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Normal antistreptolysin O titers of children by age group in the Gyeonggi-Incheon region

Korean Journal of Pediatrics 2007;50(10):965-969.
Published online October 15, 2007.
Normal antistreptolysin O titers of children by age group in the Gyeonggi-Incheon region
Jihun Lee, Yoo Jung Kim, Joong Hyun Bin, Ja Young Hwang, Seong Hoon Hahn, So Young Kim, Hyun Hee Kim, Wonbae Lee
Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul
경인지역에서 조사한 소아의 연령별 antistreptolysin O 역가
이지헌, 김유정, 빈중현, 황자영, 한승훈, 김소영, 김현희, 이원배
가톨릭대학교 의과대학 소아과학교실
Correspondence: 
Wonbae Lee, Email: leewb@catholic.ac.kr
Abstract
Purpose
: Measurement of antistreptolysin O (ASO) is often necessary to confirm a clinical diagnosis of recent streptococcal infection, especially in patients suspected of rheumatic fever and acute glomerulonephritis. Standard normal ranges for ASO should be established locally for each age group. We analyzed ASO to determine the upper limit of normal (ULN) ASO in children in the Gyeonggi-Incheon area.
Methods
: ASO in normal individual concentrations were measured quantitatively by nephelometry on sera from 753 children (Male : 381, Female : 372). ULN were determined by separating the upper 20% from the lower 80% of the group (80 percentile).
Results
: The mean ASO concentration calculated in a total cases was 149.9?.2 IU/mL. The ASO concentration in neonates was 83.4?0.7 IU/mL, and lowest in the 1 year of age group, 26.7?.6 IU/ mL, and increased to 318.0?3.2 IU/mL gradually in the 9 years of age group. Thereafter, ASO concentration decreased. The ULN for neonates was 122 IU/mL, for 0-3 years, 40 IU/mL; for 4-6 years, 113 IU/ mL; for 7-9 years, 489 IU/mL; for 10-19 years, 433 IU/mL; for 20-29 years, 122 IU/mL.
Conclusion
: The age-specific ULN for children in the Gyeonggi-Incheon area were determined. The distribution of ASO concentration according to age groups was different from previous reports. These results should be of clinical value to physicians to interprete the ASO results of their patients.
Key Words: Antistreptolysin O, Pediatrics, Reference Values


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