- Original Article
- Comparison of gastric and other bowel perforations in preterm infants: a review of 20 years' experience in a single institution
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Do Kyung Lee, So Yeon Shim, Su Jin Cho, Eun Ae Park, Sun Wha Lee
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Clin Exp Pediatr. 2015;58(8):288-293. Published online August 21, 2015
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Purpose In this study, we aimed to review the clinical presentation of preterm infants with gastrointestinal perforations and compare the clinical features of gastric perforation with other intestinal perforations. MethodsThe medical records of preterm neonates with pneumoperitoneum, admitted to the neonatal intensive care unit (NICU) between January 1994 and December 2013, were retrospectively reviewed. ResultsTwenty-one preterm infants underwent exploratory laparotomy to investigate the... |
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- The relationship between eosinophilia and bronchopulmonary dysplasia in premature infants at less than 34 weeks' gestation
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Joo Yun Yang, Jihei Cha, So-Yeon Shim, Su Jin Cho, Eun Ae Park
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Clin Exp Pediatr. 2014;57(4):171-177. Published online April 30, 2014
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Purpose Eosinophilia is common in premature infants, and its incidence increases with a shorter gestation period. We investigated the clinical significance of eosinophilia in premature infants born at <34 weeks gestation. MethodsWe analyzed the medical records of premature infants born at <34 weeks gestation who were admitted to the neonatal intensive care unit at Ewha Womans University Mokdong Hospital between January 2003... |
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- Case Report
- A girl with sternal malformation/vascular dysplasia association
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Na Yong Lee, Hye Kyung Cho, Kyung-Hyo Kim, Eun Ae Park
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Clin Exp Pediatr. 2013;56(3):135-138. Published online March 18, 2013
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Sternal malformation/vascular dysplasia association is a rare congenital dysmorphology, which has not yet been reported in Korea. Its typical clinical features include a sternal cleft covered with atrophic skin, a median abdominal raphe extending from the sternal defect to the umbilicus, and cutaneous craniofacial hemangiomata. We report a case of a full-term newborn who presented with no anomalies at birth,... |
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- The first Korean case of poland-Möbius syndrome associated with dextrocardia
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Jiyoung Jung, Han Gyu Kim, Hae-Mi Ahn, Su Jin Cho, Eun Ae Park
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Clin Exp Pediatr. 2009;52(12):1388-1391. Published online December 15, 2009
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Poland syndrome is characterized by unilateral absence or hypoplasia of the pectoralis muscle and variable degree of ipsilateral hand anomalies. Möbius syndrome is a congenital neurological disorder characterized by complete or partial facial paralysis. Although the pathogeneses of these diseases are not well-characterized, diminished blood flow to the affected side is thought to play a role. A male infant weighing... |
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- Relationship between cord blood level of IL-12 in
preterm newborns and development of wheezing
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Hyo Jung Yu, Eun Ae Park, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye Sook Park, Eun Hee Ha
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Clin Exp Pediatr. 2008;51(7):754-759. Published online July 15, 2008
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Purpose : Abnormal activation patterns of Th1/Th2-cells have been suggested to increase the prevalence of allergic diseases. Prevention is regarded as an important corner stone in the management of allergic diseases. In this study, we have investigated the relationship between cord blood levels of IL-4, IL-10, and IL-12 in preterm newborns and the development of allergic respiratory diseases in infancy
Methods... |
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- Bacterial meningitis in children experienced at a university hospital, 1993-2006
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Sung Yoon Cho, Tae Yeon Kim, Hyunju Lee, Kyung Hyo Kim, Eun Sun Yoo, Hae Soon Kim, Eun Ae Park, Kyung Ha Ryu, Jeong Wan Seo, Sejung Sohn, Seung Joo Lee
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Clin Exp Pediatr. 2008;51(10):1077-1084. Published online October 15, 2008
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Purpose : Despite the seriousness of bacterial meningitis in children, there is little information on the incidence, causative organisms, mortality rate and age distribution. We studied the frequency by age group and causal pathogens, and clinical characteristics in children with bacterial meningitis in the private sector in Korea.
Methods : The medical records containing the data on bacterial meningitis patients... |
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- Cord blood IL-10, IL-12 in preterm newborns as predictors of
respiratory distress syndrome and bronchopulmonary dysplasia
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Jee Yoon Park,, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye sook Park, Eun Hee Ha, Eun Ae Park
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Clin Exp Pediatr. 2007;50(3):248-254. Published online March 15, 2007
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Purpose : Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood of preterm newborns with RDS or BPD.
Methods : Forty preterm newborns whose mothers received antenatal care at Ewha Womans University Mokdong Hospital between January 2003 to June 2005, and... |
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- The influence of some intrauterine growth variables on neonatal blood pressure
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Jungwon Min, Eun Ae Park, Kyoungae Kong, Bohyun Park, Juhee Hong, Young Ju Kim, Hwayoung Lee, EunHee Ha, Hyesook Park
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Clin Exp Pediatr. 2006;49(9):966-971. Published online September 15, 2006
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Purpose : ‘Programming’ describes the process that stimulus at a critical period of development has lifelong effects. The fact that low birth weight links to the risk of elevated blood pressures in adult life is well known. This study aims to examine whether this link is evident in the newborn by investigating the relationship of the intrauterine growth indices and... |
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- Effects of NG-monomethyl-L-arginine and L-arginine on cerebral hemodynamics and energy metabolism during reoxygenation-reperfusion after cerebral hypoxia-ischemia in newborn piglets
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Sun Young Ko, Saem Kang, Yun Sil Chang, Eun Ae Park, Won Soon Park
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Clin Exp Pediatr. 2006;49(3):317-325. Published online March 15, 2006
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Purpose : This study was carried out to elucidate the effects of nitric oxide synthase(NOS) inhibitor, NG-monomethyl-L-arginine(L-NMMA) and nitric oxide precursor, L-arginine(L-Arg) on cerebral hemodynamics and energy metabolism during reoxygenation-reperfusion(RR) after hypoxia- ischemia(HI) in newborn piglets.
Methods : Twenty-eight newborn piglets were divided into 4 groups; Sham normal control(NC), experimental control(EC), L-NMMA(HI & RR with L-NMMA), and L-Arg(HI & RR... |
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- The Change in Intestinal Lactobacillus Count among Healthy Neonates
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Hyun Joo Lee, Hyun Ji Lee, Su Jin Cho, Jung Wan Seo, Seung Joo Lee, Eun Ae Park
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Clin Exp Pediatr. 2004;47(8):833-838. Published online August 15, 2004
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Purpose : Enhancing overall health by preventive and therapeutic use of probiotics has shown great promise on inflammatory, infectious, neoplastic disorders, allergies, et al. To attain preliminary data for the use of probiotics, we have studied the change in intestinal flora, Lactobacillus count among healthy, full term neonates.
Methods : Fresh stool samples were collected on the 2nd or 5th day... |
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- Antithrombin III in the Diagnosis and Treatment of Disseminated Intravascular Coagulation in Premature Infants
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Su Jin Cho, Hye Ryung Choi, Young Mi Hong, Kyung Hee Kim, Keun Lee, Eun Ae Park
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Clin Exp Pediatr. 2004;47(7):740-745. Published online July 15, 2004
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Purpose : We evaluated the diagnostic implications and therapeutic efficacy of antithrombin III(AT III) in the disseminated intravascular coagulation(DIC) of premature infants.
Methods : Ninety-two premature infants diagnosed with DIC and treated with AT III from March, 2000 to May, 2003 were retrospectively reviewed. Clinical manifestations, complete blood counts, coagulation tests, and AT III levels were compared between the two groups... |
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- Prevention of Chronic Lung Disease with Early Dexamethasone Treatment in less than 32 Weeks Premature : Randomized Controlled Study
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So Yun Shim, Su Jin Cho, Eun Ae Park
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Clin Exp Pediatr. 2004;47(5):521-526. Published online May 15, 2004
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Purpose : The optimal timing and the consequences of dexamethasone therapy in chronic lung disease remain unknown. The purpose of this study was to determine whether early dexamethasone therapy would reduce the incidence of chronic lung disease and to determine the adverse effects and complications of prematurity associated with such therapy.
Methods : Twenty neonates with hyaline membrane disease(dexamethasone n=10, placebo... |
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- Case Report
- A Case of Cutis Verticis Gyrata due to Cerebriform Intradermal Nevus in the Neonate
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Hye Ryung Choi, Hyun Joo Lee, Eun Ae Park
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Clin Exp Pediatr. 2004;47(2):223-226. Published online February 15, 2004
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Cutis verticis gyrata(CVG) is a morphologic syndrome of the scalp characterized by folds and furrows resembling the surface of brain. The primary form of cutis verticis gyrata is commonly associated with a neuropsychiatric condition and a secondary form occurs as a response of inflammatory or neoplastic process. The patient was a 1-day-old girl, who had a 15?1 cm sized, convoluted... |
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- Original Article
- A Clinical Manifestation of Meckel's Diverticulum
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Jin Beom Lee, Yong Soon Lee, Eun Sun Yoo, Hae Soon Kim, Se Jeong Son, Eun Ae Park, Seung Joo Lee, Sun Hee Sung, Jeong Wan Seo
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Clin Exp Pediatr. 2002;45(4):466-472. Published online April 15, 2002
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Purpose : The diagnosis of Meckel's diverticulum is difficult and delayed because it presents with various clinical symptoms. We evaluated clinical, imaging and pathologic findings of Meckel's diverticulum to facilitate detection of Meckel's diverticulum in children.
Methods : Review of clinical, imaging, surgical and pathological findings in 10 children aged 7 days to 14 years with Meckel's diverticulum during an 8-year... |
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- Usefulness of Serum Prealbumin Concentration as a Marker for
Nutritional Adequacy in Premature Infants
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Soo Jin Lee, Eun Ae Park, Jeong Wan Seo
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Clin Exp Pediatr. 2001;44(8):867-874. Published online August 15, 2001
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Purpose : Serum prealbumin concentration has been proposed as a useful nutritional marker that responds rapidly and sensitively to calory and protein intake. But the reports of prealbumin in premature infants are not sufficient and variable. The purpose of this study was to evaluate the usefulness of serum prealbumin concentration as a marker for nutritional adequacy in premature infants.
Methods... |
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- Evaluation of Health Status and Growth and Developmental
Outcome of Intrauterine Growth-Retarded Infants
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Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 2001;44(6):635-641. Published online June 15, 2001
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Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants.
Methods : Sixty five intrauterine growth retarded... |
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- The Utility of Serum Prealbumin as a Biochemical Marker for
Nutritional Adequacy in Neonates
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Ji A Jung, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee
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Clin Exp Pediatr. 2000;43(5):605-610. Published online May 15, 2000
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Purpose : The purpose of this study was to determine the utility of serum prealbumin as a biochemical marker for nutritional adequacy in neonates.
Methods : From March 1998 to May 1999, 71 fullterm(54 AGA, 9 LGA, 8 SGA) and 46 preterm neonates were enrolled. The correlations among prealbumin, albumin, birth weight and gestational age were obtained. Serum concentrations of albumin... |
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- Effects of Umbilical Arterial Catheterization on
Intestinal Hemodynamics
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Sejung Sohn, Su Jung Choi, Jung An Yang, Eun Ae Park
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Clin Exp Pediatr. 2000;43(5):650-657. Published online May 15, 2000
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Purpose : An umbilical arterial catheter(UAC) in the high position reduces the lumen of the aorta and may thereby impair blood supply to the intestine. Effects of UAC on intestinal blood flow were investigated.
Methods : With the measurement of the aortic diameter, pulsed Doppler ultrasonography was performed in 23 fasting newborns to measure blood flow velocities(peak systolic velocity, end-diastolic velocity,... |
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- Diagnostic Value of Urine Latex Test In Bacterial Meningitis
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Seung Min Lee, Eun Ae Park, Seung Joo Lee
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Clin Exp Pediatr. 2000;43(1):55-59. Published online January 15, 2000
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Purpose : Bacterial meningitis in childhood carries significant mortality and morbidity, so accurate
and rapid diagnosis is important. Cerebrospinal fluid(CSF) latex agglutination test has been used
for rapid diagnosis of bacterial meningitis. However, urine may be the best specimen for a latex
test, because bacterial antigens are concentrated in the urine. The study tried to determine the
diagnostic value of urine latex test in... |
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- Inhibitory Effects of Dexamethasone on Production IL-1α and TNF-α in Peripheral Blood Mononuclear Cells
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Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 1999;42(7):921-927. Published online July 15, 1999
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Purpose : IL-1α and TNF-α have a seminal role in the intial events of inflammation. An area of intense interest is the assessment of new therapeutic modalities that regulate inflammatory response in acute bacterial infection. We conducted this study to compare the inhibitory effects of dexamethasone on the secretion of proinflammatory cytokines, such as IL-lα and TNF-α from cord... |
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- Effects of Two Different Surfactants on RBC Membrane and Type Ⅱ Alveolar Epithelial Cell in Vitro
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Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1999;42(1):32-39. Published online January 15, 1999
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Purpose : Respiratory distress syndrome(RDS) is a major cause of death in premature babies. For the treatment of RDS, various artificial pulmonary surfactants have been used. The incidence of pulmonary hemorrhage is increased in association with surfactant therapy in extremely low birth weight infants. But the pathogenesis of this increased incidence is not clear. So we conducted this study... |
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- The Diagnostic Value of CSF Tumor Necrosis Factor-α for Early Diagnosis of Bacterial Meningitis
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So Young Park, Soo Ja Hwang, Eun Ae Park, Jung Wan Seo, Seung Joo Lee
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Clin Exp Pediatr. 1998;41(8):1078-1083. Published online August 15, 1998
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Purpose : During the course of bacterial meningitis, TNF-α produced by macrophages and monocytes in response to LPS and other inflammatory and immune stimulation, is now recognized as a primary mediator in the pathogenesis of infection, injury and inflammation and in the process of host defence. TNF-α was increased vascular permeability by inducing morphologic and structural changes of endothelial cells... |
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- Random Urine Ca/Cr Ratio in Healthy Neonates
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Hea Young Lee, So Young Park, Eun Sun Yoo, Eun Ae Park, Seung Joo Lee
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Clin Exp Pediatr. 1998;41(3):378-382. Published online March 15, 1998
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Purpose : Recently, in high risk preterm infants, we experienced high incidence of hypercalciuria, nephrolithiasis & nephrocalcinosis. To screen hypercalciuria, we need the normal value of random urine Ca/Cr ratio in healthy neonates according to gestational age, postnatal age, milk and calcium intake.
Methods : Random urine Ca/Cr ratio was checked in 260 healthy full-term infants at the 2-7th day, and... |
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- Serum G-CSF Level Changes in Neonatal Sepsis
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Kyung Ha Ryu, Eun Ae Park, Kyung Hyo Kim, Gyung Hee Kim
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Clin Exp Pediatr. 1998;41(1):12-18. Published online January 15, 1998
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Purpose : The neonate is susceptible to severe and overwhelming bacterial infections. One of the most important deficiency in the neonatal host defense system seems to be quantitative and qualitative deficiency of the myeloid and the phagocytic system. Granulocyte colony-stimulating factor(G-CSF) has been shown to induce neutrophilia and enhance mature effector neutrophil function. We examined serum levels of G-CSF in... |
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- Production of Interleukin-1α and Tumor Necrosis Factor-α by Human Cord and Adult Blood Mononuclear Cells Stimulated by TSST-1 and LPS
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Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 1997;40(5):690-700. Published online May 15, 1997
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Purpose : Immature immunological defens mechanism in the neonate may contribute to the high susceptibility to overwhelming sepsis. S. aureus TSST-1 and E. coli LPS known as one of the important pathogens of septic shock or toxic shock induce massive release of various cytokines, such as tumor necrosis factor-alpha(TNF-α) and interleukin-1α(IL-1α) produced from peripheral blood mononuclear cells(PBMC). In contrast, limited... |
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- Varicella Zoster Virus Spicific IgG Antibody Titer in Vaccinated and Infected Children
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Young Eun Lee, Eun Ae Park, Kyung hee Kim
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Clin Exp Pediatr. 1996;39(7):934-942. Published online July 15, 1996
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Purpose : Varicella is mild self limited disease with vesicular skin eruption but highly
contagious and accompanied many complications. Especially, varicella is fatal in leukemic children
and immunocompromised children. The live varicella zoster virus was first developed by
Takahashi et al. in the 1974. This vaccine has now been licensed for general use in Europe and
the United States as well as in Korea..
The... |
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- Serum IgE Standardized for Age in Korean Children and Its Diagnostic Reliability in Childhood Asthma
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Myung Su Lee, Eun Sun Yoo, Hye Sun Kim, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee
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Clin Exp Pediatr. 1996;39(3):397-403. Published online March 15, 1996
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Purpose : IgE was identified by Ishizaka as an antibody that is reacted at Type I
hypersensitivity reaction, and has been used in the diagnosis of allergic disease and the differential diagnosis of extrinsic and intrinsic asthma. But there was some confusing in the diagnosis because of the broad range of measured serum IgE. Recently it was reported that serum IgE... |
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- Case Report
- An Autopsy Case of Tracheal Agenesis Type 2
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Hyun Joo Lee, Eun Ae Park, Seung Joo Lee, Mi Jeong Kim, Soon Hee Seong
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Clin Exp Pediatr. 1996;39(12):1759-1762. Published online December 15, 1996
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Tracheal agenesis is the rare and uniformly lethal anomaly that presents with severe
respiratory distress and aphonia after birth. In this anomaly, the trachea is usually absent and air is reaching the bronchi through a communication with the esophagus. The diagnosis should be suspected in a nowborn infant with respiratory distress whose intubation is difficult.
We report an autopy case of tracheal... |
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- Original Article
- Diagnostic Value of 99mTc-DMSA Renal Scan for Early Diagnosis of Acute Pyelonephritis in Children with Febrile Urinary Tract Infection
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Soo Ja Hwang, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee, Sun Whan Lee
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Clin Exp Pediatr. 1996;39(11):1586-1593. Published online November 15, 1996
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Purpose : For prevention of renal scar, early diagnosis and treatement of acute pyelonephritis
are important in children with febrile urinary tract infection. But it has been difficult to
differentiate acute pyelonephritis from lower urinary tract infection. We have performed this study
to evaluate the diagnostic value of 99mTc-DMSA renal scan and to clarify the relationship among
acute pyelonephritis, vesico-ureteral reflux and renal scar.
Methods... |
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- Case Report
- A Case of Meckel-Gruber Syndrome
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Hye Jin Lee, Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1995;38(9):1299-1303. Published online September 15, 1995
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We report a case of male neonate that showed multiple congenital anomalies that could be designated as Meckel-Gruber syndrome.
The principle signs of Meckel-Gruber syndrome are encephaolcelem, polydactly, and polycystic kidneys with normal karyotype. Due to rarity of the Meckel-Gruber syndrome, the cause was still unknown. At present, autosomal recessive is thought to be as one of the causes. This malformation... |
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- Case Report
- Laryngotracheoesophageal Cleft Type III A Report of 1 Case
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Myung Su Lee, Young Eun Lee, Eun Ae Park, Gyoung Hee Kim, Eun Chul Chung, Hac Soo Gyu
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Clin Exp Pediatr. 1995;38(5):719-724. Published online May 15, 1995
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Laryngotracheoesophageal cleft is rare congenital anomaly due to failure of fusion of the e sophagus and the larynx.
We experienced 1 case of larygotracheoesophageal cleft type III in neonate which was confirmed by autopsy.
One day of age male newborn infant with grunting, retraction, and copious secretion canofirm diagnosis as laryngotracheoesophageal cleft type Ill by several radiographic studies and sutopsy.
Brief review and... |
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- Original Article
- The Changes of Fetal Hemoglobin in Preterm and Small for Gestational Age Newborn Infants
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Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1993;36(7):919-927. Published online July 15, 1993
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The fetal hemoglobin, which is structurally different from adult hemoglobin, has higher affinity for oxygen and higher resistance to denaturation with alkali than adult hemoglobin. Intrauterine growth retarded neonates have highter mortality and morbidity than normal neonates.
In this article, to determine the changes of fetal hemoglobin by gestational age in infants appropriate in wieght for gestational age (AGA) and to... |
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- Dermatophagoides Farinae Specific IgG-Subclass Antibody in Allergic Children
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Young Mi Hong, Kyung Hyo Kim, Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1993;36(10):1651-1358. Published online October 15, 1993
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For determining the distribution of specific IgE and IgG-subclass antibodies and their role in allergic disorders, we measured the serum levels of specific IgG-subclass and IgE antibodies to Dermatophagoides farinae(Df) on 60 atopic children, aged between 8 to 12. All of them had positive skin test to Df, and was grouped into three: children with asthma only (group 1), with... |
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- A case of neonatal systemic candidiasis.
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Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1991;34(9):1286-1293. Published online September 30, 1991
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Systemic infection with Candida albicans in very premature infants is frequently fatal or associated
with significant morbidity in survivors. Several common practices in newborn intensive care units,
such as insertion of indwelling catheters, provision of parenteral nutrition, and prolonged administra-
tion of broad-spectrum antibiotics or aminophylline, are associated with an increased risk of systemic
disease.
We have experienced a case of systemic candidiasis in 1/365... |
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- The relationship between diuresis and pulmonary function in respira- tory distress syndrome of the newborn.
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Eun Ae Park, Yung Sook Ko, Gyoung Hee Kim
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Clin Exp Pediatr. 1991;34(8):1086-1092. Published online August 31, 1991
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The purpose of this study was to determine the relationship between improvement of pulmonary,
function and diuresis in respiratory distress syndrome. This study was based on 24 cases of RDS
infants admitted in NICU of Ewha Womans University from January 1988 to December 1990.
The results were as follows.
1) Mean birth weight of study cases was 2.11 kg with gestational age between 29〜39 weeks.
2) Maximum... |
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- A case of posterior urethral valve of the newborn.
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Eun Ae Park, Gyoung Hee Kim
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Clin Exp Pediatr. 1991;34(10):1439-1445. Published online October 31, 1991
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Posterior urethral valve is the most common obstructive abnormality in male children affecting
both kidneys and likely arise from maldevelopment of the mesonephric duct.
We have experienced a case of posterior urethral valve with urinary ascites in 10/365 year old male
neonate. Abdominal distension, oligouria, and azotemia were improved by urinary catheterization.
Pelvo-ureterostomy operation was done, and this case had excellent results with much... |
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- The Apgar Score and Umbilical Arterial pH in the Newborn.
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Hoo Jae Hann, Eun Ae Park, Kyung Hee Kim
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Clin Exp Pediatr. 1990;33(8):1048-1056. Published online August 31, 1990
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In this prospective study, the relation between the Apgar scores and umbilical arterial pH at birth
was assessed. 314 newborns of gestational age 24 to 42 weeks were included in this study； (95 were
preterm and 219 were full-term) The l and 5-minute Apgar scores were directly related to gestational
age. In preterm babies, the Apgar scores tend to be low in spite... |
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