Journal of the Korean Pediatric Society 1991;34(6):857-862.
Published online June 30, 1991.
Mannitol induced acute oliguric renal failure.
Young Mi Chung, Jae Seung Lee, Chang Jun Coe
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea
Mannitol에 의한 핍뇨성 급성 신부전 1례
정영미, 이재승, 고창준
연세대학교 의과대학 소아과학교실
Received: 8 February 1991   • Accepted: 11 March 1991
Mannitol known as non-electrolytic, osmotic diuretic agent is widely used in clinic for the purpose of diagnosis and prevention of acute oliguric renal failure, cerebral edema as well as glaucoma and dialysis-disequilibrium syndrome. That mannitol may cause serious life-threatening situation if administered in a patient with renal problem has been well known. Recently, it has been published that mannitol may be nephrotoxic in patient without preexisting nephrologic disorder. We experi- enced a case of acute oliguric renal failure in a patient with bacterial meningitis who had been treated with high dose of mannitol to reduce intracranial pressure. This patient did not have any preexisting renal problem, and the renal failure was successfully treated by peritoneal dialysis. We are reporting this unusual clinical experience with recent literature review.
Key Words: Mannitol, Acute renal failure

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