| A comparison between remission and nonremission groups of hepatitis B virus-associated membranous nephropathy in children. |
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Kang Yong Park1, Hye Won Park1, Yon Ho Choe1, Tae Sun Ha1, Il Soo Ha1, Yong Choi1, Kwang Wook Ko1, Hyun Soon Lee2, Yong Il Kim2 |
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea
2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea |
| B형 간염 바이러스 관련 소아 막성 신염의
완해군과비완해군의 비교 |
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박강용1, 박혜원1, 최연호1, 하태선1, 하일수1, 최용1, 고광욱1, 이현순2, 김용일2 |
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 병리학교실 |
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Received: 31 August 1991 • Accepted: 22 October 1991 |
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| Abstract |
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We analyzed medical records of 35 patients with Hepatitis B virus-associated Membranous
Nephropathy proven by kidney biopsy at SNUCH from Jan. 1975 to Jun. 1990. Clinical presentation,
laboratory and pathologic findings were compared between remission group (who are free of
proteinuria and edema in current status) and nonremission group (who have either proteinuria or
edema).
Age at onset was younger in remission group (4.51 ±2.93 years) than nonremission group (7.08±3.42
years). Heavy proteinuria (above 1 gm/d/m2) and decrease in serum complements (C3 and C4) were
more frequent in nonremission groups. There was no difference between two groups in clinical
presentations such as edema, gross hematuria, and hypertension. Also there were no difference
between two groups in microscopic hematuria, increased serum creatinine, selectivity index of
proteinuria, and hypercholesterolemia.
Serologic negative conversion rate of Hepatitis B virus surface antigen was low in both groups and
showed no difference. Serologic negative conversion rate of HBeAg was higher in remission group
(81.8%) than nonremission group (25.0%). Pathologic stages were more advanced in nonremission
group. There was no difference in the position of electron dense deposits. Steroid treatment had no
effect on the remission of HBV-associated membranous nephropathy.
In conclusion, remission group of HBV-associated MN in children seemed to have causal relation-
ship with the negative conversion of HBeAg. But 2 patients of remission group had persistent HBeAg
in their blood. Further study is necessary about the role of HBeAg.
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| Key Words:
Hepatitis B virus, Membranous Nephropathy, Remission |
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