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Original Article
Correlaton between soluble transferrin receptor concentration and inflammatory markers
So Young Kim, Meong Hi Son, Jung suk Yeom, Ji sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2009;52(4):435-440.   Published online April 15, 2009
Purpose : The concentration of soluble transferrin receptor (sTfR) is estimated as an iron parameter to evaluate erythropoiesis and iron status. The aim of our study is to evaluate the correlation between sTfR concentration and inflammatory parameters and to distinguish iron deficiency anemia from anemia of inflammation. Methods : One hundred and forty-four infants younger than two years of age who...
Factors affecting the contamination of bag urine culture in febrile children under two years
Wook Hyun Choi, In Seok Lim
Clin Exp Pediatr. 2009;52(3):346-350.   Published online March 15, 2009
Purpose : Since children under two years with suspected urinary tract infections (UTIs) cannot control urination, urine cultures in such children are usually performed via urine bags. This method is noninvasive but has a high contamination rate. We studied the contamination rate of bag urine culture in diagnosing UTI in infants under two years and the factors responsible for contamination. Methods...
Short-term clinical outcomes of late preterm infants
Ji Youn Na, Narimi Park, Eun Sun Kim, Jin-A Lee, Gyu Hong Shim, Jin-A Lee, Chang Won Choi, Ee-Kyung Kim, Han-Suk Kim, Beyong Il Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2009;52(3):303-309.   Published online March 15, 2009
Purpose : To identify the short-term clinical outcomes of late preterm infants and to test the hypothesis that late preterm infants have more clinical problems during the early postnatal period than term infants. Methods : One hundred late preterm infants [gestational age (GA) 34+0-36+6 weeks] and the same number of term infants (GA 37+0-41+6 weeks) were randomly selected from 289 late...
Gastrointestinal surgery in very low birth weight infants : Clinical characteristics
Ji Eun Kim, Hye Soo Yoo, Hea Eun Kim, Soo Kyoung Park, Yoo Jin Jeong, Seo Heui Choi,, Hyun Joo Seo, Yun Sil Chang, Jeong Meen Seo, Won Soon Park, Suk Koo Lee
Clin Exp Pediatr. 2009;52(3):295-302.   Published online March 15, 2009
Purpose : To report our experience of gastrointestinal (GI) operations (OP) performed in very low birth weight infants (VLBWI) and to evaluate their clinical characteristics. Methods : Among the 1,117 VLBWI admitted to the SMC neonatal intensive care unit from November 1994 to February 2007, the medical records of 37 infants who underwent GI OP (except inguinal hernia OP) and 1,080...
The association between serum IGF-1 and neonatal growth and disease in a NICU
Jung Ok Kim, Hae Ri Lim, Heng Mi Kim
Clin Exp Pediatr. 2009;52(2):176-180.   Published online February 15, 2009
Purpose : The objective of this study was to establish the serum IGF-1 level in newborn infants, and investigate its association with growth and diseases. Methods : In a retrospective study, serum IGF-1 levels were measured for newborn infants admitted to NICU at Kyungpook University Hospital from March 2007 to July 2007. Birth data, disease history, and hospital course were...
Review Article
Neurodevelopmental outcomes of very low birth weight infants and extremely low birth weight infants in Korea, 1984-2008
In Kyung Sung
Clin Exp Pediatr. 2009;52(1):14-21.   Published online January 15, 2009
Neurodevelopmental outcomes of very low birth weight infants (VLBWI) and extremely low birth weight infants (ELBWI) in Korea on 14 reports from 1984 to 2008 were analyzed. Follow-up rates were varied from 42.9% to 90.2%. Duration of follow-up ranged from 4 months to 5 years. The prevalence of cerebral palsy (CP) of VLBWI was as follows: 4.3-5.3% in 1980s, 7.1-9.1...
Case Report
A case of herpes zoster in a 4-month-old infant
Ji Hyun Kim, Jung Ju Lee, Sin Weon Yun, Soo Ahn Chae, In Seok Lim, Dong Keun Lee, Eung Sang Choi, Byoung Hoon Yoo
Clin Exp Pediatr. 2008;51(12):1368-1371.   Published online December 15, 2008
Herpes zoster in infancy is very rare but can be developed following intrauterine or postnatal exposure to varicella zoster virus. We report a case of herpes zoster in a 4-month-old male infant. He had no prior history of primary varicella or varicella vaccination. His mother had no history of varicella infection and no contact history with varicella during pregnancy. He...
Original Article
Epidemiologic study of Kawasaki disease in 6 months old and younger infants
Yong Won Park, Ji Whan Han, In Sook Park, Chang Hwi Kim, Sung Ho Cha, Jae Sook Ma, Joon Sung Lee, Tae Chan Kwon, Sang Bum Lee, Chul Ho Kim, Heung Jae Lee, Yong Soo Yun
Clin Exp Pediatr. 2008;51(12):1320-1323.   Published online December 15, 2008
Purpose : The aim of this study was to investigate the epidemiologic status of Kawasaki disease (KD) in infants ≤6 months of age. Methods : For the epidemiologic study of KD in Korea, data from 22,674 KD patients were collected from 1997 to 2005 on a 3-year basis by a retrospective survey. From this survey, data of 1,739 KD patients ≤6...
Periventricular leukomalacia induced by in utero clamping of pregnant rat aorta in fetal rats
Yun Sil Chang, Dong Kyung Sung, Saem Kang, Soo Kyung Park, Yu Jin Jung, Hyun Joo Seo, Seo Heui Choi, Won Soon Park
Clin Exp Pediatr. 2008;51(8):874-878.   Published online August 15, 2008
Purpose : This study was undertaken to develop an animal model of periventricular leukomalacia (PVL) induced by in utero clamping of pregnant rat aorta in fetal rats. Methods : A timed pregnanct Sprague-Dawley rat on embryonic day 21 just prior to delivery was sedated and anesthetized, and a Harvard ventilator for small animals was applied. Following laparotomy, the maternal aorta was...
A comparative study on iron deficiency anemia based on feeding patterns of nine-month-old infants
Hyun Jin Yun, Eun Jeong Choi, Eun Jin Choi, Su Young Hong
Clin Exp Pediatr. 2008;51(8):820-826.   Published online August 15, 2008
Purpose : This study was conducted to evaluate the red cell indices and frequency of iron deficiency anemia based on the feeding patterns of nine-month-old infants. Methods : Blood tests were performed on 253 nine-month-old infants, who visited Il Sin Christian Hospital for health check- ups from January to December 2007. Their parents answered telephonic questions regarding their feeding patterns...
Relationship between cord blood level of IL-12 in preterm newborns and development of wheezing
Hyo Jung Yu, Eun Ae Park, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye Sook Park, Eun Hee Ha
Clin Exp Pediatr. 2008;51(7):754-759.   Published online July 15, 2008
Purpose : Abnormal activation patterns of Th1/Th2-cells have been suggested to increase the prevalence of allergic diseases. Prevention is regarded as an important corner stone in the management of allergic diseases. In this study, we have investigated the relationship between cord blood levels of IL-4, IL-10, and IL-12 in preterm newborns and the development of allergic respiratory diseases in infancy Methods...
Growth and clinical efficacy of fortified human milk and premature formula on very low birth weight infants
Heewon Chueh, Myo Jing Kim, Young-A Lee, Jin-A Jung
Clin Exp Pediatr. 2008;51(7):704-712.   Published online July 15, 2008
Purpose : A prospective, controlled trial was conducted to evaluate growth, efficacy, safety and nutritional status for very low birth weight infants fed with human milk fortified with Maeil human milk fortifier (Maeil HMF ; Maeil Dairies Co., Ltd.). Methods : We enrolled 45 premature infants with a birth weight <1,500 g and gestational age <33 weeks, who were born at...
Case Report
A case of Menkes disease with unusual hepatomegaly
Go Un Jeong, Anna Cho, Hee Hwang, Yong Seung Hwang, Ki Joong Kim, Jong Hee Chae, Jeong Kee Seo
Clin Exp Pediatr. 2008;51(5):538-541.   Published online May 15, 2008
Menkes disease is an X-linked recessive copper transport disorder characterized by neurological deterioration, connective- tissue damage, and abnormal hair growth. It is caused by the mutation of the ATP7A gene. This report describes a four- month-old boy with neurological symptoms typical of Menkes disease plus unusual liver involvement. He developed seizures at three months of age and exhibited hypotonia, cephalhematoma,...
Review Article
Trends in survival rate for very low birth weight infants and extremely low birth weight infants in Korea, 1967-2007
Ki-Soo Kim, Chung-Woo Bae
Clin Exp Pediatr. 2008;51(3):237-242.   Published online March 15, 2008
To investigate the trends in the survival rate (SR) for very low birth weight infants (VLBW) and extremely low birth weight infants (ELBWI) in Korea, a total of 43 articles pertaining to SR were analyzed, covering the years from 1967 to 2007. The changes in SR were compared using 5 year periods. The SR for VLBWI has increased remarkably, from...
Changes in birth rates of low birth weight and premature infants in Korea over the past 7 years
Min Hee Kim
Clin Exp Pediatr. 2008;51(3):233-236.   Published online March 15, 2008
In recent years, Korea has experienced a steadily declining birth rate, which is a serious social problem in the country. Although living conditions have improved, the birth rates for low birth weight infants and preterm babies has increased because more and more women choose to give birth later in life and the social environment has changed. The rise in low...
Overview of the national health screening program for infant and children
Baik-Lin Eun, Seong Woo Kim, Young Key Kim, Jung Wook Kim, Jin Soo Moon, Su Kyung Park, In Kyung Sung, Son Moon Shin, Sun Mi Yoo, So Hee Eun, Hea Kyoung Lee, Hyun Taek Lim, Hee Jung Chung
Clin Exp Pediatr. 2008;51(3):225-232.   Published online March 15, 2008
The mission of National Health Screening Program for Infant and Children is to promote and improve the health, education, and well-being of infants, children, families, and communities. Although the term 'diagnosis' usually relates to pathology, a similar diagnostic approach applies to the child seen primarily for health supervision. In the case of health, diagnosis determines the selection of appropriate health...
Case Report
Small bowel obstruction caused by an anomalous congenital band in an infant
Tae-Jung Sung, Ji-Woong Cho
Clin Exp Pediatr. 2008;51(2):219-221.   Published online February 15, 2008
Intestinal obstruction is not uncommon in infants. The common causes of intestinal obstruction in the neonatal period are Hirschsprung disease, intestinal atresia, meconium ileus, and intussusception. However, small bowel obstruction caused by a congenital band is very rare. We report a 27-day-old baby who was admitted with abdominal distension and fever. The abdominal X-ray revealed massive bowel dilatation and the...
Original Article
A case of neonatal amoebiasis with after-birth vomiting and bloody stool
Jimin Kahng, So-Young Kim
Clin Exp Pediatr. 2007;50(12):1257-1260.   Published online December 15, 2007
E. histolytica has a simple life cycle with two stages: an infective cyst and an invasive trophozoite. It lives on humans as its host. Its infection occurs through the ingestion of the cyst form, and the disease begins when the trophozoite, converted at the small intestine, adheres to colonic epithelial cells with a latent period of two days to four...
Improved survival rate with decreased neurodevelopmental disability in extreme immaturity
Ga Won Jeon, Myo Jing Kim, Sung Shin Kim, Jae Won Shim, Yun Sil Chang, Won Soon Park, Mun Hyang Lee
Clin Exp Pediatr. 2007;50(11):1067-1071.   Published online November 15, 2007
Purpose : The aim of this study was to determine whether improved survival of extremely low birth weight infants (ELBWI) was associated with decreased neurodevelopmental disability later in life, and also to identify the factors influencing this disability. Methods : ELBWI admitted to the neonatal intensive care unit of Samsung Medical Center, survived, and followed up until the corrected age...
Case Report
A case of pulmonary thromboembolism in a healthy infant
Woo-Yeon Choi, Young-Seok Choi, Soo-Min Oh, Young-Kuk Cho, Jae-Sook Ma
Clin Exp Pediatr. 2007;50(10):1030-1033.   Published online October 15, 2007
A pulmonary thromboembolism (PTE), which is a sudden blockage in a pulmonary artery, usually due to a blood clot, is rare in children. The clinical presentation is often subtle or masked by the underlying clinical condition and the condition must be suspected during clinical testing. Although the choice of treatment depends on the clinical presentation, anticoagulation is the mainstay of...
Original Article
Factors influencing birth weight premature infants
Ji A Aum, Hee Jin Jung, Jae Won Huh, Su Young Hong
Clin Exp Pediatr. 2007;50(10):954-958.   Published online October 15, 2007
Purpose : The purpose of this study was to identify factors influencing premature infants who are small for their gestational ago. Methods : The medical records of 1,010 premature infants of 26 to 35 weeks of gestational age born at Il-Sin Christian Hospital, Busan from January 2000 to August 2006 were reviewed. We collected data on gestational age, birth weight, infant...
Platelet count and mean platelet volume in low birth weight infants (≤2,000 g) with sepsis
Wan-soo Lee, Jin-young Cho, Seung-taek Yoo, Chang-woo Lee, Doo-young Choi, Jong-duck Kim, Yeon-kyun Oh
Clin Exp Pediatr. 2007;50(7):643-648.   Published online July 15, 2007
Purpose : Sepsis is a common complication in Neonatal Intensive Care Units (NICU), seen especially in low birth weight (LBW) infants. A recent study showed that fungal or gram-negative sepsis is associated with a greater degree of thrombocytopenia than is seen with gram-positive sepsis. So, this study was undertaken to examine the platelet counts and platelet indices in LBW infants...
Fluconazole prophylaxis in high-risk, very low birth weight infants
Soo Young Kim, Soon Joo Lee, Mi Jeong Kim, Eun Song Song, Young Youn Choi
Clin Exp Pediatr. 2007;50(7):636-642.   Published online July 15, 2007
Purpose : Fluconazole prophylaxis for very low birth weight (VLBW) infants has been shown to reduce invasive fungal infection and its mortality. This study aims to evaluate the effect of fluconazole prophylaxis in VLBW infants on the incidence and mortality of fungal infection. Methods : VLBW infants with endotracheal intubation and central vascular access admitted to the Neonatal Intensive Care...
The factors associated with the efficacy of indomethacin treatment in premature infants with patent ductus arteriosus
Min Jeong Yoon, Hye Sun Yoon, Sung Hoon Chung, Mi Young Han, Chong Woo Bae
Clin Exp Pediatr. 2007;50(6):531-535.   Published online June 15, 2007
Purpose : Indomethacin treatment is successful in about 90% of patent ductus arteriosus (PDA) in premature infants, but in some, repeated administration or surgical closure is required. The object of the present study is to determine the factors affecting the efficacy of indomethacin treatment and to predict the treatment result. Method : The 29 preterm neonates, admitted to neonatal intensive...
The immunogenicity and safety of three-component DTaP vaccine in Korean infants
Jin Han Kang, Jong Hyun Kim, Jung Hyun Lee, Soo Young Lee, Young Jin Hong, Chang Hwi Kim
Clin Exp Pediatr. 2007;50(4):355-362.   Published online April 15, 2007
Purpose : We conducted the study to evaluate the immunogenicity and safety of three component DTaP vaccine (Infanrix ) in a group of Korean healthy infants on a three-dose primary vaccination. And we compared the immunogenicity of this DTaP vaccine with two component DTaP vaccine which has been widely used in Korea. Methods : We enrolled one hundred fifty one healthy...
High-resolution computed tomography findings of lung parenchyme changes in very low birth weight infants treated with oxygen
Young Man Jin, David Chanwook Chung, Young Pyo Chang, Yung Suk Lee, En Sun Lee
Clin Exp Pediatr. 2007;50(3):255-261.   Published online March 15, 2007
Purpose : The objective of this study is to observe high-resolution computed tomography (HRCT) findings of lung parenchyme in very low birth weight (VLBW) infants between the corrected age of 38-42 weeks who were treated with oxygen after birth, and to compare them to the clinical severity of bronchopulmonary dysplasia (BPD). Methods : The lungs of fourty-four VLBW infants with gestational...
Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia
Jee Yoon Park,, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye sook Park, Eun Hee Ha, Eun Ae Park
Clin Exp Pediatr. 2007;50(3):248-254.   Published online March 15, 2007
Purpose : Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood of preterm newborns with RDS or BPD. Methods : Forty preterm newborns whose mothers received antenatal care at Ewha Womans University Mokdong Hospital between January 2003 to June 2005, and...
The auditory evoked potential in premature small for gestational age infants
Il Hong Moon, Kee Soo Ha, Gui Sang Kim, Byung Min Choi, Baik-Lin Eun, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee
Clin Exp Pediatr. 2006;49(12):1308-1314.   Published online December 15, 2006
Purpose : This study aimed to evaluate the usefulness of auditory evoked potential (AEP) in clarifying neuronal development in premature small for gestational age (SGA), and appropriate for gestational age (AGA) infants. Methods : A total of 183 premature infants who were born from August 2002 to July 2005, were examined with AEP. They were divided into three groups; AGA, symmetric-SGA...
Diagnostic classification and clinical aspects of floppy infants in the neonatal and pediatric intensive care units
Eun Sun Kim, Kyung Eun Jung, Sang Duk Kim, Eo Kyung Kim, Jong Hee Chae, Han Suk Kim, June Dong Park, Ki Joong Kim, Beyong Il Kim, Yong Seung Hwang, Jung-Hwan Choi
Clin Exp Pediatr. 2006;49(11):1158-1166.   Published online November 15, 2006
Purpose : The purpose of this study is to make a diagnostic classification and discuss a diagnostic strategy of floppy infants by investigating clinical, neurological, electrophysiological, and genetic analysis of infants admitted to intensive care units with the complaint of hypotonia. Methods : A retrospective study was performed from Jan. 1993 to Dec. 2005 in neonatal and pediatric intensive care units...
Comparison of total parenteral nutrition-associated cholestasis according to amino acid mixtures in very low birth weight infants
Jin-Sung Choi, Yun-Jin Bae, Young Ah Lee
Clin Exp Pediatr. 2006;49(9):972-976.   Published online September 15, 2006
Purpose : The purpose of this study was to evaluate the effect of amino acid mixtures on incidence and severity of total parenteral nutrition associated-cholestasis(PNAC) in very low birth weight infants. Methods : Retrospective review of 63 very low birth weight infants(birth weight ≤1,500 g) who received total parenteral nutrition(TPN) in our neonatal intensive care unit from January 2000 to...


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