| Varicella Zoster Virus Spicific IgG Antibody Titer in Vaccinated and Infected Children |
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Young Eun Lee, Eun Ae Park, Kyung hee Kim |
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Department of Pediatrics, Ewha Womans University Hospital, Seoul, Korea |
| 소아에서 수두 예방 접종아와 감염 면역아의 수두 특이 IgG 항체가에 대한 연구 |
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이영은, 박은애, 김경희 |
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이화여자대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: Varicella is mild self limited disease with vesicular skin eruption but highly
contagious and accompanied many complications. Especially, varicella is fatal in leukemic children
and immunocompromised children. The live varicella zoster virus was first developed by
Takahashi et al. in the 1974. This vaccine has now been licensed for general use in Europe and
the United States as well as in Korea..
The porpose of this study was to estimate the VZV IgG antibody titer and evaluate the
efficacy of vaccination.
Methods
: The VZV IgG antibody titers were estimated in 246 healthy children, 32 vacccinated
and 43 naturally infected children by FAMA method. In some children of the these groups, VZV
specific IgG subclasses were estimated by ELISA method.
Results
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1) In 246 healthy children, VZV IgG antibody titers were increased according to the age.
2) The positive rates VZV IgG antibody titer according to age were lowest at 1 to 2 years of
the age with 22.4% and highest at 6 to 7 years of the age with 77.7%.
3) Comparing of the VZV IgG antibody titer in each groups according to the age, in children
ranging from 1 year to 5 years of age, the VZV IgG antibody titer in vaccinated group was
significantly increased compared with control group(p<0.05). In children over 6 years old, the
VZV IgG antibody titer in disease groups was significantly increased compared with control
group(p<0.05).
4) The VZV IgG antibody titers were decreased according to the duration after infection.
5) VZV specific IgG1 between control group and other groups were statistically different(
p<0.05). IgG3 in infected group was significantly increased compared with control
group(p<0.05). IgG4 in vaccinated group was significantly increased compared with control
group(p<0.05).
Conclusion
: The live attenuated vaccine is recommended for preventing of varicella infection,
but further evaluation and longterm follow up are necessary for protective efficacy of the VZV
vaccine and about the VZV specific IgG subclass. |
| Key Words:
Varicella Zoster virus specific IgG, Live attenuated varicella vaccine |
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