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A Case of Neonatal Hyperthyroidism with Unilateral Ear Anomaly

Journal of the Korean Pediatric Society 1998;41(6):845-849.
Published online June 15, 1998.
A Case of Neonatal Hyperthyroidism with Unilateral Ear Anomaly
Kwang Ok Chung, Na Yeon Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Department of Pediatrics, College of Medicine, Dongguk University, Kyongju, Korea
편측 소이증 및 외이도 무형성을 동반한 신생아 갑상선 기능 항진증 1례
정광옥, 김나연, 조성민, 이동석, 김두권, 최성민
동국대학교 의과대학 소아과학교실
Correspondence: 
Kwang Ok Chung, Email: 1
Abstract
Neonatal hyperthyroidism is a very rare disorder occurring typically in the offspring of patients with Graves' disease or chronic thyroiditis. It is caused by the transplacental passage of thyroid stimulating antibodies(TSAb) from the mother to the fetus. There has been few reports of neonatal hyperthyroidism associated with congenital anomalies. We experienced a case of neonatal hyperthyroidism with unilateral microtia and agenesis of external auditory canal in a female neonate born to a mother who had euthyroid but with a thyroid stimulating antibody. The patient was presented with unusual alertness, tachycardia, tachypnea, watery diarrhea, periorbital swelling and exophthalmos. Diagnosis was made by thyroid function tests and TSAb. She was treated with Lugol solution, PTU and propranolol. New she is 6 months old and in good condition with no symptoms of hyperthyroidism.
Key Words: Neonatal hyperthyroidism, Thyroid-stimulating antibody(TSAb), Ear anomaly


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