Journal of the Korean Pediatric Society 1990;33(8):1097-1103.
Published online August 31, 1990.
A Clinical Study on the Posterior Subcapsular Cataracts in Childhood Nephrotic Syndrome.
Dong Kyu Jin1, Ja Wook Koo1, Hae Il Cheong1, Yong Choi1, Kwang Wook Ko1, Jong Hoon Lee2, Young Suk Yu2
1Department of Pediatrics, Seoul National University, College of Medicine Seoul, Korea
2Department of Ophthalmology, Seoul National University, College of Medicine Seoul, Korea
소아 신증후군에서 발생한 후낭하 백내장에 대한 임상적 고찰
진동규1, 구자욱1, 정해일1, 최용1, 고광욱1, 이종훈2, 유영석2
1서울대학교 의과대학 소아과학교실
2서울대학교 의과대학 안과학교실
Received: 9 March 1990   • Accepted: 16 June 1990
Abstract
A clinical study was carried out in 73 children with nephrotic syndrome who had had regular ophthalmologic examination annually at Seoul National University Children’s Hospital from March 1976 to February 1990 with the aim of finding the relationship between the posterior subcapsular cataract (PSC) and the effect of corticosteroids. The results were summarized as follows: 1) The number of patients with PSC were 23 cases (32%), and the spontaneous reversal occurred in 3 cases (13%). 2) The presence of PSC did not show any significant relationship with follow-up period, onset age and sex ratio statistically. 3) The patients with PSC used more steroids (23.5±24.4 gm) than those without PSC (13.9±11.2 gm) (p=0.03), but the percentage of alternate dose to total dose was not different between the 2 groups. 4) The duration from the start of steroid treatment to the detection of PSC was less than 1 year in 2 cases (9%) and 3 years in 11 cases (48%). The total dose from the start of steroid treatment to the detection of PSC was less than 5 gm in 5 cases, and 20 gm in 15 cases(65%). So we could find that there was no safe dose or duration to prevent PSC in steroid treated nephrotic syndrome patients, so regular ophthalmologic examination is needed to detect the cataract early.
Key Words: Posterior Subcapsular Cataract, Steroid, Nephrotic Syndrome




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