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Original Article
Comparison between Pathologically and Clinically Diagnosed Group of Acute Postinfectious Glomerulonephritis
Chul Hong Kim, Su Yung Kim
Clin Exp Pediatr. 1999;42(12):1696-1701.   Published online December 15, 1999
Purpose : Postinfectious acute glomerulonephritis usually needs no renal biopsy. But atypical clinical course and laboratory results indicate a need for renal biopsy. Therefore, to investigate clinicopathological characteristics of postinfectious acute glomerulonephritis, we compared clinical manifestations of biopsy group with those of non-biopsy group. Methods : We reviewed the records of clinical and pathological data of 20 cases diagnosed by...
Clinical Evaluation of Diagnostic Criteria for Early Prediction of Bacterial Infection in Febrile Neonates
Jai Il Cho, Sang Chun Lee, Hwan Il Kim, Cheol Am Kim, Kil Seo Kim
Clin Exp Pediatr. 1999;42(12):1661-1667.   Published online December 15, 1999
Purpose : A retrospective study was undertaken to test the hypothesis that febrile neonates, who have bacterial infections, can be accurately predicted early by diagnostic criteria. Methods : We conducted a retrospective study of 152 infants, 28 days or less of age, whose rectal temperature was at least 38℃. Past history, family history, finding on physical examinations and results of CBC,...
Case Report
Dapsone in a Case with Chronic Recurrent Henoch-Schönlein Purpura
Jin Choi, Soo Jung Lee, Dae Kyun Koh
Clin Exp Pediatr. 1999;42(11):1574-1578.   Published online November 15, 1999
The most clearly delineated condition with prominent cutaneous leukocytoclastic vasculitis which presents to a pediatrician is Henoch-Schönlein purpura. There is general agreement that in Henoch-Schönlein syndrome the skin manifestations have a very benign long-term course and that corticosteroids are of little value. Dapsone appears to be of special value in diseases characterized by an accumulation of polymorphonuclear neutrophils notably leukocytoclastic...
A Case of Bilateral Perineal Ectopic Testes Treated with Hormone Therapy and Orchiopexy
Jae Hyoun Kim, Hung Min Park, Woo Gun Lee, Sung Kwang Chung, Cheol Woo Ko
Clin Exp Pediatr. 1999;42(10):1464-1466.   Published online October 15, 1999
Follow up of a Case of Primary Intestinal Lymphangiectasia
Su Jeong Ha, Soo Jung Lee, Dae Kyun Koh
Clin Exp Pediatr. 1999;42(10):1452-1458.   Published online October 15, 1999
Primary intestinal lymphangiectasia is a rare congenital disorder characterized by diffuse or localized ectasia of the enteric lymphatics, often in association with lymphatic abnormalities elsewhere in the body. The pathogenesis of these abnormal lymphatic structures is uncertain. Ectatic lymphatics may be located in the mucosa, submucosa, or subserosa, leading to a loss of protein and lymphocytes into the gut or...
Original Article
Gastrointestinal Disease in Children with Iron Deficiency Anemia
Yong Joo Kim, Sung Kyun Park, Ho Joon Lim, Hahang Lee
Clin Exp Pediatr. 1999;42(5):697-703.   Published online May 15, 1999
Purpose : The authors performed this study to find out the associated GI disease and H. pylori infection in children with iron-deficiency anemia(IDA). Methods : Twenty-six children older than 2 years with IDA and no history of insufficient iron intake were investigated from 1994 to 1998. Gastrofiberoscopic examination and biopsy and rapid urease test were performed with serum H. pylori IgG....
Clinical Profiles and Anatomic Classification of Intestinal Malrotation
Jung A Kim, Jae Seong Ko, Jeong Kee Seo, Kwi Won Park, Woo Sun Kim, In One Kim
Clin Exp Pediatr. 1999;42(4):526-534.   Published online April 15, 1999
Purpose : Intestinal malrotation is a developmental anomaly and may be complicated by volvulus and intestinal necrosis. We performed anatomic classification and compared clinical profiles to understand their relationship. Methods : Twenty-eight children were diagnosed as intestinal malrotation at Seoul National University Children's Hospital between Jan. 1980 to Dec. 1995. The patients were classified into 4 groups by age at...
Clinical Observations of Coarctation of the Aorta
Hui Jung Cho, Chang Ho Ha, Dong Seok Lee, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1999;42(4):519-525.   Published online April 15, 1999
Purpose : Due to controveries surrounding in the incidence of coarctation of aorta which reports previously stated rare among Orientals, we evaluated clinical characteristics, natural courses of coarctation of aorta and effects of different surgical modalities. Methods : Medical records of 51 patients with coarctation of aorta, diagnosed by 2-dimensional echocardiography in Kyungpook University Hospital Pediatric Cardiac Laboratory from June 1985...
Treatment Outcomes in Children with High-Risk Acute Lymphoblastic Leukemia
Kyu Chang Park, Ho Joon Im, Sang Yun Ahn, Hahng Lee
Clin Exp Pediatr. 1999;42(3):383-389.   Published online March 15, 1999
Purpose : The survival rate of those with acute lymphoblastic leukemia(ALL) has been affected by several prognostic factors and previous reports show that a 4-year event-free survival(EFS) for high-risk(HR) group(Age≥10 years and/or WBC≥50,000/mm3 at diagnosis) was approximately 64%. We analyzed treatment outcomes and risk factors in HR-ALL. Methods : Medical records of 27 patients with HR-ALL diagnosed between May, 1985 and...
Clinical Significance of CD7 Expression in Acute Myelocytic Leukemia
Gye Jin Yoon, Pill Sang Jang, Young Choi, Jun A Lee, Hyo Jung Han, Hyoung Soo Choi, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1999;42(3):374-382.   Published online March 15, 1999
Purpose : It has been shown that a considerable number of acute myeloid leukemia(AML) patients had both myeloid and lymphoid antigens. CD7 is a lymphoid antigen, often expressed in AML cells. We investigated 40 AML patients to clarify the relationship between the cellular characteristics and clinical features. Methods : We reviewed 8 CD7 positive(CD7＋) AML patients and 32 CD7 negative(CD7－)...
Case Report
A Case of Allergic Bronchopulmonary Aspergillosis During Childhood
Kyoung Ah Ha, Chang Keun Kim, Churl Young Chung, Jung Sook Kim
Clin Exp Pediatr. 1999;42(2):284-288.   Published online February 15, 1999
Allergic bronchopulmonary aspergillosis(ABPA) is an inflammatory disease which causes a hypersensitivity to Aspergillus spores growing in the bronchi. The clinical syndrome is characterized by asthma, recurrent pulmonary infiltrations or mucoid impaction, eosinophilia, and central bronchiectasis. A 12-year-old boy was admitted to our hospital because of right lower chest pain and cystic mass-like shadows on a chest X-ray film. He had...
A Case of Acute Myeloblastic Leukemia Transformed from Transient Myeloproliferative Disorder with Down Syndrome
Jae Eun Lee, Seung Woo Baeck, Wan Seob Kim, Chun Hee Lee
Clin Exp Pediatr. 1999;42(1):128-132.   Published online January 15, 1999
Individuals with Down syndrome have a high incidence of hematologic diseases such as transient myeloproliferative disorder(TMD) & acute leukemia. Because it is difficult to distinguish TMD from acute myeloblastic leukemia, the diagnosis in neonate, who have Down syndrome, should be made with extreme caution. TMD usually undergoes spontaneous remission within a few months, but acute leukemia can develope after remission...
Original Article
Changing Social Background Pattern of Children in Adoption Institutions(the 4th Report)
Hye Jeong Kim, Jin A Son, Jae Youn Kim, Don Hee Ahn
Clin Exp Pediatr. 1999;42(1):115-121.   Published online January 15, 1999
Purpose : A study was undertaken to assess the social background of abandoning children at adoption institutions. The results were compared to those of three previous reports from the institution. Methods : A total of 536 children who had been admitted to the institution during the period of 1993 to 1996 were subjected to the study. The medical records were...
Clinical Study of Multiple Intestinal Ulcerations and Perforations Caused by Methicillin-Resistant Staphylococcus aureus in Infants
Seok Joo Han, Poong Man Jung, Jai-Eok Kim, Jeong Hong, Hoguen Kim, Inwha Seong, Eui Ho Hwang
Clin Exp Pediatr. 1999;42(1):77-87.   Published online January 15, 1999
Purpose : In recent years, the authors experienced a distinctive clinical entity of multiple intestinal ulcerations and perforations in infants. The purpose of this study was to describe the clinical characteristics of this entity, examine th possible pathogenesis and the effective treatment. Methods : Seven infants underwent abdominal exploration under suspicion of surgical abdomen and were noted to have multiple intestinal...
Microdeletion of Chromosome 7 in Williams Syndrome and Supravalvular Aortic Stenosis
Ho Sung Kim, Yoon Sung Kang, Kyung Hyo Kim, Young Mi Hong, Yong Soo Yun, Kwang Ho Lee
Clin Exp Pediatr. 1999;42(1):47-59.   Published online January 15, 1999
Purpose : Williams syndrome is characterized by supravalvular aortic stenosis, mental retardation and peculiar facial appearance. Its genetic etiology is considered to be a hemizygotic deletion in Chromosome 7q11.23, which includes the elastin gene. We examined the hemizygotic deletion of Chromosome 7q11.23 in 12 Korean Williams syndrome patients and 8 patients with isolated supravalvular aortic stenosis and performed deletion mapping...
Longterm Follow-up of Autosomal Recessive Polycystic Kidney Disease
June Huh, Il Soo Ha, Hae Il Cheong, Jeong Kee Seo, Yong Choi
Clin Exp Pediatr. 1998;41(12):1693-1699.   Published online December 15, 1998
Purpose : This study was aimed to assess the clinical manifestations and courses of autosomal recessive polycystic kidney disease(ARPKD). Methods : The medical records of 10 children diagnosed as infantile or juvenile ARPKD at Seoul National University Children's Hospital between January, 1984 and December, 1996, were reviewed, retrospectively. Results : The average age at diagnosis was 3 8/12 years(4months-7 3/12 years)...
Anogenital Index of Normal Children and Its Clinical Significance in Children with Constipation
Kyung Rye Moon
Clin Exp Pediatr. 1998;41(12):1669-1674.   Published online December 15, 1998
Purpose : The purpose of this study was to find an objective criteria to determine the position of normal anus in Korean children and to evaluate the clinical significance of anterior displacement of anus in children with constipation. Methods : Three hundred and thirty-nine normal children and 24 children with idiopathic constipation represented the basis of this study. The position of the normal anus...
A Clinical Study of Histiocytosis Syndrome
Jong Jin Kim, Jae Kook Cha, Kon Hee Lee, Jong Young Park
Clin Exp Pediatr. 1998;41(11):1575-1582.   Published online November 15, 1998
Case Report
A Case of Ectopic Pancreas with Malrotation
Il Song Kang, Kil Soo Chung, Jae Kook Cha, Kon Hee Lee, Kwan Seop Lee, Byung Chun Kim, Eun Sook Nam
Clin Exp Pediatr. 1998;41(10):1438-1441.   Published online October 15, 1998
Ectopic pancreas is defined as pancreatic tissue lacking anatomical and vascular continuity with the main body of the pancreas. Common symptoms are epigastric pain, hemorrhage, chest pain, weight loss, nausea and vomiting. A 2-month-old male patient was hospitalized because of continuous bile stained vomiting for 2 days. Abdominal ultrasonography and colon study showed malrotation of the intestine. Surgical exploration revealed...
A Case of Inappropriate ADH Secretion Secondary to Vinblastine Therapy
Eun-Hye Park, Hyun-Sang Cho, Hae-Sook Yoo, Chuhl-Joo Lyu, Chang-Hyun Yang, Kir-Young Kim
Clin Exp Pediatr. 1998;41(10):1430-1432.   Published online October 15, 1998
Inappropriate secretion of antidiuretic hormone(ADH) secondary to vincristine therapy has been reported frequently. But there has been five previous reports of vinblastine associated SIADH in the world and in 4 reports, bleomycin and cis-platinum were used along with vinblastine together. Because penetration of vinka alkaloids into CSF of humans is known to be poor, it has been suggested that lowering...
A Case of Congenital Self-Healing Reticulohistiocytosis
Taek Sun Kim, Chang Wan Kim, Eun Ryoung Kim, You Mee Kang, Kye Yong Song
Clin Exp Pediatr. 1998;41(10):1424-1429.   Published online October 15, 1998
Congenital self-healing reticulohistiocytosis(CSHR) is a rare variant of cutaneous reticulohistiocytosis. We report a newborn who had about 25 reddish brown papulonodular lesions on whole body at birth. No extracutaneous involvement was found. All skin lesions involuted within 4 months spontaneously. Biopsy of a skin lesion showed marked aggregated histiocytic infiltration with some eosinophils. S-100 protein and lysozyme were positive. Electron...
Original Article
Thyroid Hormone Concentrations in Preterm Infants
Sung Keun Moon, Jeong Nyun Kim, Mi Jung Park, Myung Jae Choi, Chrul Young Chung
Clin Exp Pediatr. 1998;41(10):1324-1328.   Published online October 15, 1998
Purpose : To establish reference ranges for thyroid hormone concentrations in premature infants, we measured T4 and thyroid stimulating hormone(TSH) concentrations and analyzed the relation to gestational age and birth weight. Methods : Serum T4 and TSH concentrations were measured by radioimmunoassay for 391 premature infants born in Sanggye Paik Hospital for two years and eight months. Results : Gestational age of...
Case Report
A Case of Congenital Intestinal Lymphangiectasia
Pan Joo Lim, Jae Ock Park, Dong Hwan Lee, Sang Mann Shin, Dong Won Ki
Clin Exp Pediatr. 1998;41(9):1293-1298.   Published online September 15, 1998
Intestinal lymphangiectasia is a primary or secondary disorder of lymphatics which is associated with protein-losing enteropathy, hypoalbuminemia, edema, abdominal distension and growth failure. The patients with this disease lose albumin, immunoglobulins, and lymphocytes through the bowel. We have experienced one case of intestinal lymphangiectasia in 8 month-old boy, whose chief complaint was abdominal distension and watery diarrhea. He had hypoalbuminemia(1.7gm/dl)....
Original Article
Correlation Between Clinical and Pathological Prognositic Factors of IgA Nephropathy in Children
Hwang Jae Yoo, Bon Su Ku, Young Tak Lim, Su Yung Kim
Clin Exp Pediatr. 1998;41(8):1093-1101.   Published online August 15, 1998
Purpose : Clinical and pathological prognostic factors of idiopathic IgA nephropathy have been reported, but mostly in adults and a few in children. Especially studies about correlation between those factors are very rare. Methods : We studied 58 children patients who were hospitalized to our clinics and diagnosed as IgA nephropathy by renal biopsy from Jan. 1989 to Jun 1996. They...
Case Report
A Case of Neonatal Hyperthyroidism with Unilateral Ear Anomaly
Kwang Ok Chung, Na Yeon Kim, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(6):845-849.   Published online June 15, 1998
Neonatal hyperthyroidism is a very rare disorder occurring typically in the offspring of patients with Graves' disease or chronic thyroiditis. It is caused by the transplacental passage of thyroid stimulating antibodies(TSAb) from the mother to the fetus. There has been few reports of neonatal hyperthyroidism associated with congenital anomalies. We experienced a case of neonatal hyperthyroidism with unilateral microtia and agenesis of external auditory canal...
Original Article
Immunomodulation Therapy in Aplastic Anemia : Relapse Rate, Complications and Long-term Survival During Follow-up for More than 1 Year
Jun Ah Lee, Hyoung Jin Kang, Hyo Jeong Han, Hyoung Soo Choi, Eun Sun Yoo, Hee Young Shin, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(6):775-784.   Published online June 15, 1998
Purpose : We evaluated the response to immunomodulation therapy, long-term survival and relapse rate of aplastic anemia during follow-up for more than 1 year. Methods : Twenty-eight children, with moderate to severe aplastic anemia were followed for more than one year and 7 children expired after therapy, were analyzed. Antilymphocyte globulin(ALG) or antithymocyte globulin(ATG) by itself was given to 27 patients, and cyclosporine A(CsA)...
A Clinical Study of Survival Rate and Prognostic Factors in Advanced Neurobalstoma in Children
Seung Yang, Ho Joon Im, Nam Su Kim, Hahng Lee
Clin Exp Pediatr. 1998;41(5):684-694.   Published online May 15, 1998
Purpose : Despite the use of improved therapeutic modalities, long-term survival remains poor in patients in stage Ⅲ or Ⅳ of neurobalstoma and for over 1 year olds at diagnosis. We evaluated the long-term survival rate and related prognostic factors in advanced neuroblastoma. Methods : Twenty-nine children diagnosed with stage Ⅲ or Ⅳ neuroblastoma after 1 year of age, between May...
Etiological Analysis of Gynecomastia in Children
Jai Keun Kim, Ki Keun Oh, Choon Sik Yoon, Jae Hyun Park
Clin Exp Pediatr. 1998;41(2):224-229.   Published online February 15, 1998
Purpose : The purpose of this study is to analyze the etiology of gynecomastia confirmed by breast operation among children under the age of 15 exhibiting clinical symptoms. Methods : Twenty patients under the age of 15 were diagnosed as having gynecomastia in the past 10 years. The number of pathologically confirmed gynecomastia patients was 15. The causes or related...
Serum Pepsinogen Ⅰ, Ⅱ Levels and Upper Gastrointestinal Diseases in Children with H. pylori Infection
Je Woo Kim, Ki Sup Chung
Clin Exp Pediatr. 1998;41(2):200-208.   Published online February 15, 1998
Purpose : In H. pylori infection serum pepsinogen Ⅰ/Ⅱ ratio decreases and pepsinogen Ⅱ level is increased. Increased serum pepsinogen Ⅱ level correlates with pathologic severity of gastritis. We assayed serum pepsinogen Ⅰ, Ⅱ levels and pepsinogen Ⅰ/Ⅱ ratio to evaluate the relationship between the serum pepsinogen level and upper gastrointestinal diseases. Methods : One hundred and sixty-five children who had...
A Result of Treatment of Malignant Germ Cell Tumors in Childhood
Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
Clin Exp Pediatr. 1997;40(12):1707-1718.   Published online December 15, 1997
Purpose : Germ cell tumors have variable clinical characteristics according to the age, sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the clinical characteristics, response to the treatment, and prognostic factors were analyzed. Methods : Medical records of 57 children who were diagnosed as malignant germ cell tumor in Seoul National University Children' s Hospital from January 1986 till June 1996 were...
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