Journal of the Korean Pediatric Society 2001;44(12):1395-1403.
Published online December 15, 2001.
The Study of the Changes of Myocardial Histology and Left Ventricular Function according to the Total Doses of Doxorubicin in Rabbits
Jeong Hwa Choi1, Hee Ju Park1, Young Tak Lim1, Bong Seon Kim2, Eun Young Huh2
1Department of Pediatrics, College of Medicine, Pusan National University, Pusan, Korea
2Department of Anatomy, College of Medicine, Pusan National University, Pusan, Korea
가토에서 Doxorubicin 투여량에 따른 심근의 조직학적 변화와 좌심실 기능과의 관계에 관한 연구
최정화1, 박희주1, 임영탁1, 김봉선2, 허은영2
1부산대학교 의과대학 소아과학교실
2부산대학교 의과대학 해부학교실
Abstract
Purpose
: We'd like to evaluate the relationship between the degree of cardiac damage and that of cardiac function according to the total injected dose of doxorubicin.
Methods
: 12 rabbits(body weight : 2.0-3.2 kg) were used and 30 mg/m2/week of doxorubicin hydrochloride was injected intravenously. The cardiac function was checked under anesthesia, after which the thorax was opened and cardiac samples were evaluated with light and electron microscopics.
Results
: Regardless of total injected dose of doxorubicin, there was no difference between the general appearance, sizes and thickness of both atria and ventricles of doxorubicin injected rabbits and those of normal control. The rabbits with total cumulative dose <180 mg/m2 showed no differences with the rabbits of normal control in the cardiac histology. The rabbits with cumulative doses of 210 mg/m2 had an increased number of vacuoles in the interspaces of the myofibrils and glucogen granules in myocytes. The rabbits with the cumulative dose of 240 mg/m2 had focal necrosis and degeneration of myocytes with fibrous cells infiltration. The rabbits with cumulative doses of 300 mg/m2 demonstrated severe and diffuse degenerations with markedly decreased numbers of myocytes and increased intracellular vacuoles. All the rabbits with total cumulative doses <240 mg/m2 showed no difference in the aortic pressure, left ventricular(LV) maximal dP/dt and left ventricular end diastolic pressure(LVEDP) compared to normal control. The rabbit with total cumulative doses of 300 mg/m2 showed no difference in the aortic pressure and LV maximal dP/ dt, but revealed significantly elevated LVEDP compared to normal control.
Conclusion
: These results showed doxorubicin induced cardiotoxicity is dose related and may be certain at total cumulative dose >200 mg/m2, although cardiac function is normal.
Key Words: Doxorubicin, Total cumulative dose, Aortic pressure, LV maximal dP/dt, LVEDP, Rabbit


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