Korean Journal of Pediatrics 2005;48(4):376-379.
Published online April 15, 2005.
Human Surfactant Protein-A(SP-A) Gene Locus Associated with Mycoplasma pneumoniae Pneumonia in Korean Children
Seung Soo Kim1, In Kyu Lee1, Jung Ho Ko2, Myung Ho Oh1, Chong Woo Bae3
2Protein Section, Laboratory of Metabolism(LM), National Cancer Institute(NCI), National Institute of Health(NIH), USA
3Department of Pediatrics, College of Medicine, Kyunghee University, Seoul, Korea
Mycoplasma pneumoniae 폐렴과 관련된 폐 표면 활성제 단백-A(Human Surfactant Protein-A) 유전자 대립 형질
김승수1, 이인규1, 고정호2, 오명호1, 배종우3
2Protein Section, Laboratory of Metabolism(LM), National Cancer Institute(NCI), National Institute of Health(NIH)
3경희대학교 의과대학 소아과학교실
Correspondence: 
Myung Ho Oh, Email: omh@schch.co.kr
Abstract
Purpose
: Mycoplasama pneumoniae is a leading cause of pneumonia and exacerbates other respiratory conditions such as asthma. Surfactant protein A(SP-A) is involved in surfactant physiology and surfactant structure, and plays a major role in innate host defense and inflammatory processes in the lung. In this study, SP-A mediated mycoplasma cidal activity. The candidate-gene approach was used to study the association between the SP-A gene locus and Mycoplasama pneumoniae pneumonia in the genetically homogeneous Korean population.
Methods
: PCR-cRFLP-based methodology was used to detect SP-A genotype. The forty nine children with Mycoplasama pneumoniae pneumonia were matched to 50 nomal neonates.
Results
: The specific frequencies for the alleles of the SP-A1 and SP-A2 gene in the study population were : 6A2=21 percent, 6A3=45 percent, 6A4=11 percent, 6A8=9 percent, 6A14=8 percent, 1A=11.3 percent, 1A0=38 percent, 1A1=12.7 percent, 1A2=9.2 percent, 1A5=15.5 percent, 1A7=2.9 percent, 1A8=4.9 percent, 1A9=2.2 percent, others=3.3 percent. The frequencies of specific genotypes such as 1A2 was higher than control group, significantly.
Conclusion
: 1A2 are susceptible factors for Mycoplasama pneumoniae pneumonia. We conclude that the SP-A gene locus(1A2) is an important determinant for predisposition to Mycoplasama pneumoniae pneumonia in children.
Key Words: Surfactant , Pulmonary surfactant-associated protein A , Mycoplasama pneumoniae


METRICS Graph View
  • 2,360 View
  • 14 Download


Close layer
prev next