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Perinatal Factors Affecting Thyroid Stimulating Hormone(TSH) and Thyroid Hormone Levels in Cord Blood

Korean Journal of Pediatrics 2005;48(2):143-147.
Published online February 15, 2005.
Perinatal Factors Affecting Thyroid Stimulating Hormone(TSH) and Thyroid Hormone Levels in Cord Blood
Eun Young Kim1, Sang Kee Park1, Chang Hun Song2, Sung-Chul Lim3
1Department of Pediatrics, College of Medicine, Chosun University, Gwangju, Korea
2Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea
3Department of Pathology, College of Medicine, Chosun University, Gwangju, Korea
제대혈 갑상선 자극호르몬과 갑상선 호르몬 농도에 영향을 주는 주산기 인자들
김은영1, 박상기1, 송창훈2, 임성철3
1조선대학교 의과대학 소아과학교실
2조선대학교 의과대학 산부인과학교실
3조선대학교 의과대학 병리학교실
Correspondence: 
Sung-Chul Lim, Email: sclim@chosun.ac.kr
Abstract
Purpose
: The aim of the this study was to evaluate the effect of various perinatal conditions on TSH and thyroid hormone levels in cord blood.
Methods
: Cord blood samples were collected from 130 neonates immediately after birth. TSH, T3, and free T4 levels were measured by the radioimmunoassay(RIA) method. The effects of gestational age, sex, birth weight, delivery method, perinatal asphyxia, maternal diabetes mellitus(DM), and preeclampsia on TSH and thyroid hormone levels were assessed by ANOVA test, Student t-test, and multiple regression analysis.
Results
: Birth weight and sex did not affect TSH and thyroid hormone levels. TSH level increased according to gestational age(P<0.05). TSH level was 4.42?.66 IU/mL in infants born vaginally, which was higher than that of cesarian section delivery(3.31?.33 IU/mL)(P<0.05). TSH level was 5.18?.93 IU/mL in asphyxiated newborns and 2.97?.84 IU/mL in non-asphyxiated newborns(P< 0.05). TSH level in infants with maternal DM(8.911?.25 IU/mL) was higher than that of infants without maternal DM(4.32?.42 IU/mL)(P<0.05). TSH level was 5.28?.42 IU/mL in infants with maternal preeclampsia and 3.65?.46 IU/mL in infants without maternal preeclampsia(P<0.05). Thyroid hormones were lower in infants with perinatal asphyxia(P<0.05). In asphyxiated infants, T3 level was 75.33?5.65 ng/mL and free T4 was 0.54?.21 ng/mL. T3 and free T4 level was 109.85?1.77 ng/mL and 0.76?.22 ng/mL each in infants without perinatal asphyxia. Among the perinatal factors, gestational age, 1 min Apgar score and maternal DM influenced TSH level independently.
Conclusion
: In our study, cord blood TSH and thyroid hormone levels were affected by perinatal stress events.
Key Words: Cord blood , Thyrotropin , Thyroid hormones


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