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Original Article
Whole Blood and Plasma Vitamin C Level in Healthy Middle and High School Students in Chinju
Yang-Suk Jung, Jae-Young Lim, Eun-A Kim, Yun-Kyeong Cho, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Gyung-Hyuck Ko, Seung-Chul Baik, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Rhee
Clin Exp Pediatr. 1999;42(6):748-755.   Published online June 15, 1999
Purpose : Recommended dietary allowance of vitamin C was determined without considering the important function of vitamin C as a first-line antioxidant. We measured the whole blood and plasma vitamin C concentrations of healthy middle and high school students in Chinju to assess the optimal daily vitamin C requirement in these age groups. Methods : Whole blood and plasma vitamin C...
Study on Changes in Bone Metabolism with Growth Hormone Treatment in Children with Growth Hormone Deficiency - Changes in the Serum Levels of Bone Markers -
Eun Young Kim, Sei Won Yang
Clin Exp Pediatr. 1999;42(5):704-710.   Published online May 15, 1999
Gastrointestinal Disease in Children with Iron Deficiency Anemia
Yong Joo Kim, Sung Kyun Park, Ho Joon Lim, Hahang Lee
Clin Exp Pediatr. 1999;42(5):697-703.   Published online May 15, 1999
Purpose : The authors performed this study to find out the associated GI disease and H. pylori infection in children with iron-deficiency anemia(IDA). Methods : Twenty-six children older than 2 years with IDA and no history of insufficient iron intake were investigated from 1994 to 1998. Gastrofiberoscopic examination and biopsy and rapid urease test were performed with serum H. pylori IgG....
Effects of Thioredoxin on Oxidative Neuronal Cell Injury
Hyunmi Kim, Gyoung Hee Kim, Yoon Song Lee
Clin Exp Pediatr. 1999;42(5):686-696.   Published online May 15, 1999
Purpose : Thioredoxin is an endogenous antioxidant which directly scavenges reactive oxygen species(ROS) and regenerates oxidatively damaged protein by reducing potential at the redox active disulfide(-Cys-Gly-Pro-Cys-) site. Under oxidative stress, thiredoxin plays a protective and adaptative role by inducing expressions. The aim of this study was to clarify the role of thioredoxin on oxidative neuronal cell injury. We investigated the...
Age-Related Criteria for Signal-Averaged Electrocardiographic Late Potentials in Children
Heon-Seok Han, Ki-Moon Cha
Clin Exp Pediatr. 1999;42(5):679-685.   Published online May 15, 1999
Purpose : Ventricular late potentials have been shown to predict malignant ventricular arrhythmia and sudden cardiac death in patients with myocardial infarction and cardiomyopathy. Low amplitude and high frequency potentials at the end of the QRS complex can be detected on the body surface using signal-averaged electrocardiogram(SAECG). This study determines the age-related criteria of SAECG parameters and age-related differences. Methods :...
Clinical Significance of Serum ECP in Mycoplasma Pneumoniae Pneumonia
Young Ghil Rah, Dong Keun Lee, In Seok Lim, Eung Sang Choi, Soo Ahn Chae
Clin Exp Pediatr. 1999;42(5):672-678.   Published online May 15, 1999
Purpose : Allergic inflammation of the lower respiratory tract is a characteristic clinical feature in asthma patients, in which eosinophils play an important role. The activity of eosinophil may be determined by measuring the level of eosinophil cationic protein(ECP) in sputum or serum as a potential marker of the inflammatory severity. Methods : We measured the serum concentrations of ECP...
Intralipid Infusions Effect on Nutrophil Elastase Level in Newborns
Sue Jeen Min, Yong Woon Baek, Yong Woon Baek, Yong Woon Baek
Clin Exp Pediatr. 1999;42(5):666-671.   Published online May 15, 1999
Purpose : Parenteral nutrition is given to infants who tempararily cannot take oral feeding adequately. A lipid emulsion is added to the parenteral to supply essential fatty acids. In neonatal sepsis, elastase from azuropilic granules of the neutrophils is released and rapidly bound to α1- Proteinase Inhibitor(α1-PI). The lipid emulsion has been noted to markedly inhibit chemotaxis of neutrophils, so...
Pain Reduction Effects of Continuous Fentanyl Infusion to Intensive Care Neonates
Wi Kyung Hwang, Heng Mi Kim
Clin Exp Pediatr. 1999;42(5):657-665.   Published online May 15, 1999
Purpose : To determine whether pain control using fentanyl would effectively reduce behavioral distress, physiologic and hormonal responses to postoperative pain and mechanical ventilation in neonates. Methods : Neonates who were admitted to the NICU(neonate intensive care unit) of Kyungpook University Hospital, requiring surgery or mechanical ventilation were evaluated. Twelve neonates undergoing operation were randomised into two groups. After operation, one...
Study of the Analgesic Effect of Sucrose and Non-sucrose Sweet Substances(Aspartam, Dextrose) in Full Term Neonates
Doo San Kim, Myung Ho O, Jay Geon Sim, Kee Hyuck Kim, Min Hee Kim
Clin Exp Pediatr. 1999;42(5):650-656.   Published online May 15, 1999
Pulmonary Inflammatory Cells in Preterm Infants with Respiratory Distress Syndrome Followed by Surfactant Treatment
Hyeon-Soo Lee, Myung-Seo Kang
Clin Exp Pediatr. 1999;42(5):644-649.   Published online May 15, 1999
Purpose : The effect of surfactant treatment on inflammatory cell populations has not been determined. I evaluated the effect of surfactant treatment on a number and distribution of inflammatory cells in bronchoalveolar lavage fluid(BALF) from the preterm infants who were dependent on mechanical ventilation over the 1st week of life. Methods : This study included 8 preterm infants with respiratory distress...
Neonatal Cord Blood Leptin : Its Relationship to Birth Weight
Byung Churl Lee, In Kyung Sung, Byung Kyu Suh, Moon Young Song
Clin Exp Pediatr. 1999;42(5):637-643.   Published online May 15, 1999
Purpose : The purpose of this study was to correlate birth weight, skinfold thickness, gestational age, BMI and ponderal index of neonates and maternal status with cord serum leptin concentration. Methods : Sixty newborns were enrolled in this study. Standard growth curves were used to categorize infants as appropriate(AGA), large(LGA), or small for gestational age(SGA). Gestational age, birth weight, length, skinfold...
Balloon Valvuloplasty of Pulmonary Stenosis in Patients Younger than 6 Months of Age
Yang Park, Do Jun Cho, Woo Sub Sim, In Seung Park, Eun Jung Bae, Seong Ho Kim
Clin Exp Pediatr. 1999;42(5):631-636.   Published online May 15, 1999
Purpose : Balloon valvuloplasty(BVP) is the treatment of choice for valvular pulmonary stenosis (PS). However, this procedure was usually performed in children older than 2 years. The purpose of the present study was to assess the safety and efficacy of BVP in young infants. Methods : Retrospective analysis of the medical records of 25 infants younger than 6 months of age...
Cell Proliferation and Apoptosis in Heart of Trisomy 16 in Mice
Eun Jung Bae, Yong Soo Yun, Jung Sun Kim, Jeong-Wook Seo
Clin Exp Pediatr. 1999;42(5):621-630.   Published online May 15, 1999
Purpose : Although abnormal developments of cushion and atrioventricular septum have been suggested, the exact mechanism for the development of atrioventricular septal defect is not well known. We aimed to identify the role of cell proliferation and apoptosis on cardiac morphogenesis in trisomy 16 mice(an animal model for Down's syndrome in human). Methods : We examined the difference in cardiac...
A Survey of Breast-Feeding in Jeon-ju City Area
Kyoung Bae Park, Byoung Rae Oh, Young Taek Jang
Clin Exp Pediatr. 1999;42(5):614-620.   Published online May 15, 1999
Purpose : While the rate of breast-feeding has been rising recently in many countries, it has been gradually falling in Korea. Accordingly, we took a survey in Jeon-ju to discover the actual state of breast-feeding and find a solution. Methods : Eight hundred and sixty-four questionnaires of filled out by mothers who visited the seven local pediatric clinics and the clinic...
Comparison of Phototherapy Guidelines for Neonatal Jaundice in Healthy Term Newborns
Hyo-Jung Kim, Chang-Ryul Kim, Jae-Won Oh, Myung-Kul Yum, Soo-Jee Moon
Clin Exp Pediatr. 1999;41(5):606-613.   Published online May 15, 1999
Purpose : We hypothesized that phototherapy, if the total serum bilirubin(TSB) is ≥14mg/dl, would decrease not only in frequency and duration, but complications due to phototherapy, such as weight loss, rash, temperature instability, feeding intolerance, and diarrhea, would decrease when compared to phototherapy TSB ≥10mg/dl after 48 hours of life in healthy term newborns without hemolysis. Methods : Forty healthy newborns...
Usefulness of Minimal Model Analysis : Measurement of Insulin Sensitivity, Glucose Effectiveness, and Insulin Secretory Capacity from Pancreatic Islet Cells in Children with Simple Obesity or Type 2 Diabetes Mellitus
Se Young Kim, Sei Won Yang
Clin Exp Pediatr. 1999;42(4):561-570.   Published online April 15, 1999
Purpose : It is known that insulin resistance and compensatory hyperinsulinemia from pancreatic islet cells to overcome insulin resistance could develop in children with simple obesity. When insulin resistance is aggravated by decompensation of high insulin secretion, obese children frequently progress to overt type 2 diabetes mellitus(DM). The purpose of the present study was to measure insulin sensitivity, glucose effectiveness,...
Immunohistochemical Expression of c-fos Protein and Histologic Findings after Instillation of Kainic Acid in Hippocampus of Neonatal Rat Brain
Soo Ahn Chae, Yong Soo Kim, Byoung Hoon Yoo, Won Bok Lee
Clin Exp Pediatr. 1999;42(4):553-560.   Published online April 15, 1999
Purpose : c-fos is rapidly and transiently induced in the intact CNS by a wide variety of exogenous stimuli that include seizures, glutamate receptor activation, sensory stimulation and stress. In adult animals, systemic KA administration produces limbic seizures that results in c-fos protein expression, irreversible morphological changes and localized neuronal death. So we studied the pattern of c-fos protein expression...
The Risk Factors of Renal Scar in Childhood Acute Pyelonephritis
Soo Ja Hwang, Seung Joo Lee
Clin Exp Pediatr. 1999;42(4):545-552.   Published online April 15, 1999
Purpose : To observe the risk factors of renal scar in children with first acute pyelonephritis (APN) who had photopenic defects on initial 99mTc-DMSA spect renal scan. Methods : Forty-seven children with first APN(M : F=33 : 14) who were admitted to Ewha Womans University Hospital from September, 1993 to Febrary, 1998, were divided into renal scar group(N=17, Kidney unit(KU)=18) and...
Congenital Esophageal Stenosis : with Special Reference to Diagnosis and Postoperative Complications
Ju Young Jang, Jae Seong Ko, Kwi Won Park, Woo Seon Kim, In Won Kim, Ja Jun Jang, Jeong Kee Seo,
Clin Exp Pediatr. 1999;42(4):535-544.   Published online April 15, 1999
Purpose : Congenital esophageal stenosis(CES) is one of the rare causes of recurrent vomiting during infancy and childhood. We studied the diagnostic and therapeutic tools and postoperative complications for early diagnosis and adequate management of CES. Methods : Fourteen cases of CES were evaluated for clinical manifestations, findings of esophagogram and esophagoscopy, classification of pathologic findings and postoperative complications. Results : Most...
Clinical Profiles and Anatomic Classification of Intestinal Malrotation
Jung A Kim, Jae Seong Ko, Jeong Kee Seo, Kwi Won Park, Woo Sun Kim, In One Kim
Clin Exp Pediatr. 1999;42(4):526-534.   Published online April 15, 1999
Purpose : Intestinal malrotation is a developmental anomaly and may be complicated by volvulus and intestinal necrosis. We performed anatomic classification and compared clinical profiles to understand their relationship. Methods : Twenty-eight children were diagnosed as intestinal malrotation at Seoul National University Children's Hospital between Jan. 1980 to Dec. 1995. The patients were classified into 4 groups by age at...
Clinical Observations of Coarctation of the Aorta
Hui Jung Cho, Chang Ho Ha, Dong Seok Lee, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1999;42(4):519-525.   Published online April 15, 1999
Purpose : Due to controveries surrounding in the incidence of coarctation of aorta which reports previously stated rare among Orientals, we evaluated clinical characteristics, natural courses of coarctation of aorta and effects of different surgical modalities. Methods : Medical records of 51 patients with coarctation of aorta, diagnosed by 2-dimensional echocardiography in Kyungpook University Hospital Pediatric Cardiac Laboratory from June 1985...
Effect of Low-Dose Aspirin Therapy on Platelet Aggregation in Kawasaki Disease
Ju Yeon Yeo, Heon Eui Le, Young Mi Hong, Ki Sook Hong, Wha Soon Chung
Clin Exp Pediatr. 1999;42(4):510-518.   Published online April 15, 1999
Purpose : Aspirin(acetylsalicylic acid) has been used to treat unstable angina and acute myocardial infarction in adults and Kawasaki disease in children. The antithrombotic effect of aspirin was attributed to its ability to inhibit platelet aggregation by inhibiting platelet cyclooxygenase, which leads to decreased thromboxane synthesis. The purpose of this study was to evaluate the effect on the platelet aggregation...
Prevalence and Identification of Rotaviruses in Stool Specimens of Patients with Acute Diarrhea from Several Regions of Korea
Dong Soo Kim, Beom Soo Park, Dong Hyuk Jung, Jae Moon Ahn, Chul Joong Kim, Shien Young Kang
Clin Exp Pediatr. 1999;42(4):501-509.   Published online April 15, 1999
Purposes : Rotaviruses are the main cause of infantile diarrheal diseases worldwide. The purpose of this study is to obtain epidemiologic data of rotavirus infections in Korea. Methods : Stool specimens were collected from 150 patients with acute diarrheal symptoms, who were admitted to Yonsei Medical Center and Chungbuk National University Hospital. After isolating the virus from the specimens, the viruses...
Positivity of cagA and vacA Genes of Helicobacter pylori by PCR Assay of Gastric Biopsy Specimens and Gastric Inflammation in Children
Jeong Wan Seo, Mi Ae Lee, Woon Sup Ha
Clin Exp Pediatr. 1999;42(4):491-500.   Published online April 15, 1999
Purpose : The aim of the present study is to detect cagA and vacA genes of Helicobacter pylori(H. pylori) strain in gastric biopsy specimens and to evaluate its association with gastric inflammation in children. Methods : The cagA and vacA genes were detected by a direct polymerase chain reaction(PCR) assay of gastric biopsy specimens in 22 patients who were...
Rehospitalization of Low-birth-weight Infants Who Were Discharged from NICU
Kyung Dan Choi, Young Suk Chae, Oh Kyung Lee
Clin Exp Pediatr. 1999;42(4):484-490.   Published online April 15, 1999
Purpose : We tried to compare normal term infants with low-birth-weight infants discharged from NICU by evaluating morbidity. So we studied rates of rehospitalization, reasons for rehospitalization and neonatal risk factors that affect rehospitalization of normal term infants and low-birth-weight infants discharged from NICU. Methods : This study was performed on 217 low-birth-weight infants discharged from NICU and 126 normal term...
Clinical Trial of Domestically Developed Bovine Lung Surfactant YY-38 in Neonatal Respiratory Distress Syndrome
Chul Lee, Jeong Nyun Kim, Min-Soo Park, Moon Sung Park, Shin Won Yoon, Wook Chang, Ran Namgung, Kook In Park, Dong-Gwan Han
Clin Exp Pediatr. 1999;42(4):472-483.   Published online April 15, 1999
Purpose : We previously reported modified bovine lung surfactant YY-38(NewfactanⓇ) had a low surface tension, good hysteresis, and exhibited good pressure-volume curve in animal experiment (J Korean Pediatr Asso 1997;40:771-85). We performed multicenter clinical trial of NewfactanⓇ in neonatal RDS. Methods : Seventy-seven infants with RDS(GA 31.8¡¾2.9 wks and BW 1,809¡¾592 gm) in 4 NICU were enrolled. After administration of...
Fcr Receptor and Mac-1 Expression and Functional Differentiation of HL-60 Cells by All-trans Retinoic Acid
Hae Soon Kim, Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh,
Clin Exp Pediatr. 1999;42(4):462-471.   Published online April 15, 1999
Purpose : During differentiation of HL-60 cells by all-trans retinoic acid(ATRA), we analyzed the expression of Fcr receptors and Mac-1 by molecules of equivalent soluble fluorochromes(MESF) and functional studies. Methods : HL-60 cells were induced to differentiate by adding 1μM ATRA. On the 4th and 7th day after stimulation as well as before stimulation, the cells were analyzed for phenotypic and...
MELAS Syndrome Confirmed by Mitochondrial DNA Analysis in Siblings
Young Ghil Rah, Soo Ahn Chae, In Suk Lim, Dong Keun Lee, Byoung Hun Yoo, Tae Sung Ko, Han Wook Yoo
Clin Exp Pediatr. 1999;42(3):412-418.   Published online March 15, 1999
MELAS(mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is a major subgroup of mitochondrial myopathy. Recent advances in molecular genetics revealed specific mutations in mitochondrial DNA which cause MELAS. We described here clinical and molecular genetic findings of sister and brother with MELAS syndrome. For molecular genetic studies, DNAs from peripheral blood nucleated cells were used. And the substitution...
The Relationship between Total Serum IgE, Allergen-Specific IgE, and Skin Prick Test in Children with Atopic Asthma
Myung Hyun Lee, Jin Hwa Cheong, Young Yull Koh, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 1999;42(3):403-411.   Published online March 15, 1999
Purpose : Skin prick test and determination of allergen-specific IgE antibodies in serum are methods commonly used to diagnose allergies. Several studies indicate that skin test and specific IgE have roughly the same diagnostic precision, although discrepancies exist. The objective of this study was to evaluate the influence of total serum IgE on the relation between skin prick test and...
The Usefulness of Serum Total IgE Test by Multiple Allergosorbent Test-Chemiluminescent Assay(MAST-CLA) : Comparison with Paper Radioimmunosorbent Test(PRIST)
Hyun Chul Lee, Chang Keun Kim, Churl Young Chung
Clin Exp Pediatr. 1999;42(3):397-402.   Published online March 15, 1999
Purpose : Multiple allergosorbent test-chemiluminescent assay(MAST-CLA) is a semiquantitative method for detecting total IgE and specific IgE in serum. The purposes of this study are to investigate the correlation between MAST-CLA and Paper radioimmunosorbent test(PRIST), and to find out whether MAST-CLA can replace PRIST in measuring of serum total IgE. Methods : Data of 162 subjects were analyzed by linear...
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