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A comparison between impulse oscillometry system and spirometry for spirometry for detecting airway obstruction in children
Hae Young Hur, Ji Hee Kwak, Hyoung Yun Kim, Da Wun Jung, Yoon Ho Shin, Man Yong Han
Clin Exp Pediatr. 2008;51(8):842-847.   Published online August 15, 2008
Purpose : Measurement of forced expiratory volume in 1 second (FEV1) is usually difficult to obtain in children under six years of age because it requires active cooperation. This study evaluates the sensitivity of impulse oscillometry system (IOS) parameters for detecting airway obstruction in comparison with FEV1. Methods : We studied 174 children who performed the lung function and methacholine challenge...
Detection and clinical manifestations of twelve respiratory viruses in hospitalized children with acute lower respiratory tract infections : Focus on human metapneumovirus, human rhinovirus and human coronavirus
Kum Hyang Kim, Jung Ho Lee, Dong Shin Sun, Dong Shin Sun, Young Jin Choi, Joon Soo Park, Chang Jin Kim, Dong Jun Jung
Clin Exp Pediatr. 2008;51(8):834-341.   Published online August 15, 2008
Purpose : This study was perfomed to analyze in detail the viral etiology of acute lower respiratory tract infections (ALRI) in Cheunan, Korea by multiplex RT-PCR, including human rhinovirus (hRV) and newly identified viruses such as human metapneumovirus (hMPV) and human coronavirus (HCoV-OC43, HCoV-229E/NL63). Method : Nasopharyngeal aspirates (NPA) were collected from 863 hospitalized children with ALRI on the first day...
Reticulocyte hemoglobin content for the diagnosis of iron deficiency in young children with acute infection
Jon Soo Kim, Jun Seok Choi, Doo Young Choi, Chur Woo You
Clin Exp Pediatr. 2008;51(8):827-833.   Published online August 15, 2008
Purpose : Early identification of iron deficiency in young children is essential to prevent damaging long-term consequences. It is often difficult for the pediatrician to know which indices should be used when diagnosing these conditions especially in hospitalized young children. This study investigated the clinical significances of reticulocyte hemoglobin content in young children with acute infection. Methods : We studied...
A comparative study on iron deficiency anemia based on feeding patterns of nine-month-old infants
Hyun Jin Yun, Eun Jeong Choi, Eun Jin Choi, Su Young Hong
Clin Exp Pediatr. 2008;51(8):820-826.   Published online August 15, 2008
Purpose : This study was conducted to evaluate the red cell indices and frequency of iron deficiency anemia based on the feeding patterns of nine-month-old infants. Methods : Blood tests were performed on 253 nine-month-old infants, who visited Il Sin Christian Hospital for health check- ups from January to December 2007. Their parents answered telephonic questions regarding their feeding patterns...
Eight cases of incidentally diagnosed as subclinical rickets
Ji-Young Seo, Curie Kim, Hee-Woo Lee, Young-Min Ahn
Clin Exp Pediatr. 2008;51(8):812-819.   Published online August 15, 2008
Purpose : Vitamin D plays a key role in bone mineralization of the skeleton and vitamin D deficiency can lead to rickets. It is well known that vitamin D deficiency is common in breast fed infants. Of these patients, clinically, some have no signs of rickets, but laboratory and radiographic findings are diagnostic for vitamin D deficiency rickets (subclinical vitamin...
Infantile risk factors for obesity in preschool children
Sun Ju Park, Jae Won Moon, Hyun Ji Kim, Min Jung Cho
Clin Exp Pediatr. 2008;51(8):804-811.   Published online August 15, 2008
Purpose : Childhood obesity is a problem that places a child at great risk for becoming an obese adult. To prevent obesity, it is important to focus on early life risk factors that may contribute to childhood obesity. The aim of this study is to find obesity-causing infantile risk factors in preschool children. Methods : A total of 223 children aged...
Relationship between cord blood level of IL-12 in preterm newborns and development of wheezing
Hyo Jung Yu, Eun Ae Park, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye Sook Park, Eun Hee Ha
Clin Exp Pediatr. 2008;51(7):754-759.   Published online July 15, 2008
Purpose : Abnormal activation patterns of Th1/Th2-cells have been suggested to increase the prevalence of allergic diseases. Prevention is regarded as an important corner stone in the management of allergic diseases. In this study, we have investigated the relationship between cord blood levels of IL-4, IL-10, and IL-12 in preterm newborns and the development of allergic respiratory diseases in infancy Methods...
Early assessment of atherosclerosis in children with type 1 diabetes
So-Yoon Park, Seok Jeong Kang, Kwang Hae Choi, Yong Hoon Park, Young Hwan Lee
Clin Exp Pediatr. 2008;51(7):747-753.   Published online July 15, 2008
Purpose : Diabetes mellitus is a major risk factor for the development of cardiovascular disease. Early atherosclerotic changes in the arterial walls begin in adolescence and the risk factors are associated with its development. To assess the usefulness of carotid artery intima-media thickness (IMT), as a marker of early atherosclerosis, we evaluated the structural and functional characteristics of the carotid...
Effects and adverse-effects of growth hormone therapy in children with Prader-Willi syndrome: A two year study
Su Jin Kim, Joong Bum Cho, Min Jung Kwak, Eun Kyung Kwon, Kyung Hoon Paik, Dong-Kyu Jin
Clin Exp Pediatr. 2008;51(7):742-746.   Published online July 15, 2008
Purpose : The objective of this study was to evaluate the effects and adverse side-effects of growth hormone (GH) therapy in children with Prader-Willi syndrome (PWS). Methods : Forty-one patients who had been treated with GH for more than two years (24 boys and 17 girls, mean age 7.3?.3 years during treatment initiation) were enrolled for this study. Results : After...
Is routine screening examination necessary for detecting thromboembolism in childhood nephrotic syndrome?
Mun Sub Kim, Ja Wook Koo, Soung Hee Kim
Clin Exp Pediatr. 2008;51(7):736-741.   Published online July 15, 2008
Purpose : The incidence of thromboembolic episodes in children with nephrotic syndrome (NS) is low; however, these episodes are often severe. Moreover, both pulmonary thromboembolism (PTE) and renal vein thrombosis (RVT) rarely show clinical symptoms. This study was performed to determine the benefits of routine screening in the detection of thrombosis in childhood NS. Methods : Among 62 children with...
Chlamydia trachomatis respiratory infection in Korean young infants
Ki Bae Hong, Youn Shim Shin, Eui-Jung Roh, Eun Hee Chung
Clin Exp Pediatr. 2008;51(7):729-735.   Published online July 15, 2008
Purpose : Chlamydia trachomatis is one of the most common sexually transmitted diseases and is also a cause of pneumonia in infants. Respiratory infections by respiratory viruses are also common for infants. The objectives of this study were to identify the clinical manifestations and to determine the prevalence of C. trachomatis respiratory infections and coinfections by respiratory viruses in infants...
The relationship between adiponectin, leptin, insulin, insulin-like growth factor and IGF binding protein-3 in cord blood and neonatal anthropometric parameters
Hai Jung Cho, Ji Young Kim, Me Jin Kim, Il Tae Hwang, Hae Ran Lee
Clin Exp Pediatr. 2008;51(7):722-728.   Published online July 15, 2008
Purpose : This study was designed to examine the effects of adiponectin, leptin, insulin, insulin-like growth factor (IGF)-I and IGF binding protein (BP)-3 levels in cord blood on weight, length, and adiposity at birth in healthy term infants. In addition, we evaluated the mechanism to change the hormone levels in appropriate for gestational age (AGA) during the first month. Methods :...
Clinical characteristics of severe meconium aspiration syndrome
Chang Won Choi, Beyong Il Kim, Hyun Ju Lee, Kyoung Eun Joung, Gyu Hong Shim, In Suk Lim, Jin-A Lee, Ee-Kyung Kim, Han-Suk Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2008;51(7):713-721.   Published online July 15, 2008
Purpose : This study aims to describe the clinical characteristics of severe meconium aspiration syndrome (MAS) which required mechanical ventilation over 48 h and to delineate the progress of respiratory failure and radiographic findings in severe MAS. Methods : Twelve infants admitted to the Neonatal Intensive Care Unit (NICU) of the Seoul National University Bundang Hospital diagnosed with severe MAS from...
Growth and clinical efficacy of fortified human milk and premature formula on very low birth weight infants
Heewon Chueh, Myo Jing Kim, Young-A Lee, Jin-A Jung
Clin Exp Pediatr. 2008;51(7):704-712.   Published online July 15, 2008
Purpose : A prospective, controlled trial was conducted to evaluate growth, efficacy, safety and nutritional status for very low birth weight infants fed with human milk fortified with Maeil human milk fortifier (Maeil HMF ; Maeil Dairies Co., Ltd.). Methods : We enrolled 45 premature infants with a birth weight <1,500 g and gestational age <33 weeks, who were born at...
Clinical manifestations patterns of allergic disease in Korean children under the age of 6 : multi-center study
Dong Il Kim, Hyeon Jong Yang, Young Mean Park, Yeong Ho Rha, Ji Tai Choung, Bok Yang Pyun
Clin Exp Pediatr. 2008;51(6):640-645.   Published online June 15, 2008
Purpose : It is widely known that allergic diseases progress through an allergic march. However, there have not been any recent reports in Korea on how the diseases progress. Methods : Parents who visited one of the Pediatric Allergy Clinics of four university hospitals in Seoul with a child under the age of 6 years during the period from May...
A comparative study of the puberty suppression effect of gonadotropin-releasing hormone agonist in precocious or early puberty girls
Kye-Shik Shim, Chong-Woo Bae, You-Jung Yang
Clin Exp Pediatr. 2008;51(6):634-639.   Published online June 15, 2008
Purpose : There has been considerable disagreement regarding the most appropriate dosage of gonadotropin-releasing hormone agonist in cases of central precocious puberty. The aim of this study was to determine the appropriate dosage for suppression of the puberty in girls with central precocious or early puberty. Methods : Twenty-two girls with early puberty were randomly subjected to 3 types of dosages...
Coronary artery diameter of normal children aged 3 months to 6 years
Jeong Jin Yu, Suk Kyung Cho, Yong-Mean Park, Ran Lee, Sochung Chung, Sun Hwan Bae
Clin Exp Pediatr. 2008;51(6):629-633.   Published online June 15, 2008
Purpose : This study was designed to investigate normal domestic values for the diameter of the left main coronary artery (LCA), the left anterior descending coronary artery (LAD) and the right coronary artery (RCA). These data are necessary to define dilatation of coronary arteries in Kawasaki disease cases. Methods : Study subjects were 43 normal healthy children whose ages ranged from...
Immunogenicity of 7-valent pneumococcal conjugate vaccine related to booster immunization in Korean children
So Eun Park, Hyunju Lee, Soo Young Lim, Kyung Hyo Kim
Clin Exp Pediatr. 2008;51(6):622-628.   Published online June 15, 2008
Purpose : The purpose of this study was to evaluate the immunogenicity of the booster immunization with pneumococcal conjugate vaccine in Korean children. Methods : Thirty-nine children aged 12-23 months who visited Kangnam CHA Hospital between September 2006 and December 2006 were enrolled. The children were divided into primary and booster groups depending on their vaccination status for the 7-valent pneumococcal...
Interpretation of screening for congenital adrenal hyperplasia in preterm infants
Hye Rim Chung, Choong Ho Shin, Sei Won Yang, Kyong Ah Yun, Young Ah Lee, So Eun Park, Chang Won Choi, Byung Il Kim, Jung Hwan Choi, Junghan Song
Clin Exp Pediatr. 2008;51(6):616-621.   Published online June 15, 2008
Purpose : This study was undertaken to identify factors that influence 17-OHP levels in preterm infants and to suggest a reasonable follow-up schedule of screening for congenital adrenal hyperplasia (CAH) in preterm infants. Methods : The 17-OHP concentrations in filter paper blood spots of 427 preterm infants were obtained. The effects of gestational age (GA), systemic diseases, and antenatal dexamethasone...
Clinical features of vaccination-associated thrombocytopenic purpura in children
Wan Soo Lee, Seung Taek Yu, Sae Ron Shin, Du Young Choi
Clin Exp Pediatr. 2008;51(6):610-615.   Published online June 15, 2008
Purpose : Idiopathic thrombocytopenic purpura (ITP) is a relatively common hematological disease in children. It generally occurs after exposure to a common viral infection episode; however, it may occasionally follow immunization with measles, measles-mumps-rubella (MMR), hepatitis B (HBV), influenza, diphtheria tetanus-pertussis (DTP), or chickenpox vaccines. In this study, the incidence, clinical characteristics, and treatment outcome of vaccination-associated ITP were investigated...
The utility of ambulatory blood pressure monitoring in obese children
Myung Jin Kim, Jin Young Song
Clin Exp Pediatr. 2008;51(6):604-609.   Published online June 15, 2008
Purpose : Obesity in children and adolescence is highly correlated with adult obesity, which can provoke hypertension. Therefore, it is important to evaluate the blood pressure of obese children regularly. In this study, the results of ambulatory blood pressure monitoring (ABPM) in obese children and adolescents were evaluated. Methods : ABPM was conducted for selected patients who visited Handong University...
Leptin, adiponectin, interleukin-6 and tumor necrosis factor- in obese adolescents
Joo Hyun Gil, Jung Ah Lee, Ji Young Kim, Young Mi Hong
Clin Exp Pediatr. 2008;51(6):597-603.   Published online June 15, 2008
Purpose : Obesity is associated with insulin resistance. Insulin resistance and the presence of pro-inflammatory mediators are thought to cause a state of vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation. These chronic inflammatory responses, which are characterized by abnormal cytokine production, lead to activation of a pro-inflammatory signaling pathway. Leptin is an important mediator of inflammatory...
Therapeutic compliance and its related factors in pediatrics patients
Ki Soo Park, Sin Kam, Heung Sik Kim, Jeong Kwon Lee, Jin-Bok Hwang
Clin Exp Pediatr. 2008;51(6):584-596.   Published online June 15, 2008
Purpose : This study was conducted to investigate treatment compliance and related factors in pediatric patients. Methods : Three hundred and fifty-five patients diagnosed with various acute diseases at a teaching hospital or clinic in October 2003 were enrolled. Data were analyzed using the Health Belief Model, which includes items on self-efficacy and family assistance. Results : The study found that...
Transforming growth factor-β gene promoter polymorphism : its association with renal involvement in Henoch-Sch lein Purpura in childhood
Seung Ho Lee, Hwa Young Jee, Hwang Min Kim, Byung Il Yeh
Clin Exp Pediatr. 2008;51(5):523-527.   Published online May 15, 2008
Purpose : Several cytokines play important roles in the inflammatory process of Henoch-Sch lein Purpura (HSP). It is likely that transforming growth factor-β (TGF-β) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether TGF-β promoter polymorphism is associated with the renal involvement of childhood HSP. Methods : Thirty-four patients younger than 15 years, who...
An epidemiological study on enuresis in children of two elementary schools in Suwon
Hyun Jung Lee, Kang Gyoon Lee, Eun Jin Kim, Ki-Soo Pai, Sang Don Lee
Clin Exp Pediatr. 2008;51(5):518-522.   Published online May 15, 2008
Purpose : The purpose of this study was to investigate the prevalence of enuresis in association with voiding habits and socioeconomic status in elementary school children. Methods : A dynamic survey was done of 1,514 students from two elementary schools in Suwon, Korea in December 2006. Data regarding gender, age, height and weight, voiding habits, and monthly family incomes were...
The characteristics of neurocardiogenic syncope in children
Kyung Yeon Lee, Jin Young Lee, Myoung Hyun Kim, Jeong Eun Lee, Yong Dae Kim, Eun Ju Lee, Young Su Lim, Won Seop Kim
Clin Exp Pediatr. 2008;51(5):512-517.   Published online May 15, 2008
Purpose : Syncope is relatively common in children and adolescents. Among the etiologies of syncope, neurocardiogenical syncope is the most common, but it is often confounded with seizure. We investigated the clinical features of patients under the age of 15 with neurocardiogenical syncope, compared to patients with neurologic disorders including epilepsy. Methods : Among the children who visited the...
The effect of education and training with balloons on pulmonary function test in children
Yong Hee Hong, Sun Mi Ha, You Hoon Jeon, Hyeon Jong Yang, Bok Yang Pyun
Clin Exp Pediatr. 2008;51(5):506-511.   Published online May 15, 2008
Purpose : The results of pulmonary function test (PFT) in children are variable according to the patient's cooperation and comprehensiveness. This study has intended to figure out the effectiveness of pre-education and training with balloons on PFT in children. Methods : One hundred six children mean aged 9.35?.92 years were tested. All participants performed PFT twice in 30 minutes intervals....
Clinical features of transient small bowel intussusception in children
Ji Seung Heo, Eun Min Seo, Eun Jung Shim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Kwan Seop Lee
Clin Exp Pediatr. 2008;51(5):500-505.   Published online May 15, 2008
Purpose : We analyzed the clinical features, management and outcome of small bowel intussusception in children compared with ileocolic intussusception. Methods : We retrospectively reviewed the records of 210 children with documented intussusception, in whom intussusception was initially diagnosed by ultrasonography during the four-year period of 2002 to 2005. Results : A total of 191 children were diagnosed with ileocolic intussusception and...
Gastric mucosal immune response of Helicobacter pylori-infected children
Hye Won Yom, Jeong Wan Seo
Clin Exp Pediatr. 2008;51(5):492-499.   Published online May 15, 2008
Purpose : Helicobacter pylori infection is one of the most common gastrointestinal infections worldwide; it almost invariably causes chronic gastritis. Pediatric studies may provide important insights into the mucosal immune response of H. pylori-infection, as children are not submitted to environmental factors such as alcohol, tobacco and anti-inflammatory medication. The aim of the present study was to investigate the mucosal...
Increased vascular endothelial growth factor in children with acute Mycoplasma pneumoniae pneumonia and wheezing
Young Seo, Byung Keun Yu, Yeon Joung Oh, Yoon Lee, Young Yoo, Ji Tae Choung, Young Yull Koh
Clin Exp Pediatr. 2008;51(5):487-491.   Published online May 15, 2008
Purpose : Although Mycoplasma pneumoniae (M. pneumoniae) infection can cause wheezing in non-asthmatic children, the mechanisms of this symptom remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability, and is also known to be elevated in cases of chronic pulmonary disease such as asthma. We hypothesized that VEGF may increase in children with...
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