| Clinical features of vaccination-associated thrombocytopenic purpura in children |
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Wan Soo Lee1, Seung Taek Yu1, Sae Ron Shin2, Du Young Choi1 |
1Department of Pediatrics, Wonkwang University School of Medicine, Iksan, Korea
2Department of Family Medicine, Wonkwang University School of Medicine, Iksan, Korea |
| 예방접종과 관련된 소아 혈소판 감소 자반병의 임상적 특성 |
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이완수1, 유승택1, 신새론2, 최두영1 |
1원광대학교 의과대학 소아과학교실
2원광대학교 의과대학 가정의학과학교실 |
Correspondence:
Du Young Choi, Email: cdy8118@wonkwang.ac.kr
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| Abstract |
Purpose
: Idiopathic thrombocytopenic purpura (ITP) is a relatively common hematological disease in children. It generally occurs after exposure to a common viral infection episode; however, it may occasionally follow immunization with measles, measles-mumps-rubella (MMR), hepatitis B (HBV), influenza, diphtheria tetanus-pertussis (DTP), or chickenpox vaccines. In this study, the incidence, clinical characteristics, and treatment outcome of vaccination-associated ITP were investigated and compared with non-vaccination-associated ITP.
Methods
: The admission records of 105 pediatric ITP patients between 0-14 years of age admitted to Department of Pediatrics, Wonkwang University Hospital from January 1994 to July 2007 were retrospecitively reviewed. Patients were grouped into a vaccination-associated group and a non-vaccination-associated group according to vaccination history within the previous 1 month, and various clinical features between the two groups were statistically analyzed.
Results
: Thirteen patients (12%) had a preceding vaccination. Eight had received DTP vaccination, 2 had received hepatitis B, and 1 each had received influenza, MMR, and Japanese B encephalitis vaccination. However, none of the patients had a recurrent thrombocytopenia after subsequent vaccinations. In the vaccination-associated group, the age was significantly lower, anemia was more common, and the risk period with blood platelet count <20?09/L was significantly shorter than for the in non-vaccination-associated group. Also, wet purpura was less prominent and the remission within 1month was more frequently achieved in the vaccination-associated ITP group.
Conclusion
: Vaccination-associated ITP patients showed mild symptoms with a more benign and shorter lasting course than non-vaccination-associated ITP patients. Moreover, platelet count assessment at the time of the next immunization may not be necessary. |
| Key Words:
Vaccination, Thrombocytopenic purpura |
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