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Original Article
The Prognosis and Factors of Neonatal Thyroid Dysfunction
Yun Yee Kim, Kyoung Sim Kim, Yong Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 2000;43(1):23-33.   Published online January 15, 2000
Purpose : The function of the neonatal thyroid is affected transiently or consistently by various maternal thyroid diseases, neonatal diseases, drugs, and more as well as thyroid dysgenesis. In this study, we analyzed several factors of neonatal thyroid dysfunction through neonatal screening test and investigated the prognosis. Methods : From January 1992 to July 1997, we reviewed 66 newborn patients, who showed abnormal thyroid function...
Re-Evaluation of Neonatal Screening Tests for Inborn Errors of Metabolism with Dried Filter Paper Blood Spots
Kye Shik Shim, Jin Soon Hwang, Jung Sub Lim, Se Young Kim, Choong Ho Shin, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Jung-Han Song
Clin Exp Pediatr. 1999;42(12):1639-1644.   Published online December 15, 1999
Purpose : There have been high rates of false positive and recall in neonatal screening test using the cut-off points set by the manufacturing company. So, it is necessary to re-evaluate the cut off values to minimize the false positive rates. Methods : We collected capillary blood in dry filter paper from 996 healthy neonates on the third day in cases...
Therapeutic Effect of Nimodipine in Neonatal Rat Model of Cerebral Hypoxia-Ischemia
Ihn-Hee Hong, Heng-Mi Kim
Clin Exp Pediatr. 1999;42(11):1552-1558.   Published online November 15, 1999
Purpose : Recent studies suggest that nimodipine, a potent calcium-channel blocker, may improve neurological outcome after experimental hypoxia-ischemic brain injury. This study was conducted to evaluate the therapeutic effect of nimodipine on hypoxia-ischemia in immature rat brain. Methods : Seven-day postnatal rats were subjected to hypoxia-ischemia by unilateral common carotid artery occlusion combined with 2 hours of hypoxia(in 8% oxygen...
The Protective Effect of Vitamin E and Desferrioxamine on Cultured Cerebral Neurons of Neonatal Mouse Damaged by Ischemic Condition
So-ra Lee, Yeon-kyun Oh, Seung-taek Park
Clin Exp Pediatr. 1999;42(10):1426-1433.   Published online October 15, 1999
Purpose : Perinatal asphyxia is an important cause of neurologic morbidity. Experiments in animal models of hypoxic-ischemic brain injury demonstrate that brain damage starts during hypoxia-ischemia. In order to evaluate the ischemic condition-induced neurotoxic effect in view of oxi- dative stress, we examined the cytotoxic effect in cultured cerebral neurons of neonatal mouse. Methods : Dissociated cell cultures were prepared...
The Effects of Glutamate Receptor Antagonists on Cultured Cerebral Cortical Neurons of Neonatal Mouse Damaged by Oxidative Stress
Dae-ho Choi, Yeon-kyun Oh, Seung-taek Park
Clin Exp Pediatr. 1999;42(8):1096-1103.   Published online August 15, 1999
Purpose : To evaluate neurotoxic effects induced by oxygen-radicals, which were generated by adding xanthine oxidase(XO) and hypoxanthine(HX), and protective effects of glutamate receptor antagonist such as MK-801 and 6-cyano-7-nitroquinoxaline(CNQX). Methods : Dissociated cell cultures were prepared from cerebrum of neonatal mouse. Tissues were dissected and diced into small pieces in phosphate buffered saline and were incubated at 37℃. Isolated cells...
Case Report
A Case of Transient Neonatal Pustular Melanosis
Young Ju Shin, Ruey Tsai Wang, Il Hwan Kim, Kyung Burm Kim, Young Kyoo Shin, Baik Lin Eun
Clin Exp Pediatr. 1999;42(6):879-882.   Published online June 15, 1999
Transient neonatal pustular melanosis(TNPM) is a benign, self-limited, cutaneous disorder of unknown etiology. Significant physical findings are limited to the skin. Hematologic and serological tests are normal. Cultures of blood and pustule are negative. Biopsy specimens from pustules show a intracorneal or subcorneal separation containing neutrophils and also some eosinophils. TNPM produces only cutaneous lesions and requires no treatment. So...
A Case of Nonsyndromic Paucity of Interlobular Bile Ducts in Down Syndrome
Chun Hyuk Chang, Jun Ho Kim, Sun Ju Le, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Tae Jung Jang
Clin Exp Pediatr. 1999;42(6):858-862.   Published online June 15, 1999
The nonsyndromic paucity of interlobular bile ducts, which belongs to intrahepatic biliary atresia, is characterized by conjugated hyperbilirubinemia, suggesting cholestasis in newborn infants it has little relationship with extrahepatic congenital abnormalities. Pathologic findings through percutaneous liver biopsy show portal changes(duct paucity and fibrosis) and lobular changes(cholestasis, giant cell transformation, extramedullary hematopoiesis and perisinusoidal fibrosis). The overall incidence of intrahepatic biliary...
Original Article
Intralipid Infusions Effect on Nutrophil Elastase Level in Newborns
Sue Jeen Min, Yong Woon Baek, Yong Woon Baek, Yong Woon Baek
Clin Exp Pediatr. 1999;42(5):666-671.   Published online May 15, 1999
Purpose : Parenteral nutrition is given to infants who tempararily cannot take oral feeding adequately. A lipid emulsion is added to the parenteral to supply essential fatty acids. In neonatal sepsis, elastase from azuropilic granules of the neutrophils is released and rapidly bound to α1- Proteinase Inhibitor(α1-PI). The lipid emulsion has been noted to markedly inhibit chemotaxis of neutrophils, so...
Immunohistochemical Expression of c-fos Protein and Histologic Findings after Instillation of Kainic Acid in Hippocampus of Neonatal Rat Brain
Soo Ahn Chae, Yong Soo Kim, Byoung Hoon Yoo, Won Bok Lee
Clin Exp Pediatr. 1999;42(4):553-560.   Published online April 15, 1999
Purpose : c-fos is rapidly and transiently induced in the intact CNS by a wide variety of exogenous stimuli that include seizures, glutamate receptor activation, sensory stimulation and stress. In adult animals, systemic KA administration produces limbic seizures that results in c-fos protein expression, irreversible morphological changes and localized neuronal death. So we studied the pattern of c-fos protein expression...
Clinical Efficiency of Cardiac Troponin T for Myocardial Damage in Neonatal Asphyxia
Nam Soo Kang, Jae Kyun Yoon, Chang Sung Son, Joo Won Lee, Young Chang Tokgo, Sang Hee Kim
Clin Exp Pediatr. 1999;42(2):195-202.   Published online February 15, 1999
Purpose : The aim of this study was to evaluate the clinical efficiency of cardiac troponin T (cTnT) in detecting myocardial damage in neonatal asphyxia and to compare the diagnostic value of cTnT with creatine kinase MB(CK-MB). Methods : Sixty-three neonates were enrolled in this study, consisting of 27 asphyxiated infants (asphyxiated group; 1-min or 5-min Apgar score≤6) and 36 healthy...
Clinical Effect and Complication of High Frequency Ventilation on Respiratory Failure
Man Hoe Hur, Yong Gook Kim, Ji Yun Baek, Sang Geel Lee
Clin Exp Pediatr. 1999;42(2):164-172.   Published online February 15, 1999
Purpose : Flow interruptor high frequency ventilator(HFV) on neonatal respiratory failure caused by various disorders has been applied in order to assess its therapeutic effect and safety. Methods : Premature babies below 1.8kg with respiratory failure from 1991 to 1997 in the Fatima neonatal intensive care unit(NICU) for 6 year and 4 months are included. Flow interruptor HFV with low...
Significance of Acute Phase Reactants(APR) Score for the Early Detection of Neonatal Bacterial Infection
Seong Woo Kim, Myung Ho Oh, Kee Hyuk Kim, Jay G. Sim
Clin Exp Pediatr. 1998;41(11):1491-1497.   Published online November 15, 1998
Purpose : We performed acute phase reactants(APR) test to evaluate as an appropriate screening test for the early detection of neonatal bacterial infection. Methods : We selected 174 neonates and divided into two groups; sepsis group and well-baby group. We performed APR test. Results : There are no significant difference in total leukocyte count, immature to mature rentrophil ratio, toxic granules, and...
Clinical and Pathological Comparison of Neonatal Hepatitis and Extrahepatic Biliary Atresia in Korean Children
Jae Hong Park, Ju Suk Lee, Su Eun Park, Chang Hun Lee
Clin Exp Pediatr. 1998;41(10):1372-1379.   Published online October 15, 1998
Purpose : Neonatal hepatitis and congenital extrahepatic biliary atresia are two major causes of neonatal cholestasis. But the method of therapeutic trials used for each disease is essentially different. Nonetheless, it is very difficult to differentiate these diseases clinically and histologically. This study is aimed to find out major differences between the two by clinical characteristics and scoring of various...
Prognostic Factors for Mortality in Neonates with Respiratory Distress Syndrome After Surfactant Replacement Therapy
Nam Soo Kang, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(9):1188-1197.   Published online September 15, 1998
Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors. Methods : Sixty-seven neonates with respiratory distress syndrome(RDS) were divided into two groups; group I(n=51) who survived and group II(n=16) who died within the first 28 days of life after one...
C-Reactive Protein and Duration of Antibiotic Therapy in Neonatal Bacterial Infection
Jae Il Yoo, Jin Hwa Jeong, Jeong Ho Lee, Jong Dae Cho
Clin Exp Pediatr. 1998;41(7):901-908.   Published online July 15, 1998
Purpose : To determine whether C-reactive protein(CRP) can be used as a parameter to assess the safety of discontinuing antibiotic therapy and allows a shorter course of therapy in neonates treated for suspected bacterial infection. Methods : We have experienced 193 cases of suspected neonatal bacterial infection at Pusan Maryknoll Hospital. CRP levels were measured daily by immunonephelometry. Infants with initial...
Compatibility of Neonatal Parenteral Nutrient Solutions with Commonly Used Drugs during Y-site Delivery in NICU
Ju Hun Choi, Kyong Ju Jeong, Ha Ryung Cho, Dong Soo Yim, Seung Ki Choi, Kyu Hyung Lee
Clin Exp Pediatr. 1998;41(7):893-900.   Published online July 15, 1998
Purpose : Because vascular access sites in neonates are limited, intravenous(IV) medications must often be mixed with maintenance fluids, including parenteral nutrient(PN) solutions. This study was done to determine whether IV medications commonly prescribed in the neonatal in- tensive care unit(NICU) are compatible with the two neonatal PN solutions. Methods : The compatibility of neonatal PN solutions and selected other drugs...
Case Report
A Case of Neonatal Hyperthyroidism with Unilateral Ear Anomaly
Kwang Ok Chung, Na Yeon Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(6):845-849.   Published online June 15, 1998
Neonatal hyperthyroidism is a very rare disorder occurring typically in the offspring of patients with Graves' disease or chronic thyroiditis. It is caused by the transplacental passage of thyroid stimulating antibodies(TSAb) from the mother to the fetus. There has been few reports of neonatal hyperthyroidism associated with congenital anomalies. We experienced a case of neonatal hyperthyroidism with unilateral microtia and agenesis of external auditory canal...
Original Article
Effect of Oral Administration of Cholestylamine with Phototherapy in the Treatment of Neonatal Hyperbilirubinemia
Myung Ho O, Jay Gun Sim, Kee Hyuck Kim
Clin Exp Pediatr. 1998;41(6):741-746.   Published online June 15, 1998
Purpose : Cholestylamine has been shown to release chloride ion and absorbs bile acid in the intestine, forming a nonabsorbable complex preventing enterohepatic circulation. The purpose of this study is to clarify the value of cholestylamine and the adequate dosage, in combination with phototherapy, as well as to confirm whether it shorten the duration of hospitalization. Methods : Total 80 full-term neonates with a...
Retrospective 3-year Clinical Study of Enterobacter Bacteremia in Neonatal Intensive Care Unit
Kwang Ok Chung, Chun Hyuk Chang, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(4):466-471.   Published online April 15, 1998
Purpose : Enterobacter is one of the important organisms in neonatal intensive care unit. We reviewed the clinical characteristics, underlying diseases, invasive procedures during admission, mortality and antibiotic sensitivity of Enterobacter infection in NICU. Methods : We retrospectively reviewed 21 neonatal patients whose blood cultures yielded Enterobacter between June 1994 and June 1997 at Dongguk University Hospital. Results : Blood cultures were positive in 62...
The Efficacy of Fetal Ultrasonography and Postnatal Abdominal Ultrasonography for the Diagnosis of Neonatal Abdominal Mass
Hee Eun Lee, Ee Kyung Kim, Hee Seok Kim, Yun Kyoung Lee, Chan Hwu Park, Kyung Ran Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Gui Won Park, Hwang Choi, Yong Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(3):299-306.   Published online March 15, 1998
Purpose : Most neonatal abdominal masses are benign in nature, but early detection and management is important to avoid the development of complications. So, we studied the causes of neonatal abdominal masses and the efficacy of ultrasonography for early detection and diagnosis. Methods : We reviewed 36 newborn infants with abdominal masses who had been admitted to the nursery and Neonatal...
Diurnal Variation in Serum Bilirubin Concentration of Normal Newborn Infant
Cheol Am Kim, Jin Geong Jeong, Eui Tak Oh, Hong Ja Gang, Gil Seu Kim
Clin Exp Pediatr. 1998;41(1):33-37.   Published online January 15, 1998
Purpose : We investigated whether there are independent intradaily changes in bilirubin levels in normal neonates. Methods : During the period of January 1996 till July 1996, 100 healthy newborn infants were studied for at least 3 consecutive days. Starting from the third day of life, consistent intradaily changes of bilirubin concentration were observed. And obstetric history, birth history, weight change at 3 days were...
The Significance of Increased Circulating Intercellular Adhesion Molecule 1(cICAM-1) in Neonatal Sepsis
Hai Lee Chung, Eun Jung Park, Young Ho An, Jin Bok Hwang, Chang Ho Han, Young Dae Kwon, Sang Gyoung Kim
Clin Exp Pediatr. 1997;40(12):1651-1659.   Published online December 15, 1997
Purpose : The early and efficient diagnosis of neonatal sepsis still remains a difficult task. Reliable laboratory test is not available yet and treatment is mainly based on the physical appearance of infants. And high number of negative blood cultures in cases of clinically diagnosed sepsis further emphasize the need for a more reliable index for early diagnosis. Intercellular adhesion molecule 1(ICAM-1) has been...
The Pathophysiology of the Transient Neonatal Tricuspid Regurgitation
Dong-Chul Park, Churl-Young Chung, Seauck-Joong Yoon
Clin Exp Pediatr. 1997;40(8):1131-1140.   Published online August 15, 1997
Purpose : This study was carried out to evaluate the role of the septal leaflet of the tricuspid valve. The hypothesis was that the neonatal tricuspid regurgitation(TR) was related to a transient elevation of right ventricular pressure in the neonatal period, that deviated ventricular septum and pull the anchored septal leaflet of the tricuspid valve. The pulled septal leaflet created the incomplete coaptation between...
Oral Agar and Conventional Phototherapy Combination in the Treament of Neonatal Hyperbilirubinemia
Seong Wha Kim, Ji Hyang Doh, Jin Woo Choi, Min Hyang Kim, Ji Won Lee, Sung Taek Kim
Clin Exp Pediatr. 1997;40(7):931-938.   Published online July 15, 1997
Purpose : Neonatal jaundice is one of the most common problems in our country leading to hospitalization. Agar is low cost, low risk, and easily fed orally; it can bind bilirubin in the intestine, decreasing its enterohepatic circulation, thereby decreasing serum bilirubin levels. At present, however, the effectiveness of agar in the prevention and treament of neonatal jaundice is quite conflicting and controversy. Recently we...
Erratum
A Case of Joubert Syndrome
Hye-Young Kim, Sun-Jun Kim, Jung-Soo Kim
Accepted January 1, 1970  
Joubert syndrome is frequently associated with developmental delay and mental retardation, neonatal tachypnea and apnea, abnormal eye movements, and ataxia. It is inherited by an autosomal recessive trait. The most significant and constant neuropathological finding is partial or total agenesis of cerebellar vermis. Absence of the vermis results in a triangular-shaped mid-fourth ventricle and a "bat-wing" shaped fourth ventricle superiorly. The superior cerebellar peduncles...
Original Article
Clinical Study of Symptoms and Various Anomalies of Patients with Joubert Syndrome
Hang Bo Jeong, Se Hee Hwang, Ki Joong Kim, Yong Seung Hwang, Seung Cheol Kim, In-One Kim
Clin Exp Pediatr. 1997;40(3):385-392.   Published online March 15, 1997
Purpose : Joubert syndrome is known tobean autosomal recessive disorder characterized by cerebellar vermian dysgenesis with many symptoms and variety of other malformations. We studied the relevant symptoms and various malformations of seven patients diagnosed as Joubert syndrome at our institution. Methods : Seven children with cerebellarvermian dysgenesis consistent with Joubert syndrome were included in ourstudy. Each child was diagnosed at the Seoul National University Children's...
Genital Mycoplasmasin the Newborn Infants: Colonization, Prevalence and Clinical Significance
Yun Sil Chang, Sung Gwon Kim, Beyong Il Kim, Won Soon Park, Bo Hyun Yoon, Eui Chong Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1996;39(8):1084-1094.   Published online August 15, 1996
Purpose : The genital mycoplasmas: Ureaplasma urealyticum and Mycoplasma hominis have recently assumed an increasing importance as neonatal pathogens especially in preterm infants. The aim of the present study was to determine the prevalence of infections with these organisms in newborn infants who were admitted in Neonatal Intensive Care Unit(NICU) and who were suspected having infection in newborn nursery Methods : Sixty four inborns who...
The Usefulness of Clinical Scoring System as Prognostic Predictor in Neonatal Seizure
Hyunmi Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(6):829-838.   Published online June 15, 1996
Purpose : Neonatal seizure is usually the presentation of underlying neurologic dysfunction rather than a disease and have high mortality and morbidity as sequalae. Therefore, the parameter predicting the neurologic prognosis is necessary. This study was performed to identify the usefulness of clinical scoring as predictor in neonatal seizure by analyzing outcomes. Methods : From 1982 to 1994, 101 neonates were admitted to Neonatal Intensive...
The Influence of the Use of Iodine during Perinatal Period on the Screening Test for Congenital Hypothyroidism
Gyu Bum Cho, Dong Hwan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1996;39(2):195-206.   Published online February 15, 1996
Purpose : This study was performed to detect the diseases of congenital hypothyroidism by the neonatal mass screening test early and to demonstrate the possible role of topical iodinated antiseptics(povidone-iodine, PVP-Ⅰ) on transient hyperthyrotropinemia in newborn infants. Methods : We performed neonatal screening tests for inborn errors of metabolism since 1985 by Guthrie test for PKU, maple syrup urine disease, histidinemia,...
Study on the Thyroid Function of Neonate Born to Mother with Hyperthyroidism
Choong Ho Shin, Se Young Kim, Sei Won Yang, Jung Hwan Choi, Chong Ku Park
Clin Exp Pediatr. 1996;39(1):106-114.   Published online January 15, 1996
Purpose : In newborns from mothers with Graves' disease, neonatal transient hyperthyroidism or hypothyroidism may develop early in life. We evaluated the incidence and prognosis of neonatal thyroid dysfunction in neonates born to mothers with hyperthyroidism during pregnancy. Methods : We measured blood T4, T3, TSH levels and TSH-R-Ab titer in 48 hyperthyroid mothers and their babies between 1988 and 1994. Results :...
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