- Review Article
- Endocrinology
- Nonalcoholic fatty liver disease and insulin resistance in children
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Kyungchul Song, Ho-Seong Kim, Hyun Wook Chae
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Clin Exp Pediatr. 2023;66(12):512-519. Published online January 9, 2023
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· The prevalence of pediatric nonalcoholic fatty liver disease (NAFLD) increased from 8.2% in 2009 to 12.1% in 2018 in Korea.
· Laboratory tests, biomarkers, and imaging studies are used for the early detection of NAFLD.
· Insulin resistance is closely related to NAFLD. |
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- Original Article
- Endocrinology
- Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study
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Junghwan Suh, Han Saem Choi, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim
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Clin Exp Pediatr. 2020;63(4):146-150. Published online December 6, 2019
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Question: Does agricultural pesticide effect precocious puberty in girls?
Finding: Dinotefuran, an insecticide of neonicotinoid class, was detected in one of 30 patients with precocious puberty, and in 2 girls of the normal control group, which was not statistically significant.
Meaning: There was no close relationship between agricultural pesticides and development of precocious puberty. |
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- Lipopolysaccharide-binding protein plasma levels as a biomarker of obesity-related insulin resistance in adolescents
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Ki Eun Kim, Young Sun Cho, Kyung Suk Baek, Lan Li, Kwang-Hyun Baek, Jung Hyun Kim, Ho-Seong Kim, Youn Ho Sheen
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Clin Exp Pediatr. 2016;59(5):231-238. Published online May 31, 2016
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Purpose Lipopolysaccharide-binding protein (LBP) is a 65-kDa acute phase protein, derived from the liver, which is present in high concentrations in plasma. Data regarding the association between circulating plasma LBP levels and obesity-related biomarkers in the pediatric population are scarce. We aimed to determine whether there was a difference in plasma LBP levels between overweight/obese and normal-weight adolescents and to assess... |
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- Review Article
- Growth hormone treatment and risk of malignancy
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Hyun-Wook Chae, Duk-Hee Kim, Ho-Seong Kim
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Clin Exp Pediatr. 2015;58(2):41-46. Published online February 28, 2015
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Growth hormone (GH) treatment has been increasingly widely used for children with GH deficiencies as the survival rate of pediatric patients with malignancies has increased. Both GH and insulin-like growth factor-I have mitogenic and antiapoptotic activity, prompting concern that GH treatment may be associated with tumor development. In this review, the authors examined the relationship between GH treatment and cancer... |
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- Clinical application of gonadotropin-releasing hormone analogs in children and adolescents
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Ho-Seong Kim
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Clin Exp Pediatr. 2010;53(3):294-299. Published online March 15, 2010
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Although the increasing incidence of central precocious puberty (CPP) in Korea has recently raised public concerns about health and growth problems, there are many areas of uncertainty regarding the pathogenesis, diagnosis, and management of CPP. In this paper, we review the definition of precocity, the assessment of CPP, and the hormonal abnormalities that support the diagnosis. In addition, we review... |
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- Original Article
- Effects of growth hormone treatment on glucose metabolism in idiopathic short stature
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Seung Yeon Kwon, Duk-Hee Kim, Ho-Seong Kim
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Clin Exp Pediatr. 2006;49(6):665-671. Published online June 15, 2006
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Purpose : To study the effects of growth hormone(GH) treatment on glucose metabolism and insulin resistance in children with idiopathic short stature(ISS).
Methods : Glucose and insulin concentrations were measured during oral glucose tolerance test (OGTT) before and after GH treatment(0.6-0.7 IU/kg/week) in 20 patients with ISS. Insulin resistance was assessed by homeostasis model assessment(HOMA).
Results : During OGTT, the mean... |
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- Clinical Lecture
- Acquired Thyroid Disorders in Childhood
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Ho-Seong Kim
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Clin Exp Pediatr. 2004;47(9):926-932. Published online September 15, 2004
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Thyroid hormones influence growth and development, oxygen consumption, heat production, nerve function, and metabolism, thus play a critical role as a regulator of nervous system myelination, of growth and of puberty. Disorders affecting thyroid function may cause irreversible and permanent nervous system damage and developmental delay, especially in early infancy. Appropriate medical care of children with thyroid disorders requires refined... |
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- Original Article
- The Prevalence of Maturity Onset Diabetes of the Young(MODY) 3 in Children with Type 2 Diabetes Mellitus
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In Kyoung Choi, Duk Hee Kim, Ho-Seong Kim, Nam Huh, Sang Hyun Paek, Seoung Young Jung
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Clin Exp Pediatr. 2004;47(6):641-646. Published online June 15, 2004
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Purpose : Maturity-onset diabetes of the young(MODY) is a subtype of type 2 diabetes defined by autosomal dominant mode of inheritance, onset of diabetes usually before the age of 25 yrs, and a primary defect in the function of the beta cells of the pancreas. MODY3 is known as the most common form and is caused by mutations in hepatocyte... |
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- Prevalence of Metabolic Syndrome in Obese Children
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Jin Ha Chang, Duk Hee Kim, Ho-Seong Kim, In Kyoung Choi, My Young Cheong, Dong Kee Kim
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Clin Exp Pediatr. 2004;47(11):1149-1156. Published online November 15, 2004
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Purpose : Obesity has been known to be a cause of insulin resistance and dyslipidemia, and along with coronary artery disease and diabetes, is associated with metabolic syndrome(MS). This study aimed to ascertain the cause and prevalence of MS in obese children and adolescents.
Methods : Two hundred and seventy-seven school children, who showed more than a 95th percentile of body... |
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