| A Nationwide Survey on the Causative Organisms of Neonatal Sepsis in Korea |
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Kyung Ah Kim1, Son Moon Shin2, Jung Hwan Choi3 |
1Departments of Pediatrics, Collage of M edicine, Ulsan University, Ulsan, Korea
2Departments of Pediatrics, Collage of M edicine, Sungkyunkwan University School of Medicine, Seoul, Korea
3Departments of Pediatrics, Collage of Medicine, Seoul National University, Seoul, Korea |
| 신생아 패혈증의 원인균에 대한 전국 조사 |
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김경아1, 신손문2, 최중환3 |
1울산대학교 의과대학 소아과학교실
2성균관대학교 의과대학 소아과학교실
3서울대학교 의과대학 소아과학교실 |
Correspondence:
Son Moon Shin, Email: smshin@smc.or.kr
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| Abstract |
Purpose
: A nationwide survey was conducted to investigate the most common causative organisms
in neonatal sepsis in Korea.
Methods
: By reviewing medical records of newborn infants who were confirmed as neonatal
sepsis by isolating organisms from blood culture during a one year study period from January to
December in 1997, data for causative organisms, risk factors, accompanying focal infections and
combinations of antibiotics were collected.
Results
: 112,351 neonates were born at 55 hospitals in 1997 and 30,767 neonates were admitted
to the neonatal units. During this period, 1,175 episodes of neonatal sepsis were recorded in 1,116
neonates. The male to female ratio was 1.17 : 1. 424 cases(36%) were born prematurely. The main
pathogens of early-onset sepsis were coagulase negative Staphylococcus(CONS, 19.3%), S. aureus
(16.1%), S. epidermidis(16.1%) and Gram negative bacilli(19.2%) including Pseudomonas(5.9%),
Klebsiella(3.9%), E. coli (3.9%), Enterobacter spp(3.5%), Acinetobacter(2.0%). Only six cases of
group B beta-hemolytic Streptococcus were isolated. Common obstetric factors were premature
rupture of membranes(17.3%), maternal leukocytosis(14.6%), fetal tachycardia(10.2%), chorioamnionitis(
3.1%) and maternal fever(3.1%). The main pathogens of late-onset sepsis were S. aureus
(20.3%), S. epidermidis(18.9%) and CONS(13.7%). Frequent focal infections accompanying sepsis
were arthritis(12.8%), meningitis(7.0%), pneumonia(5.4%) and urinary tract infection(3.1%). The
most common combination of antibiotics used in early and late neonatal sepsis was ampicillin and
gentamicin. When a nosocomial infection was suspected, a combination of vancomycin and cefotaxime
was used most frequently.
Conclusion
: S. aureus and S. epidermidis were the most common pathogens in the neonatal
sepsis. |
| Key Words:
Neonatal sepsis, Causative organism, Obstetric factor, Antibiotics |
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