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Original Article
Infection
Construction and validation of predictive models for intravenous immunoglobulin–resistant Kawasaki disease using an interpretable machine learning approach
Linfan Deng, Jian Zhao, Ting Wang, Bin Liu, Jun Jiang, Peng Jia, Dong Liu, Gang Li
Clin Exp Pediatr. 2024;67(8):405-414.   Published online July 23, 2024
Question: Is there a reliable model to predict intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD)?
Finding: We constructed 5 machine learning models to predict IVIG-resistant KD. Extreme gradient boosting (XGBoost) model was superior to logistic, support vector machine, light gradient boosting machine and multiple layers perception models. The SHAP (SHapley Additive exPlanations) value interpreted the contribution of each feature in XGBoost model.
Meaning: XGBoost model showed the excellent performance to predict IVIG-resistant KD with explainable and visualizable machine learning algorithm.
Review Article
General Pediatrics
Motor performance of children with attention deficit hyperactivity disorder: focus on the Bruininks-Oseretsky Test of Motor Proficiency
Khushboo Prashant Adhvaryu, Suruliraj Karthikbabu, Pratiksha Tilak Rao
Clin Exp Pediatr. 2022;65(11):512-520.   Published online February 17, 2022
· Children with attention deficit hyperactivity disorder (ADHD) tend to have impaired motor performance that may affect their growth and development.
· Although widely used among children with developmental disorders, the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) is used sparsely among children with ADHD.
· Assessment by the BOTMP increases our understanding of the motor repertoire of children with ADHD.
· Wider usage of the BOTMP will enable more comprehensive planning of rehabilitation goals to enhance the motor abilities of children with ADHD.
Oncology
Application of 3-dimensional printing implants for bone tumors
Jong Woong Park, Hyun Guy Kang
Clin Exp Pediatr. 2022;65(10):476-482.   Published online December 23, 2021
∙ The application of 3-dimensional (3D) printing in orthopedic oncology is summarized into bone and tumor modeling, patient-specific instruments (PSIs), custom-made implants, and tissue engineering.
∙ The 3D-printed customized implant is the most central application, while modeling and PSI often play adjunct roles.
∙ Short-term surgical outcomes of custom-made 3D-printed implants are promising.
Case Report
Urinary bladder rupture during voiding cystourethrography
Kyong Ok Lee, Se Jin Park, Jae Il Shin, Suk Young Lee, Kee Hyuck Kim
Clin Exp Pediatr. 2012;55(5):181-184.   Published online May 21, 2012

Voiding cystourethrography (VCUG) is a commonly performed diagnostic procedure for the evaluation of vesicoureteral reflux with urinary tract infection or congenital renal diseases in children. The procedure is relatively simple and cost-effective, and complications are very rare. The iatrogenic complication of VCUG range from discomfort, urinary tract infection to bacteremia, as well as bladder rupture. Bladder rupture is a rare...

Review Article
Urinary incontinence
Jung Won Lee
Clin Exp Pediatr. 2008;51(11):1136-1139.   Published online November 15, 2008
The genitourinary tract and gastrointestinal system are interdependent but share the same embryological origin, pelvic region, and sacral innervation. Although children with voiding disturbances often present with bowel dysfunction, this coexistence was considered coincidental until recently. However, it is now accepted that dysfunction in emptying of both systems is interrelated. Afferent impulses carrying sensory information are transmitted through the spinal...
Original Article
Expression of Nerve Growth Factor during Urinary Bladder Development
Kyoung Eun Lee, Chang Hee Hong, Hee Jung Kang, Dug Ha Kim
Clin Exp Pediatr. 2005;48(4):411-415.   Published online April 15, 2005
Purpose : This study was performed to determine the developmental expression pattern of nerve growth factor(NGF) in the urine of healthy children. It was hypothesized that NGF may contribute to the development of the spinobulbospinal micturition reflex that represents the adult micturition pattern. Methods : Voided urine was collected in 60 healthy children during the first 5 years of life(0-1 month,...
Manifestation of Coronary Artery Lesions after Immunoglobulin Re-treatment in Initial Immunoglobulin-resistant Kawasaki Disease
Hyo Jung Suk, In Sung Kim, Jo Won Jung
Clin Exp Pediatr. 2004;47(4):424-429.   Published online April 15, 2004
Purpose : To evaluate the predictable factors for why initial intravenous immune globulin(IVIG) therapy failed and the outcome of coronary lesions after additional IVIG retreated in initial IVIG- resistant Kawasaki disease(KD). Methods : Retrospective studies were performed on 284 cases of KD treated with one episode of high-dose IVIG and 63 cases with additional IVIG retreatment at this hospital from January...
Ultrasonographic Bladder Parameters for Successful Suprapubic Bladder Aspiration
Sung Chul Baek, Hoe Kyoung Koo, Cheol Hong Kim, Kyung Bum Kim, Hyun Hee Lee, Byung Min Choi, Kee Hwan Yoo, Young Suk Hong, Dong Gwan Han
Clin Exp Pediatr. 2004;47(2):187-192.   Published online February 15, 2004
Purpose : Suprapubic bladder aspiration(SBA) is a widely accepted method of obtaining sterile urine for culture in neonates but has a relatively low success rate and a few serious complications during SBA procedure. To improve the chance of obtaining urine, we determined the ultrasonographic bladder parameters(diameters and volume) to confirm that the bladder is adequately distended for successful aspiration of...
Case Report
A Case of Neonatal Urinary Ascites due to Bladder Perforation Treated with Urinary Drainage
Heng-Mi Kim, Su-Hee Kwak, Sung-Kwang Jung, Sang-Kwon Lee
Clin Exp Pediatr. 2001;44(8):948-953.   Published online August 15, 2001
Urinary ascites in newborns is a rare event that usually is associated with posterior urethral valves and other obstructing anomalies of the genitourinary tract. A case of neonatal urinary ascites without genitourinary tract abnormalities is reported. This premature male neonate was treated by artificial ventilation due to respiratory distress syndrome. The umbilical artery catheter was placed without difficulties and functioned...
A Case of Hinman Syndrome Successfully Treated by Non-Surgical Measures
Won Seoung Lee, Chang Weon Oh, Ki Bok Kim
Clin Exp Pediatr. 1999;42(5):722-727.   Published online May 15, 1999
Hinman syndrome is a condition caused by an incoordination between the detrusor and external urethral sphincter during bladder contraction. Manifestations include day-and-night wetting, residual urine, infected urine, vesicoureteral reflux, christmas-tree shaped bladder-wall change, and upper tract damage without neurologic lesion or anatomical obstruction. Recently, this incoordination was postulated to be due to over-compensation of the external sphincter which compensates the...
A Case of Ceftriaxone-induced Pseudocholelithiasis
Hong Kwon Kim, Jeong Ho Kim, Kyung Mo Kim, Chong Hyun Yoon
Clin Exp Pediatr. 1998;41(6):841-843.   Published online June 15, 1998
Ceftriaxone, a third-generation cephalosporin, is a very potent, broad spectrum antibiotic commonly used in patients with meningitis, osteomyelitis, pyelonephritis, Lyme disease and many other severe infectious diseases. Up to 46% of those receiving this antibiotic develop gallbladder sludge. Most of them are asymptomatic, but a small proportion may develop right upper quadrant pain, nausea, vomiting and even cholecystitis. We report...
Original Article
Clinical Study and Availability of Ultrasonography in Hemorrhagic Cystitis
Jin Park, Chi Hyung Park, Chong Woo Bae, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn, Young Tae Ko, Sun Wha Lee
Clin Exp Pediatr. 1992;35(12):1722-1727.   Published online December 15, 1992
Acute hemorrhagic cystitis characterized by gross hematuria and symptoms of bladder irritation occurs in children as a self-limited disease that must be differentiated from serious renal disease. We analyzed 22 cases of hemorrhagic cystitis which were managed in the Dept. of pediatrics, Kyung Hee university hospital and present the availability of bladder sonography for diagnosis of hemorrhagic cystitis and for follow-up. The...
Screening of urinary Tract Infection in High-Risk Neonates
Hyeon Joo Choi, Seung Joo Lee
Clin Exp Pediatr. 1992;35(12):1683-1679.   Published online December 15, 1992
Since the urinary tract infection (UTI) in neonates is often associated with major urologic anomalies, early diagnosis is essential. In the screening of UTI by urine bag, contamination is a commonly encountered problem. Suprapubic bladder puncture has therefore been recommended as the best method to confirm UTI. The purpose of this study is to assess the frequency and characteristics of...
Case Report
A Case of Addison's Dlisease
Baek Gil Lee, Hyang Sook Lee, Il Kyung Kim, Ho Sung, Chang Hee Choi
Clin Exp Pediatr. 1992;35(7):989-994.   Published online July 15, 1992
A 14-year-old Korean boy with Addison's disease probably of tuberculosis origin is presented with a brief review of the literature. The patient was admitted to our hospital on July, 23th, 1990, because of dark brown pigmentation of the skin, mucous membrane and nail beds. On physical examination, he was moderately developed, relatively poorly nourished. Skin and mucous membranes were diffusely dark brown,...
Original Article
A case of Addison's disease.
Cheol Hee Hwang, Dong Kui Lee, Myung Sug Nam, Mun Ki Cho
Clin Exp Pediatr. 1991;34(8):1169-1174.   Published online August 31, 1991
Addison’s disease is a rare disorder resulting from progressive adrenocortical destruction regardless of the nature of underlying process. A 5-year-old boy with Addison’s disease without other endocrine disorder presented with a brief review of the literature. The patient was admitted to out hospital because of poor appetite and generalized darkish brown pigmentation of skin and mucous membrane. On physical examination, skin and mucous membrane were...
A Case of Addison's Disease.
In Hoon Lee, H. D. Lee, Hee Ju Jeon, Chan Yung Kim
Clin Exp Pediatr. 1988;31(12):1689-1695.   Published online December 31, 1988
A 9-year-old girl with Addison’s disease without other endocrine disorder presented with a brief review of the literature. The patient was transferee! to our hospital because of darkish brown pigmentation of whole body and generalized weakness which had misunderstood cyanotic heart disease. On physical examination, she was poorly nourished and below 10 percentile in weight and height. Skin and mucous membrane were diffusely darkish brown,...
A Case of Typhoid Fever Complicated with Empyema of Gall Bladder.
Sang Ho Choi, Jae You Choi, Byung Hak Lim, Im Ju Kang, Sang Yun Kim
Clin Exp Pediatr. 1988;31(3):386-390.   Published online March 31, 1988
The relative prominece of certain clinical manifestations in persons infected with salmonella forms the basis for designation of several clinical syndromes: enterocolitis (gastroenteritis), enteric fever, bacteremia, localized infection, and the chronic enteric or urinary carrier state. Enteric fever is clinical syndrome produced classically by S. typhi and also at times by S. paratyphi A, S. schottmuel- leri (formerly paratyphi B), and S. hirschfeldii (formerly...
Abdominal Ultrasonographic Findings in Patients with Kawasaki Disease.
Ho Taek Kim, Chang Ho Hong, Chul Lee, Sung Kyu Lee, Pyung Kil Kim, Ki Kun Oh
Clin Exp Pediatr. 1988;31(3):348-354.   Published online March 31, 1988
Kawasaki disease, first reported in Korea in 1973, is now one of the disease commonly encountered in pediatric age group. It presents systemic symptoms including abdominal ones such as pain, nausea and vomiting, etc. There have been several case reports of hydrops of the gallbladder occuring concurrently with Kawasaki disease, and the abdominal symptoms of the disease are known to correlate with hydrops of...
A Case of Kawasaki Disease Compicated by Hydrops of Gallbladder.
Jung Sik Rhim, Chul Joo Lyu, Ki Sup Chung
Clin Exp Pediatr. 1988;31(1):124-127.   Published online January 31, 1988
The authors experienced a case of Kawasaki disease complicated by hydrops of the gallbladder in a 3-year old male patient. The main clinical features were colicky abdominal pain, vomiting, jaundice, fever and a palpable tender mass in RUQ in conjunction with the characteristic clinical manifestation of Kawasaki disease. The clinical diagnosis was confirmed by ultrasonography, and the patient was recovered by conserva- tive management without...
A Case of Mucocutaneous Lymph Node Syndrome Complicated by Aseptic Meningitis, Hydrops of the Gallbladeder and Dilatation of the Coronary Arteries.
Ho Jin Lee, Sung Sook Cho, Hyung Sik Moon, Hong Kue Lee, Soon Il Lee, Young Seok Lee
Clin Exp Pediatr. 1987;30(11):1259-1264.   Published online November 30, 1987
We experienced 1 case of mucocutaneous lymph node syndrome complicated by aseptic meningitis, hydrops of the gallbladder and dilatation of the coronary arteries in 2 year 8 month old female infant. Her clinical synptoms, laboratory data and clinical courses were presented with brief review of the literatures. This baby admitted because of high fever and vomiting for 6 days. She had injection of...
Neurological Assessment of Children with Learning Disable, Studying Disable, Studying Special Class at Primary School.
Chang Jun Coe
Clin Exp Pediatr. 1986;29(5):510-516.   Published online May 31, 1986
1) Neurological assessment has been done in children with learning disorders, who are rological problems. The high incidence of neurologic defect is thought that those children are not purely child with learning disorder but many of them are handicapped children as well as mentally retarded ones. Neurological problems they manifested are organic brain dysfunction, children with severe psychological roblem, attention...
Case Report
A Case of Gastroenteritis Complicated with Empyema of Gall Bladder Caused by Salmonella Serogroup B.
Dong Soo Kim, Ki Sup Chung, Dong Shik Chin, Seung Hoon Choi, Eui Ho Hwang
Clin Exp Pediatr. 1986;29(2):221-224.   Published online February 28, 1986
There are four main groups of clinical manifestations in salmonellosis, gastroenteritis。 enteric fever, localized infection, and chronic carrier state, that may occur individually, simultaneously or consecutively in the course of an infection. The authors experienced a case of salmonella gastroenteritis complicated with empyema of gall bladder in a 12-year-old male patient. The clinical diagnosis was confirmed on the operating table and...
Sonography in the Diagnosis and Management of Hydrops of the Gallbladder in Childern with Mucocutaneous Lymph Node Syndrome.
Byung Lyul Lee, Byung Hwan Lee, Kwang Chan Doh, Sung Il Ahn
Clin Exp Pediatr. 1982;25(6):633-637.   Published online June 30, 1982
Acute hydrops of the gallbladder is described in one patient who had mucocutaneous lymph node syndrome. During the course of her illness, acute addominal pain, vomiting and right upper guadrant tenderness were developed. Diagnosis was readily made with ultrasonography, and the patient was followed with this te-chnique. We managed her conventionally without surgical intervention. The galbladder returned to normal size...
Mucocutaneous Lymph Node Syndrome: Report of one case complicated by gallbladder hydrops and diagnosed by ultrasound.
Chul Ho Lee, Sung Won Park, Chang Soo Han, Soon Jai Lee, Yeun Ki Kim
Clin Exp Pediatr. 1981;24(9):877-881.   Published online September 15, 1981
A female patient with mucocutaneous lymph node syndrome is presented. During the course of her illness, she developed acute abdominal pain secondary to hydrops of gallbladder. The diagnosis was facilltated by ultrasound. We managed her conventionally without surgical intervention. It is interesting that the age of patients complicated by gallbladder hydrops is high compared with the age frequency of MCLS....