Korean Journal of Pediatrics 2008;51(8):842-847.
Published online August 15, 2008.
A comparison between impulse oscillometry system and spirometry for spirometry for detecting airway obstruction in children
Hae Young Hur, Ji Hee Kwak, Hyoung Yun Kim, Da Wun Jung, Yoon Ho Shin, Man Yong Han
Department of Pediatrics, College of Medicine, Pochon CHA University, Sungnam, Korea
소아의 기도 폐쇄 평가에서 impulse oscillometry system과 폐활량 측정법의 비교
허혜영, 곽지희, 김형윤, 정다운, 신윤호, 한만용
포천중문의과대학교 소아과학교실
Man Yong Han, Email: drmesh@hanmail.net
: Measurement of forced expiratory volume in 1 second (FEV1) is usually difficult to obtain in children under six years of age because it requires active cooperation. This study evaluates the sensitivity of impulse oscillometry system (IOS) parameters for detecting airway obstruction in comparison with FEV1.
: We studied 174 children who performed the lung function and methacholine challenge tests to diagnose asthma by IOS and spirometry. Children were divided into two subgroups according to their PC20, which is a parameter for bronchial sensitivity. We compared IOS parameters with FEV1 at the baseline, post-methacholine challenge, and evaluated their correlation.
: At the baseline, reactance at 5 Hz (X5) and resistance at 5 Hz (R5) significantly differed between the PC20 positive (PC20≤16 mg/mL) group and PC20 negative (PC20 >16 mg/mL) group; however, FEV1, FEV1 % predicted, FEV1_Zs (Z score) did not differ. FEV1 is correlated with X5 (r=0.45, P<0.01) and R5 (r=-0.69, P<0.01). FEV1_Zs is also correlated with X5_Zs (r=-0.26, P<0.01) and R5_Zs (r=-0.31, P<0.01). After the methacholine challenge test, dose-response slopes in FEV1 and X5 significantly differed between the two subgroups (P<0.05).
: IOS parameters were more discriminative than FEV1 for detecting decreased baseline lung function between two subgroups and have a good correlation with FEV1.
Key Words: Impulse oscillometry, Forced expiratory volume in 1 second, Spirometry, Children

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