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Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia

Korean Journal of Pediatrics 2007;50(3):248-254.
Published online March 15, 2007.
Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia
Jee Yoon Park,1, Ji Young Kim1, Soo Jin Cho1, Young Ju Kim2, Hye sook Park3, Eun Hee Ha3, Eun Ae Park1
1Departments of Pediatrics, Ewha Womans University, College of Medicine, Seoul, Korea
2Departments of Obstetrics and Gynecology, Ewha Womans University, College of Medicine, Seoul, Kore
3Departments of Preventive Medicine, Ewha Womans University, College of Medicine, Seoul, Kore
호흡곤란증후군과 기관지폐이형성증 예측 인자로서의 미숙아 제대혈 IL-10, IL-12
박지윤1, 김지영1, 조수진1, 김영주2, 박혜숙3, 하은희3, 박은애1
1이화여자대학교 의과대학 소아과학교실
2이화여자대학교 의과대학 산부인과학교실
3이화여자대학교 의과대학 예방의학과학교실
Correspondence: 
Eun Ae Park, Email: pea8639@ewha.ac.kr
Abstract
Purpose
: Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood of preterm newborns with RDS or BPD.
Methods
: Forty preterm newborns whose mothers received antenatal care at Ewha Womans University Mokdong Hospital between January 2003 to June 2005, and agreed to testing their cord blood samples were enrolled. The gestational ages were below 34 weeks. Cord blood level of IL-10 and IL-12 were determined by ELISA. We separated the patients into 2 groups (RDS group and non- RDS group, BPD group and non-BPD group) and compared the cytokine levels and clinical records of the groups.
Results
: Cord blood IL-10 level showed a significant inverse correlation with gestational age and birth weight (P=0.001, P=0.005). Preterm infants with RDS showed higher IL-10 level (1.0 vs 0.1 pg/mL; P=0.001) in the cord blood than those without RDS. The differences remained statistically significant after correction for the effect of gestational age between both preterm groups. Despite similar cord blood IL-10 levels, preterm infants with BPD showed no significant difference with those without BPD.
Conclusion
: Cord blood IL-10 levels are increased in preterm infants which may be due to the immuno-suppression occurring during pregnancy and to fetal immaturity because these levels are inversely correlated with the gestational age. So, Cord blood IL-10 level can be used as the predictor of RDS.
Key Words: Preterm infant , Respiratory distress syndrome , Broncho-pulmonary dysplasia , Interleukin-10 , Interleukin-12 , Cord blood


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