Journal of the Korean Pediatric Society 1998;41(2):224-229.
Published online February 15, 1998.
Etiological Analysis of Gynecomastia in Children
Jai Keun Kim1, Ki Keun Oh1, Choon Sik Yoon1, Jae Hyun Park2
1Department of Diagnostic Radiology Yonsei University Medical College, Seoul, Korea
2Department of Pediatrics, Yonsei University Medical, College, Seoul, Korea
소아에서 발생한 여성화유방의 원인별 분석
김재근1, 오기근1, 윤춘식1, 박재현2
1연세대학교 의과대학 진단방사선과학교실
2연세대학교 의과대학 소아과학교실
Correspondence: 
Ki Keun Oh, Email: 1
Abstract
Purpose
: The purpose of this study is to analyze the etiology of gynecomastia confirmed by breast operation among children under the age of 15 exhibiting clinical symptoms.
Methods
: Twenty patients under the age of 15 were diagnosed as having gynecomastia in the past 10 years. The number of pathologically confirmed gynecomastia patients was 15. The causes or related diseases were examined. Various clinical manifestations and radiological findings related to gynecomastia were evaluated.
Results
: Of 20 pediatric patients diagnosed as having gynecomastia, 8 cases were pubertal or idiopathic gynecomastia, but 12 cases(60%) had underlying causes. The 12 cases had an etiology, 6 cases were related to abnormal sexual differentiation, 4 cases were drug-induced, and 2 cases were obesity-related. Of the 4 drug-related cases, the past history of long-term medication of anti- tuberculous drug, INH, was present in 3 cases and thiazide in one case. In the group related to abnormal sexual differentiation, pseudohermaphroditism was found in 3 cases and Reifenstein SD, Maffucci SD, and Klinefelter SD was found in each case.
Conclusion
: Although it is known that most gynecomastia is either idiopathic or puberty-related, we were able to discover etiologic agents such as drugs, obesity, and abnormal sexual differentiation in 60% of the children under 15 of age years old. Therefore, in children with gynecomastia, the presence of any congenital diseases should be searched carefully, and the underlying cause of gynecomastia should be thoroughly searched for.
Key Words: Gynecomastia, Children


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