Korean Journal of Pediatrics 2009;52(4):435-440.
Published online April 15, 2009.
Correlaton between soluble transferrin receptor concentration and inflammatory markers
So Young Kim, Meong Hi Son, Jung suk Yeom, Ji sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Department of Pediatrics, Gyeongsang National University School of Medicine, Jinju, Korea
수용성 트랜스페린 수용체의 농도와 염증 인자와의 관련성에 관한 연구
김소영, 손명희, 염정숙, 박지숙, 박은실, 서지현, 임재영, 박찬후, 우향옥, 윤희상
경상대학교 의학전문대학원 소아과학교실
Correspondence: 
Eun Sil Park, Email: espark@gsnu.ac.kr
Abstract
Purpose
: The concentration of soluble transferrin receptor (sTfR) is estimated as an iron parameter to evaluate erythropoiesis and iron status. The aim of our study is to evaluate the correlation between sTfR concentration and inflammatory parameters and to distinguish iron deficiency anemia from anemia of inflammation.
Methods
: One hundred and forty-four infants younger than two years of age who visited Gyeongsang University Hospital for 7 years from 2000 to 2006 were enrolled. Patients who had hemoglobin (Hb) <11 g/dL and ferritin <12 mg/L were excluded. Routine hematologic lab, serum ferritin, sTfR, and inflammatory markers [C-reactive protein(CRP), interleukin-6(IL-6), and absolute neutrophil count (ANC)] were investigated.
Results
: In all patients, the sTfR concentration showed a correlation with Hb, ferritin, MCV, and ANC, but not with CRP and IL-6. In multiple regression models, positive correlations were found between sTfR concentration and IL-6 (r=0.078, P=0.043), and negative correlations were found between sTfR concentration and ANC (r=-0.117, P=0.033) and MCV (r=-0.027, P=0.009).
Conclusion
: sTfR concentration was influenced by inflammatory parameters. Therefore, sTfR does not appear to be a useful parameter for discriminating between iron deficiency anemia and anemia of inflammation in infants.
Key Words: Receptor, Transferrin, Inflammation, Infant


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