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The Change in Intestinal Lactobacillus Count among Healthy Neonates
Hyun Joo Lee, Hyun Ji Lee, Su Jin Cho, Jung Wan Seo, Seung Joo Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(8):833-838.   Published online August 15, 2004
Purpose : Enhancing overall health by preventive and therapeutic use of probiotics has shown great promise on inflammatory, infectious, neoplastic disorders, allergies, et al. To attain preliminary data for the use of probiotics, we have studied the change in intestinal flora, Lactobacillus count among healthy, full term neonates. Methods : Fresh stool samples were collected on the 2nd or 5th day...
Measles Antibodies Measured by Plaque Reduction Neutralization Test in Infants during the First Year of Life
Sung Hee Oh, Hak Won Kim, Younghee Lim, Hahng Lee
Clin Exp Pediatr. 2004;47(8):827-832.   Published online August 15, 2004
Purpose : The 2000-2001 measles epidemic resulted in more than 50,000 cases with the highest attack rate occuring in infants less than one year of age, indicating the necessity of measles immunization before 12 months of age when a measles outbreak occurs again. The study was conducted to measure maternal measles antibody in infants by plaque reduction neutralization test(PRN), for...
Effect of Histone H1 on Collagen Induced Arthritis in Mice
Jae Ho Yang, Kyung Mi Shin, Dong Soo Kim
Clin Exp Pediatr. 2004;47(7):779-788.   Published online July 15, 2004
Objective : Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule of sea urchin sperm flagella. This microtule assembly function of the histone is similar to that of taxol, which has an effect of controlling joint inflammation. In this study,...
Methylenetetrahydrofolate Reductase(MTHFR) Gene Expression in Kawasaki Disease
Hye Ryung Choi, Ae Ra Joo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Clin Exp Pediatr. 2004;47(7):774-778.   Published online July 15, 2004
Purpose : Hyperhomocysteinemia is known as an independent risk factor for cardiovascular diseases such as atherosclesosis and myocardiac infarct. A common mutation in 5, 10-methylenetetrahydrofolate reductase(MTHFR) gene results in a valine for alanine substitution, which makes enzyme thermolabile and reduces enzymal activity. We examined the relation of MTHFR genetic mutation and Kawasaki disease. Methods : We extracted DNA from the peripheral...
Evaluation of Intellectual Development in Patients with Transient Congenital Hypothyroidism at Early School Age
Pil Ju Jeong, Su Yung Kim
Clin Exp Pediatr. 2004;47(7):768-773.   Published online July 15, 2004
Purpose : Thyroxine is the hormone indispensible to the growth and development of infants. We made this study to confirm the influence of temporary depression of serum thyroxine levels on the development of intelligence. Methods : I adopted as the study group 14 patients diagnosed with depression at the pediatrics department of Pusan National University Hospital from April of 1991 to...
CSF Examination in the First Febrile Seizure
Joseph Jo, Sun Hee Yu, Young Taek Jang
Clin Exp Pediatr. 2004;47(7):762-767.   Published online July 15, 2004
Purpose : This study was launched to classify subjects of the CSF examination and improve early diagnosis of meningitis and its treatment in children who have had a first febrile seizure. Methods : From March 1995 to September 2003, children aged 3 months to 5 years who had had treatment for febrile seizure were analyzed as to their age at first...
Colonic Polyps; Experience of 34 Cases in Two Hospitals
Seoung Joon Kim, Sun Mi Kim, You Jeong Kim, Dae Chul Jeong, Won Bae Lee, Seung Yun Chung, Jin Han Kang
Clin Exp Pediatr. 2004;47(7):756-761.   Published online July 15, 2004
Purpose : Colonic polyps are among the most common causes of rectal bleeding in children. We studied the clinical spectrum, histology, malignant potential and treatment of colonic polyps in our cases. Methods : We reviewed hospital charts of all patients with colonic polyps, seen over a 15-year period from January 1988 to November 2002. Colonoscopy and/or barium enema were done for...
A Clinical Study of Neurologic Abnormalities Associated with Rotavirus Gastroenteritis
Yoon-Duk Kang, Myung-Kul Yum, Jae-Won Oh, Chang-Ryul Kim, In-Joon Seol, Jung-Oak Kang
Clin Exp Pediatr. 2004;47(7):751-755.   Published online July 15, 2004
Purpose : Reports of neurologic abnormalities associated with acute diarrhea are increasing recently. It was reported that the incidence of the neurologic abnormalities related to gastroenteritis was higher in rotavirus gastroenteritis than in non-rotavirus gastroenteritis. We investigated the incidence, the manifestations and the prognosis of the neurologic abnormalities associated with rotavirus diarrhea and non-rotavirus diarrhea in Korean children. Methods : Six...
Evaluation of Intrauterine Growth in Neonates with Congenital Heart Disease
Ji Hyun Yeo, Hee Jung Lee, Eun Sil Lee, Young Hwan Lee
Clin Exp Pediatr. 2004;47(7):746-750.   Published online July 15, 2004
Purpose : Intrauterine growth retardatation(IUGR) is very important because of high mortality and morbidity in the neonatal period. We studied the intrauterine growth retardation pattern in neonates with congenital heart disease(CHD). Methods : One hundred seventeen cases with CHD(acyanotic, 73 cases; cyanotic, 44 cases) who had no other congenital malformation or maternal diseases that might affect fetal growth were enrolled in...
Antithrombin III in the Diagnosis and Treatment of Disseminated Intravascular Coagulation in Premature Infants
Su Jin Cho, Hye Ryung Choi, Young Mi Hong, Kyung Hee Kim, Keun Lee, Eun Ae Park
Clin Exp Pediatr. 2004;47(7):740-745.   Published online July 15, 2004
Purpose : We evaluated the diagnostic implications and therapeutic efficacy of antithrombin III(AT III) in the disseminated intravascular coagulation(DIC) of premature infants. Methods : Ninety-two premature infants diagnosed with DIC and treated with AT III from March, 2000 to May, 2003 were retrospectively reviewed. Clinical manifestations, complete blood counts, coagulation tests, and AT III levels were compared between the two groups...
Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Respiratory Distress Syndrome in Korean Neonates
Jae Hoon Choe, Myung Ho Oh, Jung Ho Ko, Sun Young Kim, In Kyu Lee, Chong Woo Bae
Clin Exp Pediatr. 2004;47(7):735-739.   Published online July 15, 2004
Purpose : Respiratory distress syndrome(RDS) is caused by a deficiency of pulmonary surfactant, which is a lipoprotein complex. Both low levels of surfactant protein A(SP-A) and SP-A alleles have been associated with RDS. However, the genes underlying susceptibility to RDS are insufficiently known. The candidate-gene approach was used to study the association between the SP-A gene locus and RDS in...
Diagnostic Approach of Wiskott-Aldrich Syndrome
Dong Jin Hwang, Jun Won Yang, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(7):726-734.   Published online July 15, 2004
Objective : A probable diagnosis of Wiskott-Aldrich syndrome(WAS) should be considered in any boy presenting with unusual bleeding, congenital thrombocytopenia and small platelets. The definitive diagnosis of WAS is usually made by the detection of WASP gene mutation or a decrease or absence of the WAS protein(WASP) in blood cells using molecular genetic analysis. However, these methods are too time-consuming...
A Study for Adiponectin in Obese Adolescents with Hypertension
Jee Yoon Park, Su Jin Cho, Kyung Hyo Kim, Young Mi Hong, Keun Lee
Clin Exp Pediatr. 2004;47(7):719-725.   Published online July 15, 2004
Purpose : The adipocyte has traditionally been known as a reservoir for energy, but currently there is growing evidence that the adipocyte plays an important role in the pathogenesis of energy metabolism and homeostasis. Adipocytokine released from the adipocyte has been known to play a role in diabetes mellitus, coronary artery disease and other diseases related with obesity. The purpose...
Cardioprotective Effects of Minocycline in Rat Myocardiac Cell Culture Induced by Hypoxia
Bum Seok Yang, Hye Jin Park, Hong Tae Kim, Jong Won Lee, Dong Suk Lee, Un Seok Nho, Hai Lee Chung, Woo Taek Kim
Clin Exp Pediatr. 2004;47(6):685-690.   Published online June 15, 2004
Purpose : Minocycline appears to reduce the mortality rate of patients with myocardial infarction. Therefore, the cardioprotective effects of minocycline through reduction of apoptosis were studied in a rat myocardiac cell culture induced by hypoxia. Methods : Cultured cells from the hearts of Sprague-Dawley rats were divided into two sets of groups : normoxia groups treated with 5% O2 and...
Effect of a Flavon Extracted from Artemisia absinthium on Collagen Induced Arthritis in Mice
Kyong Min Choi, Dae Hwan Hwang, Kyung Mi Shin, Do-Young Yoon, Dong Soo Kim
Clin Exp Pediatr. 2004;47(6):677-684.   Published online June 15, 2004
Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies...
Association of Angiotensin-converting Enzyme Gene Polymorphism with the Disease Activity of Systemic Lupus Erythematosus in Korean Children
Kyung-Sue Shin
Clin Exp Pediatr. 2004;47(6):672-676.   Published online June 15, 2004
Purpose : Several recent studies have shown a significant association of angiotensin converting enzyme(ACE) gene polymorphism with systemic lupus erythematosus(SLE). The association has not been consistently confirmed; moreover, the association of ACE genotype with SLE in children has never been evaluated. The aim of this study is to evaluate the association of ACE gene polymorphism with SLE in Korean children. Methods...
Echocardiographic Evaluation of Left Ventricular Function in Kawasaki Disease : Effect of Immune Globulin
Mi-Jin Jung
Clin Exp Pediatr. 2004;47(6):665-671.   Published online June 15, 2004
Purpose : The purpose of this investigation was to identify the impaired myocardial function and improvement with immune globulin in Kawasaki disease. Methods : The myocardial performance and diastolic function were evaluated in 52 patients. M-mode and Doppler echocardiography were performed before(pre) and after immune globulin treatment : two to nine days(pre), five to 15 days(period one), 14 to 35...
Matrix Metalloproteinases, Tissue Inhibitors and Cytokines in Patients with Kawasaki Disease
Ae Ra Cho, Young Mi Hong
Clin Exp Pediatr. 2004;47(6):656-664.   Published online June 15, 2004
Purpose : Kawasaki disease(KD) is a multisystemic inflammatory vasculitis of unknown etiology, but immunological abnormalities have been documented and implicated in the pathogenesis of KD. Matrix metalloproteinases(MMPs) have proteolytic activity against connective tissue proteins, and increased activity of MMPs and a quantitative imbalance between MMP and tissue inhibitor of MMP (TIMP) can result in several pathologic conditions. MMP and TIMP...
The Effects of Gonadotropin-Releasing Hormone Agonists on Final Height and its Related Factors in Patients with True Precocious Puberty
Sung Yeon Ahn, Jae Ho Yoo, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2004;47(6):647-655.   Published online June 15, 2004
Purpose : The aim of this study was to evaluate the effects of treatment with GnRH agonists on final height(FH) and the influencing factors on height gains. Methods : Twenty-five girls and five boys with true precocious puberty, who were treated with GnRH agonists for more than one year and had attained final height, were evaluated retrospectively. We analysed auxological parameters...
The Prevalence of Maturity Onset Diabetes of the Young(MODY) 3 in Children with Type 2 Diabetes Mellitus
In Kyoung Choi, Duk Hee Kim, Ho-Seong Kim, Nam Huh, Sang Hyun Paek, Seoung Young Jung
Clin Exp Pediatr. 2004;47(6):641-646.   Published online June 15, 2004
Purpose : Maturity-onset diabetes of the young(MODY) is a subtype of type 2 diabetes defined by autosomal dominant mode of inheritance, onset of diabetes usually before the age of 25 yrs, and a primary defect in the function of the beta cells of the pancreas. MODY3 is known as the most common form and is caused by mutations in hepatocyte...
The Significance of Serologic Allergy Tests in Children with Recurrent Pneumonia
Yoon Hee Sim, Sin Weon Yun, Soo Ahn Chae, Dong Keun Lee
Clin Exp Pediatr. 2004;47(6):634-640.   Published online June 15, 2004
Purpose : Pneumonia is one of the most common respiratory diseases in hospitalized children, and often recurs. It has been reported that asthma is one of the significant contributing factors to recurrent pneumonia. On the basis of similarities between asthma and recurrent pneumonia, we intended to evaluate the influence of allergy on recurrent pneumonia. Methods : Seventy one children with...
Etiologic Diagnosis and Clinical Characteristics of Chronic Recurrent Chest Pain in Children
Eun-Jung Choi, Eun-A Lee, Chang-Woo Lee, Du-Young Choi, Yeon-Geun Oh, Jong-Duk Kim, Hyang-Suk Yoon
Clin Exp Pediatr. 2004;47(6):628-633.   Published online June 15, 2004
Purpose : To identify the causes and clinical characteristics, and the efficacy of various diagnostic approaches, we studied, prospectively, pediatric patients with chronic recurrent chest pain. Methods : A prospective study of 122 patients with chronic recurrent chest pain from June 1998 to June 2003 was performed. The male and female ratio was 81 : 41, age 9.3?.1 year. A...
Is Acute Nonspecific Mesenteric Lymphadenitis Associated with Acute Abdominal Pain in Epidemic Aseptic Meningitis?
Hae Rim Kim, Kiyoung Ku, Young Hwan Lee, Sin Kam, Jin-Bok Hwang
Clin Exp Pediatr. 2004;47(6):623-627.   Published online June 15, 2004
Purpose : Acute abdominal pain in an epidemic aseptic meningitis which is mostly an enterovirus as causative agent, is noted in 23-55% of patients. An enterovirus is also known as one of the causes of acute nonspecific mesenteric lymphadenitis(ANML). The purpose of this study was to see if ANML was associated with acute abdominal pain in epidemic aseptic meningitis. Methods :...
Clinical Studies of Sinus Headache in Children
Eun Ah Lee, Chang Woo Lee, Doo Young Choi
Clin Exp Pediatr. 2004;47(6):617-622.   Published online June 15, 2004
Purpose : Headache is a common reason for children to seek medical care. There are many causes of headaches in children, such as migraine and its variants, tension, intracranial masses, and sinusitis. A high frequency of diagnosis of sinus headache, which specialists consider to be relatively rare, raises the possibility that migraine and other headache types are sometimes mistaken for...
Epidemiological Study of Pneumococcal Nasal Carriage and Serotypes Among Korean Children
Sun Mi Kim, Jae Kyun Hur, Kyung Yil Lee, Young Kil Shin, Su Eun Park, Sang Hyuk Ma, Ahn Youn Min, Jin Han Kang
Clin Exp Pediatr. 2004;47(6):611-616.   Published online June 15, 2004
Purpose : The aim of this study was to determine the prevalence of pneumococcal nasal carriage and confirm the distribution of pneumococcal capsular serotypes in Korean children below aged 5 years old. Another reason this study was performed was to identify the theoretical coverage by seven valent conjugate pneumococcal vaccine, and confirm the penicillin resistant rate. Methods : This study included...
Clinical Outcomes of Infants with Failure to Gain Weight among Out-patients
Byoung Cheol Lee, Hae Rim Kim, Chan Lack Sohn, Sin Kam, Jin-Bok Hwang
Clin Exp Pediatr. 2004;47(6):604-610.   Published online June 15, 2004
Purpose : The three categories of failure to thrive are based on anthropometric measurements of weight, length, and head circumference for age. Type 1 is a failure to gain weight(FGW) due mainly to malnutrition. This study was performed to observe the clinical outcomes of infants with FGW, Type 1, among out-patients. Methods : Between October 2002 and July 2003, data from...
Comparison of Cytokine Expressions among Kawasaki Disease and Its Symptom-related Diseases
Ran Lee, So Hyun Park, Yu Jeong Kim, So Young Kim, Hyun Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2004;47(5):567-573.   Published online May 15, 2004
Purpose : Kawasaki disease(KD) is an important acute febrile systemic vasculitis disease. Various cytokines have been studied to evaluate the pathogenesis of vascular injury. Some cytokines have been implicated for vascular injury, but there has been no direct evidence. We compared cytokine profiles of KD with Henoch-Sch nlein purpura(HSP), and febrile infections. Methods : We investigated the serum concentrations of...
Aseptic Meningitis Secondary to High-Dose Intravenous Immunoglobulin Therapy in Kawasaki Disease
Ae Ra Cho, Jee Yoon Park, Kyung Hyo Kim, Young Mi Hong
Clin Exp Pediatr. 2004;47(5):561-566.   Published online May 15, 2004
Purpose : Kawasaki disease is a multisystemic inflammatory vasculitis and associated with neurologic features such as aseptic meningitis. High-dose intravenous immunoglobulin(IVIG) is used to treat Kawasaki disease and generally considered to be safe, but rare cases of aseptic meningitis with unknown etiology have been reported. The aseptic meningitis associated with Kawasaki disease was compared with meningitis as the adverse reaction...
Cause and Prognosis of Pediatric Acute Respiratory Failure by Intrapulmonary Lesion
Hye-Young Lee, Ji-Suk Park, Hee-Ra Choi, Ji-Hyun Seo, Jeum-Su Kim, Jae-Young Lim, Myoung-Bum Choi, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2004;47(5):555-560.   Published online May 15, 2004
Purpose : Respiratory failure arises from derangements in pulmonary gas exchange. The causes may be classified as due to either lung disease or respiratory pump dysfunction. Problems with lung mechanics is an important cause of acute respiratory failure in children clinically. The aims of this study were to survey the cause and prognosis of children diagnosed with acute respiratory failure...
Therapeutic Effect of Helicobacter pylori Eradication in Children with Recurrent Abdominal Pain Associated with H. pylori
Ji Hyun Uhm, Ki Sup Chung
Clin Exp Pediatr. 2004;47(5):547-554.   Published online May 15, 2004
Purpose : In order to clarify the role of Helicobacter pylori(H. pylori) in recurrent abdominal pain, we investigated prospectively the effect of eradication of H. pylori based on symptom improvement in children with recurrent abdominal pain. Methods : Children with recurrent abdominal pain were evaluated with diagnostic upper gastrointestinal endoscopy to rule out peptic ulcer disease, etc. During endoscopy, biopsies were...
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