- Original Article
- Food allergen sensitization in young children with typical signs and symptoms of immediate-type food allergies: a comparison between monosensitized and polysensitized children
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Na Yeon Kim, Ga Ram Kim, Joon Hwan Kim, Ji Hyeon Baek, Jung Won Yoon, Hye Mi Jee, Hye Sung Baek, Yong Ho Jung, Sun Hee Choi, Ki Eun Kim, Youn Ho Shin, Hye Yung Yum, Man Yong Han, Kyu-Earn Kim
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Clin Exp Pediatr. 2015;58(9):330-335. Published online September 21, 2015
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Purpose The clinical interpretation of children sensitized to allergens is challenging, particularly in children with food allergies. We aimed to examine clinical differences between children with monosensitization and those with polysensitization to common food allergens and to determine risk factors for polysensitization in young children <10 years of age with immediate-type food allergies. MethodsThe study included children <10 years of age with... |
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- Increased B cell-activating factor (BAFF) level in the sputum of children with asthma
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Hye Mi Jee, Bong Seok Choi, Kyung Won Kim, Myung Hyun Sohn, Man Yong Han, Kyu-Earn Kim
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Clin Exp Pediatr. 2010;53(8):795-800. Published online August 31, 2010
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Purpose B cell-activating factor (BAFF) is a tumor-necrosis factor (TNF) superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is observed in naïve cells as well as in effector/memory T cells. We aimed to explore whether BAFF in sputum is expressed at elevated levels in asthmatic airways and associated with eosinophilic inflammation, pulmonary... |
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- Case Report
- Thymolipoma in a 13-year-old Korean girl
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Su-Jin Park, Ji Young Baek, Junjeong Choi, Kyung Won Kim, Myung Joon Kim, Myung Hyun Sohn, Kyu-Earn Kim
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Clin Exp Pediatr. 2010;53(1):103-105. Published online January 15, 2010
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Thymolipoma is a rare benign tumor of anterior mediastinum. Most patients are asymptomatic with incidental finding of the tumor during a diagnostic workup of other medical problems. We present a case of 13-year-old girl with anterior mediastinal thymolipoma, surgically removed after an incidental diagnosis. |
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- Original Article
- Toll-like receptor 9 expression and interferon-α secretion upon
CpG-ODN stimulation in allergic subjects
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Man Yong Han, Hye Mi Jee, Hyeong Yoon Kim, Cho Ae Lee, Hyo-Jin Cho, Seong-Gyu Hwang, Kyu-Earn Kim
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Clin Exp Pediatr. 2009;52(9):1015-1020. Published online September 15, 2009
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Purpose:The aim of this study is to explore the effect of the Toll-like receptor 9 (TLR9) expressed in plasmacytoid dendritic cells (pDCs) that respond to antigen to Th2 immune deviation in allergic patients.
Methods:Subjects consisted of 19 allergic patients and 17 healthy volunteers. Skin prick tests and nasal provocation tests were performed for the two groups. Peripheral blood mononuclear cells (PBMCs)... |
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- Review Article
- Mycoplasma and chlamydia infection in Korea
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Kyung Won Kim, Kyu-Earn Kim
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Clin Exp Pediatr. 2009;52(3):277-282. Published online March 15, 2009
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Pneumonia, which usually requires hospitalization for children, is caused by various pathogens. According to recent surveys, the prevalence of atypical pneumonia caused by Mycoplasma or Chlamydia has increased, especially in preschool children. Also, the evidence has been accumulated that Mycoplasma or Chlamydia infection is associated with asthma including both inception and exacerbation. Therefore, it is important to consider how the... |
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- Original Article
- Nationwide surveillance of acute interstitial pneumonia in Korea
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Byoung-Ju Kim, Han A Kim, Young-Hwa Song, Jinho Yu, Seonguk Kim, Seong Jong Park, Kyung Won Kim, Kyu-Earn Kim, Dong Soo Kim, June Dong Park, Kang Mo Ahn, Hyo-Bin Kim, Hyang-Min Jung, Chun Kang, Soo-Jong Hong
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Clin Exp Pediatr. 2009;52(3):324-329. Published online March 15, 2009
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Purpose : Acute interstitial pneumonia (AIP) is a rare disease, but its prognosis is fatal because of lack of efficient treatment modality. Recently, it has been reported that there was epidemic AIP in Korea. This study aims to investigate the past and current status of AIP in Korea.
Methods : We performed a nationwide survey and a prospective study. From August... |
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- Review Article
- The prevalences of asthma and allergic diseases in Korean children
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Soo-Jong Hong, Kang-Mo Ahn, Soo-Young Lee, Kyu-Earn Kim
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Clin Exp Pediatr. 2008;51(4):343-350. Published online April 15, 2008
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Asthma and allergic diseases are one of the most common disorders in children. Due to its increased prevalence, as well as the increased morbidity and mortality from these diseases, asthma and allergic diseases have come to be recognized as a major worldwide public health issue. In addition, socioeconomic burden of asthma and allergic diseases has increased in Korea also.
The... |
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- Original Article
- Utility of a forced expiratory flow of 25 to 75 percent
as a predictor in children with asthma
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Jung Wan Kang, Kyung Won Kim, Eun Soo Kim, Jun Young Park, Myung Hyun Sohn, Kyu-Earn Kim
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Clin Exp Pediatr. 2008;51(3):323-328. Published online March 15, 2008
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Purpose : Asthma is defined as chronic inflammation of the lower small airways, and bronchial hyperreactivity (BHR) is a pathophysiologic feature of asthma. It has been proposed that although there is no direct variable capable of assessing the small airways, a forced expiratory flow of between 25 and 75 percent (FEF25-75) might be considered a more sensitive early marker of... |
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- Mycoplasma pneumoniae-induced production of proasthmatic mediators in airway epithelium
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Kyung Won Kim, Byung Chul Lee, Kyung Eun Lee, Eun Soo Kim, Tae Won Song, Mi Yeoun Park, Myung Hyun Sohn, Kyu-Earn Kim
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Clin Exp Pediatr. 2006;49(9):977-982. Published online September 15, 2006
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Purpose : There has been an increasing amount of literature concerning the association between Mycoplasma pneumoniae and asthma pathogenesis. Interleukin(IL)-6 stimulates the differentiation of monocytes, and can promote Th2 differentiation and simultaneously inhibit Th1 polarization. IL-8 is a potent chemoattractant and, it has been suggested, has a role in asthma pathogenesis. Nitric oxide (NO) synthesized by airway epithelium may be... |
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- Effects of Hyperosmolar Stimuli on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
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Byoung Chul Kwon, Eun Soo Kim, Kyung Won Kim, Tae Won Song, Myung Hyun Sohn, Myeong Heon Shin, Kyu-Earn Kim
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Clin Exp Pediatr. 2005;48(8):881-885. Published online August 15, 2005
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Purpose : Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils.
Methods : Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide... |
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