- Original Article
- The relationship between catechol-O-methyltransferase gene polymorphism and
coronary artery abnormality in Kawasaki disease
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Hyo Jin Lee, Myung Sook Lee, Ji Sook Kim, Eun Ryoung Kim, Sung Wook Kang, Soo Kang Kim, Joo Ho Chun, Kyung Lim Yoon, Mi Young Han, Seong Ho Cha
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Clin Exp Pediatr. 2009;52(1):87-92. Published online January 15, 2009
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Purpose : Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O- methyltransferase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT... |
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- Glutathione S-transferase polymorphism of
neonatal hyperbilirubinemia in Korean neonates
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Chang Seok Kang, Seung Su Hong, Ji Sook Kim, Eun Ryoung Kim
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Clin Exp Pediatr. 2008;51(3):262-266. Published online March 15, 2008
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Purpose : Glutathione S-transferase (GST) is a polymorphic supergene family of detoxification enzymes that are involved in the metabolism of numerous diseases. Several allelic variants of GSTs show impaired enzyme activity and are suspected to increase the susceptibility to diseases. Bilirubin is bound efficiently by GST members. The most commonly expressed gene in the liver is GSTM1, and GSTT1 is... |
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- The relation between angiotensin converting enzyme (ACE) gene
polymorphism and neonatal hyperbilirubinemia in Korea
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Mi Yeoun Kim, Jae Myoung Lee, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Seo Hyun Yoon, Joo Ho Chung
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Clin Exp Pediatr. 2007;50(1):28-32. Published online January 15, 2007
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Purpose : Human angiotensin converting enzyme (ACE) gene shows an insertion/deletion polymorphism in 16 intron, and three genotypes are determined by whether a 287 bp fragment of the DNA is present or not; II, ID and DD genotype. DD genotype has been suggested as a risk factor of chronic nephrotic disease such as IgA nephropathy and diabetic nephropathy, various cardiovascular... |
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- 1828G>A polymorphism of the UDP-glucuronosyltransferase gene (UGT1A1) for neonatal hyperbilirubinemia in Koreans
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Ja Young Kim, Mi Yeoun Kim, Ji Sook Kim, Eun Ryoung Kim, Seo Hyun Yoon, Hee Jae Lee, Joo Ho Chung
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Clin Exp Pediatr. 2006;49(1):34-39. Published online January 15, 2006
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Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in Caucasians. However, its metabolic basis has not been clearly explained. The UDP-glucuronosyltransferase gene(UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia. We studied whether neonatal hyperbilirubinemia is associated with the 1828G>A(rs 10929303) polymorphism of the UGT1A1 gene, which encodes for a... |
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- The Association of Neonatal Hyperbilirubinemia with UGT1A1 and CYP1A2 Gene Polymorphism in Korean Neonates
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Hoon Kang, Jun Ho Lim, Ji Sook Kim, Eun Ryoung Kim, Sung Do Kim, Hee Jae Lee, Joo Ho Chung
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Clin Exp Pediatr. 2005;48(4):380-386. Published online April 15, 2005
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Purpose : The incidence of nonphysiologic neonatal hyperbilirubinemia is twice as high in East Asians as in whites. Recently, UGT1A1 mutation was found to be a risk factor for neonatal hyperbilirubinemia. In congenitally-jaundiced Gunn rats, which lack expression of UDP-glucuronosyltransferase, alternative pathways can be stimulated by inducers of CYP1A1 and CYP1A2 enzymes. CYP1A2 plays a major role in bilirubin degradation... |
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- Polymorphism of UDP-glucuronosyltransferase Gene(UGT1A1) of Neonatal Hyperbilirubinemia in Korea
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Ki Woong Hong, Hoon Kang, Soo Kim, Ji Sook Kim, Eun Ryoung Kim, Hee Jae Lee, Sheng-Yu Jin, Joo Ho Chung
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Clin Exp Pediatr. 2004;47(1):18-23. Published online January 15, 2004
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Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in whites and its metabolic basis has not been clearly explained. Recently, UDP-glucuronosyltransferase gene (UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia in Japanese and Taiwanese Chinese. We studied whether neonatal hyperbilirubinemia is associated with mutation of UGT1A1, which is a... |
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- Nitroglycerin Treatment in Persistent Pulmonary Hypertension of the Newborn
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Ji Sook Kim, Sung Sook Jeon, Son Sang Seo
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Clin Exp Pediatr. 1997;40(11):1529-1536. Published online November 15, 1997
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Purpose : Persistent pulmonary hypertension(PPHN) of the newborn has been treated
with some vasodilators including tolazoline. But these drugs have many side effects,
especially systemic hypotension . To investigate the usefulness of the nitroglycerin as a
specific vasodilator with few side effects, this study was done.
Methods : Nitroglycerin was administered within 1st one day after birth in 8 newborn
infants who were diagnosed as... |
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- Case Report
- An Autopsy Case of Double Aortic Arch
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Ji Sook Kim, Yong Myung Jo, Kyung Hee Ko, Eun Ryoung Kim, Je Grun Chi
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Clin Exp Pediatr. 1996;39(5):727-731. Published online May 15, 1996
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Double aortic arch is the most common type of symptomatic vascularring. In most
patients, the symptoms are manifested at birth or in early infancy. Double aortic arch usually has more severe symptoms than other types of complete vascular rings.
We experienced one case of complete duplicated double aortic arch with left
descending aorta and left patent ductus arteriosus. A one-day-old female neonate was
transferred... |
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