylene diphosphonate, and delayed wedge-shaped contrast enhancements in renal computed tomography. These findings can be explained by focal renal vasoconstriction of interlobar arteries or arcuate arteries, which may be considered as one of the... |
The measurement of body weight, height and blood pressure, urine sugar, oral glucose tolerance test, S-GOT, S-GPT, cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol tests were made in 324 severely obese elementary, middle and high school students (218 boys and 106 girls) to know the incidence of complication in these children. . The results were as follow: 1) S-GOT or S-GPT were increased abnormally in 38.3% and fatty livers were... |
A retrospective analysis of clinical with findings in 24 children continuous ambulatory peritoneal dialysis (CAPD) who were admitted to the Department of Pediatrics, Seoul National University Children’s Hospital from March, 1987 till August, 1990 was performed and the results were as follows; 1) The male to female ratio was 16:8, and the age distribution at the beginning of CAPD was from 59 days to 16.5... |
Hypomelanosis of Ito (incontinentia pigmenti achromians) is a cutaneous abnormality consisting of bizarre, whorly, linear, or patchy hypopigmentation over variable portion of body surface. Multiple assocaited defects in other systems occur in three quarters of the affected individuals. Most common- ly, the central nervous system, eye, and musculoskeletal structures are involved. It is suggested that the cutaneous abnormality, which is often detectable at birth... |
In this study we compared between the patients with recurrent gross hematuria (group 1, n=45) and * with nephrotic range proteinuria (group 2, n=21) in IgA nephropathy who were admitted to Seoul National University Children’s Hospital during the period from January, 1980 to December, 1989. The results of the study were as follows. 1) Age of onset and sex ratio were not different between the... |
A clinical study was carried out in 73 children with nephrotic syndrome who had had regular ophthalmologic examination annually at Seoul National University Children’s Hospital from March 1976 to February 1990 with the aim of finding the relationship between the posterior subcapsular cataract (PSC) and the effect of corticosteroids. The results were summarized as follows: 1) The number of patients with PSC were 23 cases... |
A clinical study was carried out to evaluate the efficacies of rHuEPO (recombinant human erythropoietin) in anemia of 7 chronic renal failure patients under dialysis at Seoul National University Children's Hospital from Feb. 1989 to Nov. 1989. The results were as follows; - 1) There was progressive increase of hematocrit levels in all 6 hemodialysis patients and mainte- nance dosage of rHuEPO to sustain hemoglobin... |
We experienced a case of acute renal failure associated with rhabdomyolysis after Carbon Monoxide intoxication in a 12 year old Korean girl who had marked soft tissue swelling of the left thigh, reddish brown colored urine and oliguria. Diagnosis was made by clinical features, markedly elevated serum muscle enzymes and serum myoglobin, and Tc 99m-MDP bone scan which revealed increased radioactivity at the left... |
Juvenile nephronophthisis is a chronic tubulo-interstitial renal disease characterized by an early onset of polyuria and polydipsia, decreased urinary concentrating ability, anemia, growth retardation and progressive renal disease. It is recognized as an important cause of chronic renal failure in the childhood. However only one case was reported in the Korean literatures. In this paper we have reported the second documented case of juvenile... |
A variety of urinary tract anomalies were detected in 1,569 children with congenital heart disease during their cardiac evaluation with cardiac cineangiography in the Department of Pediatrics, Seoul National University Children’s Hospital within a period from October 1985 to April 1988. The incidence, nature and course of these urinary tract anomalies were analyzed and the results were as follows; 1) The number of male children... |
We studied the cyclophosphamide-induced hemorrhagic cystitis in 72 cases of acute lymphocytic leukemia or Non-Hodgkin lymphoma, which had been treated at Seoul National University Children' s Hospital from June, 1985 to May, 1988 1) Among 72 cases treated with cyclophosphamide, 6 cases(12.8%) developed hemorrhagic cystitis in 47 cases of acute lymphocytic leukemia and 2 cases(8.0%) in 25 cases of Non-Hodgkin lymphoma. 2) The development of... |
Ten children with gross hematuria were diagnosed as hypercalciuria in the Department of Pediatrics, Seoul National University Children’s Hospital during the period from June 1983 to Aug. 1987. We reviewed their clinical data, retrospectively, and could obtain the following results. 1) The age at the onset of gross hematuria ranged from 4 months to 10 7/12 years, and the male to female ratio was... |
Among those who were admitted to the Pediatric Intensive Care Unit (PICU), Seoul National University Children’s Hospital and developed acute renal failure (ARF) during the disease course, 11 children received continuous arteriovenous hemofiltration (CAVH) by pediatricians during a 3-year- period from Nov. 85 to Oct. 88. Their clinical findings were analyzed retrospectively, and the results were as follows; 1) They were 5 boys and 6... |
1978년 1월부터 1987년 12월까지 만 10년간 서울대학교 소아병원 소아과에 입원한 환자중 신질환 환아를 대상으로 후향적 인 임상통계학적 고찰을 시 행하여 다음과 같은 결과를 얻었다. 1) 10년기간중 신질환 환아는 총 2,023명으로 이는 동일기간 전체 소아과 입원환아(28,611)의 7.1 %에 해당하였고,전체 환아에 대한 신질환 환아의 비는 매년 거의 일정하였다. 2) 전체 신질환 환아의 남여 비 는 2.2 : 1이 었다. 3) 신증후군(38.8%), 요로감염(18.0%), 급성사구체신염(12.1%) 이 3대 질병을 이루었으며 다음 으로는 반복성 혈뇨(7.6%),... |
We have studied morphological alterations in urinary RBC as a tool for the differential diagnosis of hematuria in children, that is, differentiation of glomerular bleeding from nonglomerular bleeding, and the results were as follows; 1) Urinary RBCs from glomerular diseases showed higher rate of dysmorphism (84.3±16.8%), and those from nonglomerular diseases did lower one (15.2 ±12.9%) with phase contrast microscopic examination. 2) Simple light microscopic examination after Wright’s... |
PRA’s in peripheral vein, both renal veins, and inferior vena cava (IVC) were measured in 25 normotensive children without renal disease undergoing cardiac catheterization for their underlying cyanotic congenital heart disease. And we presented the results as reference values/ranges of PRA in children. 1) There was no significant difference in PRA between both side renal veins at any absolute PRA levels with a mean ratio (RT/LT)... |
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