- Original Article
- Allergy
- Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis
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Yeonu Choi, Haeun Jeon, Eun Ae Yang, Jong-Seo Yoon, Hyun Hee Kim
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Clin Exp Pediatr. 2019;62(9):353-359. Published online April 24, 2019
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Background: Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic cutoff values of EPO for use as a one-time test for allergic diseases such as allergic rhinitis have not been established.
Purpose: To identify the correlation... |
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- Baseline heart rate variability in children and adolescents with vasovagal syncope
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Sun Hee Shim, Sun-Young Park, Se Na Moon, Jin Hee Oh, Jae Young Lee, Hyun Hee Kim, Ji Whan Han, Soon Ju Lee
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Clin Exp Pediatr. 2014;57(4):193-198. Published online April 30, 2014
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Purpose This study aimed to evaluate the autonomic imbalance in syncope by comparing the baseline heart rate variability (HRV) between healthy children and those with vasovagal syncope. MethodsTo characterize the autonomic profile in children experiencing vasovagal syncope, we evaluated the HRV of 23 patients aged 7-18 years and 20 healthy children. These children were divided into preadolescent (<12 years) and adolescent groups.... |
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- The effect of rhinovirus on airway inflammation in a murine asthma model
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Eugene Kim, Huisu Lee, Hyun Sook Kim, Sulmui Won, Eu Kyoung Lee, Hwan Soo Kim, Kyongwon Bang, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Jin Tack Kim, Joon Sung Lee
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Clin Exp Pediatr. 2013;56(11):482-489. Published online November 27, 2013
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Purpose The aim of the present study was to investigate the differences in lower airway inflammatory immune responses, including cellular responses and responses in terms of inflammatory mediators in bronchoalveolar lavage fluid (BALF) and the airway, to rhinovirus (RV) infection on asthma exacerbation by comparing a control and a murine asthma model, with or without RV infection. MethodsBALB/c mice were intraperitoneally injected... |
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- Effect of respiratory syncytial virus infection on regulated on activation, normal T-cells expressed and secreted production in a murine model of asthma
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Yanghua Ju, Seung Jun Choi, Huisu Lee, Hyun Sook Kim, Sulmui Won, Yoon Hong Chun, Jong-Seo Yoon, Hyun Hee Kim, Joon Sung Lee
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Clin Exp Pediatr. 2011;54(11):456-462. Published online November 30, 2011
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Purpose Synthesis of regulated on activation, normal T-cells expressed and secreted (RANTES) in the airway has previously been shown to be elevated after respiratory syncytial virus (RSV) infection. However, since few studies have examined whether RSV-infected asthma patients express a higher level of RANTES than do normal individuals, we used a murine model of asthma to address this question. MethodsWe prepared Dermatophagoides... |
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- Clinical manifestations of CNS infections caused by enterovirus type 71
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Cheol Soon Choi, Yun Jung Choi, Ui Yoon Choi, Ji Whan Han, Dae Chul Jeong, Hyun Hee Kim, Jong Hyun Kim, Jin Han Kang
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Clin Exp Pediatr. 2011;54(1):11-16. Published online January 31, 2011
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Purpose Enterovirus 71, one of the enteroviruses that are responsible for both hand-foot-and-mouth disease and herpangina, can cause neural injury. During periods of endemic spread of hand-foot-andmouth disease caused by enterovirus 71, CNS infections are also frequently diagnosed and may lead to increased complications from neural injury, as well as death. We present the results of our epidemiologic research on the... |
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- Review Article
- Oral food challenges in children
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Hye Yung Yum, Hyeon Jong Yang, Kyung Won Kim, Tae Won Song, Woo Kyung Kim, Jung Hee Kim, Kang Mo Ahn, Hyun Hee Kim, Soo Young Lee, Bok Yang Pyun
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Clin Exp Pediatr. 2011;54(1):6-10. Published online January 31, 2011
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Many patients assume that allergic reactions against foods are responsible for triggering or worsening their allergic symptoms. Therefore, it is important to identify patients who would benefit from an elimination diet, while avoiding unnecessary dietary restrictions. The diagnosis of food allergy depends on the thorough review of the patients's medical history, results of supplemented trials of dietary elimination, and in... |
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- Original Article
- A rise and fall in AST and ALT level in nonspecific reactive hepatitis
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Tai Sung Kim, Tae Hyung Hur, Sun Jeong Lim, Joong Hyun Bin, Seung Hoon Hahn, So Young Kim, Hyun Hee Kim, Wonbae Lee
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Clin Exp Pediatr. 2008;51(4):396-400. Published online April 15, 2008
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Purpose : The study was performed to assess the distribution of the diseases associated with nonspecific reactive hepatitis (NRH) for the past 10 years and to evaluate the change in the level of AST and ALT, and the difference by several variable factors.
Methods : From January 1997 to December 2006, 646 patients had elevated liver enzymes among 22,763 patients admitted... |
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- Review Article
- Allergic rhinitis, sinusitis and asthma
- evidence for respiratory system integration -
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Hyun Hee Kim
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Clin Exp Pediatr. 2007;50(4):335-339. Published online April 15, 2007
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The link between upper airway disease (allergic rhinitis and sinusitis) and lower airway disease (asthma) has long been of interest to physicians. Many epidemiological and pharmacological studies have provided a better understanding of pathophysiologic interrelationship between allergic rhinitis and asthma. The vast majority of patients with asthma have allergic rhinitis, and rhinitis is a major independent risk factor for asthma... |
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- Original Article
- Normal antistreptolysin O titers of children by age group in the Gyeonggi-Incheon region
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Jihun Lee, Yoo Jung Kim, Joong Hyun Bin, Ja Young Hwang, Seong Hoon Hahn, So Young Kim, Hyun Hee Kim, Wonbae Lee
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Clin Exp Pediatr. 2007;50(10):965-969. Published online October 15, 2007
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Purpose : Measurement of antistreptolysin O (ASO) is often necessary to confirm a clinical diagnosis of recent streptococcal infection, especially in patients suspected of rheumatic fever and acute glomerulonephritis. Standard normal ranges for ASO should be established locally for each age group. We analyzed ASO to determine the upper limit of normal (ULN) ASO in children in the Gyeonggi-Incheon area.
Methods... |
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- The causative organisms of pediatric empyema in Korea
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Hye-yung Yum, Woo Kyung Kim, Jin Tak Kim, Hyun Hee Kim, Yeong Ho Rha, Yong Min Park, Myung Hyun Sohn, Kang Mo Ahn, Soo Young Lee, Su Jong Hong, Hae Ran Lee
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Clin Exp Pediatr. 2007;50(1):33-39. Published online January 15, 2007
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Department of Pediatrics , College of Medicine, Hallym University
Purpose : In spite of medical advances, empyema is a serious complication of pneumonia in children. Vaccination practices and antibiotic prescribing practices promote the change of clinical manifestations of empyema and causative organisms. So we made a nationwide clinical observation of 122 cases of empyema in children from 32 hospitals during... |
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- The effects of high-dose intravenous immunoglobulin on plasma protein and lipid levels in the patients with Kawasaki disease
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Keun Young Lee, Dong-Un Kim, Hyun Seung Lee, Pil Sang Jang, Young-Hoon Kim, Jin Tack Kim, Hyun Hee Kim, Kyung-Yil Lee, Joon-Sung Lee
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Clin Exp Pediatr. 2006;49(12):1348-1353. Published online December 15, 2006
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Purpose : The reticuloendothelial system is composed of sinusoidal capillaries, through which even large protein molecules are freely movable between plasma and interstitial space, including the lymphatic system. Therefore, high-dose intravenous immunoglobulin (IVIG) would cause a redistribution of proteins between two compartments. To investigate this hypothesis, we measured plasma protein and lipid levels in patients with Kawasaki disease before and... |
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- Comparison of Cytokine Expressions among Kawasaki Disease and Its Symptom-related Diseases
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Ran Lee, So Hyun Park, Yu Jeong Kim, So Young Kim, Hyun Hee Kim, Wonbae Lee
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Clin Exp Pediatr. 2004;47(5):567-573. Published online May 15, 2004
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Purpose : Kawasaki disease(KD) is an important acute febrile systemic vasculitis disease. Various cytokines have been studied to evaluate the pathogenesis of vascular injury. Some cytokines have been implicated for vascular injury, but there has been no direct evidence. We compared cytokine profiles of KD with Henoch-Sch nlein purpura(HSP), and febrile infections.
Methods : We investigated the serum concentrations of... |
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- Case Report
- A Case of G-6-PD Guadalajara
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Gi Bum Lee, Sun Ju Lee, Yoo Jung Kim, So Young Kim, Hyun Hee Kim, Bin Cho, Wonbae Lee
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Clin Exp Pediatr. 2004;47(2):210-213. Published online February 15, 2004
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Glucose-6-phosphate dehydrogenase(G-6-PD) deficiency is a disease that shows hemolytic anemia and jaundice caused by injury of erythrocytes. The gene of G-6-PD has 13 exons and locates in Xq28, and over 150 mutations of this gene have been reported. We experienced a G-6-PD deficienct male patient who was suffering hemolytic anemia and jaundice confirmed by measuring low G-6-PD activity in the... |
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- Original Article
- Detection of Cytokeratin-19 caused by Intestinal Epithelial Cell Damage in Childhood Diarrhea
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Ja Young Hwang, Se Young Seo, Seong Hoon Hahn, So Young Kim, Hyun Hee Kim, Won-Bae Lee
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Clin Exp Pediatr. 2004;47(11):1193-1197. Published online November 15, 2004
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Purpose : Acute gastroenteritis in infancy is a very common disease with a frequency of a billion diarrhea per year, leading to 3 to 5 million deaths. Since the etiology is not always clear, the treatment plan can be quite difficult to make. The laboratory examinations of stool culture, along with complete blood counts may sometimes be helpful to find... |
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- Original Article
- Plasma G-CSF and GM-CSF Concentrations and Expression of their Receptors on the Granulocyte in Children with Leukocytosis
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Won Seok Choi, Kyung Hwan Ryu, You Jeong Kim, So Young Kim, Hyun Hee Kim, Wonbae Lee
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Clin Exp Pediatr. 2003;46(3):271-276. Published online March 15, 2003
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Purpose : Granulocyte-colony stimulating factor(G-CSF) and granulocyte macrophage-colony stimulating factor(GM-CSF) are principal cytokines in granulopoiesis and their physiologic effects are mediated through binding to specific cell surface receptors. Although it is known that the level of serum G-CSF and GM-CSF, and presentation of the receptors are increased in infectious diseases, there have been no studies to find the correlation between... |
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- Case Report
- Two Cases of Hydrometrocolpos in Neonate
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Min Young Park, Bo Ra Son, So Young Kim, Young You Kim, Hyun Hee Kim, Won-Bae Lee, In Kyung Sung, Chung Sik Chun, Su Aa Lim
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Clin Exp Pediatr. 2002;45(2):278-283. Published online February 15, 2002
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Imperforated hymen, vaginal atresia or high transverse vaginal septum are caused by incomplete vaginal canalization. The infant may be present with distention of the vagina and the uterus with glandular secretions stimulated by maternal estrogens, known as hydrometrocolpos. We report two cases of hydrometrocolpos. In the first case, distal vaginal atresia with cystovaginal fistula was revealed by a contrast fluoroscope... |
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- A Case of Congenital Solitary Liver Abscess
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Sang Hee Kim, So Young Kim, You Jeong Kim, Hyun Hee Kim, Won Bae Lee, Kyung Tai Whang
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Clin Exp Pediatr. 2002;45(11):1426-1429. Published online November 15, 2002
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Congenital solitary liver abscess in newborns is an extremely rare and serious disease. Only one case was reported in the literature. Most a liver abscesses have a postnatal origin. We encountered a premature infant who had a low. Apgar score and an elevated right diaphragm at birth. Pyogenic solitary liver abscess was diagnosed by ultrasound and computed tomography. Staphylococcus aureus... |
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- A Case of Shaken Baby Syndrome
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Jin Choi, Hyun Hee Kim, Won Bae Lee
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Clin Exp Pediatr. 2000;43(6):851-855. Published online June 15, 2000
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Shaken baby syndrome refers to the group of nonaccidental injuries occuring in infants and children as a consequence of violent shaking. The characteristic injuries include subdural and subarachnoid hemorrhages, retinal hemorrhages, traction-typed metaphyseal fracture of long bone and fractures of the ribs. General physical findings may include bruising and burns, but sometimes no extracranial injuries are detected. Affected children are... |
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- A Case of Trichosporon beigelii Pneumonia in a Boy with Normal Immunological Status
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Hyun Hee Kim, Hai Lee Chung, in Bok Hwang, Cheal Woo Ko
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Clin Exp Pediatr. 2000;43(2):300-305. Published online February 15, 2000
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Invasive diseases caused by Trichosporon beigelii are rare, usually fatal, opportunistic infections that occur exclusively in immunocompromised patients. This fungus has been known to produce cutaneous involvement in immunocompetent hosts, and is rarely reported to cause systemic disease in patients with cardiac valve replacement. In this report, we described a case of invasive Trichosporon beigelii pneumonia in a 9-year-old boy... |
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- Original Article
- Detection Limit of Minimal Residual Disease in Leukemia Using Fluorescence in situ Hybridization
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Jung Hyun Lee, So Young Kim, Hyun Hee Kim, Byung Kyu Suh, Wonbae Lee, Kyung Tai Whang
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Clin Exp Pediatr. 2000;43(10):1364-1371. Published online October 15, 2000
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Purpose : The close relationship between the size of a tumor burden and the curability of acute leukemia is well established. Therefore, it is very important to detect residual leukemia accurately at low levels. Fluorescence in situ hybridization(FISH) techniques rely on chromosome-specific and gene specific DNA probes to identify numerical and structural chromosomal abnormalities. But the detection limit of FISH... |
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- Use of Fluorescent in Situ Hybridization to Evaluate the Number of Chromosomes in Buccal Smear Cells in Normal Newborn Infants
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Byoung Chan Lee, Jee Yeon Song, So Young Kim, Hyun Hee Kim, Seunghoon Han, Jong-In Byun, Wonbae Lee, Kyong Su Lee
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Clin Exp Pediatr. 1995;38(11):1470-1475. Published online November 15, 1995
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Purpose : The diagnosis for chromosomal anomality has been made by obtaining cells in metaphase from peripheral blood and fresh tissue culture. But this method is difficult to perform because somewhat invasive and necessary time for cell culture and staining(48-72hr). Recently, the method to find numerical abnormalities in, autosome and sex chromosome of adult buccal mucosal smear by FISH was... |
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