Korean Journal of Pediatrics 2004;47(6):611-616.
Published online June 15, 2004.
Epidemiological Study of Pneumococcal Nasal Carriage and Serotypes Among Korean Children
Sun Mi Kim1, Jae Kyun Hur1, Kyung Yil Lee1, Young Kil Shin2, Su Eun Park3, Sang Hyuk Ma4, Ahn Youn Min5, Jin Han Kang1
1Department of Pediatrics, College of Medicine, The Catholic University of Korea, Korea
2Department of Pediatrics, College of Medicine, Korea University, Korea
3Department of Pediatrics, College of Medicine, Busan National University, Korea
4Department of Pediatrics, Masan Fatima Hospital, Korea
5Department of Pediatrics, College of Medicine, Eul Ji University, Korea
국내 소아의 비강 내 폐구균 보균율과 혈청형에 관한 역학연구
김선미1, 허재균1, 이경일1, 신영규2, 박수은3, 마상혁4, 안영민5, 강진한1
1가톨릭대학교 의과대학 소아과학교실
2고려대학교 의과대학 소아과학교실
3부산대학교 의과대학 소아과학교실
4마산 파티마병원 소아과
5을지대학교 의과대학 소아과학교실
Jin Han Kang, Email: kjhan@olmh.cuk.ac.kr
: The aim of this study was to determine the prevalence of pneumococcal nasal carriage and confirm the distribution of pneumococcal capsular serotypes in Korean children below aged 5 years old. Another reason this study was performed was to identify the theoretical coverage by seven valent conjugate pneumococcal vaccine, and confirm the penicillin resistant rate.
: This study included 213 children, who visited out patient clinic or were hospitalized in six hospitals between August 2001 and April 2002. Nasopharyngeal swabs and cultures for S. pneumoniae were performed. Serotyping of isolated samples was performed by the Quellung reaction at the Statens Seruminstitut in Copenhagen. Penicillin MICs were determined by the agar dilution method, and interpreted according to the NCCLS guide line.
: The prevalence of pneumococcal nasal carriage rate in this study was 34.3%. A total of 31 of 73 isolates(42.5%) had intermediate resistance to penicillin, and 29 of 73 isolates(39.7%) showed a high resistance to penicillin. The predominant serotype of the S. pneumoniae isolates was 23F(22%), and the percentages of vaccine serotypes(46.6%) and associated serotypes(37%) which belong to the seven-valent pneumococcal conjugate vaccine were 83.6%. The resistance pattern of pneumococcal isolates to penicillin was different among the serotypes.
: Pneumococcal isolates from nasal colonization of Korean children showed a high penicillin resistant rate. We assumed that newly developed seven-valent pneumococcal conjugate vaccine may offer a high theoretical coverage for the isolated strains.
Key Words: S. pneumoniae, Nasal carriage rate, Serotype, Penicillin resistance

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