- Review Article
- Infection
- Etiological and pathophysiological enigmas of severe coronavirus disease 2019, multisystem inflammatory syndrome in children, and Kawasaki disease
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Jung-Woo Rhim, Jin-Han Kang, Kyung-Yil Lee
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Clin Exp Pediatr. 2022;65(4):153-166. Published online November 23, 2021
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· Severe cases of coronavirus disease, Kawasaki disease (KD), and multisystem inflammatory syndrome in children (MIS-C) share similar findings: a protracted clinical course, multiorgan involvement, and similar activated biomarkers.
· Here we propose etiological agents in KD and MIS-C as species in the microbiota and introduce a common pathogenesis through the protein-homeostasis-system hypothesis.
· Early proper dose of corticosteroids and/or intravenous immunoglobulin may help to reduce morbidity and mortality in these diseases. |
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- Original Article
- Infection
- Febrile urinary tract infection in children: changes in epidemiology, etiology, and antibiotic resistance patterns over a decade
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Woosuck Suh, Bi Na Kim, Hyun Mi Kang, Eun Ae Yang, Jung-Woo Rhim, Kyung-Yil Lee
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Clin Exp Pediatr. 2021;64(6):293-300. Published online October 14, 2020
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Question: How has the antibiotic susceptibility of urinary pathogens changed and what does it imply?
Finding: A yearly increase in multidrug-resistant and extended-spectrum β-lactamase (ESBL)–producing pathogens was observed. A higher recurrence rate was observed in cases of febrile urinary tract infection caused by ESBL producers in patients with underlying vesicoureteral reflux (VUR).
Meaning: The initial empirical antibiotic should reflect the changing susceptibility patterns and underlying VUR status. |
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- Review Article
- Immunology
- Immunopathogenesis of COVID-19 and early immunomodulators
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Kyung-Yil Lee, Jung-Woo Rhim, Jin-Han Kang
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Clin Exp Pediatr. 2020;63(7):239-250. Published online June 18, 2020
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The novel coronavirus disease 2019 (COVID-19) is spreading globally. Although its etiologic agent is discovered as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), there are many unsolved issues in COVID-19 and other infectious diseases. The causes of different clinical phenotypes and incubation periods among individuals, species specificity, and cytokine storm with lymphopenia as well as the mechanism of damage to organ... |
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- Original Article
- Cardiology
- Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment
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Yu-Mi Seo, Hyun-Mi Kang, Sung-Churl Lee, Jae-Won Yu, Hong-Ryang Kil, Jung-Woo Rhim, Ji-Whan Han, Kyung-Yil Lee
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Clin Exp Pediatr. 2018;61(5):160-166. Published online May 28, 2018
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Purpose This study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients. MethodsClinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between... |
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- Original Article
- Epidemiological comparison of three Mycoplasma pneumoniae pneumonia epidemics in a single hospital over 10 years
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Eun-Kyung Kim, You-Sook Youn, Jung-Woo Rhim, Myung-Seok Shin, Jin-Han Kang, Kyung-Yil Lee
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Clin Exp Pediatr. 2015;58(5):172-177. Published online May 22, 2015
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Purpose Mycoplasma pneumoniae (MP) pneumonia epidemics have occurred in 3- to 4-year cycles in Korea. We evaluated the epidemiologic characteristics of MP pneumonia in Daejeon, Korea, from 2003 to 2012. MethodsWe retrospectively analyzed 779 medical records of children (0-15 years of old) with MP pneumonia admitted to our institution and compared the data from 3 recent epidemics. ResultsIn 779 patients, the mean age... |
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- Outbreaks of mumps: an observational study over two decades in a single hospital in Korea
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Ji-Ung Ryu, Eun-Kyung Kim, You-Sook Youn, Jung-Woo Rhim, Kyung-Yil Lee
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Clin Exp Pediatr. 2014;57(9):396-402. Published online September 30, 2014
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Purpose The introduction of the mumps vaccine has dramatically reduced the number of mumps cases, but outbreaks have recently occurred among highly vaccinated populations in developed countries. Epidemiological and clinical characteristics of patients with mumps admitted between 1989 and 2012 in a single hospital in Korea are described in the present study. MethodsWe retrospectively evaluated inpatients with mumps between 1989 and 2012... |
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- Review Article
- Mycoplasma pneumoniae pneumonia in children
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You-Sook Youn, Kyung-Yil Lee
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Clin Exp Pediatr. 2012;55(2):42-47. Published online February 14, 2012
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Mycoplasma pneumoniae (MP), the smallest self-replicating biological system, is a common cause of upper and lower respiratory tract infections, leading to a wide range of pulmonary and extra-pulmonary manifestations. MP pneumonia has been reported in 10 to 40% of cases of community-acquired pneumonia and shows an even higher proportion during epidemics. MP infection is endemic in larger communities of the... |
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- Original Article
- Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell line
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Sun-Young Kim, Kyung-Yil Lee, Dae-Chul Jeong, Hak-Ki Kim
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Clin Exp Pediatr. 2010;53(7):753-758. Published online July 31, 2010
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Purpose It has been suggested that p16 has a role in glucocorticoid (GC)-related apoptosis in leukemic cells, but the exact mechanisms have yet to be clarified. We evaluated the relationship between the GC response and p16 expression in a lymphoma cell line. MethodsWe used p16 siRNA transfection to construct p16-inactivated cells by using the B-cell lymphoblast cell line NC-37. We compared glucocorticoid... |
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- The effects of high-dose intravenous immunoglobulin on plasma protein and lipid levels in the patients with Kawasaki disease
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Keun Young Lee, Dong-Un Kim, Hyun Seung Lee, Pil Sang Jang, Young-Hoon Kim, Jin Tack Kim, Hyun Hee Kim, Kyung-Yil Lee, Joon-Sung Lee
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Clin Exp Pediatr. 2006;49(12):1348-1353. Published online December 15, 2006
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Purpose : The reticuloendothelial system is composed of sinusoidal capillaries, through which even large protein molecules are freely movable between plasma and interstitial space, including the lymphatic system. Therefore, high-dose intravenous immunoglobulin (IVIG) would cause a redistribution of proteins between two compartments. To investigate this hypothesis, we measured plasma protein and lipid levels in patients with Kawasaki disease before and... |
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- Case Report
- Giant Coronary and Axillary Aneurysms in an Infant with Kawasaki Disease Associated with Thrombocytopenia
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Sei Young Seo, Jin Hee Oh, Jong-Hyun Kim, Ji-Whan Han, Kyung-Yil Lee, Dae Kyun Koh
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Clin Exp Pediatr. 2005;48(8):901-906. Published online August 15, 2005
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Kawasaki disease (KD) is a leading cause of acquired heart disease in children. Yet the etiology of KD is still unknown and diagnosis depends on the exclusion of other diseases and the clinical manifestations meeting the defined criteria. Young infants frequently show atypical clinical courses and are frequently complicated with coronary aneurysms. Some cases show thrombocytopenia, which is known as... |
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- Original Article
- Clinico-epidemiologic Study of Mycoplasma pneumoniae Pneumonia(1993 through 2003)
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Seung-Hyun Lee, Suk-Man Noh, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Joon-Sung Lee, Byung-Chul Lee
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Clin Exp Pediatr. 2005;48(2):154-157. Published online February 15, 2005
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Purpose : We evaluated the epidemiologic and clinical characteristics of mycoplasma pneumonia.
Methods : A total of 559 medical records of children with mycoplasma pneumonia admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, were retrospectively analyzed.
Results : The mean annual number of cases was 51. There was a higher occurrence in autumn (September-November, 41.7%) and in winter(26.7%). Outbreaks... |
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- Clinico-epidemiologic Study of Henoch-Sch nlein Purpura in Children, 1987 through 2003
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Sun-Mee Choi, Kyung-Yil Lee
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Clin Exp Pediatr. 2005;48(2):174-177. Published online February 15, 2005
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Purpose : We evaluated children with Henoch-Sch nlein purpura(HSP) in terms of epidemiology and clinical characteristics.
Methods : A total of 424 medical records of children with HSP admitted to The Catholic University of Korea, Daejeon St. Mary's Hospital, from 1987 to 2003 were retrospectively analyzed.
Results : The mean annual number of cases was 25.1?.9 and no one year showed an... |
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- Case Report
- A Case of Meningococcal Meningitis with Complement 9 Deficiency
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Sun-Mee Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Churl Lee
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Clin Exp Pediatr. 2005;48(1):101-103. Published online January 15, 2005
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Meningococcal disease is not rarely associated with abnormalities of the complement system. We experienced a case of C9 deficiency with meningococcal meningitis from a 12-year-old girl. Identification of complement deficiency has implications for management, including family studies, prophylaxis, vaccination, and altered threshold for infection screening and treatment. |
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- Original Article
- Epidemiologic Study of Aseptic Meningitis in Daejeon, Korea(1987 through 2003)
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Jung-Hoon You, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Chul Lee
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Clin Exp Pediatr. 2004;47(11):1181-1185. Published online November 15, 2004
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Purpose : To evaluate the epidemiologic characteristics of aseptic meningitis in Daejeon, Korea from 1987 to 2003.
Methods : A total of 2201 medical records of children with aseptic meningitis admitted to the Catholic University of Korea, Daejeon St. Mary's Hospital, was retrospectively analyzed.
Results : The mean annual number of cases was 129, with a higher rate of occurrence in the... |
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- Prediction of Intravenous Immunoglobulin Non-responders in Patients with Kawasaki Disease
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Gi Bum Lee, Ji-Won Lee, Kyung-Yil Lee
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Clin Exp Pediatr. 2004;47(1):90-94. Published online January 15, 2004
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Purpose : We evaluated the effects of intravenous immunoglobulin(IVIG) on the levels of laboratory indices examined serially according to the responsiveness to IVIG therapy in children with Kawasaki disease(KD).
Methods : Children with KD(n=63) who had been treated with IVIG at a dosage of 2.0 g/kg were classified into two groups : the IVIG-resistant(consistent fever over 48 hours after initiation... |
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- Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease
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Ji-Won Lee, Kyung-Yil Lee
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Clin Exp Pediatr. 2003;46(8):817-820. Published online August 15, 2003
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Purpose : Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD).
Methods : Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times... |
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- Roxithromycin Treatment of Tsutsugamushi Disease (Scrub Typhus) in Children
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Hye-Jin Park, Kyung-Yil Lee
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Clin Exp Pediatr. 2003;46(7):710-713. Published online July 15, 2003
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Purpose : Although chloramphenicol and doxycycline have been used for the treatment of tsutsugamuchi disease, a difficulty exists in determining which drugs to use in treating children because of potential complications such as aplastic anemia or teeth discoloration. We evaluated the effect of roxithromycin, a macrolide antibiotic, on tsutsugamushi disease in children.
Methods : A retrospective analysis was conducted on 39... |
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- Clinical Significance of C-reactive Protein in Measles
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Sang-Lim Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Kyung-Tai Whang
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Clin Exp Pediatr. 2003;46(5):480-483. Published online May 15, 2003
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Purpose : We evaluated clinical manifestations and laboratory findings in patients with measles according to C-reactive protein(CRP) concentration.
Methods : A retrospective analysis was performed using the medical records of patients with measles at The Catholic University of Korea, Daejeon St. Mary's Hospital from October 1999 to May 2000. We divided the patients with measles into four groups according to CRP... |
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- Causative Organisms in Children with Bacterial Meningitis(1992-2002)
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Hyun-Jung Kim, JI-Won Lee, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Seung-Hoon Hahn, Kyung-Tai Whang
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Clin Exp Pediatr. 2003;46(11):1085-1088. Published online November 15, 2003
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Purpose : This study was performed to assess the difference of organisms causing bacterial meningitis according to time.
Methods : We analyzed retrospectively 40 medical records of bacteriologically proven meningitis from 1992 to 2002. We divided them into two groups; neonate's group(14 cases), and children's group(26 cases). The results of the neonate's group were compared with those of previously reported articles... |
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- Case Report
- Arthritis in the Subacute Stage of Kawasaki Disease after
Responding to Intravenous Immunoglobulin Treatment
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Kyung-Yil Lee, Jin-Hee Oh, Dea-Kyun Koh
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Clin Exp Pediatr. 2003;46(11):1124-1127. Published online November 15, 2003
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We evaluated the clinical and laboratory characteristics of five children with Kawasaki disease who had showed arthritis after responding to intravenous immunoglobulin(IVIG) treatment. Age distribution was between 13 months and six years of age(mean 3.2?.6 years). There were two males and three females. Arthritis occurred when acute symptoms were subsiding, with the average onset on day 5.8?.8 after final IVIG... |
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- Original Article
- A Comparative Study of Measles According to Age
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Eun-Sung Eun, Sang-Lim Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Jin-Han Kang, Kyung-Tai Whang
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Clin Exp Pediatr. 2003;46(1):33-36. Published online January 15, 2003
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Purpose : We evaluated clinical manifestations and laboratory findings in patients with measles according to age distribution.
Methods : Retrospective analyses were performed using medical records of patients with measles admitted to The Catholic University of Korea, Daejon St. Mary's Hospital from October 2000 to May 2001. We divided the patients with measles into three age groups, i.e., those who were... |
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- An Epidemiologic Study of Kawasaki Disease(1987-2000) :
Incidence of Coronary Artery Complication in the Acute Stage
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Kyung-Yil Lee, Min-Young Park, Ji-Whan Han, Hyung-Shin Lee, Jin Choi, Kyung-Tai Whang
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Clin Exp Pediatr. 2002;45(6):783-789. Published online June 15, 2002
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Purpose : We evaluated the epidemiologic characteristics and incidence of coronary artery sequele of children with KD according to treatment.
Methods : We retrospectively analyzed 506 medical records of children with KD, who were admitted at Daejeon St. Mary's Hospital from Jan. 1987 to Dec. 2000.
Results : The mean annual incidence was 36.1±11.1 cases per year. There was a slightly higher... |
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- Radiographic Findings and Atelectasis in Children Admitted to
Hospital with Acute Asthma
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Yoo-Jin Jung, Hye-Jin Jung, Kyung-Yil Lee, Won-Bae Lee, Dong-Hurn Yang
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Clin Exp Pediatr. 2002;45(4):519-523. Published online April 15, 2002
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Purpose : We aimed to evaluate the abnormalities of chest radiographs including atelectasis in children who were admitted with bronchial asthma.
Methods : We retrospectively analyzed the 357 chest radiographs and the clinical and laboratory features of the 144 children with asthma, who were admitted at Daejoen St. Mary's Hospital from April 1994 to May 1998.
Results : Clinical and laboratory... |
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- Case Report
- A Case of Acute Renal Failure Following Intravenous Immunoglobulin Therapy in a Child
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Sung-Wook Park, Kyung-Yil Lee, Kyung-Yil Lee, Kye-Nam Yoon, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Kyung-Tai Whang
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Clin Exp Pediatr. 2000;43(5):720-724. Published online May 15, 2000
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Intravenous immunoglobulin(IVIG) therapy is associated with a number of complications, including rare acute renal failure(ARF). Although the cause of IVIG-associated ARF is unknown, it may be related to the stabilizing agent used in IVIG preparations. ARF following IVIG infusion has not been previously described in children. We report a 4-year-old girl with Kawasaki disease who suffered from ARF following IVIG... |
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- A Case of Acute Renal Failure Following Intravenous Immunoglobulin Therapy in a Child
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Sung-Wook Park, Kyung-Yil Lee, Kyung-Yil Lee, Kye-Nam Yoon, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Kyung-Tai Whang
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Clin Exp Pediatr. 2000;43(5):720-724. Published online May 15, 2000
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Intravenous immunoglobulin(IVIG) therapy is associated with a number of complications, including rare acute renal failure(ARF). Although the cause of IVIG-associated ARF is unknown, it may be related to the stabilizing agent used in IVIG preparations. ARF following IVIG infusion has not been previously described in children. We report a 4-year-old girl with Kawasaki disease who suffered from ARF following IVIG... |
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- Original Article
- Clinical Study of Recurrent Parotitis in Children
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Sam-Hwa Yim, Kye-Nam Yoon, Kyung-Yil Lee, Sang-Won Cha, Dong-Jun Lee, Ji-Whan Han, Jin-Han Kang, Kyung-Tai Whang
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Clin Exp Pediatr. 2000;43(5):619-624. Published online May 15, 2000
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Purpose : Recurrent parotitis is defined as a recurrent parotid inflammation, generally associated with sialectasis of the parotid gland. It can often be misdiagnosed as recurrent mumps. We studied the clinical and laboratory features of recurrent parotitis.
Methods : Outpatient clinical records of 23 cases were analyzed retrospectively between April 1993 and March 1999. Follow-up after the last outpatient clinic... |
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- Case Report
- A Case of Common Variable Immunodeficiency with Autoimmune Hemolytic Anemia
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Kyung-Yil Lee, Yon-Joo Lee, Sang-Won Cha, Dong Joon Lee, Ji-Whan Han, Kyung-Tae Whang, Joong-Gon Kim
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Clin Exp Pediatr. 2000;43(1):117-122. Published online January 15, 2000
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Common variable immunodeficiency(CVID) is a heterogeneous collection of disorders with hypogammaglobulinemia
with recurrent bacterial infections and high incidence of autoimmune disorders
as its hallmark. We report a 7-year-old girl suffering from CVID with Coombs' test positive
hemolytic anemia. She had been relatively well until 23-months old when she was admitted to
Taejon St. Mary' s Hospital with pneumonia 5 years ago. Afterwards, she had... |
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- A Case of Guillain-Barré Syndrome Coinciding with Bronchial Asthma associated with Mycoplasma Pneumonia
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Kyung-Yil Lee, Dong-Joon Lee, Ji-Whan Han, Sang-Won Ch, John-Sung Lee, Kyung-Tai Whang
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Clin Exp Pediatr. 1999;42(8):1165-1169. Published online August 15, 1999
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Mycoplasma pneumoniae is the most common etiologic agent of pneumonia in school-aged children and young adults. It involves not only the respiratory system but includes extrapulmonary complications such as exanthem, hemolysis, arthritis, hepatic dysfuction, cardiac disease, and central nervous system disease. The pathogenesis of extrapulmonary involvements may be an autoimmune phenomena. Recent studies suggest that bronchial asthma can be initiated... |
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- Original Article
- Clinical Analysis and Comparison of Kawasaki Disease between Patients Younger than One Year of Age and Those over One Year of Age
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Hee-Sun Chung, Kyung-Yil Lee, Ji-Whan Han, Sang-Won Cha, Dong-Joon Lee, Kyung-Tai Whang
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Clin Exp Pediatr. 1999;42(7):936-942. Published online July 15, 1999
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Purpose : To identify the risk factors for coronary sequelae in Kawasaki disease, we analyzed and compared the clinical features and laboratory findings of Kawasaki disease in patients younger than one year of age with those over one year of age.
Methods : A retrospective chart review was conducted of all children with Kawasaki disease who were admitted to the... |
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- Case Report
- A Case of Kawasaki Disease Diagnosed with the Assistance of Ophthalmologic Examination
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Soo-Jung Ha, Kyung-Yil Lee, Sang-Won Cha, Dong-Joon Lee, Ji-Whan Han, Kyung-Tai Whang, Ik-Soo Kim
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Clin Exp Pediatr. 1999;42(7):1014-1018. Published online July 15, 1999
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Kawasaki disease is a systemic vasculitis in which bilateral nonexudative conjunctivitis and anterior uveitis are common early findings in the course of illness. We report an eleven-year-old boy with atypical Kawasaki disease who was diagnosed with the help of an ophthalmologic examination. The patient presented with fever, epigastric pain with vomiting, erythematous rash, and severe bilateral conjunctival injection, a red... |
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- Original Article
- Seroepidemiolgy of Cytomegalovirus in Taejon, Korea, in 1966
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Kyung-Yil Lee
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Clin Exp Pediatr. 1998;41(6):754-759. Published online June 15, 1998
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Purpose : The prevalence of cytomegalovirus(CMV) depends mainly on socioeconomic status. It
is well noted that the prevalence of hepatitis A which is a representive agent of the fecal-oral
route has changed since the last 10-20 years. In order to evaluate the time of primary CMV
infection in childhood and to get help for interpretating the patterns of infection and prevention,
we studied the... |
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- Immunologic Alterations of Peripheral Mononuclear Cells by Intravenous Immunoglobulin in the Acute Stage of Kawasaki disease
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Ji-Whan Han, Kyung-Yil Lee, Kyong-Su Lee
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Clin Exp Pediatr. 1998;41(6):813-824. Published online June 15, 1998
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Purpose : High dose intravenous immunoglobulin(IVIG) therapy is effective in reducing the
incidence of coronary artery aneurysm in Kawasaki disease(KD) patients, however, the precise
mechanisms by which IVIG reverses the immune activation is unknown.
Methods : The sera and peripheral mononuclear cells(PBMCs) were obtained from 10 KD patients
in the acute stage(24 hrs before) and 24 hrs after one dose of IVIG(2g/kg) treatment. We
measured... |
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- Case Report
- Reccurent Unilateral Lung Collapse in an Asthmatic Child
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Yul-Yi Yeon, Kyung-Yil Lee, Dong-Jun Lee, Ji-Whan Han, Sung-Soo Hwang, Kyong-Su Lee
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Clin Exp Pediatr. 1998;41(6):850-854. Published online June 15, 1998
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Abnomalities in the production and transport of airway secretions play an important role in the
pathophysiology of asthma. Segmental atelectasis as a complication of asthma, is relatively common
in children. On the other hand, massive atelectasis such as the collapse of one lung is a very
rare occurence. We report a seven-year-old male asthmatic patient with right lung collapse caused
by mucoid impaction. Fourteen... |
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- Original Article
- Seroepidemiology of Hepatitis A in Taejon, Korea 1996
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Kyung-Yil Lee, Ki-Hun Song, Jin-Han Kang
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Clin Exp Pediatr. 1998;41(1):53-61. Published online January 15, 1998
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Purpose : We experienced an outbreak of hepatitis A in Taejon, Korea for the summer of 1996.
Recently a shift in hepatitis A incidence from children to adults has been well noted in Korea. For
the purpose of possible measures in preventing hepatitis A, we studied a seroepidemiology of
hepatitis A in Taejon.
Methods : We measured IgG anti-HAV antibody(HAVAB MEIA, Abbott) from 722... |
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- Treatment of Intravenous Immune-Globulin Resistant Kawasaki Disease with Corticosteroids
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Dae-Eui Hong, Kyung-Yil Lee, Ji-Whan Han, Sung-Soo Hwang, Kyong-Su Lee
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Clin Exp Pediatr. 1997;40(10):1453-1457. Published online October 15, 1997
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Purpose : To evaluate the efficacy of steroid therapy on prevention of development and progression
of coronary artery aneurysm in intravenous immune globulin(IVIG)-resistant Kawasaki disease, we
treated three children with high dose of intravenous methylprednisolone followed by low dose oral
prednisolone.
Methods : We selected three children with Kawasaki disease who did not repond or who initially
responded but soon developed recrudescent fever after retreatment... |
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- Case Report
- A Case of Acute Viral Myositis
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Jong-Hoon Kwak, Kyung-Yil Lee, Ji-Whan Han, Sung-Soo Hwang, Jae-Kyun Huh, Kyong-Su Lee
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Clin Exp Pediatr. 1996;39(4):572-576. Published online April 15, 1996
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Diffuse myalgia is common in transient systemic viral infections but overt myositis, with weakness and signs of muscle inflammation, rarely accompanies viral infection in chidren. We describe a 8-year-old boy with severe myalgia and tenderness in both lower extremities, whose unusual skeletal muscle uptake on Technetium-methylene diphosphate bone scan helped to diagnosis of myositis. Clinical course, muscle-derived enzyme studies(AST, ALT,... |
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