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Therapeutic Effect of Helicobacter pylori Eradication in Children with Recurrent Abdominal Pain Associated with H. pylori

Korean Journal of Pediatrics 2004;47(5):547-554.
Published online May 15, 2004.
Therapeutic Effect of Helicobacter pylori Eradication in Children with Recurrent Abdominal Pain Associated with H. pylori
Ji Hyun Uhm, Ki Sup Chung
Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea
Helicobacter pylori 양성인 반복성 복통 환아에 대한 제균 요법의 효과
엄지현, 정기섭
연세대학교 의과대학 소아과학교실
Ki Sup Chung, Email: kschung@yumc.yonsei.ac.kr
: In order to clarify the role of Helicobacter pylori(H. pylori) in recurrent abdominal pain, we investigated prospectively the effect of eradication of H. pylori based on symptom improvement in children with recurrent abdominal pain.
: Children with recurrent abdominal pain were evaluated with diagnostic upper gastrointestinal endoscopy to rule out peptic ulcer disease, etc. During endoscopy, biopsies were taken and sent for CLO test and histologic evaluation with H-E stain and Alcian-Yellow stain. Twenty four out of 28 H. pylori infected children didn't have peptic ulcer disease. They underwent triple therapy with bismuth subcitrate, amoxicillin and clarithromycin. Four weeks after the end of the therapy, patients were evaluated with regard to their symptoms.
: In patients with H. pylori eradication, the mean total symptom score decreased significantly at four weeks' follow-up after the treatment(9.1?.6 vs. 1.4?.5; P<0.001). The frequency of abdominal pain per week also decreased significantly from 26.0?1.1 times/week to 1.4?.5 times/ week after eradication of H. pylori(P<0.001). Age, duration of symptom and endoscopic findings did not prove to be positive predictive factors of significant improvement of symptoms after H. pylori eradication.
: We strongly recommend looking for H. pylori infection in children complaining of recurrent abdominal pain. Eradication of this organism will effectively and significantly reduce the extent of symptoms associated with recurrent abdominal pain.
Key Words: Recurrent abdominal pain, Helicobacter pylori, Upper gastrointestinal tract, Endoscopy

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