Korean Journal of Pediatrics 2008;51(7):742-746.
Published online July 15, 2008.
Effects and adverse-effects of growth hormone therapy in children with Prader-Willi syndrome: A two year study
Su Jin Kim, Joong Bum Cho, Min Jung Kwak, Eun Kyung Kwon, Kyung Hoon Paik, Dong-Kyu Jin
Department of Pediatrics, Sungkyunkwan University School of Medicine, Seoul, Korea
Prader-Willi 증후군 소아에서 성장호르몬 치료의 효과와 부작용
김수진, 조중범, 곽민정, 백경훈, 권은경, 진동규
성균관대학교 의과대학 소아과학교실
Correspondence: 
Dong-Kyu Jin, Email: jindk.@skku.edu
Abstract
Purpose
: The objective of this study was to evaluate the effects and adverse side-effects of growth hormone (GH) therapy in children with Prader-Willi syndrome (PWS).
Methods
: Forty-one patients who had been treated with GH for more than two years (24 boys and 17 girls, mean age 7.3?.3 years during treatment initiation) were enrolled for this study.
Results
: After 2 years of GH therapy, the height and weight standard deviation scores (SDS) increased significantly (?.19?.37 vs. ?.02?.45, and 1.02?.42 vs. 1.63?.22, P<0.002); however the percentage body fat decreased (44.6?.9% vs. 38.1?0.5%, P<0.001). Further, no change was observed in the thyroid and serum glucose levels, but the total cholesterol level decreased. GH therapy did not impact glucose control in the patients with diabetes. The most common adverse effects of GH therapy were the progression of scoliosis and adenoid hypertrophy.
Conclusion
: GH therapy improved the height SDS and body composition in patients with PWS. However, GH should be used with caution in patients with scoliosis and adenoid hypertrophy.
Key Words: Prader-Willi syndrome, Growth hormone, Growth hormone therapy, Adverse effect


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