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The Effect of Anticonvulsants on Serum Copper and Zinc Concentrations
Hee Jeong Jeong, Hye Won Youn, Keon Su Lee
Clin Exp Pediatr. 2005;48(4):406-410.   Published online April 15, 2005
Purpose : Anticonvulsants have a number of side effects and some of them may be attributed to a disturbance of serum trace metal homeostasis. Although they are minor building components in tissues, they play important functional roles in the peripheral and central nervous system. We measured serum copper and zinc levels in epileptic children who were treated with anticonvulsants to...
Clinical Study of Children Using Home Mechanical Ventilation
Young Joon Ahn, Seung Hyeon Lee, Hyo-Bin Kim, Seong Jong Park, Tae Sung Ko, Soo-Jong Hong
Clin Exp Pediatr. 2005;48(4):401-405.   Published online April 15, 2005
Purpose : The use of mechanically-assisted ventilators at home reduces morbidity and improves the quality of life in children with chronic respiratory failure. But in Korea there is no clinical data of children with home mechanical ventilation. We investigated ventilator types, duration, the causes of failure or death, and the cost needed for care. Methods : We retrospectively analyzed the medical...
Risk Factors of Nosocomial Rotavirus Infections in Children
Sin Ae Park, Sun Hee Yu, Seon Woong Lim, Kyung Dan Choi
Clin Exp Pediatr. 2005;48(4):395-400.   Published online April 15, 2005
Purpose :Rotavirus is one of the most important causes of nosocomial infections among children. The aim of this study is to determine the risk of nosocomial rotavirus infections and to evaluate the effectiveness of breast-feeding and probiotics in the prevention of nosocomial rotavirus infections. Methods : This study was carried out on admitted children without diarrhea between March 1, 2003 and...
Reevaluation of the Neonatal Screening Test for Congenital Hypothyroidism
So Young Kang, Young Pyo Chang, Jeesuk Yu
Clin Exp Pediatr. 2005;48(4):387-394.   Published online April 15, 2005
Purpose : We performed this study to compare the TSH and free T4 levels according to gestational age and birth weight, and to reevaluate the cut-off values in the neonatal screening test for congenital hypothyroidism. Methods : Total 2,133 neonates(1,749 healthy newborns and 384 sick neonates) were screened in Dankook University Hospital from May 2000 to January 2003. Neonates with abnormal...
The Association of Neonatal Hyperbilirubinemia with UGT1A1 and CYP1A2 Gene Polymorphism in Korean Neonates
Hoon Kang, Jun Ho Lim, Ji Sook Kim, Eun Ryoung Kim, Sung Do Kim, Hee Jae Lee, Joo Ho Chung
Clin Exp Pediatr. 2005;48(4):380-386.   Published online April 15, 2005
Purpose : The incidence of nonphysiologic neonatal hyperbilirubinemia is twice as high in East Asians as in whites. Recently, UGT1A1 mutation was found to be a risk factor for neonatal hyperbilirubinemia. In congenitally-jaundiced Gunn rats, which lack expression of UDP-glucuronosyltransferase, alternative pathways can be stimulated by inducers of CYP1A1 and CYP1A2 enzymes. CYP1A2 plays a major role in bilirubin degradation...
Human Surfactant Protein-A(SP-A) Gene Locus Associated with Mycoplasma pneumoniae Pneumonia in Korean Children
Seung Soo Kim, In Kyu Lee, Jung Ho Ko, Myung Ho Oh, Chong Woo Bae
Clin Exp Pediatr. 2005;48(4):376-379.   Published online April 15, 2005
Purpose : Mycoplasama pneumoniae is a leading cause of pneumonia and exacerbates other respiratory conditions such as asthma. Surfactant protein A(SP-A) is involved in surfactant physiology and surfactant structure, and plays a major role in innate host defense and inflammatory processes in the lung. In this study, SP-A mediated mycoplasma cidal activity. The candidate-gene approach was used to study the...
A Cost-benefit Analysis on Neonatal Screening of Phenylketonuria and Congenital Hypothyroidism in Korea
Hoe Cheol Yoon, Nyeon Cheon Kim, Dong Hwan Lee
Clin Exp Pediatr. 2005;48(4):369-375.   Published online April 15, 2005
Purpose : Many inborn errors of metabolism can be completely cured with early detection and early treatment. This is why neonatal screening on inborn errors of metabolism is implemented worldwide. In this study, a cost-benefit analysis was performed on the neonatal screening of phenylketonuria and congenital hypothyroidism in Korea. Methods : This study included 2,908,231 neonates who took the neonatal screening...
Smoking Adolescents' Acquisition of Cigarettes and Status of Proof of Age
Hee Ra Kim, Ji Young Kim, Gee Hyung Lee, Ji Tae Choung, Sang Hee Park
Clin Exp Pediatr. 2005;48(4):363-368.   Published online April 15, 2005
Purpose : The aim of this study is to identify where and how adolescents acquire cigarettes and how many were asked for identification while purchasing cigarettes. Methods : This study was conducted in 2003; participants were 2,200 students in middle and high schools, aged from 13 to 18 years old(males 1,098; females 1,102) in Ansan, Korea. The questionnaire assured them of...
Expression of Toll-like Receptor-2 on the Peripheral Blood Monocytes in Kawasaki Disease Patients
Dae Hwan Hwang, Jung Woo Han, Kyung Min Choi, Kyung Mi Shin, Dong Soo Kim
Clin Exp Pediatr. 2005;48(3):315-320.   Published online March 15, 2005
Objective : Toll like receptor(TLR) is known to be involved in innate immunity. Many microbial antigens stimulate TLR, and as a result of intracellular signal transduction, they activate nuclear factor-kB which produces diverse inflammtory cytokines. Until now, many research topics in Kawasaki disease focused on cytokine increasement. In this study, we aim to reveal TLR increasement which might be associated...
A Clinical Study on Relationship of Surgical Glove and Back Pain after Lumbar Puncture in Children
Sung Ryoung Han, Wan Suk Choi, Hae Jeong Lee, Hyun Seok Kim, Ju Suk Lee, Kyung Lae Cho
Clin Exp Pediatr. 2005;48(3):310-314.   Published online March 15, 2005
Propose : In this study, we evaluated whether powder on surgical gloves is a cause of postpuncture backpain in children. Mothods : In 164 children with meningitis between July and September 1997, we did not remove powder from surgical gloves. However, in 149 children with menigitis between May and October 2001 the powder was removed from the surgical gloves. Results : Out...
Benign Transient Hyperphosphatasemia of Infancy and Childhood
Jung Hyun Kwon, Ji Hye Park, Hae Soon Kim, Seung Joo Lee, Mi Ae Lee
Clin Exp Pediatr. 2005;48(3):306-309.   Published online March 15, 2005
Purpose : The aim of study is to investigate the clinical manifestations and the etiology of markedly-elevated serum alkaline phosphatase(ALP) levels in children without accompanying liver or bone disease. Methods : The serum ALP and other biochemical laboratory data of 4,989 patients attending the pediatric department of Ewha Womans University Mokdong Hospital between January 2002 to December 2002 were studied. The...
Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and IGFBP-3 Levels in Healthy Korean Children
Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
Clin Exp Pediatr. 2005;48(3):298-305.   Published online March 15, 2005
Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex. Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood;...
Clinical Characteristics of Autoimmune Thyroid Disease Developed in Patients with Type 1 Diabetes Mellitus
Se Min Lee, Hye Rim Chung, Su Young Hong, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2005;48(3):292-297.   Published online March 15, 2005
Purpose : It is known that 3-50 percent of type 1 diabetes mellitus(T1DM) patients develop autoimmune thyroid disease. We analyzed the clinical characteristics of autoimmune thyroid disease(AITD) developed in patients with T1DM in Korean. Methods : The medical records of 139 patients, who were followed up in Department of Pediatrics, Seoul National University Children's Hospital from Jan. 1981 to Jul. 2004,...
Clinical Significance of Immature Reticulocyte Fraction and Reticulocyte Cellular Indices in Pediatric Anemia Patients
Young Seo, Hye Lim Jung, Jae Won Shim, Deok Su Kim, Jeong Yeon Shim, Moon Soo Park
Clin Exp Pediatr. 2005;48(3):284-291.   Published online March 15, 2005
Purpose : Flow cytometric automated reticulocyte analysis is a superior method to manual reticulocyte counting, with respect to precision and sensitivity. Furthermore, flow cytometric analysis is able to measure immature reticulocyte fraction(IRF) and reticulocyte cellular indices(RCI : cell hemoglobin content : CHr, mean cell volume : MCVr, cell hemoglobin concentration mean : CHCMr, distribytion width : RDWr, HDWr, CHDWr). In...
Correlation of Body Mass Index, Body Fat Distribution, Aminotranferases and Computed Tomography in Obese Children with Fatty Liver
So Eun Park, Hye Ran Yang, Ju Young Chang, Jae Sung Ko, Jeong Kee Seo, Whal Lee, Woo Sun Kim
Clin Exp Pediatr. 2005;48(3):276-283.   Published online March 15, 2005
Purpose : Visceral fat accumulation plays a major role in metabolic complications of obesity. It is known that nonalcoholic fatty liver in obese adults is associated with visceral fat accumulation. Body mass index(BMI) is used as the index of obesity in children. The aim of this study is to evaluate the correlation of BMI and visceral adipose tissue(VAT), and the...
Epidemiology and Clincal Analysis of Acute Viral Respiratory Tract Infections in Children(September, 1998-May, 2003)
Su-Jin Lee, Eon-Woo Shin, Eun-Young Park, Phil-Soo Oh, Kwang-Nam Kim, Hae-Sun Yoon, Kyu-Man Lee
Clin Exp Pediatr. 2005;48(3):266-275.   Published online March 15, 2005
Purpose : Acute respiratory tract infections are the most common illnesses in children. The great majority of these infections involving lower respiratory tracts infections(LRTIs) are caused by respiratory viruses such as respiratory syncytial virus(RSV), parainfluenza virus(PIV), influenza virus (Flu), and adenovirus(ADV), etc. Our purpose was to determine seasonal epidemiology and clinical characteristic features of each viral infection. Methods : Nasopharyngeal aspirate(NPA)s...
Retrospective Study for the Isolation of Influenza Virus and Prevalence Period in Busan from 2000 to 2002
Chang Hwan Oh, Byeong Hee Son, Ki Dae Kim, Jung A Lee, Sung Won Kim, Kyung Soon Cho
Clin Exp Pediatr. 2005;48(3):260-265.   Published online March 15, 2005
Purpose : During epidemics, influenza induces a high mortality and morbidity, and when influenza is prevalent, it is revealed by increased pneumonia, hospitalization due to influenza-like illness, and mortality in community. We aimed at the isolation of influenza virus and prevalence period in Busan from 2000 to 2002. Methods : For 3 years from 2000 to 2002, we analyzed the patterns...
Gene Expression of Metalloproteinases, Tissue Inhibitors of Metalloproteinases and Cytokines in Adriamycin-induced Cardiomyopathy
Young Mi Hong
Clin Exp Pediatr. 2005;48(2):197-203.   Published online February 15, 2005
ity has been reported to occur in both clinical and experimental forms of dilated cardiomyopathy. There was no report about MMP in adriamycin(ADR)-induced cardiomyopathy. The purpose of this study was to investigate gene expression of MMP and tissue inhibitor of metalloproteinases(TIMP) in ADR-induced cardiomyopathy and clarify the relationship between MMP and cytokines. Methods : Male Sprague-Dawley rats were divided into two...
Factors Affecting Final Adult Height in Patients with Turner Syndrome
Jae Hyun Kim, Sung Soo Lee, Su Young Hong, Hye Rim Chung, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 2005;48(2):191-196.   Published online February 15, 2005
Purpose : Short stature is one of the characteristic features of Turner syndrome. We investigated the factors affecting final adult height(FAH) in patients with Turner syndrome. Methods : The study group was comprised of 60 patients who were diagnosed with Turner syndrome by chromosomal study and clinical phenotypes and attained FAH. Data were obtained from retrospective review of the medical records....
Responses and Toxicities of Risk-adapted Chemotherapy in Pediatric Intracranial Germ Cell Tumors
Dong Kil You, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Do Hoon Lim, Hyung Jin Shin, Hong Hoe Koo
Clin Exp Pediatr. 2005;48(2):186-190.   Published online February 15, 2005
Purpose : The purpose of this study was to evaluate the responses and toxicities of risk-adapted chemotherapy in pediatric intracranial germ cell tumors(IC-GCT). Methods : Fourteen patients who were diagnosed as IC-GCT from October 2002 to December 2003 received chemotherapy as an initial treatment modality. The low risk(LR) group was defined as follows : Pure germinoma and normal AFP level....
Allogeneic Hematopoietic Stem Cell Transplantation in Juvenile Myelomonocytic Leukemia
Keon Hee Yoo, Dong Kil You, Soo Hyun Lee, Ki Woong Sung, Eun Joo Cho, Hong Hoe Koo
Clin Exp Pediatr. 2005;48(2):178-185.   Published online February 15, 2005
Purpose : The purpose of this study was to evaluate the outcome of children with juvenile myelomonocytic leukemia(JMML) treated with allogeneic hematopoietic stem cell transplantation(allo- HSCT). Methods : Eleven JMML patients aged 8-39 months underwent allo-HSCT. The sources of grafts were unrelated donors(n=7), HLA-matched siblings(n=3) and an HLA 1-antigen mismatched familial donor. All patients had received chemotherapy ?13-cis-retinoic acid(CRA) before...
Clinico-epidemiologic Study of Henoch-Sch nlein Purpura in Children, 1987 through 2003
Sun-Mee Choi, Kyung-Yil Lee
Clin Exp Pediatr. 2005;48(2):174-177.   Published online February 15, 2005
Purpose : We evaluated children with Henoch-Sch nlein purpura(HSP) in terms of epidemiology and clinical characteristics. Methods : A total of 424 medical records of children with HSP admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, from 1987 to 2003 were retrospectively analyzed. Results : The mean annual number of cases was 25.1?.9 and no one year showed an...
Follow-Up Method in Patients with Kawasaki Disease who had No Coronary Artery Abnormalities in the Convalescent Period
Hee Jung Joo, Min Seob Song, Chul Ho Kim
Clin Exp Pediatr. 2005;48(2):165-173.   Published online February 15, 2005
Purpose : We performed the study to evaluate the value of the follow-up echocardiogram performed 6 months to 1 year after the onset of Kawasaki disease(KD), as recommended by American Heart Association(AHA) guidelines, when echocardiograms in the convalescent period were normal. Methods : Patients were selected from 147 cases diagnosed with KD at Pusan Paik hospital from January 2000 to October...
Impact of Device Evolution in Transcatheter Closure of Patent Ductus Arteriosus Using Duct-Occlud Coils : Comparison of Mid-term Results
Myung Kwan Kim, Dong Ki Han, Jae Young Choi, Yuria Kim, Byung Won Yoo, Deok Young Choi, Jun Hee Sul, Sung Kue Lee
Clin Exp Pediatr. 2005;48(2):158-164.   Published online February 15, 2005
Purpose : We reviewed the therapeutic results of various Duct-Occlud coils(pfm AG, K ln, Germany) to evaluate the efficacy of the most-recently modified Duct-Occlud coil(Nit-Occlud) in the transcatheter closure of patent ductus arteriosus(PDA), including large defects more than 4 mm in diameter. Methods : Two hundred and five patients who underwent percutaneous PDA occlusion using Duct- Occlud devices from March...
Clinico-epidemiologic Study of Mycoplasma pneumoniae Pneumonia(1993 through 2003)
Seung-Hyun Lee, Suk-Man Noh, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Joon-Sung Lee, Byung-Chul Lee
Clin Exp Pediatr. 2005;48(2):154-157.   Published online February 15, 2005
Purpose : We evaluated the epidemiologic and clinical characteristics of mycoplasma pneumonia. Methods : A total of 559 medical records of children with mycoplasma pneumonia admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, were retrospectively analyzed. Results : The mean annual number of cases was 51. There was a higher occurrence in autumn (September-November, 41.7%) and in winter(26.7%). Outbreaks...
Serum Albumin Concentrations and Clinical Disorders by Gestational Ages in Preterm Babies
Mia Lee, Soo Youn, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 2005;48(2):148-153.   Published online February 15, 2005
Purpose : The aim of this study was to determine the reference ranges of serum albumin levels depending on the gestational ages of preterm infants. We also intended to compare the mean serum albumin levels between groups of preterm infants that did not develop clinical disorders later, and groups that did develop clinical disorders such as respiratory distress syndrome, intraventricular...
Perinatal Factors Affecting Thyroid Stimulating Hormone(TSH) and Thyroid Hormone Levels in Cord Blood
Eun Young Kim, Sang Kee Park, Chang Hun Song, Sung-Chul Lim
Clin Exp Pediatr. 2005;48(2):143-147.   Published online February 15, 2005
Purpose : The aim of the this study was to evaluate the effect of various perinatal conditions on TSH and thyroid hormone levels in cord blood. Methods : Cord blood samples were collected from 130 neonates immediately after birth. TSH, T3, and free T4 levels were measured by the radioimmunoassay(RIA) method. The effects of gestational age, sex, birth weight, delivery method,...
Prevalence of Orthostatic Dysregulation in Elementary School Students and Frequency of Individual Symptoms
Eun Seok Yang, Eun-Young Kim, Kyoung-Rye Moon, Sang Kee Park, Young Bong Park, Young Il Rho
Clin Exp Pediatr. 2005;48(2):138-142.   Published online February 15, 2005
Purpose : The purpose of the present study was to access the prevalence of orthostatic dysregulation(OD) and the frequency of each category for major and minor criteria among elementary school students using the OD questionnaire. Methods : We carried out inquiry by questionnaire as to the frequency of OD among two elementary schools with 725 students, 10 to 12 years of...
Tibial Torsion in Children of the Jeju Area
Dong Ho Song, Baik-Lin Eun, Sang Hee Park, Joon Young Lee, Young Chang Tockgo
Clin Exp Pediatr. 2005;48(1):75-80.   Published online January 15, 2005
Purpose : Internal tibial torsion is prevalent in East Asian countries such as Korea and Japan, where sitting on the floor is common behavior. Internal tibial torsion or excessive lateral tibial torsion may cause esthetical, functional, or psychological problems and also may induce degenerative arthritis in older age. The purpose of this study is to measure the tibial torsion in...
Outcome of Continuous Renal Replacement Therapy in Children
Yeon Jung Lim, Hyun-seung Jin, Hyewon Hahn, Sei Ho Oh, Seong Jong Park, Young Seo Park
Clin Exp Pediatr. 2005;48(1):68-74.   Published online January 15, 2005
Purpose : There is growing use of continuous renal replacement therapy(CRRT) for pediatric patients, but reports about the use and outcome of CRRT in children is rare in Korea. We report our experiences of CRRT in critically ill pediatric patients. Methods : We reviewed the medical records of 23 pediatric patients who underwent CRRT at Asan Medical Center between May 2001...
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