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A Study on the Status of Utilization and Criteria for Selection of Medical Care Facilities of Elementary School Children
Seung Pyo Han, Eun Young Kim, Young Il Rho, Eun Seok Yang, Sang Kee Park, Yeong Bong Park, Kyung Rye Moon
Clin Exp Pediatr. 2002;45(2):166-173.   Published online February 15, 2002
Purpose : The aim of this study is to find out the distribution of illness, patterns of medical care utilization and factors determining medical care utilization in elementary school children. Methods : We performed the questionnaires in Gwangju city on 2,036 children of two elementary schools from June 1 to June 30, 1998. Results : The prevalence rate of illness was 32.3%....
The Study of Serum Vascular Endothelial Growth Factor in the Acute Febrile Phase of Kawasaki Disease
Minshik Kim, Kyungsook Kim
Clin Exp Pediatr. 2002;45(1):114-119.   Published online January 15, 2002
Purpose : Kawasaki Disease(KD) is a febrile disease with acute multisystemic vasculitis associated with early development of acute myocarditis and coronary artery abnormalities. The cause and etiologic agents are still unknown. Clinical studies suggest that KD is one of the autoimmune disorders caused by infectious agent, but this is not proved yet. The study was performed to investigate the levels of vascular endothelial growth...
Clinical Characteristics of Infant Kawasaki Disease
Yeun Keun Choi, Jung Min Hong, Su Mi Ihn, Hae Kyeung Lim, Hong Ryang Kil
Clin Exp Pediatr. 2002;45(1):109-113.   Published online January 15, 2002
Purpose : To assess the incidence of coronary artery lesion(CAL) and the efficacy of intravenously administered immune globulin(IVGG) and aspirin therapy, identify risk factors for CAL, and analyze clinical characteristics in infants less than 12 months of age with Kawasaki disease. Methods : Retrospective chart review of children less than 12 months of age with Kawasaki disease between 1994 and 1998, diagnosed at Chungnam...
Analysis of Treatment in Pediatric Germ Cell Tumor
Young Dai Kim, Su Hyun Kim, Ki Joong Kim, Ho Joon Im, Hahng Lee
Clin Exp Pediatr. 2002;45(1):103-108.   Published online January 15, 2002
Purpose : This report is an analysis of our experience with surgery, multi-agent chemotherapy and radiotherapy, in pediatric germ cell tumors(GCTs). Methods : This report included all children(age < 15 years) who were registered between November 1985 and May 2001 with a histologically confirmed diagnosis of GCT and received surgery, chemotherapy and radiotherapy. Retrospective analysis of the medical records of these patients was performed. In...
Study on the Frequency of Receptor Insensitivity to Androgen Using the Androgen-receptor Binding Assay in the Genetic Male Children with Abnormalities of Sexual Differentiation
Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2002;45(1):95-102.   Published online January 15, 2002
Purpose : The development of external genitalia in genetic male is dependent on the transcriptional regulatory activity of dihydrotestosterone(DHT)-androgen receptor complex in the genital skin. The abnormality of androgen receptor encompasses a wide range of phenotypes. We investigated the androgen receptor binding capacity of genetic males with ambiguous genitalia(grade was determined by Prader grade) for the availability as screening test. Methods : The binding capacity...
Changes of Body Weight and Lipid Profiles According to Apolipoprotein E Polymorphism in Children with Antiepileptics
Seung Hee Jang, Eun Kyoung Choi, So Hee Eun, Sun Jun Kim
Clin Exp Pediatr. 2002;45(1):88-94.   Published online January 15, 2002
Purpose : Weight changes, especially weight gain, is a side effect of antiepileptics(especially valproate and carbamazepine). This may be sufficiently severe to cause noncompliance or to require the withdrawal of effective treatment. Unfortunately, the exact mechanism of weight change is not illustrated. Several reports and our experiment suggested that weight gain highly correlated with a familial tendency of obesity. The genetic makeup is a...
Clinical Spectrum and Lung Pathology in Children with Interstitial Lung Disease
Ji-Hyun Chung, Seung-Ju Ha, Bong-Seong Kim, Soo-Jong Hong
Clin Exp Pediatr. 2002;45(1):79-87.   Published online January 15, 2002
Purpose : Interstitial lung disease(ILD) is a rare and poorly characterized disorder in children with poor prognosis. To understand the ILD in children, we reviewed our experience with 21 patients who were diagnosed interstitial lung disease during 9-year period at Asan Medical Center retrospectively. Methods : Severity-of-illness score was measured by the Denver protocol. We evaluated underlying diseases, clinical manifestations, high resolution computed tomography findings,...
Diagnostic Value of 99mTc-DMSA Pinhole Imaging in Childhood Urinary Tract Infection with Renal Cortical Defect
Tae Won Lee, Seung Jun Seong, Byung Moon Ahn, Ie Ryung Yoo, Il Soo Kim, Eun Ryoung Kim, Sung Hoon Kim, Yong-Whee Bahk
Clin Exp Pediatr. 2002;45(1):72-78.   Published online January 15, 2002
Purpose : The aim of this study was to assess the diagnostic value of the 99mTc-DMSA pinhole imaging by comparing the detection rate of cortical defects identified from planar and pinhole imaging. Methods : 99mTc-DMSA planar and pinhole imaging, voiding cystoureth-rogram(VCUG), renal ultrasonography were performed in 67 patients diagnosed with urinary tract infection at the Department of Pediatrics, Sung-Ae General Hospital, from September, 1999 to...
The Clinical and Prognostic Survey of The Preterm Infants Delivered from Pregnancy-induced Hypertension Mothers
Seoung Pyo Han, Sang Kee Park, Chang Hoon Song, Jong Park, Kyoung Sim Kim, Young Youn Choi
Clin Exp Pediatr. 2002;45(1):64-71.   Published online January 15, 2002
Purpose : This study was undertaken to review the clinical and hematologic findings of the preterm infants delivered from pregnancy induced hypertension(PIH) mothers. Methods : The data were collected by reviewing the medical records on the current prognosis of preterm birth and sending questionnaires on the status of NICU. We reviewed the medical records from two university hospitals and two resident training hospitals in...
A Nationwide Survey on the Causative Organisms of Neonatal Sepsis in Korea
Kyung Ah Kim, Son Moon Shin, Jung Hwan Choi
Clin Exp Pediatr. 2002;45(1):55-63.   Published online January 15, 2002
Purpose : A nationwide survey was conducted to investigate the most common causative organisms in neonatal sepsis in Korea. Methods : By reviewing medical records of newborn infants who were confirmed as neonatal sepsis by isolating organisms from blood culture during a one year study period from January to December in 1997, data for causative organisms, risk factors, accompanying focal infections and combinations of antibiotics...
Protein and Genetic Analysis of Bruton's Tyrosine Kinase(Btk) in Three Korean X-linked Agammaglobulinemia(XLA) Families
Eun-Kyeong Jo, Chang-Hwa Song, Jeong-Kyu Park, Oh Kyung Lee, Dong-Soo Kim
Clin Exp Pediatr. 2002;45(1):44-54.   Published online January 15, 2002
Purpose : Mutations in the Bruton' s tyrosine kinase(Btk) gene are responsible for X-linked agammaglobulinemia( XLA), an immunodeficiency caused by a block in B cell differentiation. In this report we characterize the protein expression and genetic mutations of Btk in four Korean patients with three unrelated XLA families. Methods : The resulting Btk proteins were characterized by a flow cytometry and the mutations were analyzed...
The Amino Acid Compositions of Formula for Children with Inherited Metabolic Disorder
Kyung Hwa Ryu, Jong Soo Kim, Eun Ha Lee, Il Sun Kwon, Si Houn Hahn
Clin Exp Pediatr. 2002;45(1):37-43.   Published online January 15, 2002
Purpose : This study aimed to determine the amino acids composition, safety and efficacy of formulas recently developed by Korean dairy companies for children with inherited metabolic disorder. Methods : The determination of amino acids concentration was performed on eight Korean formula samples. The samples were hydrolyzed with 6N HCL or performic acid and analyzed by amino acid analyzer. Results : No phenylalanine, methionine or...
A Study of the Misinformed Methods of Childcare
Seon Ja Cho, Kang Ho Lee, Young Taek Jang
Clin Exp Pediatr. 2002;45(1):24-36.   Published online January 15, 2002
Purpose : An inexperienced mother depends on the recommendation by an experienced person on how to bring up her child. Therefore, we performed a study to evaluate the wrong methods of childcare and to establish effective childcare counselling. Methods : Two thousand eighty questionnaires filled out by mothers who visited local pediatric clinics and medical centers in Chonbuk, from March 2001 to April 2001,...
A Study of Menarche and Dysfunctional Uterine Bleeding in Adolescent School Girls in Ansan City
Yeon Kyeong Jung, Jae Hee Soh, Dae Hun Pee, Young Kyoo Shin, Kee Hyoung Lee, Baik Lin Eun, Sang Hee Park
Clin Exp Pediatr. 2002;45(1):16-23.   Published online January 15, 2002
Purpose : We investigated the menstrual features of adolescent school girls to know the characteristics of menarche and dysfunctional uterine bleeding in adolescents. Methods : In March, 2001, 1,434 primary and middle school girls(10-15 years of age) in Ansan City were investigated for the menacheal age and several aspects of menstruation through questionnaire. Results : Mean age of the total subjects were...
The Relationship Between Obesity and Depressive Trends in Elementary School Children
Seon Mi Park, Eun Young Kim, Young Il Rho, Sang Kee Park, Yeong Bong Park, Kyung Rye Moon, Kyung Sik Pyo
Clin Exp Pediatr. 2002;45(1):10-15.   Published online January 15, 2002
Purpose : This study was designed to evaluate the relationship between obesity and depressive trends in elementary school children. Methods : In 1999, we surveyed 2,091 elementary school children(1,079 boys and 1,012 girls) whose ages ranged from 10 to 12 years. Obesity was defined as an obesity index over 20 percent. The degree of depression was compared between the obese group...
Clinical Analysis of Atypical Kawasaki Disease : Comparison of Kawasaki Disease Between Typical and Atypical Types
Eun Ju Jeong, Jae Hong Park, Hee Ju Park
Clin Exp Pediatr. 2001;44(12):1448-1453.   Published online December 15, 2001
Purpose : Kawasaki disease(KD) is known as one of the most important causes of acquired heart disease in children. But the incidence of acquired heart disease can be reduced by early diagnosis and treatment with large amounts of intravenous γ-globulin(IVGG). For early diagnosis and treatment of atypical KD, we analyzed and compared the clinical features, laboratory findings and coronary lesions in patients with typical...
The Usefulness of the Head-up Tilt Test for Diagnosis of Syncope in Pediatric Patients
Hye Jin Yun, Sun Hee Rim, So Young Yun, Jae Kon Ko, Young Hwue Kim, In Sook Park
Clin Exp Pediatr. 2001;44(12):1441-1447.   Published online December 15, 2001
Purpose : The purpose of this study is to examine the usefulness of the head-up tilt test for diagnosis of unexplained syncope in children. Methods : Head-up tilt test results and clinical features of 41 children with unexplained syncope, presyncope, dizziness and seizure were studied from January, 1997 through January, 2001 at Asan Medical Center. Medical records of children were reviewed retrospectively. The children...
The Immunohistochemical Expression of Neuronal Nitric Oxide Synthase in Rat Hippocampus after Pentylenetetrazole-Induced Seizures
Doo-Kwun Kim, Tae-Jung Jang
Clin Exp Pediatr. 2001;44(12):1432-1440.   Published online December 15, 2001
Purpose : In order to determine the effect of neuronal nitric oxide synthase(nNOS) in seizure-related neuronal vulnerability of the hippocampus, the expression patterns of nNOS were examined in pentylenetetrazole(PTZ)-induced seizure groups and in PTZ seizure groups which were pretreated with nNOS inhibitors. Methods : Male Sprague-Dawley rats weighing 200-300 g were used in PTZ(40 mg/kg)-induced seizure experiments. A specific inhibitor, 50 mg/kg 7-nitroindazole(7-NI), and a...
Clinical Features of Acute Scrotum in Children
Ja Yun Yun, Mi Ran Kim, Kon Hee Lee, Kwang Nam Kim
Clin Exp Pediatr. 2001;44(12):1424-1431.   Published online December 15, 2001
Purpose : The acute scrotum is a clinical syndrome that is defined as an acute, painful swelling of the scrotum or its contents. The symptoms and signs of acute scrotum are similar and its pathognomonic features are rarely detected. This study was performed to find a proper way to diagnose and treat acute scrotum promptly and correctly. Methods : From January 1990 through December...
Quantification of Age-related Reference Values for Urinary Organic Acids in the Healthy Korean Population
Yong Jae Choi, In Cheol Kim, You Kyoung Choi, Hong Jin Lee, Bong Sung Kim, Won Il Park, Kyoung Ja Lee, T. Giudic, M. Blaskovics
Clin Exp Pediatr. 2001;44(12):1413-1423.   Published online December 15, 2001
Purpose : For the accurate diagnosis of organic acidopathies, quantification of urinary organic acid should be done and we should know the normal ranges of each organic acid excreted in the urine. The amount of organic acids excreted in the urine shows wide variability according to ethnic group, diet and age. We have quantified 82 organic acids to make a Korean reference value. Methods...
Results of Balloon Angioplasty in Patients with Coarctation of the Aorta
Hyun Kyung Roh, Bong Hee Seo, Jae Young Choi, Jin Sung Ko, Jong Kyun Lee, Jun Hee Sul, Sung Kyu Lee
Clin Exp Pediatr. 2001;44(12):1404-1412.   Published online December 15, 2001
Purpose : This study was undertaken to analyze and compare the effects of percutaneous balloon angioplasty(BAP) on postoperative re-coarctation and native coarctation of the aorta(CoA) and to thereby contribute to the development of treatment methods for CoA. Methods : The subjects in this study were 21 children who had undergone BAP from Jan. 1996 to Dec. 2000 in the Division of Yonsei Pediatric Cardiology....
The Study of the Changes of Myocardial Histology and Left Ventricular Function according to the Total Doses of Doxorubicin in Rabbits
Jeong Hwa Choi, Hee Ju Park, Young Tak Lim, Bong Seon Kim, Eun Young Huh
Clin Exp Pediatr. 2001;44(12):1395-1403.   Published online December 15, 2001
Purpose : We'd like to evaluate the relationship between the degree of cardiac damage and that of cardiac function according to the total injected dose of doxorubicin. Methods : 12 rabbits(body weight : 2.0-3.2 kg) were used and 30 mg/m2/week of doxorubicin hydrochloride was injected intravenously. The cardiac function was checked under anesthesia, after which the thorax was opened and cardiac samples were evaluated...
Methemoglobinemia Associated with Diarrheal Disease before 2 Months of Ag
Ji Ah Jung, Jung Won Lee, Jeong Wan Seo
Clin Exp Pediatr. 2001;44(12):1387-1394.   Published online December 15, 2001
Purpose : Methemoglobinemia has been observed during a diarrheal illness among those who were not exposed to oxidizing agents in neonates and young infants. We performed the study to determine predisposing factors in this entity. Methods : The medical records of 24 patients were reviewed, who were admitted for diarrhea with methemoglobinemia to Ewha Womans University MokDong Hospital, from February 1994 to November 2000. The...
The Effect of Soothing Classic Music on the Behavior and Initial Weight Loss of Newborn Infants
Min Jung Cho, Son Moon Shin
Clin Exp Pediatr. 2001;44(12):1381-1386.   Published online December 15, 2001
Purpose : As there are some reports that music affects some physiological parameters and behavior of preterm infants, we have attempted to evaluate the effect of soothing classic music on the behavior and initial weight loss of full term infants. Methods : A clinical study was conducted on newborn infants born at Youngnam University Hospital from July to August, 1999. Forty normal full term...
Development of a Screening Kit for Early Diagnosis and Prevention of Wilson`s Disease
Sihoun Hahn, Soo-Young Lee, Young-Ju Jang, Soon-Nam Kim, Ha-Cheol Shin, Sun-Young Park, Joo-Hyoung Kang, Eun-Sun You
Clin Exp Pediatr. 2001;44(12):1374-1380.   Published online December 15, 2001
Purpose : Wilson`s disease is an autosomal recessive disorder characterized by copper accumulation in the liver, brain, and other organs due to defected copper metabolism. The incidence of Wilson`s disease is approximately one in 30,000 population in the world, more common than phenylketonuria in Korea. The early diagnosis or presymptomatic diagnosis of Wilson`s disease is critical in order for them...
Predisposing Factors of Risk Taking Behaviors in Korean Adolescents
Jae Hee Soh, Yeon Kyeong Jung, Gi Young Jang, Young Kyoo Shin, Kee Hyoung Lee, Baik Lin Eun, Sang Hee Park
Clin Exp Pediatr. 2001;44(12):1364-1373.   Published online December 15, 2001
Purpose : Risk-taking behaviors are defined as patterns of behavior initiated during adolescence which are responsible for the majority of negative health outcomes occurring during the rest of the life. The study was to explore the relationship between the risk-taking behaviors and their predisposing factors among adolescents. Methods : The study used a survey design with an anonymous self-report questionnaire administered to 1,076 students from...
Six Year Follow-up of Childhood Obesity
Eun Young Kim, Young Il Rho, Eun Seok Yang, Sang Kee Park, Yeung Bong Park, Kyung Rye Moon, Chul Gab Lee
Clin Exp Pediatr. 2001;44(11):1295-1300.   Published online November 15, 2001
Purpose : To examine the prevalence of obesity in elementary school-aged children in Gwangju, and long term courses of those obese children. Methods : We examined children aged 7 to 12 in the total number of 3,028 elementary school students consisting of 1,579 boys and 1,449 girls between 1994 and 1999. Obesity was defined as weight that exceeded the standard weight...
A Clinical Study on Varicella zoster Virus Infection, Relating Factors and Treatment in Pediatric Cancer Patients
Yoon Sook Chung, Su Hyun Kim, Ki Joong Kim, Hahng Lee
Clin Exp Pediatr. 2001;44(11):1289-1294.   Published online November 15, 2001
Purpose : We performed this study to contribute to the prevention and treatment of Varicella zoster virus infection in pediatric cancer patients through understanding of VZV infection, acyclovir efficacy and varicella vaccination. Methods : A retrospective study was performed by reviewing chart from January 1988 to January 2001. Results : The diseases among 19 cases were leukemia. 12 cases were solid...
Effect of Resuscitation with High Concentration Oxygen on a Rat Model of Neonatal Hypoxic-Ischemic Brain Injury
Dong Seok Lee, Su-Hee Kwak, Heng-Mi Kim, Yoon Kyung Sohn
Clin Exp Pediatr. 2001;44(11):1278-1288.   Published online November 15, 2001
Purpose : This study was undertaken to determine whether any features of apoptosis would occur in the established model of cerebral hypoxia-ischemia in neonatal rats. It was also undertaken to evaluate the effect of post-insult hyperoxia on hypoxic ischemic cerebral injury. Methods : Seven-day-old neonatal rats underwent unilateral carotid artery dissection followed by 2 hours of hypoxia. To this end...
Factors Related to Weight Changes in Epileptic Children Treated with Vigabatrin
Sang-Nam Bae, Bong-Seok Choi, Sang-Ook Nam, Hee-Ju Park
Clin Exp Pediatr. 2001;44(11):1269-1277.   Published online November 15, 2001
Purpose : This study was undertaken to investigate factors related to weight changes in children treated with vigabatrin(VGB). Methods : We have analyzed mean weight standard deviation scores(SDS) retrospectively and interviewed 35 childhood epileptic patients attending Pusan National University Hospital on VGB monotherapy followed over 36 months. Putative risk factors including sex, age, duration of VGB administration, mean weight SDS...
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