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Editorial
Cardiology
Recent research trends in Kawasaki disease-related infection
Hyang-Ok Woo
Clin Exp Pediatr. 2022;65(11):538-539.   Published online July 22, 2022
The incidence of Kawasaki disease has reportedly decreased since the coronavirus disease 2019 (COVID-19) quarantine. However, multisystem inflammatory syndrome in children has reportedly occurred more frequently in areas where COVID-19 was prevalent than in previous years. Research into the etiology of childhood and adolescent systemic vasculitis in infection-related immune responses during the COVID-19 pandemic has increased accordingly.
Review Article
Cardiology
Understanding the importance of cerebrovascular involvement in Kawasaki disease
Jung Sook Yeom, Jae Young Cho, Hyang-Ok Woo
Clin Exp Pediatr. 2019;62(9):334-339.   Published online May 16, 2019
Kawasaki disease (KD) is a systemic vasculitis in infants and young children. However, its natural history has not been fully elucidated because the first case was reported in the late 1960s and patients who have recovered are just now entering middle age. Nevertheless, much evidence has raised concerns regarding the subclinical vascular changes that occur in post-KD patients. KD research...
Editorial
Predictive risk factors of coronary artery aneurysms in Kawasaki disease
Hyang-Ok Woo
Clin Exp Pediatr. 2019;62(4):124-125.   Published online February 19, 2019
Case Report
Neurology
Mild encephalopathy with a reversible splenial lesion in a girl with acute pyelonephritis
Jung Sook Yeom, Chung Mo Koo, Ji Sook Park, Ji-Hyun Seo, Eun Sil Park, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2018;61(2):64-67.   Published online February 28, 2018

We report the case of a 12-year-old girl who had mild encephalopathy with a reversible splenial lesion (MERS) associated with acutepyelonephritis caused by Escherichia coli. The patient was admitted with a high fever, and she was diagnosed with acute pyelonephritis based on pyuria and the results of urine culture, which detected cefotaxime-sensitive E. coli. Although intravenous cefotaxime and tobramycin were...

Infection
Distinctive clinical features of HPeV-3 infection in 2 neonates with a sepsis-like illness
Jung Sook Yeom, Ji Sook Park, Ji-Hyun Seo, Eun Sil Park, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Ok Jeong Lee, Tae-Hee Han, Ju-Young Chung
Clin Exp Pediatr. 2016;59(7):308-311.   Published online July 31, 2016

We report a human parechovirus-3 (HPeV-3) infection in 2 neonates who had prolonged fever (>5 days) with palmar-plantar erythema. This distinctive rash was observed 4–5 days after fever onset, just before defervescence. Elevated aspartate aminotransferase, lactate dehydrogenase, and ferritin levels were characteristic laboratory findings in the 2 cases, suggesting tissue damage caused by hypercytokinemia. Case 1 was treated with intravenous...

Original Article
Neurology
Factors associated with mumps meningitis and the possible impact of vaccination
Kyuyol Rhie, Heung-Keun Park, Young-Soo Kim, Jung Sook Yeom, Ji Sook Park, Ji-Hyun Seo, Eun Sil Park, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2016;59(1):24-29.   Published online January 22, 2016
Purpose

Mumps meningitis is a common complication of mumps infection; however, information on mumps meningitis in the postvaccine era is limited. The purpose of the present study was to determine factors associated with mumps meningitis and to discuss the effect of vaccination on this disease.

Methods

We retrospectively reviewed patients younger than 19 years with mumps, diagnosed at a university hospital in Korea...

Case Report
The first pediatric case of tularemia in Korea: manifested with pneumonia and possible infective endocarditis
Jung Sook Yeom, Kyuyol Rhie, Ji Sook Park, Ji-Hyun Seo, Eun Sil Park, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2015;58(10):398-401.   Published online October 21, 2015

Tularemia is a potentially severe zoonotic disease caused by Francisella tularensis. A lack of awareness about tularemia can be embarrassing and could result in delayed treatment because of improper diagnosis. The diagnosis of tularemia is difficult, because the infections are rare and the clinical spectrum is broad. As only 1 adult case has been reported in Korea thus far, pediatricians...

Review Article
Antibiotics resistance of Helicobacter pylori and treatment modalities in children with H. pylori infection
Ji-Hyun Seo, Hyang-Ok Woo, Hee-Shang Youn, Kwang-Ho Rhee
Clin Exp Pediatr. 2014;57(2):67-71.   Published online February 24, 2014

Pediatric infection with Helicobacter pylori may occur early in childhood and persist lifelong. Global pediatric clinical studies have reported a decreasing tendency in the overall rate of H. pylori eradication. In pediatric patients with H. pylori infection, pediatric patients with peptic ulcer, and the first-degree relatives of patients with a history of gastric cancer, it is commonly recommended that H....

Original Article
Orthostatic symptoms does not always manifest during tilt-table test in pediatric postural orthostatic tachycardia syndrome patients
Tae-Eon Huh, Jung Sook Yeom, Young-Soo Kim, Hyang-Ok Woo, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Ki-Jong Park, Hee-Shang Youn
Clin Exp Pediatr. 2013;56(1):32-36.   Published online January 29, 2013
Purpose

Chronic day-to-day symptoms of orthostatic intolerance are the most notable features of postural orthostatic tachycardia syndrome (POTS). However, we have encountered patients with such symptoms and excessive tachycardia but with no symptoms during the tilt-table test (TTT). We aimed to investigate whether POTS patients with chronic orthostatic intolerance always present orthostatic symptoms during the TTT and analyze the factors underlying...

Correlaton between soluble transferrin receptor concentration and inflammatory markers
So Young Kim, Meong Hi Son, Jung suk Yeom, Ji sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2009;52(4):435-440.   Published online April 15, 2009
Purpose : The concentration of soluble transferrin receptor (sTfR) is estimated as an iron parameter to evaluate erythropoiesis and iron status. The aim of our study is to evaluate the correlation between sTfR concentration and inflammatory parameters and to distinguish iron deficiency anemia from anemia of inflammation. Methods : One hundred and forty-four infants younger than two years of age who...
Clinical characteristics of deep neck abscess in children; 15 year experience in a university hospital
Min-Ji Goo, Jeong-Suk Yeom, Eo-Jin Kim, Jung-Je Park, Ji-Hyun Seo, Eun-Sil Park, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2007;50(7):649-654.   Published online July 15, 2007
Purpose : The objective of this study was to clarify the presentation, associated preceding illness, pathologic organisms, treatment and outcome of deep neck abscess in children according to age and location. Methods : We retrospectively reviewed the in-patient charts of children treated at our hospital for deep neck abscess. Thirty-five such patients were identified as having been treated...
Case Report
Two cases of congenital atretic encephalocele misdiagnosed as dermoid cyst
Jae-Hui Kim, Jae-Min Cho, Jin-Myung Jung, Eun-Sil Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2006;49(9):1000-1004.   Published online September 15, 2006
Atretic cephalocele is a degenerative form of encephalocele, which is detected as a cystic mass in the head, primarily in infants. Its presentation and prognosis vary and depend on various factors, including the nature of the tissues within the cyst, other concomitant anomalies, the site of development, and the presence or absence of an embryonic straight sinus. We here report...
A case of true thymic hyperplasia in the mediastinum with ectopic thymus in the neck
Hyun-Jung Kim, Sun-Hwa Jang, Ji-Sook Park, Eun-Sil Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2006;49(9):996-999.   Published online September 15, 2006
True thymic hyperplasia and ectopic thymus are very rare in children. In embryologic aspect, thymus is distributed around cervical area and ends up in mediastinum. This case is simultaneous thymic hyperplasia of neck and mediastinum. Ectopic thymus in the neck and thymic hyperplasia in the mediastinum in children were reported 2 and 7 cases respectively in Korea. In Clinical aspects,...
Original Article
A clinical study on the etiology of parapneumonic effusion in children
Jung-Sook Yeom, Won-Tae Bae, Eun-Sil Park, Ji-Hyun Seo, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2006;49(1):56-63.   Published online January 15, 2006
Purpose : This study was designed to document the etiologies and the characteristics of parapneumonic effusion in children. Methods : During a 17-year period from 1987 to 2004, parapneumonic effusion was confirmed in 86 children at Gyeongsang National University Hospital. The clinical records of these children were reviewed and radiological findings and laboratory data, especially results of thoracentesis, were analyzed retrospectively. Results...
Cause and Prognosis of Pediatric Acute Respiratory Failure by Intrapulmonary Lesion
Hye-Young Lee, Ji-Suk Park, Hee-Ra Choi, Ji-Hyun Seo, Jeum-Su Kim, Jae-Young Lim, Myoung-Bum Choi, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2004;47(5):555-560.   Published online May 15, 2004
Purpose : Respiratory failure arises from derangements in pulmonary gas exchange. The causes may be classified as due to either lung disease or respiratory pump dysfunction. Problems with lung mechanics is an important cause of acute respiratory failure in children clinically. The aims of this study were to survey the cause and prognosis of children diagnosed with acute respiratory failure...
Values of Lung CT in Children with a Vague History of Aspiration
Myoung-Bum Choi, Hyang-Ok Woo, Jum-Su Kim, Ji-Hyoun Seo, Jae-Young Lim, Chan-Hoo Park, Jin-Jong You, Hee-Shang Youn
Clin Exp Pediatr. 2004;47(4):399-404.   Published online April 15, 2004
Purpose : The purpose of this study was to investigate the diagnostic value of spiral computed tomography (CT) using contiguous slices with partially thin sections around the hilar level in the bronchial foreign bodies of children with a vague history of aspiration. Methods : Fourteen children were identified to be examined with spiral CT due to obscure histories of aspiration episodes....
Case Report
A Case of ARCI Syndrome with Hypoplasia of Corpus Callosum and Heart Anomaly
Eo-Jin Kim, Young-Ran Yoon, Min-Hae Lee, Ki-Su Kang, Jae-Young Lim, Myoung-Bum Choi, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2003;46(8):826-830.   Published online August 15, 2003
ARCI syndrome consists of arthrogryposis, renal tubular acidosis, cholestatic jaundice and icthyosis. We experienced an ARCI syndrome case with corpus callosum hypoplasia and atrial septal defect. This case had oral feeding difficulty, multiple joint contracture, renal tubular acidosis and neurogenic muscular atrophy at neonatal period. At two months of age, icthyosis and cholestatic jaundice were diagnosed. The case was hospitalized...
Original Article
Pattern of Occurrence of Mycoplasma pneumoniae Pneumonia in Admitted Children : Southern Central Korea, from 1989 to 2002
Ki Su Kang, Hyang-Ok Woo
Clin Exp Pediatr. 2003;46(5):474-479.   Published online May 15, 2003
Purpose : The determination of exposure and prevalence of Mycoplasma pneumoniae pneumonia of any region should be helpful for clinical diagnosis. We studied the pattern of occurrence of M. pneumoniae pneumonia among children living in southern central Korea during the last 13 years. This area has a relatively small population and less mobility compared with metropolitan areas. Methods : We performed...
Case Report
Monosomy 21 Mosaicism in a Child with Dyserythropoiesis
Jae-Young Lim, Ji-Hyoun Seo, Myoung-Bum Choi, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2003;46(4):397-399.   Published online April 15, 2003
All complete monosomy 21 appear to be lethal early in their development in humans and only survive in mosaic forms. Complete monosomy 21 is a very rare and usually debilitating genetic disorder. Partial monosomy 21 is also rare and is thought to constitute a clinical syndrome consisting of peculiar faces, hypertonia, psychomotor retardation, and slow growth. We experienced a case...
Original Article
Epidemiological Study of Kawasaki Disease in Kyung Nam Area
Jeong Soo Yang, Eun Young Cho, Hae Sung Jung, Ji Young Hwang, Dong-Jin Lee, Eun Suk No, Myoung-Bum Choi, Chan-Hoo Park, Hee-Shang Youn, Hyang-Ok Woo
Clin Exp Pediatr. 2002;45(7):896-901.   Published online July 15, 2002
Purpose : The aim of this study was to determine the epidemiology of Kawasaki disease in the Kyung Nam area and to evaluate whether the results of this epidemiological study could support infectious etiology. Methods : We sent a questionnaire to three training hospitals in the Kyung Nam area and retrospectively reviewed their medical records of Kawasaki disease from Jun....
Detection of Helicobacter pylori by Pre-embedding Immunoelectron Microscopy -Comparison with Immunoblotting Method
Hae-Seoung Jung, Eun-Jung Kim, Eun-A Kim, Ji-Hoe Park, Jin-Su Jun, Ji-Hyoun Seo, Jae-Young Lim, Myoung-Bum Choi, Hyang-Ok Woo, Hee-Shang Youn, Gyung-Hyuck Ko, Seung-Chul Baik, Woo-Kon Lee, Myung-Je Cho, and Kwang-Ho Rhee
Clin Exp Pediatr. 2002;45(7):862-874.   Published online July 15, 2002
Purpose : We tried to evaluate whether the detection rate of Helicobacter pylori in gastric biopsy specimens could be improved by using pre-embedding immunoelectron microscopy. Methods : A total of 119 children who complained of upper gastrointestinal symptoms were endoscoped at the Gyeongsang National University Hospital from July, 1996 to July, 1999. Five biopsy specimens(three for urease test, one for...
Case Report
A Case of Trisomy 22 with Pulmonary Hypoplasia in a Liveborn Infant
Myoung-Bum Choi, Ki Su Kang, Chan-Hoo Park, Hyang-Ok Woo, Jeong-Hee Lee, Jae-Ik Lee, Won Young Paik, Hee-Shang Youn
Clin Exp Pediatr. 2002;45(6):804-808.   Published online June 15, 2002
We report a case of trisomy 22 in a liveborn male infant which was confirmed by fluorescence in situ hybridization(FISH), macrocultures and GTG-banding, and RHA-banding procedures of peripheral white blood cells. The infant showed lung hypoplasia, which is a unique presentation, with other clinical manifestations of previously reported cases of trisomy 22, such as intrauterine growth retardation, cleft palate, micrognathia,...
Original Article
A Review of Endoscopic Removal Methods in 127 Cases of the Esophageal Foreign Bodies
Jum Su Kim, Jung Soo Yang, Hae Sung Jung, Min Hye Lee, Chan-Hoo Park, Myoung Bum Choi, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2002;45(4):459-465.   Published online April 15, 2002
Purpose : The aim of this study was to evaluate the latest tendency of esophageal foreign body's extraction and to obtain a consensus from recent trends of indications and techniques of flexible endoscopy of esophageal FB in children. Methods : We retrospectively reviewed medical records of 127 cases with foreign bodies in esophagus at Dept. of Pediatrics and Otorhinolaryngology, Gyeongsang National...
Case Report
A Mesenteric Lymphangioma Causing Billous Vomiting and Bloody Stool in a 3-day-old Infant
Jeum-Su Kim, Hae-Seoung Jung, Ki Su Kang, Yong-Suk Kim, Chan-Hoo Park, Myoung Bum Choi, Hyang-Ok Woo, Gyung-Hyuck Ko, Hee-Shang Youn
Clin Exp Pediatr. 2001;44(11):1316-1319.   Published online November 15, 2001
Mesenteric lymphangioma, which is rare and often diagnosed incidentally, is a benign tumor in infants and children. Most cases of lymphangioma are in the neck and axilla. About 5% of these lesions are in the mediastinum, mesentery or retroperitoneal region. Although most lymphangioma produce no symptoms, it may present an acute surgical condition suggesting acute intestinal obstruction. We report one...
Nonrhizomelic Type of Chondrodysplasia Punctata Suspected in the Brothers
Jeum-Su Kim, Hae-Seoung Jung, Yong-Suk Kim, Chan-Hoo Park, Myoung Bum Choi, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 2001;44(10):1187-1192.   Published online October 15, 2001
Chondrodysplasia punctata is a heterogenous skeletal dysplasia characterized by small focal calcifications in articular and other cartilages in infancy, with subsequent epiphysial dysplasia and associated anomalies of the face, eyes, and skin. Chondrodysplasia punctata is classified with autosomal recessive rhizomelic type, autosomal dominant nonrhizomelic type(Conradi-Hunermann type), and X-linked dominant type. These types have different clinical manifestations respectively. We report cases...
A Case of Gastric Perforation Presenting with Secondary Localized Peritonitis Due to Bamboo in Stomach
Ji Hyoun Seo, Ji Young Hwang, Ki Su Kang, Chan-Hoo Park, Hyang-Ok Woo, Myoung Bum Choi, Hee-Shang Youn
Clin Exp Pediatr. 2001;44(7):837-840.   Published online July 15, 2001
Perforation after foreign body ingestion is rare. We report a 25-month-old girl who was diagnosed with a stomach perforation with secondary localized peritonitis caused by long, sharp bamboo. On admission, she had abdominal pain and fever. Simple abdominal erect & supine X-ray, abdominal ultrasonogram and computed tomography scan were normal. On the 6 th hospital day, gastrofiberoscopy was performed because...
Original Article
A Clinical Study of Shigellosis Epidemics over 10 Years in the Kyung Nam Area
Ji-Young Hwang, Ji-Hyoun Seo, Su-Jin Lee, Myoung-Bum Choi, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Jung-Hee Kim, Eun-Jung Kim, Chul Kyu Kim, Yang-Suk Jung, Dong-Jin Lee
Clin Exp Pediatr. 2001;44(5):517-522.   Published online May 15, 2001
Purpose : The occurrence of shigellosis patients has increased radically in 2 recent years. For this, the authors investigated the epidemic aspect of shigellosis by regional groups to know whether the epidemic aspect of shigellosis is a general situation which occurs identically in various areas of Kyung Nam. Methods : We reviewed pediatric patients who were hospitalized in Ulsan(eastern), in Masan(central),...
Whole Blood and Plasma Vitamin C Concentrations in Children of 1-6 Years of Age in the Chinju Area
Hyang-Ok Woo, Jin-Su Jun, Ji-Hoe Park, Young-Suk Kim, Eun-A Kim, Jae-Young Lim, Myoung-Bum Choi, Chan-Hoo Park, Hee-Shang Youn, Gyung-Hyuck Ko, Chan-Hoo Park, Woo-Kon Lee, Myung-Je Cho, Kwang-Ho Rhee
Clin Exp Pediatr. 2001;44(5):501-508.   Published online May 15, 2001
Purpose : Vitamin C among antioxidants in human is a physiological antioxidant for protection against diseases. We measured the vitamin C concentrations of whole blood and plasma among children in early childhood at normal condition in order to know the presence of vitamin C deficiency. Methods : The venous blood was collected from 471 subjects at 1-6 years of ages in...
Changes in Incidence of Infantile Transient Methemoglobinemia Associated with Infectious Diarrhea during 1989-1999 in Kyungnam Province
Young Suk Kim, Eun-A Kim, Jae-Young Lim, Myoung-Bum Choi, Chan-Hoo Park, Hyang-Ok Woo, Byung-Kiu Park, Hee-Shang Youn, Yang-Suk Jung, Dong-Jin Lee, Jung Hee Kim, Eun Jeong Kim, Chul Kyu Kim
Clin Exp Pediatr. 2000;43(12):1569-1576.   Published online December 15, 2000
Purpose : Infantile transient methemoglobinemia(ITM) may develop in association with infectious diarrhea without exposure to any toxic oxidizing agents. We observed that the number of ITM associated with infectious diarrhea have increased at the Gyeongsang National University Hospital (GNUH), located in the western area of Kyungnam province during the last 4 years. To determine whether this phenomenon was similarily observed...
Case Report
Two Cases of Bart`s Syndrome in Mother and Daughter
Si-Eun Lee, Yong-Suk Kim, Su-Jin Lee, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Jeong-Hee Lee
Clin Exp Pediatr. 2000;43(2):306-311.   Published online February 15, 2000
We experienced two cases of congenital localized skin defect and neonatal onset of relapsing subepidermal blisters associated with minor trauma in a female newborn infant and her mother. The mother of index case showed toe nail dystrophy at delivery of her daughter, but the index case did not reveal nail dystrophy until 14 months of age. The congenital skin defects...
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