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Clin Exp Pediatr > Accepted Articles
DOI: https://doi.org/10.3345/cep.2019.00416    [Accepted]
Published online December 2, 2019.
Effect of agricultural pesticide on precocious puberty in urban children: an explorative study
Junghwan Suh  , Han Saem Choi  , Ahreum Kwon  , Hyun Wook Chae  , Ho-Seong Kim 
Department of Pediatrics, Severance Children’s Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea
Correspondence: 
Ho-Seong Kim, Tel: +82-2-2228-2069, Fax: +82-2-393-9118, Email: kimho@yuhs.ac
Received: 3 May 2019   • Revised: 23 October 2019   • Accepted: 1 December 2019
Abstract
Background
The incidence of precocious puberty has been increased throughout the 20th century. The association between precocious puberty and endocrine disrupting chemicals (EDCs) including agricultural pesticides has been a subject of global study, but insufficient human subject data exist.
Purpose
We investigated the relationship between agricultural pesticides and development of precocious puberty.
Methods
We enrolled 60 female subjects at Severance Children’s Hospital from December 2015 to January 2017. Thirty patients were diagnosed with precocious puberty, while 30 pre-pubertal girls were enrolled into the normal control group. We investigated clinical characteristics, and analyzed urinary levels of 320 different agricultural pesticides.
Results
Agricultural pesticide was detected in one out of 30 patients with precocious puberty (3.3%), while in two girls in the normal control group (3.3 % vs 6.7%, p=0.554). Dinotefuran, which is an insecticide of neonicotinoid class, was detected in all three positive subjects.
Conclusion
Our results showed no relationship between agricultural pesticides and development of precocious puberty. Larger sample sizes and robustly controlled variables are necessary for further investigations.
Key Words: Endocrine disrupting chemicals, Agricultural pesticide, Precocious puberty




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