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Association of Angiotensin-converting Enzyme Gene Polymorphism with the Disease Activity of Systemic Lupus Erythematosus in Korean Children

Korean Journal of Pediatrics 2004;47(6):672-676.
Published online June 15, 2004.
Association of Angiotensin-converting Enzyme Gene Polymorphism with the Disease Activity of Systemic Lupus Erythematosus in Korean Children
Kyung-Sue Shin
Department of Pediatrics, Cheju National University College of Medicine, Jeju, Korea
소아기 전신성 홍반성 루푸스에서 질병 활동성과 안지오텐신 전환 효소의 유전자 다형태와의 연관성
신경수
제주대학교 의과대학 소아과학교실
Correspondence: 
Kyung-Sue Shin, Email: kyungsue@cheju.ac.kr
Abstract
Purpose
: Several recent studies have shown a significant association of angiotensin converting enzyme(ACE) gene polymorphism with systemic lupus erythematosus(SLE). The association has not been consistently confirmed; moreover, the association of ACE genotype with SLE in children has never been evaluated. The aim of this study is to evaluate the association of ACE gene polymorphism with SLE in Korean children.
Methods
: Eighty-four children with SLE and 171 controls were recruited in this study. The ACE genotypes were determined by polymerase chain reaction. The serum levels of anti-double stranded (ds)-DNA antibody and serum complement levels(C3 and C4) were measured in all patients for disease activity of SLE. The SLE disease activity index(SLEDAI) were scored for the clinical activity of SLE.
Results
: The frequency of the ACE genotype DD, DI, and II in children with SLE were 13%, 52%, and 35%, respectively, similar to those in controls(16%, 48%, and 36%, respectively). The disease activity of SLE in children among the three groups of each genotype was independent of the ACE gene polymorphism.
Conclusion
: The result of this study did not show a significant association between the ACE polymorphism and the disease activity of SLE in Korean children.
Key Words: Angiotensin-converting enzyme, Gene polymorphism, Systemic lupus erythematosus, Children, Disease activity


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