Journal of the Korean Pediatric Society 1983;26(9):866-871.
Published online September 30, 1983.
Clinical Study of C-Reactive Protein in Neonatal Bacterial Infections.
Kyung Shin Kim, Myung Sung Moon, Jin Choi, Keun Soo Lee
Department of Pediatrics,College of Medicine,Hanyang University
新生兒 細菌性 感染疾患에 있어서 C-Reactive Protein (CRP) 에 關한 臨床的 考察
김경신, 문명성, 최 진, 이근수
한양대학교 의과대학 소아과학교실
Bacterial infections, such as sepsis, meningitis, pneumonia and urinary tract infection are frequent causes of death during neonatal period. Further more clinical symptoms of neonatal infections are often quite vague and the illnesses unexpectedly progress rapidly. The causative organisms are detected with difficulty in many instances. Therefore a quick, simple and.reliable laboratory test is obviously needed for easy recognization of neonatal bacterial infections in order to start early antimicrobial therapy. In recent years, several authors have reported the usefulness of CRP in the early detectioa of neonatal infection. The author conducted a prospective study of CRP in neonatal cases with various bacterial infections at the Hanyang University Hospital during the period from. March 1980 to September 1981, The results obtained were as follows. 1) Among 100 cases, 76 cases were male and all were under 1 month of age. 2) Among 100 cases, bacterial infections outnumbered, eg, sepsis: 20 cases, pneumonia:11 cases, gastroenteritis: 10 cases, omphalitis: 7 cases, neonatal tetanus: 6 cases, infection suspected but site undetermind: 26 cases. 3) The CRP positive prevalance rate in order of frequency were sepsis(90%), urinary tract infection(75%), meningtis(71.4%), pneumonia(63.6%), gastroenteritis(50%). 4) Among 20 sepsis cases, CRP positive prevalance rate(90%) were obviously higher than the other laboratory data of WBC(<5,000/cumm or>20,000/cumm: 50%), Band/neutrophil ratio(≥0.2: 45%), ESR(≥15mm: 45%). 5) Among 80 cases of other various infectious disease, CRP positive prevalance rate was also higher than the other laboratory data of WBC, Band/neutrophil ratio, ESR. 6) These data suggested positive CRP in the neonatal infections was a quite reliable indicator of bacterial infections to be initiated early antibiotic treatment
Key Words: C-reactive protein, Neonatal bacterial infections.

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