| The influence of some intrauterine growth variables on neonatal blood pressure |
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Jungwon Min1, Eun Ae Park2, Kyoungae Kong1, Bohyun Park1, Juhee Hong1, Young Ju Kim3, Hwayoung Lee4, EunHee Ha1, Hyesook Park1 |
1Department of Preventive Medicine College of Medicine, Ewha Womans University, Seoul, Korea
2Department of Pediatrics College of Medicine, Ewha Womans University, Seoul, Korea
3Department of Obstetrics and Gynecology College of Medicine, Ewha Womans University, Seoul, Korea
4Department of Anatomy College of Medicine, Ewha Womans University, Seoul, Korea |
| 태아기 자궁내 성장지표와 신생아 혈압과의 관련성 |
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민정원1, 박은애2, 공경애1, 박보현1, 홍주희1, 김영주3, 이화영4, 하은희1, 박혜숙1 |
1이화여자대학교 의과대학 예방의학교실
2이화여자대학교 의과대학 소아과학교실
3이화여자대학교 의과대학 산부인과학교실
4이화여자대학교 의과대학 해부학교실 |
Correspondence:
Hyesook Park, Email: hpark@ewha.ac.kr
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| Abstract |
Purpose
: ‘Programming’ describes the process that stimulus at a critical period of development has lifelong effects. The fact that low birth weight links to the risk of elevated blood pressures in adult life is well known. This study aims to examine whether this link is evident in the newborn by investigating the relationship of the intrauterine growth indices and neonatal blood pressure(BP).
Methods
: We studied 127 neonates who were born at Ewha Womans' Hospital and their mothers enrolled our cohort study during pregnancy. Data on the mothers and details of the birth records were tracked and collected from medical charts. Neonatal BP was measured within 24 hours after birth.
Results
: Neonatal SBP was positively correlated to intrauterine growth indices; birth weight(BW)(r= 0.4), head circumference(HC)(r=0.4), and birth height(r=0.3). However, an inverse relationship existed, between HC/BW ratio and neonatal SBP(r=-0.4). After adjusting for the baby's sex, maternal BP, and gestational age, neonatal SBP still associated with intrauterine growth indices. SBP was 7 mmHg higher in the highest BW group(≥90 percentiles) compared to the lowest group(<10 percentiles). On the other hand, SBP was 17 mmHg lower in the highest HC/BW group(≥90 percentiles) compared in the lowest group(<10 percentiles).
Conclusion
: This study could not find the evidence that intrauterine growth retardation affect on elevated neonatal BP. It suggests that the initiating events of BP programming may occur during postnatal growth period. To identify the critical starting period that intrauterine growth retardation leads to elevated BP, a study tracking BP changes from birth to childhood is required. |
| Key Words:
Neonatal blood pressure , Intrauterine growth indices , Blood pressure programming |
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