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Analysis of Affecting Factors for Cortisol Level in Cord Blood

Journal of the Korean Pediatric Society 2003;46(2):183-187.
Published online February 15, 2003.
Analysis of Affecting Factors for Cortisol Level in Cord Blood
Hyun Jung Lim1, Chang Hun Song1, Eun Young Kim2, Sang Kee Park2
1Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, Korea
2Department of Pediatrics, College of Medicine, Chosun University, Gwangju, Korea
제대혈 Cortisol 농도에 영향을 미치는 인자에 대한 연구
임현정1, 송창훈1, 김은영2, 박상기2
1조선대학교 의과대학 산부인과학교실
2조선대학교 의과대학 소아과학교실
Correspondence: 
Eun Young Kim, Email: sskey@chosun.ac.kr
Abstract
Purpose
: Long-term stress to the fetus causes alterations in adrenal steroidogenesis. The purpose of this study was to analyze the association of cord blood cortisol with stress during delivery.
Methods
: Cord blood samples were collected from 58 neonates at once to labor. Cortisol was measured by RIA method(DPC, USA). Cortisol level according to gestational age(<34, 34-37, >38 wks) and method of delivery(Cesarean section vs. vaginal delivery), Apgar score and uterine contraction, were compared to know stress during labor.
Results
: Cortisol of cord blood had considerable differences between each group, according to gestational age(P<0.001). It was statistically higher in the cases of vaginal delivery than cessarian delivery(P<0.001). The concentration of cortisol was significantly higher according to duration of labor (P<0.05). There was a significant relationship between cortisol level and uterine contraction(P<0.05). The concentration of cortisol was significantly low when Apgar score at 1 min was low(P<0.05).
Conclusion
: Cord cortisol has close association with stress during labor. And so do with post birth prognosis of neonate.
Key Words: Cord cortisol, Stress during labor


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