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Original Article
Immune response induced by live attenuated varicella vaccine(Biken@) in children with acute lymphoblastic leukemia.
Hyo Seop Ahn, Joong Gon Kim
Clin Exp Pediatr. 1991;34(9):1255-1260.   Published online September 30, 1991
To determine the safety and efficacy of varicella vaccine, we studied 10 healthy children and 12 children in remission from acute lymphoblastic leukemia. They were immunized with the Oka strain of live attenuated varicella vaccine (Biken®). All the healthy children and 6 children with leukemia received the vaccine of 1,000 plaque-forming units (PFU), and 6 leukemic children received the vaccine of 500 PFU. The...
The diagnostic significance of APR score in early detection of neonatal bacterial infection.
Ki Won Park, Kyeong Choi, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 1991;34(9):1223-1230.   Published online September 30, 1991
An accurate and rapid diagnostic test is essential in the management of bacterial infection in neonates because they lack specific symptoms and the bacterial infections in neonates tends to have rapid progression and poor prognosis. As for the method, APR (acute phase reactants), a score measuring C-reactive protein (CRP), 상racid glycoprotein (이-AG) and Haptoglobin (Hp) by latex agglutination seems to be one of promising methods. In...
A case of bone marrow necrosis in acute lymphoblastic leukemia.
Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(8):1163-1168.   Published online August 31, 1991
Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke- mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections. Recently it is regarded as a more common finding frequently overlooked and carrying not so poor prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of diagnosis and achieved complete...
Acute renal failure with back pain after exercise.
Hae Jung Park, Mi Jung Kim, Dong Kyu Jin, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Jung Mi Park, Kyung Mo Yeun
Clin Exp Pediatr. 1991;34(6):863-868.   Published online June 30, 1991
We have experienced one case of acute renal failure without clinical rhabdomyolysis characterized by preceding exercise and back pain. This patient showed patch renal increased uptakes in bone scan with 99mTechnetium-methylene diphosphonate, and delayed wedge-shaped contrast enhancements in renal computed tomography. These findings can be explained by focal renal vasoconstriction of interlobar arteries or arcuate arteries, which may be considered as one of the...
Mannitol induced acute oliguric renal failure.
Young Mi Chung, Jae Seung Lee, Chang Jun Coe
Clin Exp Pediatr. 1991;34(6):857-862.   Published online June 30, 1991
Mannitol known as non-electrolytic, osmotic diuretic agent is widely used in clinic for the purpose of diagnosis and prevention of acute oliguric renal failure, cerebral edema as well as glaucoma and dialysis-disequilibrium syndrome. That mannitol may cause serious life-threatening situation if administered in a patient with renal problem has been well known. Recently, it has been published that mannitol may be nephrotoxic in patient...
A case of acute lymphoblastic leukemia complicating neuroblastoma in remission.
Dong Woo Son, Bum Soo Park, Jun Jae Kim, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(5):720-729.   Published online May 31, 1991
As childhood cancer survivors are now increasing in number owing to the improvements in diagnosis, staging, and treatment, concerns have been raised regarding the quality of survival of these patients. One of the limitation to quality and length of survival has been the development of second malignant neoplasm (SMN). In Korea, only one case of SMN has been reported. However, one can expect that...
Acute pyogenic arthritis of hip in neonate and infant.
Mi Jung Kim, Young Ah Lee, Young Pyo Chang, Hoan Jong Lee, Jung Hwan Choi, Chong Ku Yun, Hak Jin Min, In Ho Choi
Clin Exp Pediatr. 1991;34(2):197-205.   Published online February 28, 1991
Acute pyogenic arthritis of hip is a serious infection that can lead to truly devastating complica- tions especially in neonatal period and infancy. Clinical survey on twelve neonates and infants (14 hip joints) with acute pyogenic arthritis of hip who were admitted to the Departments of Pediatrics and Orthopedic Surgery, Seoul National University Hospital from Jan. 1980 to Dec. 1989 were done. The results...
Molecular analysis of childhood acute lekemia.
Hack Ki Kim, Kyong Su Lee, Sung Hoon Cho, Du Bong Lee
Clin Exp Pediatr. 1991;34(2):164-171.   Published online February 28, 1991
Immunoglobulin (Ig) and T cell receptor 0 chain (TcR分) gene rearrangements can be used as ”genetic marker” of lineage and clonality in the study of lymphoproliferative disease. We analyzed genomic DNA of the bone marrow mononuclear cells from twenty six patients with acute leukemia in children. The patients were seventeen cases of acute lymphocytic leukmia (ALL), seven cases of acute nonlymphocytic leukemia (ANL) and...
Clinical considerations of acute leukemia or transient myeloprolifo- rative disorder in Down syndrome.
Eun Sil Dong, Sung Hee Jang, Hong Hoe Koo, Hye Lim Jung, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(1):74-82.   Published online January 31, 1991
Children with Down syndrome have an increased incidence of acute leukemia. Infants with Down syndrome are also at risk of developing a transient myeloproliferative disorder indistinguishable from acute nonlymphocytic leukemia (ANLL) except by its eventual clinical recovery. We observed 11 patients with acute leukemia or transient myeloproliferative disorder in Down syndrome who had admitted to the Departmetn of Pediatrics, Seoul National University Children’s Hospital,...
Three cases of Acute Transverse Myelitis.
Hae Young Hwang, Jong Sik Moon, Se Jung Sohn, Hak Soo Lee
Clin Exp Pediatr. 1990;33(12):1729-1734.   Published online December 31, 1990
Acute transverse myelitis can be defined as acute disorder characterized clinically by signs of lesions in motor and sensory tracts on both sides of the spinal cord. In the typical cases, there is a distinct bilateral sensory deficit level, paraparesis or quadriparesis, abonormal function of rectal and vesicular sphincters and often with the evidence of preceding or concurrent viral illness. Recently, we experienced three...
A Case of Diabetic Ketoacidosis Associated with Acute Lymphocytic Leukemia during Remission Induction Chemotherapy.
Gyu Jin Oh, Hwa Jeong Lee, Heui Jeong Kwon, In Sil Lee
Clin Exp Pediatr. 1990;33(11):1598-1603.   Published online November 30, 1990
L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase are hypersensitivity reaction, hepatotoxicity, pancreatitis, transient diabetes mellitus, CNS toxicity, disorders of coagulation system and mild cytotoxicity. We report a female patient with acute lymphocytic leukemia develop- ing diabetic ketoacidosis during induction chemotherapy with L-asparaginase, parednisolone, vincris- tine and intrathecal methotrexate, who...
A Case of Acute Megakaryoblastic Leukemia in infantwith down Syndrome.
Jang Sik Moon, Hae Young Hwang, Sejung Sohn, Hak Soo Lee, Heum Rye Park
Clin Exp Pediatr. 1990;33(10):1441-1446.   Published online October 31, 1990
Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have more than relationship to it. The authors report a case of acute megakaryoblastic leukemia in a 17 day-old male patient who was admitted for evaluation of high fever and dyspnea. The infiltration of atypical megakaryocytes...
A Case of Acute Mixed Lineage Leukemia (ANLL with TII) with neutropenic Enterocolitis.
Hyeon Joo Choi, Young Suk Koh, Young Mee Hong, Seung Joo Lee, Kee Suk Hong, Keum Ja Choi
Clin Exp Pediatr. 1990;33(9):1281-1287.   Published online September 30, 1990
We report a case of acute mixed lineage leukemia with both lymphoid and myeloid lineage characteristics (ANLL with Til) in a twelve-year-old girl who presented with fever and multiple petechiae. Bone marrow remission was obtained by treatment with acute lymphoid leukemia regiman (CCSG 106A). During induction chemotherapy, the patient was complicated by intestinal perforation due to neutropenic enterocolitis but recovered by surgical intervention and...
A Case of Acute Interstitial Nephritis Associated with Yersinia Pseudotuberculosis Infection.
Keun Hee Chung, Yoo Mee Kim, Mee Won Kim, Soon Gi Kim, Moon Soo Park, Jin Keun Chang
Clin Exp Pediatr. 1990;33(8):1123-1128.   Published online August 31, 1990
Authors recently experienced a case of acute interstitial nephritis associated with Yersinia pseudotuberculosis infection in 10-8/12 year old boy, who was admitted to prolonged high fever. On 3rd hospital day, puffy face and oliguria were noted. BUN and serum creatinine rose to peak level, 94.1 mg/dl and 10.1 mg/dl, respectively on 7th hospital day. After then renal functions were normal- ized gradually without specific...
Case Report
A Case of Subacute Necrotizing Lymphadenitis.
S Y Song, W H Kwon, C H Han, H R Chung, S Y Kim, Y D Kwon
Clin Exp Pediatr. 1990;33(5):714-720.   Published online May 31, 1990
We experienced a case of subacute necrotizing lymphadenitis in a 6 year old boy which has been originally described in Japan. The diagnosis was made by clinical features(fever, adenopathy), laboratory(WBC, ESR, GOT, GPT, LDH etc), histopathologic, electron microscopic, and immunohistologic findings. The review of literature was made.
Original Article
A Case of Acute Renal Failure Associated with Rhabdomyolysis in Carbon Monoxide Intoxication.
Kyung Hee Park, Sei Hee Hwang, Hae Il Cheong, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1990;33(5):690-694.   Published online May 31, 1990
We experienced a case of acute renal failure associated with rhabdomyolysis after Carbon Monoxide intoxication in a 12 year old Korean girl who had marked soft tissue swelling of the left thigh, reddish brown colored urine and oliguria. Diagnosis was made by clinical features, markedly elevated serum muscle enzymes and serum myoglobin, and Tc 99m-MDP bone scan which revealed increased radioactivity at the left...
A Study on Anemia of Acute Infectious Disease in Children.
Hae Won Lee, Young Mi Hong, Seung Joo Lee, Keun Lee
Clin Exp Pediatr. 1990;33(1):75-80.   Published online January 31, 1990
The anemia of acute infectious disease has come to attention recently, since iron deficiency anemia has decreased. We screened for anemia in children admitted to Ewha Womans University Hospital due to acute infectious disease between January 1, 1986 and July 31, 1988, and studied the incidence and characteristics of anemia in acute infectious diseases. The result were as follows: 1) The incidence of anemia in acute...
A Case of Acute Rhenmatic Fever Associated with Acute Poststreptococcal Glomerulonepheitis.
Ho Kyung Choi, Dong Seok Choi, Jae Ho Lee, Young Hun Chung, Hyon Soon Lee
Clin Exp Pediatr. 1989;32(12):1744-1748.   Published online December 31, 1989
A case of acute glomerulonephritis in association with acute rheumatic fever was presented. The patient rheumatic arthritis and carditis with mitral insufficiency, who had been diagnosed as acute poststreptococcal glomeruoonephritis with non-oliguric renal failure with renal biopsy and laboratory findings. The patient was treated, and symptom and sign were improved.
The Collaborative Clinical Analysis of 985 Cases of Rheumatic Fever and Rheumatic Carditis in Children for 10 Years(1978~1987) in Korea.
Sung Ho Cha, Sang Young Jeong, Du Bong Lee, Kyong Su Lee, Sang Bum Lee, Tae Chan Kwon, Young Chang Tockgo, Chang Sung Sohn, Keun Chan Sohn, Young Jin Hong, Chan Young Kim, Chang Yee Hong, Yong Soo Yun, Jung Yun Choi, Chang Hwi Kim, Chul Ho Kim, Tae Ju Hwang, Jae Suk Ma, Chan Uhul Joo, Kyoo Hwan Rhee, Hahng Lee
Clin Exp Pediatr. 1989;32(12):1621-1631.   Published online December 31, 1989
Acute rheumatic fever and rheumatic carditis were still important disease of the acquired heart disease in children and adults, in spite of improving socioeconomic status in Korea. Recently, many outbreaks of acute rheumatic fever have been reported in the papers from developed countries. We should be aware of such outbreaks of acute rheumatic fever and should pay attention to their treatment of the patients...
Three Cases of Typhlitis during Treatment for Acute Myelocytic Leukemia in Children.
Soon Mee Park, Il Soo Ha, Hoan Jong Lee, Jeong Kee Seo, Hyo Seop Ahn, Kyung Mo Yeon
Clin Exp Pediatr. 1989;32(10):1455-1462.   Published online October 31, 1989
Typhlitis is a rare necrotizing colitis in which inflammation is confined to cecum. It occurs during chemotherapy for malignancies, in terminal stage of aplastic anemia, in transplant patients. The pathogenesis of typhlitis has included leukemic infiltration of the bowel, thrombocytopenia, direct toxic effects of chemotherapy, steroid, bacterial invasion of the bowel wall secondary to neutropenia and alteration of the bowel flora by broad-spectrum antibiotics....
A Case of Myelodysplatic Syndrome.
Sun Bok Suh, Chang Ok Soh, Sang Hoon Lee, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1989;32(9):1314-1319.   Published online September 30, 1989
We have experienced a case of myelodysplastic syndrome (RAEB) in an 11-year-old boy with the complaints of pallor and petechiae for 1 month. After diagnosis, improvement was remarkable with chemotherapy of low dose cytosine arabinoside but the RAEB was transformed to acute myeloblastic leukemia 4 months after treatmemt. Anti-leukemic therapy was tried but induction of remission was failed and he was died of sepsis...
A Trend of Serum C3 and C4 levels in Acute Poststreptococcal Glomerulonephirtis.
Dong Seok Choi, Young Hun Chung
Clin Exp Pediatr. 1989;32(7):965-971.   Published online July 31, 1989
Acute poststreptococcal glomerulonephritis is generally stated to be the most common cause of acute nephritis in childhood and secondary to an immunologic mechanism. In acute poststreptococcal glomerulonephritis, there have been several reports on the change of serum complement levels in the course of disease. This paper reports on observation of change of serum C3 & C4 levels and its clinical significance in 41 cases of...
A Clinical Study on Children with Acute Glomerulonephritis.
Jeong Ok Kim, Son Moon Shin, Yong Hoon Park
Clin Exp Pediatr. 1989;32(6):779-788.   Published online June 30, 1989
A clinical observation has been made on 111 children with acute glomerulonephritis who were admitted to Pediatric Department of Yeungnam University Hospital during 5 years period from June 1, 1983 to May 31, 1988. The incidence of acute glomerulonephritis among hospitalized patients was 1.59% and the annual incidence was decreased markedly after June 1986. Peak incidence was noticed in the wintertime from November to January...
Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.
Young Seo Park, Il Soo Ha, Soon Ki Kim, Hae Il Jung, Yong Choi, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(5):665-669.   Published online May 31, 1989
We studied the cyclophosphamide-induced hemorrhagic cystitis in 72 cases of acute lymphocytic leukemia or Non-Hodgkin lymphoma, which had been treated at Seoul National University Children' s Hospital from June, 1985 to May, 1988 1) Among 72 cases treated with cyclophosphamide, 6 cases(12.8%) developed hemorrhagic cystitis in 47 cases of acute lymphocytic leukemia and 2 cases(8.0%) in 25 cases of Non-Hodgkin lymphoma. 2) The development of...
A Clinical Study of Acute Glomerulonephritis in Children.
Sung Ho Bae, Jin Hong Park, Jong Duck Kim
Clin Exp Pediatr. 1989;32(4):525-532.   Published online April 30, 1989
A Clinical study has been made on 33 cases of acute glomerulonephritis who were admitted to pediatric department of Won Kwang University Hospital, during 2 year period from Jan. 1985 to Dec. 1986 The results were as follows: 1) Male to female ratio was 1.4:1 and the age incidence was highest among children from 4 -12 years of age group(78.8%). 2) The most common season was...
A Case of Werdnig-Hoffmann Disease.
Ok Ji Hwang, Kon Hee Lee, Ha Joo Choi, Woo Kap Chung
Clin Exp Pediatr. 1989;32(2):289-296.   Published online February 28, 1989
Acute Werdnig-Hoffmann disease is heredofamilial degeneration of anterior horn cells in the spinal cord and of motor nuclei in the brain stem, which is clinically characterized by fasciculations of the tongue, paradoxical respiration, bell shaped thorax, frog-leg posture and intact mentality. We experienced an 8 month old female infant with acute Werdnig-Hoffmann disease. We report the case with brief review of some related literatures.
Continuous Arteriovenous Hemofiltration in Children.
Hae Il Cheong, Dong Kyu Jin, Young Seo park, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1989;32(2):230-238.   Published online February 28, 1989
Among those who were admitted to the Pediatric Intensive Care Unit (PICU), Seoul National University Children’s Hospital and developed acute renal failure (ARF) during the disease course, 11 children received continuous arteriovenous hemofiltration (CAVH) by pediatricians during a 3-year- period from Nov. 85 to Oct. 88. Their clinical findings were analyzed retrospectively, and the results were as follows; 1) They were 5 boys and 6...
High-Dose Cytosine Arabinoside (HD Ara-C) Therapy for Refractory Acute Leukemia in Children.
Il Soo Ha, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(10):1328-1337.   Published online October 31, 1988
Eleven children with refractory acute leukemia were treated with high dose cytosine arabinoside (HD Ara-C), given at a dosage of 3 gm/m2 intravenously over about one hour every 12 hours for four to eight doses. The antileukemic effects were evaluable in nine of the patients, two with ALL, seven with ANLL. Six of the seven patients with ANLL attained complete remission, while neither...
A Case of Acute Megakaryoblastic Leukemia in Infant with Down's Syndrome.
Jung Soon Whang, Soon hee Kim, Moon Ja Kim, Keun Lee, Je Geun Chi
Clin Exp Pediatr. 1988;31(8):1064-1070.   Published online August 31, 1988
Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have a more than random relationship to acute megakaryoblastic leukemia. The authors reports a case of acute megakaryoblastic leukemia in a 2 month old female patient who was admitted for evaluation of hepatosplenomgaly. Multiple organ infiltration...
A Case of Cleidocranial Dysostosis with Leukemia.
Baik Lin eun, Si Hun Han, Young Sook Hong, Soon Kyum Kim
Clin Exp Pediatr. 1988;31(7):930-934.   Published online July 31, 1988
Cleidocranial dysostosis is a rare, inherited abnormality which affects the development of mem- bransous and cartilaginous bone. Authors report a case of cleidocranial dysostosis with leukemia in a 10 year old boy. The review of the literature was made briefly.
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