Journal of the Korean Pediatric Society 1991;34(9):1223-1230.
Published online September 30, 1991.
The diagnostic significance of APR score in early detection of neonatal bacterial infection.
Ki Won Park, Kyeong Choi, Young Youn Choi, Tai Ju Hwang
Department of Pediatrics, Chonnam University Medical School, Kwangju, Korea
신생아 세균 감염증의 조기진단에 있어서 APR Score의 의의
박기원, 최경, 최영륜, 황태주
전남대학교 의과대학 소아과학교실
Received: 20 March 1991   • Accepted: 20 March 1991
Abstract
An accurate and rapid diagnostic test is essential in the management of bacterial infection in neonates because they lack specific symptoms and the bacterial infections in neonates tends to have rapid progression and poor prognosis. As for the method, APR (acute phase reactants), a score measuring C-reactive protein (CRP), 상racid glycoprotein (이-AG) and Haptoglobin (Hp) by latex agglutination seems to be one of promising
methods
. In the present study, we compared APR score to the peripheral blood findings (total leukocyte count, absolute neutrophil count, immature to mature neutrophil ratio, toxic granule or vacuolization, platelet count) in 24 patients who were admitted to neonatal intensive care unit (NICU) of Chonnam University Hospital to evaluate the significance of APR in the diagnosis of neonatal bacterial infections. The results were as follows: 1) Among the types of infections, sepsis was the most frequently encountered by 11 cases. We were able to culture only 11 cases of the total (45.8%) and these include Staphylococcus aureus, Pseud- monas aeruginosa, Enterobacter cloacae in the frequency of order. 2) In the peripheral blood findings, total leukocyte count had the highest positive rate with 50% whereas among 3 acute phase reactants, CRP with 87.5% was the highest. The APR score of one or above and two or above had the positive rate of 91.6% and 75.0%, respectively. 3) Compared with peripheral blood findings, APR score of one or above was higher in the detection of neonatal bacterial infections (p<0.001). Also the positive rates of APR score were slightly higher than CRP, 이-AG and Hp. 4) In the follow up of 11 patients, APR score correlated well with clinical courses after the treatments.
Key Words: Acute phase reactants, APR-score, Neonatal bacterial infection


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