- Original Article
- Immunogenicity and Safety of Live Attenuated Vaccine(MAV/06srtain) on Healthy Children and Immunocompromised Children
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Young Mo Sohn, Chul Joo Yu, Pyung Kil Kim, Kir Young Kim, Chong Young Park, Mi Ran Kim, Woo Kap Jeung, Kyu Kye Hwang, Gyu Jin Woo, Song Yong Park
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Clin Exp Pediatr. 1995;38(6):771-777. Published online June 15, 1995
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Purpose : To study the safety and immunogenicity of new live attenuated varicella vaccine (MAV/06strain) in normal healthy children and immunocompromized children in Korea.
Methods : Blood samples for fluorescent antibody to membrane antigen(FAMA) assay were taken before the vaccination among seven hundred forth five healthy children and twenty two nine immunocompromised children. One hundred and seventy seven children and twenty... |
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- Clinical Differences by Karyotype in Patients with Turner Syndrome
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Mi Jung Park, Jin Sung Lee, Kir Young Kim, Duk Hi Kim, Ho Seoung Kim
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Clin Exp Pediatr. 1995;38(2):143-150. Published online February 15, 1995
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Purpose : The aim of this study was to evaluate clinical differences by karyotype in Turner Syndrome.
Methods : We evaluated 66 patients with Turner syndrome diagnosed at Yonsei University College of medicine from Mar.1985 to Feb.1993. We divided subproups as pure 45,X groups, mosaisism groups and structural aberration groups. Clinical features, serum estrogen, LH, FSH, concentrations, gonadotropin release after GnRH... |
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- Risk Factors for Hyperglycemia in Children with Leukemia Receiving L-asparaginase
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Min Joong Kwon, Ho Sung Kim, Kir Young Kim, Duk Hi Kim
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Clin Exp Pediatr. 1994;37(6):740-745. Published online June 15, 1994
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Hyperglycemia is a well-recognized side effect of L-asparaginase in remission induction therapy of acute lymphocytic leukemia. Since hyperglycemia has preceded fatal diabetic ketoacidosis or hyperosmotic nonketotic coma in some patients, early detection and treatment of this complication are important. We determined retrospectively the risk of hyperglycemia in 117 patients with leukemia who had received L-asparaginase (& prednisolone).
The results were as... |
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- Renal size as a Prognostic Factor in Childhood Acute Lymphocytic Leukemia
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Soo Kyung Yun, Chang Hyun Yang, Chuhl Joo Lyu, Seung Hwan Oh, Kir Young Kim, Myung Joon Kim
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Clin Exp Pediatr. 1994;37(2):174-179. Published online February 15, 1994
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The Kidney size is of special interest during the diagnostic work up of acute lymphocytic leukemia. But is still uncertain whether a finding of kidney enlargement at presentation has long-term prognostic value. We therefore reviewed the kidney size in children with acute lymphocytic leukemia by abdominal ultrasonograms at the time of diagnosis (n=54) and examined if there was any statistical... |
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- A Clinical Study of Testicular Relapse in Childhood Acute Lymphocytic Leukemia
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Hye Ok Roh, Chuhl Joo Lyu, Seung Hwan Oh, Chang Hyun Yang, Kir Young Kim, Byung Soo Kim
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Clin Exp Pediatr. 1993;36(5):680-686. Published online May 15, 1993
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From January 1984 to June 1991, we studied testicular relapsed patients among 105 cases of acute lymphocytic leukemia in children who were admitted to the Department of Pediatrics and Yonse Cancer Center, Yonsei University Severance Hospital.
The results were as follows:
1) 15 out of 105(14.4%) cases of acute lymphocytic leukemia were diagnosed as testicular relapse. According to the prevalence by the... |
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- Sodium and calcium transport in spherocytic red blood cells.
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Shin Heh Kang, Kir Young Kim, Young Ho Lee, Bok Soon Kang
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Clin Exp Pediatr. 1991;34(7):978-991. Published online July 31, 1991
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Hereditary spherocytosis (HS) is an autosomal, dominantly inherited hemolytic disorder which
shows characteristic spherocytes on peripheral smear. As spherocytes are rounder, more fragile and
susceptible to extravascular hemolysis in the spleen, HS patients suffer from variable degrees of
anemia, jaundice, splenomegaly and gall stones. However the pathogenesis is heterogenous in HS,
such as spectrin deficiency, decreased spectrin-protein 4.1 binding, increased spectrin binding to the
RBC... |
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- A case of de Novo trisomy 12p syndrome.
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Young Huuk Lee, Kir Young Kim
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Clin Exp Pediatr. 1991;34(11):1581-1586. Published online November 30, 1991
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A case of de novo trisomy 12p syndrome has deen experienced in newborn male child recently. This
male child manifested normal birth weight, weak crying, poor sucking, generalized hypotonia,
multiple congenital anomalies on face and digits, and progressive psychomotor retardation. The
diagnosis was made on the basis of typical morphologic features and chromosomal study.
As this is the first case in Korea, it is... |
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- The role of exchange transfusion as a therapy for neonatal DIC.
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Jung Tak Kim, Kook In Park, Ran Namgung, Dong Gwan Han, Kir Young Kim
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Clin Exp Pediatr. 1991;34(1):31-40. Published online January 31, 1991
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A clinical study on the effects of exchange transfusion on disseminated intravascular coagulation
was conducted on 32 patients with DIC who were admitted to the pediatric department of YUMC
from January 1984 to June 1989. We diagnosed DIC when symptoms were compatible to the diagnosis
and there were more than 3 abnormal laboratory findings out of the following 5, which were platelet
count, PT,... |
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- A Case of 9p-Syndrome.
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Bok Hoi Kim, Shin Heh Kang, Kir Young Kim, Kyung Ja Cho, Kyung Hee Ha, Bum Suk Lee
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Clin Exp Pediatr. 1990;33(9):1262-1265. Published online September 30, 1990
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We experienced a case of 9p- syndrome in a 2 year and 5 month old male child who manifested
psychomotor retardation and multiple congenital anomalies.
His karyotype was 46, XY, del (9) (p22).
A brief review of literature was also presented. |
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- A Case of Patient with Common Variable Immunodeficiency.
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Keun Cheon Kim, Chang Gee Kang, Chang Hyun Yang, Dong Soo Kim, Kir Young Kim
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Clin Exp Pediatr. 1989;32(8):1123-1127. Published online August 31, 1989
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Common variable immunodeficiency, as defined by World Health Organization classification of
primary immunodeficiency, is a heterogenous group of disorders with hypogammaglobulinemia,
decreased ability to produced antibody following antigenic challenge, and increased incidence of
infections. The disorder was often familial, but no mode of inheritance has been discerned. Clinical
fingings are recurrent bacterial infections, particularly respiratory infection.
Laboratory evaluations in common variable immunodeficiency demonstrate decrease in... |
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- Study on Antithyroid Antibody and Thyroid Functional Status in Patients with Turner Syndrome.
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Bo Young Lee, Duk Hi Kim, Kir Young Kim
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Clin Exp Pediatr. 1989;32(10):1397-1401. Published online October 31, 1989
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This study is a systematic cytogenetic and clinico-hormonal analysis of 26 cases who were
diagnosed as Turner syndrome at the Yonsei Medical Center from Jan. 1978 to Jan. 1988. Antithyroid
antibody and thyroid function tests were performed in Turner syndrome(3 groups according to
karyotypes) and control group.
The results were as follows:
1) The incidence of positive antithyroid antibody in the 26 cases was 42.3% and... |
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- A Case of Thrombotic Thrombocytopenic Purpura in Childhood.
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Dong Kun Hyun, Jung Bae Lee, Chang Hyun Yang, Kir Young Kim
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Clin Exp Pediatr. 1988;31(4):511-518. Published online April 30, 1988
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Thrombotic thrombocytopenic purpura is clinically characterized by microangiopathic hemolytic
anemia, thrombocytopenia, fever, renal disorder and transient bizarre neurological symptoms. Its
essential histological lesion consists of numerous complete or, more often, incomplete occlusions of
the arterioles and capillaries by hyaline material.
We have experienced a case of thrombotic thrombocytopenic purpura in infancy. The patient was
a one year and 4 month-old who complains petechiae on the... |
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- A Case of Multiple Congenital Abnormalities Associated with Ring Chromosome 13.
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Yung Hyuk Lee, Dong Won Choi, Chang Jun Coe, Kir Young Kim
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Clin Exp Pediatr. 1988;31(4):506-510. Published online April 30, 1988
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A case of ring chromosome 13 has been experienced in 1 year and 9 month old female child recently.
This female child manifested psychomotor retardation and multiple congenital anomalies. The
diagnosis was made on the basis of typical morphologic features and chromosome study.
As this is the first case in Korea, it is worthwhile to report with reviewing literature. |
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- A Clinical Study and Comprehensive Total Care in Hemophilia.
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Shin Heh Kang, Chang Hyun Yang, Kir Young Kim
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Clin Exp Pediatr. 1988;31(2):202-211. Published online February 28, 1988
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Hemophilia is one of the hereditary coagulation disorders characterized by deficiency in plasma
clotting facotrs such as factor VIII and IX. As life long bleeding occurs in hemophiliacs, continous
comprehensive total care is required for the patients. After the self therapy, home care program was
introduced in the 1970s’ in the United States, there was significant reduction in absentism, hospitalized
days, outpatient visits, decrease... |
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- The Direct Coombs Test and Heat Elution Test in ABO Incompatible Hemolytic Disease of the Newborn.
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Kook In PArk, Chul Lee, Ran Namgung, Dong Gwan Han, Kir Young Kim
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Clin Exp Pediatr. 1988;31(12):1633-1640. Published online December 31, 1988
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The clinical study on 28 cases of ABO HDN who were diagnosed at Pediatric Department of
Severance hospital and Yong Dong Severance hospital, Yonsei University for last 5 months was. And
in these cases, heat elution test in combined with direct Coombs test using standard techniques were
performed to evaluate the clinical significance of serological diagnosis.
The following results were obtained.
1) Of 28 ABO HDN... |
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- A Clinical Studies in Patients with Turner's Syndrome.
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Chang Hyun Yang, Duk Hi Kim, Kir Young KIm, Young Ho Yang
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Clin Exp Pediatr. 1987;30(10):1143-1151. Published online October 31, 1987
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This study is systematical cytogenetic and clinico-hormonal analysis of 42 cases who were
diagnosed as Turner’s syndrome at the Yonsei Medical Center from Jan. 1971 to Dec. 1985. The
careful history taking, physical examination, cytogenetic studies, radiologic and hormonal evalua-
tion, and GnRH stimulation test were performed.
The results were as follows.
1) The patients ranged in age from 14 months to 30 years at the... |
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- Etiological & Clinical Study for Neonatal Hepatitis & Biliary Atresia.
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Ki Sub Chung, Kir Young Kim, Hyo Kyu Kim
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Clin Exp Pediatr. 1983;26(5):440-448. Published online May 31, 1983
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The following result WBS obtained through the clinical observation of 67 cases with neonatal
hepatitis, 7 cases with extrahepaticbiliary atresia, 1 case with intrahepatic biliary atresia
admitted at Department of Pediatrics, Yonsei University Hospital during the period of
January, 1979 through October, 1982.
The clinical & etiological study was performed by the Hepatitis B marker, Liver function
test, Liver scan, pathologic findings by percutaneous liver... |
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- Clinical Observation of Dds Induced Methemoglobinemia.
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Hee Seon Auh, Kwan Hwooy Cho, Kir Young Kim, Duk Jin Yun, Sook Pyo Kwon
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Clin Exp Pediatr. 1983;26(3):257-264. Published online March 31, 1983
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Various compounds activate the oxidation of hemoglobin. These include nitrites, sulfonamides,
aniline derivatives, chlorates, quinones, acetanilid and phenacetin. The striking offender
has been DDS in infancy and childhood who live in Kangwon Do, Korea.
The common untoward effects of DDS are hemolytic anemia and methemoglobinemia.
This clinical study was carried out for analysis on 57 cases which were diagnosed as DDS
induced methemoglobinemia at... |
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- The Response of Leukocytes in the Peripheral Blood Following Exchange Transfusion in the Newborn.
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Young Mo Sohn, Yu Young Chang, Young Ho Kim, Kir Young Kim
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Clin Exp Pediatr. 1983;26(11):1049-1054. Published online November 30, 1983
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We have studied the hemoglobin level and. leukocyte count of 23 fullterm and 1 premature
jaundiced babies soon after exchange transfusion and daily thereafter until 7 days.
The resixlts are:
1) One exchange transfusion was enough in 16 patients but 8 were required more than
2times of exchange transfusion. The maximum is 6 times.
2) The postnatal age was... |
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- Allogenic bone marrow transplantation in rabbit.
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Kir Young Kim, Duk Hee Kim, Young Mo Shon, Kwan Sub Chung, Hong Jin Kim, Duk Jin Yun
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Clin Exp Pediatr. 1982;25(9):867-879. Published online September 30, 1982
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Allogenic bone marrow transplantation was done with Korean unspecified rabbits. Fresh
bone marrow cell of different sex was infused to the recipient. The study group was divid-
edfive groups according to immunosuppresive drugs.
Each group was consited of 20 rebbits, was exposed to 1200 Rad.
Group A, which were not have bone marrow transplantation, showed 100% mortality rate
after 8 weeks.
Group 8, which did not... |
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- A study in The Changes of Platelet Count in iron Deficiency Anemia among Children.
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Nam Ae Kim, Kir Young Kim
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Clin Exp Pediatr. 1982;25(10):1015-1021. Published online October 31, 1982
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Iron deficiency anemia (IDA) is the most common nutritional anemia among chidren. A
study on the changes of platelet count in IDA was conducted with 83 children who were
diagnosed at the Severance Hospital in a 5 J/2-year pericd from Jan. 1975 to Jun. 1981. The
results are summarized as follows.
1. IDA was most common among chidren younger than 2-years(61%) due to nutritional
deficiency. It... |
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- Cluster of Guillain-Barre Syndrome.
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Young Mo Sohn, Sung Sik Lee, Kwan Sub Chung, Ki Sub Chung, Seung Kyu Lee, Pyung Kil Kim, Kir Young Kim, Duk Jin Yun, Kyoung Ja Cho
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Clin Exp Pediatr. 1981;24(9):820-825. Published online September 15, 1981
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Of 7 cases of Guillain-Barre syndrome reviewed, which was admitted to the Department of Pediatrics Yonsei University, College of Medicine during 3 months period from July through September 1980, serologic surveys for an infectious agent were found to be without demonstrable causes such as cytomegalovirus and measles virus. We reviewed 87 acses of Guillain-Barre syndrome, which was admitted to our... |
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- Clinical Study on Neonatal Meningitis.
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Kyo Sun Kim, Kee Young Lee, Kir Young Kim, Duk Jin Yun
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Clin Exp Pediatr. 1981;24(8):709-722. Published online August 15, 1981
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A clinical study was made on 58 cases of neonatal meningitis occuring under the age of 1 month in the department of Pediatrics at Severance Hospital, yonsei University College of Medicine, from Jan. 1, 1965 to Dec. 31, 1978. 1. The sex ratio of male and female was approximately 1.8:1. 2. Neonatal predisposing factors significantly associated with meningitis were omphalitis(14... |
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- Case Report
- Two Cases of Cri Du Chat(5p-) Syndrome.
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Han Soo Choi, Sung Seek Lee, Chul Lee, Kwan Sub Chung, Pyung Kil Kim, Kir Young Kim, Sa Suk Han
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Clin Exp Pediatr. 1981;24(6):597-602. Published online June 15, 1981
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We have experienced two cases of the Cri Du Chat Syndrome. The first case, 1 and 11/12 year old female, was admitted to evaluated profound mental retardation and failure to thrive. The other, 3 month old female, visit this dept for cat-like cry. They had the typical clinical characteristics of the Cri Du Chat Syndrome and showed showed the classical... |
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- Original Article
- Clinical Observation of Hemolytic Anemia in Children Except Isoimmunization.
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Hak Yong Kim, Young Mo Sohn, Kwan Sub Chung, Kir Young Kim, Duk Jin Yun
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Clin Exp Pediatr. 1981;24(12):1149-1156. Published online December 15, 1981
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Hemolytic anemia is caused by early destruction of red cells and there are many etiologies,ecently, prosthetic devices are used frequently to correct cardiac diseases and they also cause hemolytic anemia.
We performed clinical analysis of 74 patients with hemolytie anemia who had been diagnosed at Severance hospital in recent 10 years. Results were as follows: 1)In 74 cases, male were 46... |
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- Case Report
- A Case of Acute(infantile) Gaucher's Disease.
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Baek Keun Lim, Kwan Sub Chung, Jae Seung Lee, Kir Young Kim, Byung Soo Kim, Duk Jin Yun, Chang Jin Kim, Chan Il Park
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Clin Exp Pediatr. 1981;24(10):982-990. Published online October 15, 1981
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A case of Acute infantile form of Gaucher's disease in Korean infant is described. The large cells characteristically found in the bone marrow and liver in Gaucher's disease have been investigated with electron microscope, as well as light microscope. The pertinent literature has reviewed briefly concerning the clinical and laboratory fingings, roentgenographic picture, pathogenesis, pathology, diagnosis and treatment of this... |
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- Original Article
- A Case of Congenital Hypoplastic Anemia.
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Dong Soo Kim, Chul Lee, Hong Kyu Lee, Kir Young Kim, Duk Jin Yun
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Clin Exp Pediatr. 1980;23(9):771-775. Published online September 15, 1980
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Authours have observed a case of congenital hypoplastic anemia in 21 months old Korean male patient who was diagnosed through aspirations of bone marrow. His hematologic improvement was followed by administrations of prednisolone. A brief review of related literature was made. |
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- The Study of Fetomaternal Transfusion in Korea.
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Chul Lee, Jun Hee Sul, Kir Young Kim, Duk Jin Yun
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Clin Exp Pediatr. 1980;23(12):983-990. Published online December 31, 1980
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Blood samples from mothers during labor and after delivery were tested for the occurrence of fetomaternal transfusing using Nierhaus acid elution technique. Fetomaternal transfusion had occured 1/2 of the mothers after delivery, 2/3 of the mothers during labor. The fetomateonal transfusions after delivery were most often less than 4.0?? and only few percent had fetomaternal transfusions more than 4.0??. Complicated... |
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- Case Report
- Histiocytic Medullary Reticulosis in childhood Report of Three Cases.
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Kwan Sub Chung, Kyo Sun Kim, Do Kwang Yun, Pyung Kil Kim, Kir Young Kim, Byung Soo Kim, Tae Jung Kwon, In Jun Chor
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Clin Exp Pediatr. 1980;23(10):833-842. Published online October 15, 1980
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Three cases of hisiocytic medullary reticulosis occurring in children aged 6 years, 9 years and 14 years, are described. In all children the diagnosis was based on anemia, granulocytopenia, thrombocytopenia and marked erythrophagocytosis by bone marrow and lymph node atypical histiocytes. They all showed immediate remission with combined chemotherapy of vinblastine and prednisolone, but Case 1 eventually died at 6... |
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- Emergencies in Hemophilia.
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Dong Soo Kim, Kwan Sub Chung, Kir Young Kim, Duk Jin Yun
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Clin Exp Pediatr. 1980;23(10):809-814. Published online October 15, 1980
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9 classic hemophilacs in Severance Hospital, Yonsei University from Dec. '77 to Aug. '79 were reviewed and analysed and the following results were obtained. 1. Intracranial hemorrhage is required the most immediate emergent therapy in hemophiliacs and computerized transverse axial tomogarhy may be essential for the accurate and noninvasive diagnosis and for the effective emergency treatment. 2. To conserve supplies... |
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- Original Article
- Clinical Study and Diagnostic Value of Monocytosis.
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Kyo Sun Kim, Chee Ok Ahn, Kee Choon Kim, Kir Young Kim, Duk Jin Yun
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Clin Exp Pediatr. 1979;22(9):773-779. Published online September 15, 1979
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The usefullness of monocytosis in routine CMC as an aid in diagnosis of several diseases was evaluated in infancy and children. 234 cases in which the absolute count was more than 750 mono cyte per cubic millimeter were the subject of this study. The following results were obtained; 1) 234 cases (2.9%) of total 8069 patients from Oct. 1977 to... |
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- Fetomaternal Transfusion.
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Dong Gwan Han, Chul Lee, Kir Young Kim, Hyo Kyu Kim
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Clin Exp Pediatr. 1979;22(4):306-312. Published online April 15, 1979
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From Feb, 1977, through Aug. 1977, 100 venous blood samples obtained from women within 48 hr after delivery were examnied for fetomaternal transfusion by the Nierhaus acid elution technique. Blood smears were scanned at 100 high power field for enumeration of fetal erythrocytes. 1. The incidence of fetomaternal transfusion was 26% 2. The incidence of fetomaternal transfusion was the highest... |
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- Case Report
- Histiocytic Medullary Reticulosis: A case record and literatures review.
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Kwang Ho Kim, Chi Ok Ahn, Byoung Soo Kim, Kir Young Kim, Dong Wha Lee, In Joon Choi
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Clin Exp Pediatr. 1978;21(5):403-411. Published online May 31, 1978
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Histiocytic medullary reticulosis was first described as a clinical and pathological entity by Scott and Robb-Smith in 1939. The clinical pictures include progressive pancytopenia, fever, wasting, lymphadenopathy, hepatosplenomegaly, jaundice and purpura. The outstanding morphological features of the disease is proliferation of histiocytes throughout the reticuloendothelial system with frequent leucoerythrophagocytosis. In spite of uniform clinical and fistologcal pictures verified by additional... |
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- Original Article
- Clinical Studies on Purpura.
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Kir Young Kim, Ki Sup Chung, Hong Kyu Lee, Hun Young Moon, Ki Young Lee, Duk Jin Yun
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Clin Exp Pediatr. 1977;20(4):271-278. Published online April 30, 1977
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We observed clinically 150 cases who were admitted with complaing of purpura at the Pediatric Department of Severance Hospital Yonsei University College of Medicine during a period of 9 years from July, 1966 to June, 1975. In 150 cases, leukemia, 33 cases (22.0%), was most common disease, followed by I.T.P., allergic purpura, meningococcemia, aplastic a nemia, sepsis in order aqnd... |
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- Simple Screening Test for the Evaluation of Thyroid Function based on 131I-T3 Resin Sponge Uptake Test in Korean Children
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Pyung Kil Kim, Chung Hi Kim, Kir Young Kim, Se Mo Suh
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Clin Exp Pediatr. 1969;12(9):501-506. Published online September 30, 1969
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131I-T3 resin sponge uptake test is one of the newly developed thyroid function test. It seems to be the most rapid, accurate, simple and in vitro test ainong the various thyroid function tests. Healthy 51 children from newborn to adolescence were employed to be tested. Their results were also compared with normal value of 19 healthly adults. The following results... |
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- Thrombotest for Coagulation Studies in the Newborn and Vitamin K Prophylaxis.
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Kir Young Kim, Kook Hoon Ko, Chong Moo Lee, J.Courtland Robinson
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Clin Exp Pediatr. 1965;8(2):43-50. Published online May 31, 1965
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Hemorrhagic disorder of the newborn infant was fist described in 1894 by Dr. Townsend. Since then the
etiology, therapy and prophylaxis pave aroused great interest. The object of the present work has been to investigate the risk of hemorrhage in newborn infants and the possible need for vitamin K prophylaxis.
In the newborn period, numerous investigators were able to demonstrate a temporary... |
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- Case Report
- A Case of Letterer-Siwe Disease.
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Kir Young Kim, Ki Young Lee, Kook Hoon Ko, Geukdong KO
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Clin Exp Pediatr. 1965;8(2):51-56. Published online May 31, 1965
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This is a report of a 10 months-old male with Letterer-Siwe disease. The patient illustrated the classical clinical features of the disease, including maculopapular rash, hemorrhagic manifestations, anemia,diarrhea, marked enlargement of the spleen & liver, and susceptibility to secondary infection. Most of these signs developed soon after birth. (Fig. 1,2, & 3) Diagnosis was confirmed by microscopic examination, of skin... |
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- A Case of child Hodgkin’s disease in 4years and 8 months old boy
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Kir Young Kim, Kook Hoon KO
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Clin Exp Pediatr. 1964;7(1):18-24. Published online June 30, 1964
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This is a report of child Hodgkin’s disease which may be the first case in Korean literature as a you ngest patient.
The patient is 4 years and 8 months old boy who was first seen with symptoms and signs of anorexia, loss of weight* relatively period of high fever (pelEbstein type), anemia, painless swelling on inguinal and
cervical region and palpable... |
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