| The Prognosis and Factors of Neonatal Thyroid Dysfunction |
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Yun Yee Kim, Kyoung Sim Kim, Yong Wook Kim, Ki Bok Kim |
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Department of Pediatrics, Kwangju Christian H ospital, Kwangju, Korea |
| 신생아기 갑상선 기능 이상에 영향을 미치는 여러 인자들과 예후 |
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김윤이, 김경심, 김용욱, 김기복 |
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광주기독병원 소아과 |
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| Abstract |
Purpose
: The function of the neonatal thyroid is affected transiently or consistently by various
maternal thyroid diseases, neonatal diseases, drugs, and more as well as thyroid dysgenesis. In
this study, we analyzed several factors of neonatal thyroid dysfunction through neonatal screening
test and investigated the prognosis.
Methods
: From January 1992 to July 1997, we reviewed 66 newborn patients, who showed
abnormal thyroid function in neonatal screening test, and analyzed 62 cases except for 3 cases of
thyroid dysgenesis and 1 case of TBG deficiency. In the end, we statistically compared the
maternal thyroid disease group with umbilical-iodinated disinfection group because the other
groups were too small in numbers.
Results
: Among 62 cases of neonatal thyroid dysfunction, maternal thyroid disease(A) group had
29 cases(46.8%), umbilical-iodinated disinfection(B) group had 22 cases(35.5%), neonatal disease(C)
group had 7 cases(11.2%), idiopathic(D) group had 4 cases(6.4%). Group A showed compensated
hypothyroidism 79.3%, transient hypothyroidism 13.8% and hyperthyroidism 6.9%, while group B
showed compensated hypothyroidism 77.3% and transient hypothyroidism 22.7%. Capillary TSH
showed that group B was significantly higher than group A(P < 0.05). The serum T4 showed that
group B was significantly lower than group A(P < 0.05). The incidence of medication showed no
significant difference between groups A and B. The duration of normalizing thyroid function
showed that group B was significantly longer than group A.
Conclusion
: The iodide-containing disinfectant caused transient thyroid dysfunction which was
longer and more severe than in the maternal thyroid disease group even though the time of causative
exposure differed. |
| Key Words:
Neonatal thyroid dysfunction, Iodide-containing compounds |
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